TY  - JOUR
A1  - Mandl, Thomas
A1  - Sinelnikova, Anna
A1  - Östlin, Christofer
A1  - Grånäs, Oscar
A1  - Brodmerkel, Maxim N.
A1  - Markl, Erik G.
A1  - Caleman, Carl
T1  - Reproducibility in the unfolding process of protein induced by an external electric field
T2  - Chemical Science
N2  - The dynamics of proteins are crucial for their function. However, commonly used techniques for studying protein structures are limited in monitoring time-resolved dynamics at high resolution. Combining electric fields with existing techniques to study gas-phase proteins, such as single particle imaging using free-electron lasers and gas-phase small angle X-ray scattering, has the potential to open up a new era in time-resolved studies of gas-phase protein dynamics. Using molecular dynamics simulations, we identify well-defined unfolding pathways of a protein, induced by experimentally achievable external electric fields. Our simulations show that strong electric fields in conjunction with short-pulsed X-ray sources such as free-electron lasers can be a new path for imaging dynamics of gas-phase proteins at high spatial and temporal resolution.
KW  - Reproducibility protein
Y1  - 
UR  - http://opus.technikum-wien.at/frontdoor/index/index/docId/2998
ER  -