@article{TomaschMaleinerHeheretal., author = {Tomasch, Janine and Maleiner, Babette and Heher, Philipp and Rufin, Manuel and Andriotis, Orestis G. and Thurner, Philipp J. and Redl, Heinz and Fuchs, Christiane and Teuschl-Woller, Andreas H.}, title = {Changes in Elastic Moduli of Fibrin Hydrogels Within the Myogenic Range Alter Behavior of Murine C2C12 and Human C25 Myoblasts Differently}, series = {Froniers in Bioengineering and Biotechnology}, volume = {10}, journal = {Froniers in Bioengineering and Biotechnology}, pages = {836520}, abstract = {Fibrin hydrogels have proven highly suitable scaffold materials for skeletal muscle tissue engineering in the past. Certain parameters of those types of scaffolds, however, greatly affect cellular mechanobiology and therefore the myogenic outcome. The aim of this study was to identify the influence of apparent elastic properties of fibrin scaffolds in 2D and 3D on myoblasts and evaluate if those effects differ between murine and human cells. Therefore, myoblasts were cultured on fibrin-coated multiwell plates ("2D") or embedded in fibrin hydrogels ("3D") with different elastic moduli. Firstly, we established an almost linear correlation between hydrogels' fibrinogen concentrations and apparent elastic moduli in the range of 7.5 mg/ml to 30 mg/ml fibrinogen (corresponds to a range of 7.7-30.9 kPa). The effects of fibrin hydrogel elastic modulus on myoblast proliferation changed depending on culture type (2D vs 3D) with an inhibitory effect at higher fibrinogen concentrations in 3D gels and vice versa in 2D. The opposite effect was evident in differentiating myoblasts as shown by gene expression analysis of myogenesis marker genes and altered myotube morphology. Furthermore, culture in a 3D environment slowed down proliferation compared to 2D, with a significantly more pronounced effect on human myoblasts. Differentiation potential was also substantially impaired upon incorporation into 3D gels in human, but not in murine, myoblasts. With this study, we gained further insight in the influence of apparent elastic modulus and culture type on cellular behavior and myogenic outcome of skeletal muscle tissue engineering approaches. Furthermore, the results highlight the need to adapt parameters of 3D culture setups established for murine cells when applied to human cells.}, subject = {Tissue Engineering}, language = {en} } @misc{HeherTomaschMaleineretal., author = {Heher, Philipp and Tomasch, Janine and Maleiner, Babette and Redl, Heinz and Fuchs, Christiane}, title = {The Importance of Biomechanical Cues for In Vitro Skeletal Myogenesis}, subject = {In Vitro}, language = {en} } @article{SchuhHeherWeihsetal., author = {Schuh, Christina and Heher, Philipp and Weihs, Anna and Fuchs, Christiane and Gabriel, Christian and Wolbank, Susanne and Mittermayr, Rainer and Redl, Heinz and R{\"u}nzler, Dominik and Teuschl, Andreas}, title = {In vitro extracorporeal shock wave treatment enhances stemness and preserves multipotency of rat and human adipose-derived stem cells}, series = {Journal of Cytotherapy}, journal = {Journal of Cytotherapy}, subject = {Shockwave}, language = {en} } @article{DeiningerWagnerHeimeletal., author = {Deininger, Christian and Wagner, Andrea and Heimel, Patrick and Salzer, Elias and Monforte Vila, Xavier and Weißenbacher, Nadja and Grillari, Johannes and Redl, Heinz and Wichlas, Florian and Freude, Thomas and Tempfer, Herbert and Teuschl-Woller, Andreas and Traweger, Andreas}, title = {Enhanced BMP-2-Mediated Bone Repair Using an Anisotropic Silk Fibroin Scaffold Coated with Bone-like Apatite}, series = {Int. J. Mol. Sci.}, volume = {23}, journal = {Int. J. Mol. Sci.}, number = {1 / 283}, abstract = {The repair of large bone defects remains challenging and often requires graft material due to limited availability of autologous bone. In clinical settings, collagen sponges loaded with excessive amounts of bone morphogenetic protein 2 (rhBMP-2) are occasionally used for the treatment of bone non-unions, increasing the risk of adverse events. Therefore, strategies to reduce rhBMP-2 dosage are desirable. Silk scaffolds show great promise due to their favorable biocompatibility and their utility for various biofabrication methods. For this study, we generated silk scaffolds with axially aligned pores, which were subsequently treated with 10× simulated body fluid (SBF) to generate an apatitic calcium phosphate coating. Using a rat femoral critical sized defect model (CSD) we evaluated if the resulting scaffold allows the reduction of BMP-2 dosage to promote efficient bone repair by providing appropriate guidance cues. Highly porous, anisotropic silk scaffolds were produced, demonstrating good cytocompatibility in vitro and treatment with 10× SBF resulted in efficient surface coating. In vivo, the coated silk scaffolds loaded with a low dose of rhBMP-2 demonstrated significantly improved bone regeneration when compared to the unmineralized scaffold. Overall, our findings show that this simple and cost-efficient technique yields scaffolds that enhance rhBMP-2 mediated bone healing.}, subject = {Tissue Engineering}, language = {en} } @article{FarokhiAleemardaniSolouketal., author = {Farokhi, Maryam and Aleemardani, Mina and Solouk, Atefeh and Mirzadeh, Hamid and Teuschl, Andreas Herbert and Redl, Heinz}, title = {Crosslinking strategies for silk fibroin hydrogels: promising biomedical materials}, series = {Biomedical Materials}, volume = {16}, journal = {Biomedical Materials}, number = {2}, pages = {022004}, abstract = {Due to their strong biomimetic potential, silk fibroin (SF) hydrogels are impressive candidates for tissue engineering, due to their tunable mechanical properties, biocompatibility, low immunotoxicity, controllable biodegradability, and a remarkable capacity for biomaterial modification and the realization of a specific molecular structure. The fundamental chemical and physical structure of SF allows its structure to be altered using various crosslinking strategies. The established crosslinking methods enable the formation of three-dimensional (3D) networks under physiological conditions. There are different chemical and physical crosslinking mechanisms available for the generation of SF hydrogels (SFHs). These methods, either chemical or physical, change the structure of SF and improve its mechanical stability, although each method has its advantages and disadvantages. While chemical crosslinking agents guarantee the mechanical strength of SFH through the generation of covalent bonds, they could cause some toxicity, and their usage is not compatible with a cell-friendly technology. On the other hand, physical crosslinking approaches have been implemented in the absence of chemical solvents by the induction of β-sheet conformation in the SF structure. Unfortunately, it is not easy to control the shape and properties of SFHs when using this method. The current review discusses the different crosslinking mechanisms of SFH in detail, in order to support the development of engineered SFHs for biomedical applications.}, subject = {Tissue Engineering}, language = {en} } @article{SchandaKeiblHeimeletal., author = {Schanda, Jakob and Keibl, Claudia and Heimel, Patrick and Monforte, Xavier and Feichtinger, Xaver and Teuschl, Andreas and Baierl, Andreas and Muschitz, Christian and Redl, Heinz and Fialka, Christian and Mittermayr, Rainer}, title = {Zoledronic Acid Substantially Improves Bone Microarchitecture and Biomechanical Properties After Rotator Cuff Repair in a Rodent Chronic Defect Model}, series = {Am J Sports Med}, volume = {2020 Jul}, journal = {Am J Sports Med}, number = {48 (9)}, pages = {2151 -- 2160}, abstract = {Background: Bone mineral density at the humeral head is reduced in patients with chronic rotator cuff tears. Bone loss in the humeral head is associated with repair failure after rotator cuff reconstruction. Bisphosphonates (eg, zoledronic acid) increase bone mineral density. Hypothesis: Zoledronic acid improves bone mineral density of the humeral head and biomechanical properties of the enthesis after reconstruction of chronic rotator cuff tears in rats. Study design: Controlled laboratory study. Methods: A total of 32 male Sprague-Dawley rats underwent unilateral (left) supraspinatus tenotomy with delayed transosseous rotator cuff reconstruction after 3 weeks. All rats were sacrificed 8 weeks after rotator cuff repair. Animals were randomly assigned to 1 of 2 groups. At 1 day after rotator cuff reconstruction, the intervention group was treated with a single subcutaneous dose of zoledronic acid at 100 µg/kg bodyweight, and the control group received 1 mL of subcutaneous saline solution. In 12 animals of each group, micro-computed tomography scans of both shoulders were performed as well as biomechanical testing of the supraspinatus enthesis of both sides. In 4 animals of each group, histological analyses were conducted. Results: In the intervention group, bone volume fraction (bone volume/total volume [BV/TV]) of the operated side was higher at the lateral humeral head (P = .005) and the medial humeral head (P = .010) compared with the control group. Trabecular number on the operated side was higher at the lateral humeral head (P = .004) and the medial humeral head (P = .001) in the intervention group. Maximum load to failure rates on the operated side were higher in the intervention group (P < .001). Cortical thickness positively correlated with higher maximum load to failure rates in the intervention group (r = 0.69; P = .026). Histological assessment revealed increased bone formation in the intervention group. Conclusion: Single-dose therapy of zoledronic acid provided an improvement of bone microarchitecture at the humeral head as well as an increase of maximum load to failure rates after transosseous reconstruction of chronic rotator cuff lesions in rats. Clinical relevance: Zoledronic acid improves bone microarchitecture as well as biomechanical properties after reconstruction of chronic rotator cuff tears in rodents. These results need to be verified in clinical investigations.}, subject = {Tissue Engineering}, language = {en} } @article{BachmannSpitzSchaedletal., author = {Bachmann, Barbara and Spitz, Sarah and Sch{\"a}dl, Barbara and Teuschl, Andreas and Redl, Heinz and N{\"u}rnberger, Sylvia and Ertl, Peter}, title = {Stiffness Matters: Fine-Tuned Hydrogel Elasticity Alters Chondrogenic Redifferentiation}, series = {Froniers in Bioengineering and Biotechnology}, volume = {2020}, journal = {Froniers in Bioengineering and Biotechnology}, number = {8}, pages = {373}, abstract = {Biomechanical cues such as shear stress, stretching, compression, and matrix elasticity are vital in the establishment of next generation physiological in vitro tissue models. Matrix elasticity, for instance, is known to guide stem cell differentiation, influence healing processes and modulate extracellular matrix (ECM) deposition needed for tissue development and maintenance. To better understand the biomechanical effect of matrix elasticity on the formation of articular cartilage analogs in vitro, this study aims at assessing the redifferentiation capacity of primary human chondrocytes in three different hydrogel matrices of predefined matrix elasticities. The hydrogel elasticities were chosen to represent a broad spectrum of tissue stiffness ranging from very soft tissues with a Young's modulus of 1 kPa up to elasticities of 30 kPa, representative of the perichondral-space. In addition, the interplay of matrix elasticity and transforming growth factor beta-3 (TGF-β3) on the redifferentiation of primary human articular chondrocytes was studied by analyzing both qualitative (viability, morphology, histology) and quantitative (RT-qPCR, sGAG, DNA) parameters, crucial to the chondrotypic phenotype. Results show that fibrin hydrogels of 30 kPa Young's modulus best guide chondrocyte redifferentiation resulting in a native-like morphology as well as induces the synthesis of physiologic ECM constituents such as glycosaminoglycans (sGAG) and collagen type II. This comprehensive study sheds light onto the mechanobiological impact of matrix elasticity on formation and maintenance of articular cartilage and thus represents a major step toward meeting the need for advanced in vitro tissue models to study both re- and degeneration of articular cartilage.}, subject = {Tissue Engineering}, language = {en} } @article{FeichtingerMonforteKeibletal., author = {Feichtinger, Xaver and Monforte, Xavier and Keibl, Claudia and Hercher, David and Schanda, Jakob and Teuschl, Andreas and Muschitz, Christian and Redl, Heinz and Fialka, Christian and Mittermayr, Rainer}, title = {Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears.}, series = {American Journal of Sports Medicine}, journal = {American Journal of Sports Medicine}, subject = {Shockwave Therapy}, language = {en} } @article{TeuschlTanglHeimeletal., author = {Teuschl, Andreas and Tangl, Stefan and Heimel, Patrick and Schwarze, Uwe Yacine and Monforte, Xavier and Redl, Heinz and Nau, Thomas}, title = {Osteointegration of a Novel Silk Fiber-Based ACL Scaffold by Formation of a Ligament-Bone Interface.}, series = {American Journal of Sports Medicine}, journal = {American Journal of Sports Medicine}, subject = {Tissue Engineering}, language = {en} } @misc{TeuschlSchuhWeihsetal., author = {Teuschl, Andreas and Schuh, Christina and Weihs, Anna and Guillaume, Olivier and Monforte Vila, Xavier and Redl, Heinz and Kaplan, David and R{\"u}nzler, Dominik}, title = {Tailoring bioactivity of silk-based biomaterials via delivering and functionalization strategies with fibrinogen/thrombin, plant lectins or laminin}, subject = {Biomaterials}, language = {en} } @article{SlezakSlezakHartingeretal., author = {Slezak, Paul and Slezak, Cyrill and Hartinger, Joachim and Teuschl, Andreas and N{\"u}rnberger, Sylvia and Redl, Heinz and Mittermayr, Rainer}, title = {A Low Cost Implantation Model in the Rat That Allows a Spatial Assessment of Angiogenesis.}, series = {Frontiers in Bioengineering and Biotechnology}, journal = {Frontiers in Bioengineering and Biotechnology}, abstract = {There is continual demand for animal models that allow a quantitative assessment of angiogenic properties of biomaterials, therapies, and pharmaceuticals. In its simplest form, this is done by subcutaneous material implantation and subsequent vessel counting which usually omits spatial data. We have refined an implantation model and paired it with a computational analytic routine which outputs not only vessel count but also vessel density, distribution, and vessel penetration depth, that relies on a centric vessel as a reference point. We have successfully validated our model by characterizing the angiogenic potential of a fibrin matrix in conjunction with recombinant human vascular endothelial growth factor (rhVEGF165). The inferior epigastric vascular pedicles of rats were sheathed with silicone tubes, which were subsequently filled with 0.2 ml of fibrin and different doses of rhVEGF165, centrically embedding the vessels. Over 4 weeks, tissue samples were harvested and subsequently immunohistologically stained and computationally analyzed. The model was able to detect variations over the angiogenic potentials of growth factor spiked fibrin matrices. Adding 20 ng of rhVEGF165 resulted in a significant increase in vasculature while 200 ng of rhVEGF165 did not improve vascular growth. Vascularized tissue volume increased during the first week and vascular density increased during the second week. Total vessel count increased significantly and exhibited a peak after 2 weeks which was followed by a resorption of vasculature by week 4. In summary, a simple implantation model to study in vivo vascularization with only a minimal workload attached was enhanced to include morphologic data of the emerging vascular tree.}, subject = {Tissue Engineering}, language = {en} } @article{BerkovitchCohenPeledetal., author = {Berkovitch, Yulia and Cohen, Talia and Peled, Eli and Schmidhammer, Robert and Hildner, Florian and Teuschl, Andreas and Wolbank, Susanne and Yelin, Dvir and Redl, Heinz and Seliktar, Dror}, title = {Hydrogel composition and laser micropatterning to regulate sciatic nerve regeneration.}, series = {Journal of Tissue Engineering and Regenerative Medicine}, journal = {Journal of Tissue Engineering and Regenerative Medicine}, pages = {1049 -- 1061}, abstract = {Treatment of peripheral nerve injuries has evolved over the past several decades to include the use of sophisticated new materials endowed with trophic and topographical cues that are essential for in vivo nerve fibre regeneration. In this research, we explored the use of an advanced design strategy for peripheral nerve repair, using biological and semi-synthetic hydrogels that enable controlled environmental stimuli to regenerate neurons and glial cells in a rat sciatic nerve resection model. The provisional nerve growth conduits were composed of either natural fibrin or adducts of synthetic polyethylene glycol and fibrinogen or gelatin. A photo-patterning technique was further applied to these 3D hydrogel biomaterials, in the form of laser-ablated microchannels, to provide contact guidance for unidirectional growth following sciatic nerve injury. We tested the regeneration capacity of subcritical nerve gap injuries in rats treated with photo-patterned materials and compared these with injuries treated with unpatterned hydrogels, either stiff or compliant. Among the factors tested were shear modulus, biological composition, and micropatterning of the materials. The microchannel guidance patterns, combined with appropriately matched degradation and stiffness properties of the material, proved most essential for the uniform tissue propagation during the nerve regeneration process.}, subject = {Tissue Engineering}, language = {en} } @misc{TeuschlHeimelMonforteVilaetal., author = {Teuschl, Andreas and Heimel, Patrick and Monforte Vila, Xavier and N{\"u}rnberger, Sylvia and Tangl, Stefan and van Griensven, Martijn and Redl, Heinz and Nau, Thomas}, title = {Anterior cruciate ligament regeneration using the silk-based RegACL scaffold}, subject = {Tissue Engineering}, language = {en} } @incollection{HackethalSchuhHoferetal., author = {Hackethal, Johannes and Schuh, Christina and Hofer, Alexandra and Meixner, Barbara and Hennerbichler, Simone and Redl, Heinz and Teuschl, Andreas}, title = {Human Placenta Laminin-111 as a Multifunctional Protein for Tissue Engineering and Regenerative Medicine}, series = {Advances in Experimental Medicine and Biology}, booktitle = {Advances in Experimental Medicine and Biology}, publisher = {Springer}, publisher = {Fachhochschule Technikum Wien}, subject = {Biomaterial}, language = {en} } @misc{SlezakRoseHercheretal., author = {Slezak, Paul and Rose, Roland and Hercher, David and Weihs, Anna and Fuchs, Christiane and Redl, Heinz and Mittermayr, Rainer and Slezak, Cyrill}, title = {Tracking therapeutic shockwaves and their impact on regeneration}, subject = {Shockwave Therapy}, language = {en} } @article{HackethalMuehlederHoferetal., author = {Hackethal, Johannes and M{\"u}hleder, Severin and Hofer, Alexandra and Schneider, Karl Heinrich and Pr{\"u}ller, Johanna and Hennerbichler, Simone and Redl, Heinz and Teuschl, Andreas}, title = {An Effective Method of Atelocollagen Type 1/3 Isolation from Human Placenta and Its In Vitro Characterization in Two-Dimensional and Three-Dimensional Cell Culture Applications}, series = {Tissue Eng Part C Methods}, volume = {23}, journal = {Tissue Eng Part C Methods}, number = {5}, pages = {274 -- 285}, subject = {Placenta}, language = {en} } @article{BerkovitchCohenPeledetal., author = {Berkovitch, Yulia and Cohen, Talia and Peled, Eli and Schmidhammer, Robert and Hildner, Florian and Teuschl, Andreas and Wolbank, Susanne and Yelin, Dvir and Redl, Heinz and Seliktar, Dror}, title = {Hydrogel Composition and Laser Micro-Patterning to Regulate Sciatic Nerve Regeneration}, series = {Journal of Tissue Engineering and Regenerative Medicine}, volume = {12}, journal = {Journal of Tissue Engineering and Regenerative Medicine}, number = {4}, subject = {Micro-Patterning}, language = {en} } @article{BernhardFergusonRiederetal., author = {Bernhard, Jonathan and Ferguson, James and Rieder, Bernhard and Heimel, Patrick and Nau, Thomas and Tangl, Stefan and Redl, Heinz and Vunjak-Novakovic, Gordana}, title = {Tissue-engineered hypertrophic chondrocyte grafts enhanced long bone repair biomaterials}, series = {Biomaterials}, journal = {Biomaterials}, number = {139}, pages = {202 -- 212}, subject = {Grafting}, language = {en} } @article{SchneiderLehmannvanOschetal., author = {Schneider, Cornelia and Lehmann, Johannes and van Osch, Gerjo and Hildner, Florian and Teuschl, Andreas and Monforte Vila, Xavier and Miosga, David and Heimel, Patrick and Priglinger, Eleni and Redl, Heinz and Wolbank, Susanne and N{\"u}rnberger, Sylvia}, title = {Systematic Comparison of Protocols for the Preparation of Human Articular Cartilage for Use as Scaffold Material in Cartilage Tissue Engineering}, series = {Tissue Eng Part C Methods}, volume = {22}, journal = {Tissue Eng Part C Methods}, number = {12}, subject = {Cartilage}, language = {en} } @inproceedings{MaleinerHeherTeuschletal., author = {Maleiner, Babette and Heher, Philipp and Teuschl, Andreas and Redl, Heinz and R{\"u}nzler, Dominik and Fuchs, Christiane}, title = {Generation of aligned skeletal muscle-like tissue based on the application of strain to a 3D fibrin scaffold}, series = {Proceedings of PACT "Designer Cells go Clinical" Symposium}, booktitle = {Proceedings of PACT "Designer Cells go Clinical" Symposium}, subject = {Tissue Generation}, language = {en} } @misc{MaleinerHeherTeuschletal., author = {Maleiner, Babette and Heher, Philipp and Teuschl, Andreas and Redl, Heinz and R{\"u}nzler, Dominik and Fuchs, Christiane}, title = {Generation of aligned skeletal muscle-like tissue based on the application of strain to a 3D fibrin scaffold}, subject = {Tissue Generation}, language = {en} } @misc{TeuschlFuchsWeihsetal., author = {Teuschl, Andreas and Fuchs, Christiane and Weihs, Anna and Heimel, Patrick and R{\"u}nzler, Dominik and Redl, Heinz and Nau, Thomas}, title = {The Silk Road from Textiles to Novel Medical Implants}, subject = {Silk}, language = {en} } @misc{TeuschlHeimelNuernbergeretal., author = {Teuschl, Andreas and Heimel, Patrick and N{\"u}rnberger, Sylvia and Redl, Heinz and Nau, Thomas}, title = {ACL Regeneration using a novel silk fiber based scaffold - Histological Results of a Large Animal Study}, subject = {Tissue Regeneration}, language = {en} } @inproceedings{BasoliChaudryCrucianietal., author = {Basoli, Valentina and Chaudry, Sidrah and Cruciani, Sara and Fuchs, Christiane and Rieger, Sabine and Dungel, Peter and Wolbank, Susanne and Ventura, Carlo and Grillari-Voglauer, Regina and Redl, Heinz and Maioli, Margherita}, title = {Epigenetic and molecular behavious of stem cells exposed to biophysical stimuli: new insights in regenerative medicine}, series = {Proceedings des Seminars zum 40. Jahresjubil{\"a}um der {\"O}sterreichischen Gesellschaft f{\"u}r Chirurgische Forschung}, booktitle = {Proceedings des Seminars zum 40. Jahresjubil{\"a}um der {\"O}sterreichischen Gesellschaft f{\"u}r Chirurgische Forschung}, subject = {Stem Cells}, language = {en} } @misc{BasoliChaudryCrucianietal., author = {Basoli, Valentina and Chaudry, Sidrah and Cruciani, Gabriele and Fuchs, Christiane and Rieger, Sabine and Dungel, Peter and Wolbank, Susanne and Ventura, Carlo and Grillari-Voglauer, Regina and Redl, Heinz and Maioli, Margherita}, title = {Epigenetic and molecular behavious of stem cells exposed to biophysical stimuli: new insights in regenerative medicine}, subject = {Stem Cells}, language = {en} } @article{HeherMaleinerPruelleretal., author = {Heher, Philipp and Maleiner, Babette and Pr{\"u}ller, Johanna and Teuschl, Andreas and Kollmitzer, Josef and Monforte Vila, Xavier and Wolbank, Susanne and Redl, Heinz and R{\"u}nzler, Dominik and Fuchs, Christiane}, title = {A novel bioreactor for the generation of highly aligned 3D skeletal muscle-like constructs through orientation of fibrin via application of static strain}, series = {Acta Biomaterialia}, journal = {Acta Biomaterialia}, subject = {Bioreactor}, language = {en} } @article{TeuschlSchuhHalbweisetal., author = {Teuschl, Andreas and Schuh, Christina and Halbweis, Robert and Pajer, Krisztian and Marton, Gabor and Hopf, Rudolf and Mosia, Shorena and R{\"u}nzler, Dominik and Redl, Heinz and Nogradi, Antal and Hausner, Thomas}, title = {A new preparation method for anisotropic silk fibroin nerve guidance conduits and its evaluation in vitro and in a rat sciatic nerve defect model}, series = {Tissue Engineering Part C: Methods}, journal = {Tissue Engineering Part C: Methods}, subject = {Fibrin}, language = {en} } @misc{TeuschlSchuhHalbweisetal., author = {Teuschl, Andreas and Schuh, Christina and Halbweis, Robert and Marton, G{\´a}bor and Pajer, Kriszti{\´a}n and Hopf, Rudolf and Mosia, Shorena and R{\"u}nzler, Dominik and N{\´o}gr{\´a}di, Antal and Hausner, Thomas and Redl, Heinz}, title = {Silk fibroin for peripheral nerve regeneration: a novel preparation method improved mechanical characteristics and supports regeneration in rat sciatic nerves}, subject = {Fibroin}, language = {en} } @misc{FuchsWeihsTeuschletal., author = {Fuchs, Christiane and Weihs, Anna and Teuschl, Andreas and Hartinger, Joachim and Slezak, Paul and Mittermayr, Rainer and Redl, Heinz and Junger, Wolfgang and Sitte, Harald and R{\"u}nzler, Dominik}, title = {Shockwave Treatment Enhances Proliferation and Improves Wound Healing via Purinergic Signaling Linked ERK 1/2 Pathways}, subject = {Shockwave treatment}, language = {en} } @misc{FuchsWeihsTeuschletal., author = {Fuchs, Christiane and Weihs, Anna and Teuschl, Andreas and Hartinger, Joachim and Slezak, Paul and Mittermayr, Rainer and Redl, Heinz and Junger, Wolfgang and Sitte, Harald and R{\"u}nzler, Dominik}, title = {Shockwave Treatment Augments Proliferation and Improves Wound Healing via Purinergic Signaling Linked ERK 1/2 Pathways}, subject = {Shockwave treatment}, language = {en} } @misc{HeherFuchsPruelleretal., author = {Heher, Philipp and Fuchs, Christiane and Pr{\"u}ller, Johanna and Babette, Maleiner and R{\"u}nzler, Dominik and Redl, Heinz}, title = {A novel bioreactor for engineering skeletal muscle-like tissue in a strained fibrin scaffold}, subject = {Bioreactor}, language = {en} } @article{GuillaumeParkMonforteVilaetal., author = {Guillaume, Olivier and Park, Jaesung and Monforte Vila, Xavier and Gruber-Blum, Simone and Redl, Heinz and Petter-Puchner, Akexander and Teuschl, Andreas}, title = {Fabrication of silk mesh with enhanced cytocompatibility: preliminary in vitro investigation toward cell-based therapy for hernia repair}, series = {Journal of Materials Science: Materials in Medicine}, journal = {Journal of Materials Science: Materials in Medicine}, subject = {Cytocompatibility}, language = {en} } @misc{WeihsFuchsTeuschletal., author = {Weihs, Anna and Fuchs, Christiane and Teuschl, Andreas and Hartinger, Joachim and Slezak, Paul and Mittermayr, Rainer and Redl, Heinz and Junger, Wolfgang and Sitte, Harald and R{\"u}nzler, Dominik}, title = {Shockwave treatment activates Erk1/2 pathways predominantly via P2Y receptor involvement}, subject = {Shockwave}, language = {en} } @article{TeuschlHeimelNuernbergeretal., author = {Teuschl, Andreas and Heimel, Patrick and N{\"u}rnberger, Sylvia and van Griensven, Martijn and Redl, Heinz and Nau, Thomas}, title = {A Novel Silk Fiber-Based Scaffold for Regeneration of the Anterior Cruciate Ligament: Histological Results From a Study in Sheep.}, series = {The American Journal of Sports Medicine}, journal = {The American Journal of Sports Medicine}, subject = {Ligament}, language = {en} } @misc{TeuschlFuchsFeichtingeretal., author = {Teuschl, Andreas and Fuchs, Christiane and Feichtinger, Georg and Heher, Philipp and Heimel, Patrick and Schuh, Christina and N{\"u}rnberger, Sylvia and Nau, Thomas and R{\"u}nzler, Dominik and Redl, Heinz}, title = {Fibrin or Fibroin - Not only the "o" Makes the Difference}, subject = {Fibrin}, language = {en} } @article{TeuschlBalmayorRedletal., author = {Teuschl, Andreas and Balmayor, Elizabeth and Redl, Heinz and van Griensven, Martijn and Dungel, Peter}, title = {Phototherapy With LED Light Modulates Healing Processes in an In Vitro Scratch Wound-Model Using 3 Different Cell Types}, series = {Dermatologic Surgery}, volume = {41}, journal = {Dermatologic Surgery}, number = {2}, pages = {261 -- 268}, subject = {Phototherapy}, language = {en} } @article{SchuhHercherStaineretal., author = {Schuh, Christina and Hercher, David and Stainer, Michaela and Hopf, Rudolf and Teuschl, Andreas and Schmidhammer, Robert and Redl, Heinz}, title = {Extracorporeal shockwave treatment: A novel tool to improve Schwann cell isolation and culture}, series = {Cytotherapy}, journal = {Cytotherapy}, subject = {Extracorporeal shockwave}, language = {en} } @misc{TeuschlNuernbergerHeimeletal., author = {Teuschl, Andreas and N{\"u}rnberger, Sylvia and Heimel, Patrick and Redl, Heinz and Nau, Thomas}, title = {Regeneration of the Anterior Cruciate Ligament Using a Silk-Fiber Based Scaffold - Histological Results}, subject = {Tissue Regeneration}, language = {en} } @article{NauRedlTeuschl, author = {Nau, Thomas and Redl, Heinz and Teuschl, Andreas}, title = {Comment on: In Vivo Evaluation of Electrospun Polycaprolactone Graft for Anterior Cruciate Ligament Engineering}, series = {Tissue Engineering Part A}, journal = {Tissue Engineering Part A}, subject = {Grafting}, language = {en} } @article{WeihsFuchsTeuschletal., author = {Weihs, Anna and Fuchs, Christiane and Teuschl, Andreas and Hartinger, Joachim and Slezak, Paul and Mittermayr, Rainer and Redl, Heinz and Junger, Wolfgang and Sitte, Harald and R{\"u}nzler, Dominik}, title = {Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation}, series = {The Journal of biological chemistry}, journal = {The Journal of biological chemistry}, subject = {Shockwave}, language = {de} } @article{SchuhHeherWeihsetal., author = {Schuh, Christina and Heher, Philipp and Weihs, Anna and Asmita, Banerjee and Wolbank, Susanne and Mittermayr, Rainer and Redl, Heinz and R{\"u}nzler, Dominik and Teuschl, Andreas}, title = {Adipose derived stem cells respond to in vitro extracorporeal shockwave treatment with increased stemness and multipotency}, series = {New Biotechnology}, journal = {New Biotechnology}, subject = {Shockwave}, language = {en} } @misc{HeherFuchsPruelleretal., author = {Heher, Philipp and Fuchs, Christiane and Pr{\"u}ller, Johanna and Maleiner, Babette and Kollmitzer, Josef and R{\"u}nzler, Dominik and Teuschl, Andreas and Wolbank, Susanne and Redl, Heinz}, title = {A bioreactor-based 3D culture system for skeletal muscle engineering in fibrin scaffolds}, subject = {Bioreactors}, language = {en} } @article{BanerjeeNuernbergerHennerbichleretal., author = {Banerjee, Asmita and N{\"u}rnberger, Sylvia and Hennerbichler, Simone and Riedl, Stefan and Schuh, Christina and Hacobian, Ara and Teuschl, Andreas and Eibl, J{\"u}rgen and Redl, Heinz}, title = {In toto differentiation of human amniotic membrane towards the Schwann cell lineage}, series = {227-239}, volume = {15}, journal = {227-239}, number = {2}, subject = {Membrane}, language = {en} } @article{TeuschlNeutschMonforteVilaetal., author = {Teuschl, Andreas and Neutsch, Lukas and Monforte Vila, Xavier and R{\"u}nzler, Dominik and van Griensven, Martijn and Gabor, Franz and Redl, Heinz}, title = {Enhanced cell adhesion on silk fibroin via lectin surface modification.}, series = {Acta Biomaterialia}, journal = {Acta Biomaterialia}, subject = {Silk}, language = {en} } @article{HohlriederTeuschlCichaetal., author = {Hohlrieder, Manfred and Teuschl, Andreas and Cicha, Klaus and van Griensven, Martijn and Redl, Heinz and Stampfl, J{\"u}rgen}, title = {Bioreactor and scaffold design for the mechanical stimulation of anterior cruciate ligament grafts}, series = {Biomedical materials and engineering}, volume = {23}, journal = {Biomedical materials and engineering}, number = {3}, pages = {225 -- 237}, subject = {Bioreactors}, language = {en} } @article{DungelTeuschlBanerjeeetal., author = {Dungel, Peter and Teuschl, Andreas and Banerjee, Asmita and Paier-Pourani, Jamile and Redl, Heinz and Kozlov, Andrey}, title = {Impact of mitochondria on nitrite metabolism in HL-1 cardiomyocytes}, series = {Frontiers in Physiology}, journal = {Frontiers in Physiology}, number = {4}, subject = {Nitrite}, language = {en} } @article{TeuschlNuernbergerRedletal., author = {Teuschl, Andreas and N{\"u}rnberger, Sylvia and Redl, Heinz and Nau, Thomas}, title = {Articular cartilage tissue regeneration: current research strategies and outlook for the future}, series = {European Surgery}, volume = {45}, journal = {European Surgery}, number = {3}, pages = {142 -- 153}, subject = {Tissue Regeneration}, language = {en} } @article{TeuschlvanGriensvenRedl, author = {Teuschl, Andreas and van Griensven, Martijn and Redl, Heinz}, title = {Sericin removal from raw Bombys mori silk scaffolds of high hierarchical order}, series = {Tissue Eng Part C Methods}, journal = {Tissue Eng Part C Methods}, subject = {Scaffold}, language = {en} } @article{SchuhBanerjeeMosiaetal., author = {Schuh, Christina and Banerjee, Asmita and Mosia, Shorena and Hopf, Rudolf and Grasl, Christian and Schima, Heinrich and Schmidhammer, Robert and Redl, Heinz and R{\"u}nzler, Dominik and Morton, Tatjana J.}, title = {Activated Schwann-like cells guided by fibrin structures enhance Axonal Regeneration}, series = {JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE}, volume = {2012}, journal = {JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE}, number = {vol. 6/no. 1}, subject = {Cells}, language = {en} } @article{RiederWeihsTeuschletal., author = {Rieder, Bernhard and Weihs, Anna and Teuschl, Andreas and Knebl, Gerald and Kollmitzer, Josef and Redl, Heinz and R{\"u}nzler, Dominik}, title = {Evaluation of cell response on permanent and pulsed atmospheric pressure stressed cells}, series = {Journal of Tissue Engineering and Regenerative Medicine}, volume = {1}, journal = {Journal of Tissue Engineering and Regenerative Medicine}, number = {6}, pages = {240 -- 240}, subject = {Cells}, language = {en} }