@article{MandlSinelnikovaOestlinetal.,
  author    = {Mandl, Thomas and Sinelnikova, Anna and {\"O}stlin, Christofer and Gr{\aa}n{\"a}s, Oscar and Brodmerkel, Maxim N. and Markl, Erik G. and Caleman, Carl},
  title     = {Reproducibility in the unfolding process of protein induced by an external electric field},
  series = {Chemical Science},
  journal   = {Chemical Science},
  abstract  = {The dynamics of proteins are crucial for their function. However, commonly used techniques for studying protein structures are limited in monitoring time-resolved dynamics at high resolution. Combining electric fields with existing techniques to study gas-phase proteins, such as single particle imaging using free-electron lasers and gas-phase small angle X-ray scattering, has the potential to open up a new era in time-resolved studies of gas-phase protein dynamics. Using molecular dynamics simulations, we identify well-defined unfolding pathways of a protein, induced by experimentally achievable external electric fields. Our simulations show that strong electric fields in conjunction with short-pulsed X-ray sources such as free-electron lasers can be a new path for imaging dynamics of gas-phase proteins at high spatial and temporal resolution.},
  subject      = {Reproducibility protein},
  language  = {en}
}