@misc{TeuschlFuchs,
  author    = {Teuschl, Andreas and Fuchs, Christiane},
  title     = {Bioreactors in Musculoskeletal Tissue Engineering},
  subject      = {Bioreactor},
  language  = {en}
}
@misc{KueenburgTeuschl,
  author    = {K{\"u}enburg, Bernhard and Teuschl, Andreas},
  title     = {Regenerative silk ligament: scale up and regulatory strategy of a textile engineered silk implant for tissue regeneration of injured human ACL (anterior cruciate ligament)},
  abstract  = {61 a93591 27-SY-1 Regenerative silk ligament: scale up and regulatory strategy of a textile engineered silk implant for tissue regeneration of injured human ACL (anterior cruciate ligament) Bernhard K{\"u}enburg，Andreas Teuschl MorphoMed, Austria In the USA around 370.000 annual ACL ruptures in the predominately young population (age 18-30) following sport injuries cause a lot of pain and long term troubles for the affected patients. The well established standard procedure of autologous tissue transplantation stabilizes the knee and allows sport activities after 9-12 months. However, harvest of autologous tissue such as patellar tendon or semitendinosus (the most frequently used autograft) weakens other body areas and long term data show an increased rate of arthroses (up to 50\% after 10 years) associated with ACL reconstructions. Based on numerous preclinical data and data from a 12-month sheep study the scale-up as well as regulatory approval process of a novel textile engineered silk implant as ACL graft have been initiated. It is planned to enter a clinical trial and strive for regulatory approval as a medical class 3 implant. The sheep data (1) have revealed an approximately 50\% degradation of the purified medical silk, which acts as scaffold for the regrowth of a new endogenous ligament. The formation of oriented collagenous tissue fibers including vascularization proves a ligament tissue regeneration for the first time. Scale-up and implementation of a commercial process require a defined set of specifications of commercial silkworm (Bombyx mori) silk, a biological raw material sourced from the textile industry as well as adequate analytical methods to characterize the depletion of sericin in the course of the production process. Based on first full scale samples, the defined biocompatibility program has to be executed, in the EU following the ISO requirements of the notified bodies, in the USA determined by the FDA. Upon submission of the full technical documentation as well as the biocompati-bility data, approval of a clinical trial can be achieved in order to demonstrate the clinical efficacy of the silk based ACL graft compared to the gold standard method in two different randomized groups. As primary endpoint the knee stability will be tested by an apparatus supported Lachmann test. In this study, besides the clinical benefit the patient safety is an important goal. The results of this study will be used for achievement of regulatory approval. References: 1) Teuschl A, Heimel P, N{\"u}rnberger S, van Griensven M, Redl H, Nau T. Am. J. Sports Med. 2016;44:1547-57. 2) Teuschl AH, van Griensven M, Redl H. Tissue Eng. Part C Methods. 2014;20:431-9.},
  subject      = {Biomaterial},
  language  = {en}
}
@misc{TeuschlSchuhWeihsetal.,
  author    = {Teuschl, Andreas and Schuh, Christina and Weihs, Anna and Guillaume, Olivier and Monforte Vila, Xavier and Redl, Heinz and Kaplan, David and R{\"u}nzler, Dominik},
  title     = {Tailoring bioactivity of silk-based biomaterials via delivering and functionalization strategies with fibrinogen/thrombin, plant lectins or laminin},
  subject      = {Biomaterials},
  language  = {en}
}
@misc{TeuschlHeimelMonforteVilaetal.,
  author    = {Teuschl, Andreas and Heimel, Patrick and Monforte Vila, Xavier and N{\"u}rnberger, Sylvia and Tangl, Stefan and van Griensven, Martijn and Redl, Heinz and Nau, Thomas},
  title     = {Anterior cruciate ligament regeneration using the silk-based RegACL scaffold},
  subject      = {Tissue Engineering},
  language  = {en}
}
@misc{SalzerRiederMonforteVilaetal.,
  author    = {Salzer, Elias and Rieder, Bernhard and Monforte Vila, Xavier and Weihs, Anna and R{\"u}nzler, Dominik and Teuschl, Andreas},
  title     = {Evaluation of a novel hydrostatic pressure bioreactor on bovine cartilage chips},
  subject      = {Bioreactor},
  language  = {en}
}
@misc{FuchsWeihsSzwarcetal.,
  author    = {Fuchs, Christiane and Weihs, Anna and Szwarc, Dorota and Mittermayr, Rainer and R{\"u}nzler, Dominik and Teuschl, Andreas},
  title     = {Shock wave treatment of muscle (stem) cells - a new implementation for regeneration},
  subject      = {Shockwave treatment},
  language  = {en}
}
@misc{TeuschlWeihsFuchsetal.,
  author    = {Teuschl, Andreas and Weihs, Anna and Fuchs, Christiane and Monforte Vila, Xavier},
  title     = {Silk as a versatile biomaterial for musculoskeletal tissue engineering},
  subject      = {Silk},
  language  = {en}
}
@misc{SzwarcFuchsWeihsetal.,
  author    = {Szwarc, Dorota and Fuchs, Christiane and Weihs, Anna and Monforte Vila, Xavier and Hanetseder, Dominik and Teuschl, Andreas and R{\"u}nzler, Dominik},
  title     = {The effect of shock waves on in vitro cartilage development in silk scaffolds},
  subject      = {Shockwave treatment},
  language  = {en}
}
@misc{MaleinerHeherTeuschletal.,
  author    = {Maleiner, Babette and Heher, Philipp and Teuschl, Andreas and Redl, Heinz and R{\"u}nzler, Dominik and Fuchs, Christiane},
  title     = {Generation of aligned skeletal muscle-like tissue based on the application of strain to a 3D fibrin scaffold},
  subject      = {Tissue Generation},
  language  = {en}
}
@misc{TeuschlFuchsWeihsetal.,
  author    = {Teuschl, Andreas and Fuchs, Christiane and Weihs, Anna and Heimel, Patrick and R{\"u}nzler, Dominik and Redl, Heinz and Nau, Thomas},
  title     = {The Silk Road from Textiles to Novel Medical Implants},
  subject      = {Silk},
  language  = {en}
}
@misc{TeuschlHeimelNuernbergeretal.,
  author    = {Teuschl, Andreas and Heimel, Patrick and N{\"u}rnberger, Sylvia and Redl, Heinz and Nau, Thomas},
  title     = {ACL Regeneration using a novel silk fiber based scaffold - Histological Results of a Large Animal Study},
  subject      = {Tissue Regeneration},
  language  = {en}
}
@misc{Teuschl,
  author    = {Teuschl, Andreas},
  title     = {Silk Processing - from Gels to ACL Replacement},
  subject      = {Silk},
  language  = {en}
}
@misc{TeuschlSchuhHalbweisetal.,
  author    = {Teuschl, Andreas and Schuh, Christina and Halbweis, Robert and Marton, G{\´a}bor and Pajer, Kriszti{\´a}n and Hopf, Rudolf and Mosia, Shorena and R{\"u}nzler, Dominik and N{\´o}gr{\´a}di, Antal and Hausner, Thomas and Redl, Heinz},
  title     = {Silk fibroin for peripheral nerve regeneration: a novel preparation method improved mechanical characteristics and supports regeneration in rat sciatic nerves},
  subject      = {Fibroin},
  language  = {en}
}
@misc{FuchsWeihsTeuschletal.,
  author    = {Fuchs, Christiane and Weihs, Anna and Teuschl, Andreas and Hartinger, Joachim and Slezak, Paul and Mittermayr, Rainer and Redl, Heinz and Junger, Wolfgang and Sitte, Harald and R{\"u}nzler, Dominik},
  title     = {Shockwave Treatment Enhances Proliferation and Improves Wound Healing via Purinergic Signaling Linked ERK 1/2 Pathways},
  subject      = {Shockwave treatment},
  language  = {en}
}
@misc{FuchsWeihsTeuschletal.,
  author    = {Fuchs, Christiane and Weihs, Anna and Teuschl, Andreas and Hartinger, Joachim and Slezak, Paul and Mittermayr, Rainer and Redl, Heinz and Junger, Wolfgang and Sitte, Harald and R{\"u}nzler, Dominik},
  title     = {Shockwave Treatment Augments Proliferation and Improves Wound Healing via Purinergic Signaling Linked ERK 1/2 Pathways},
  subject      = {Shockwave treatment},
  language  = {en}
}
@misc{WeihsFuchsTeuschletal.,
  author    = {Weihs, Anna and Fuchs, Christiane and Teuschl, Andreas and Hartinger, Joachim and Slezak, Paul and Mittermayr, Rainer and Redl, Heinz and Junger, Wolfgang and Sitte, Harald and R{\"u}nzler, Dominik},
  title     = {Shockwave treatment activates Erk1/2 pathways predominantly via P2Y receptor involvement},
  subject      = {Shockwave},
  language  = {en}
}
@misc{TeuschlFuchsFeichtingeretal.,
  author    = {Teuschl, Andreas and Fuchs, Christiane and Feichtinger, Georg and Heher, Philipp and Heimel, Patrick and Schuh, Christina and N{\"u}rnberger, Sylvia and Nau, Thomas and R{\"u}nzler, Dominik and Redl, Heinz},
  title     = {Fibrin or Fibroin - Not only the "o" Makes the Difference},
  subject      = {Fibrin},
  language  = {en}
}
@misc{TeuschlNuernbergerHeimeletal.,
  author    = {Teuschl, Andreas and N{\"u}rnberger, Sylvia and Heimel, Patrick and Redl, Heinz and Nau, Thomas},
  title     = {Regeneration of the Anterior Cruciate Ligament Using a Silk-Fiber Based Scaffold - Histological Results},
  subject      = {Tissue Regeneration},
  language  = {en}
}
@misc{HeherFuchsPruelleretal.,
  author    = {Heher, Philipp and Fuchs, Christiane and Pr{\"u}ller, Johanna and Maleiner, Babette and Kollmitzer, Josef and R{\"u}nzler, Dominik and Teuschl, Andreas and Wolbank, Susanne and Redl, Heinz},
  title     = {A bioreactor-based 3D culture system for skeletal muscle engineering in fibrin scaffolds},
  subject      = {Bioreactors},
  language  = {en}
}
@misc{HromadaTomaschWeihsetal.,
  author    = {Hromada, Carina and Tomasch, Janine and Weihs, Anna and R{\"u}nzler, Dominik and Teuschl, Andreas},
  title     = {Engineering of 3D Tissue Constructs Using our Novel MagneTissue Bioreactor as Alternatives to Animal Models},
  subject      = {Bioreactor},
  language  = {en}
}