@inproceedings{FrohnerWindischSauermannetal., author = {Frohner, Matthias and Windisch, Michael and Sauermann, Stefan and Sekora, Jiri and Forjan, Mathias}, title = {Organ Telemonitoring in Ex-vivo Nutrition Circulation of Porcine Lungs Using Interoperability Standards}, series = {Proceedings of the 12th IFAC/IEEE International Conference on Programmable Devices and Embedded Systems (PDeS 2013)}, booktitle = {Proceedings of the 12th IFAC/IEEE International Conference on Programmable Devices and Embedded Systems (PDeS 2013)}, pages = {335 -- 340}, subject = {Telemonitoring}, language = {en} } @inproceedings{LenzFrohnerSauermannetal., author = {Lenz, Gregor and Frohner, Matthias and Sauermann, Stefan and Forjan, Mathias}, title = {LUMOR: An App for Standardized Control and Monitoring of a Porcine Lung and its Nutrient Cycle}, series = {Proceedings of eHealth 2014 - Health Informatics Meets Informatics}, booktitle = {Proceedings of eHealth 2014 - Health Informatics Meets Informatics}, subject = {Lung Simulator}, language = {en} } @inproceedings{ForjanFrohner, author = {Forjan, Mathias and Frohner, Matthias}, title = {Development of the mCM - mobile circulatory module - for ex-vivo physiological tissue for breathing simulation}, series = {Abstracts of the 9th World Congress on Alternatives and Animal Use in the Life Sciences (ALTEX Proceedings) 2014}, booktitle = {Abstracts of the 9th World Congress on Alternatives and Animal Use in the Life Sciences (ALTEX Proceedings) 2014}, pages = {52 -- 52}, subject = {Lung Simulator}, language = {en} } @misc{LenzFrohnerSauermannetal., author = {Lenz, Gregor and Frohner, Matthias and Sauermann, Stefan and Forjan, Mathias}, title = {LUMOR: An App for Standardized Control and Monitoring of a Porcine Lung and its Nutrient Cycle}, subject = {Lung Simulator}, language = {en} } @misc{ForjanFrohner, author = {Forjan, Mathias and Frohner, Matthias}, title = {Development of the mCM - mobile circulatory module - for ex-vivo physiological tissue for breathing simulation}, subject = {Lung Simulator}, language = {en} } @misc{PastekaForjan, author = {Pasteka, Richard and Forjan, Mathias}, title = {Evaluation of an Active Lung Simulator for Aerosol Inhalation Test Replacement}, subject = {Lung Simulator}, language = {en} } @inproceedings{SteinerForjanKoppetal., author = {Steiner, Theresa and Forjan, Mathias and Kopp, Tamara and Bures, Zbyn{\^e}k and Drauschke, Andreas}, title = {Enhancements of a mechanical lung simulator for ex vivo measuring of aerosol deposition in lungs}, series = {Proceedings of the 46th annual conference of the German Society for Biomedical Engineering}, booktitle = {Proceedings of the 46th annual conference of the German Society for Biomedical Engineering}, pages = {838 -- 841}, subject = {Lung Simulator}, language = {en} } @article{PastekaForjanSauermannetal., author = {Pasteka, Richard and Forjan, Mathias and Sauermann, Stefan and Drauschke, Andreas}, title = {Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation}, series = {Scientific Reports}, volume = {Vol 9}, journal = {Scientific Reports}, number = {No. 1}, pages = {Article number: 19778}, abstract = {Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap between the complex, real anatomical environment and the safe, cost-effective simulation methods. The presented electro-mechanical lung simulator, xPULM, combines in-silico, ex-vivo and mechanical respiratory approaches by realistically replicating an actively breathing human lung. The reproducibility of sinusoidal breathing simulations with xPULM was verified for selected breathing frequencies (10-18 bpm) and tidal volumes (400-600 ml) physiologically occurring during human breathing at rest. Human lung anatomy was modelled using latex bags and primed porcine lungs. High reproducibility of flow and pressure characteristics was shown by evaluating breathing cycles (nTotal = 3273) with highest standard deviation |3σ| for both, simplified lung equivalents (μV˙ = 23.98 ± 1.04 l/min, μP = -0.78 ± 0.63 hPa) and primed porcine lungs (μV˙ = 18.87 ± 2.49 l/min, μP = -21.13 ± 1.47 hPa). The adaptability of the breathing simulation parameters, coupled with the use of porcine lungs salvaged from a slaughterhouse process, represents an advancement towards anatomically and physiologically realistic modelling of human respiration.}, subject = {Breathing Simulation}, language = {en} }