@misc{HeherTomaschMaleineretal., author = {Heher, Philipp and Tomasch, Janine and Maleiner, Babette and Redl, Heinz and Fuchs, Christiane}, title = {The Importance of Biomechanical Cues for In Vitro Skeletal Myogenesis}, subject = {In Vitro}, language = {en} } @inproceedings{FuchsWeihsSzwarcetal., author = {Fuchs, Christiane and Weihs, Anna and Szwarc, Dorota and Mittermayr, Rainer and R{\"u}nzler, Dominik and Teuschl, Andreas}, title = {Shock wave treatment of muscle (stem) cells - a new implementation for regeneration}, series = {Proceedings of the 20th International Congress of the ISMST}, booktitle = {Proceedings of the 20th International Congress of the ISMST}, subject = {Shockwave treatment}, language = {en} } @misc{FuchsWeihsSzwarcetal., author = {Fuchs, Christiane and Weihs, Anna and Szwarc, Dorota and Mittermayr, Rainer and R{\"u}nzler, Dominik and Teuschl, Andreas}, title = {Shock wave treatment of muscle (stem) cells - a new implementation for regeneration}, subject = {Shockwave treatment}, language = {en} } @misc{TeuschlWeihsFuchsetal., author = {Teuschl, Andreas and Weihs, Anna and Fuchs, Christiane and Monforte Vila, Xavier}, title = {Silk as a versatile biomaterial for musculoskeletal tissue engineering}, subject = {Silk}, language = {en} } @misc{SzwarcFuchsWeihsetal., author = {Szwarc, Dorota and Fuchs, Christiane and Weihs, Anna and R{\"u}nzler, Dominik}, title = {Molecular mechanisms underlying the potential of shock wave treatment for cardiac therapy}, subject = {Shockwave treatment}, language = {en} } @misc{SzwarcFuchsPurtscheretal., author = {Szwarc, Dorota and Fuchs, Christiane and Purtscher, Michaela and R{\"u}nzler, Dominik}, title = {Elucidating the molecular mechanisms underlying cardiac shock wave therapy}, subject = {Shockwave treatment}, language = {en} } @misc{Fuchs, author = {Fuchs, Christiane}, title = {The importance of mechanotransduction in myogenesis}, subject = {Mechanotransduction}, language = {en} } @article{PriglingerSchuhSteffenhagenetal., author = {Priglinger, Eleni and Schuh, Christina and Steffenhagen, Carolin and Wurzer, Christoph and Maier, Julia and N{\"u}rnberger, Sylvia and Holnthoner, Wolfgang and Fuchs, Christiane and Suessner, Susanne and R{\"u}nzler, Dominik and Redl, Heinz and Wolbank, Susanne}, title = {Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy.}, series = {Cytotherapy}, journal = {Cytotherapy}, pages = {1079 -- 1095}, abstract = {BACKGROUND: Cell-based therapies with autologous adipose tissue-derived cells have shown great potential in several clinical studies in the last decades. The majority of these studies have been using the stromal vascular fraction (SVF), a heterogeneous mixture of fibroblasts, lymphocytes, monocytes/macrophages, endothelial cells, endothelial progenitor cells, pericytes and adipose-derived stromal/stem cells (ASC) among others. Although possible clinical applications of autologous adipose tissue-derived cells are manifold, they are limited by insufficient uniformity in cell identity and regenerative potency. METHODS: In our experimental set-up, low-energy extracorporeal shock wave therapy (ESWT) was performed on freshly obtained human adipose tissue and isolated adipose tissue SVF cells aiming to equalize and enhance stem cell properties and functionality. RESULTS: After ESWT on adipose tissue we could achieve higher cellular adenosine triphosphate (ATP) levels compared with ESWT on the isolated SVF as well as the control. ESWT on adipose tissue resulted in a significantly higher expression of single mesenchymal and vascular marker compared with untreated control. Analysis of SVF protein secretome revealed a significant enhancement in insulin-like growth factor (IGF)-1 and placental growth factor (PLGF) after ESWT on adipose tissue. DISCUSSION: Summarizing we could show that ESWT on adipose tissue enhanced the cellular ATP content and modified the expression of single mesenchymal and vascular marker, and thus potentially provides a more regenerative cell population. Because the effectiveness of autologous cell therapy is dependent on the therapeutic potency of the patient's cells, this technology might raise the number of patients eligible for autologous cell transplantation.}, subject = {Shockwave Therapy}, language = {en} }