@article{ZiadlouRotmanTeuschletal.,
  author    = {Ziadlou, Reihane and Rotman, Stijn and Teuschl, Andreas and Salzer, Elias and Barbero, Andrea and Martin, Ivan and Alini, Mauro and Eglin, David and Grad, Sibylle},
  title     = {Optimization of hyaluronic acid-tyramine/silk-fibroin composite hydrogels for cartilage tissue engineering and delivery of anti-inflammatory and anabolic drugs},
  series = {Materials Science and Engineering: C},
  volume    = {120},
  journal   = {Materials Science and Engineering: C},
  number    = {111701},
  abstract  = {Injury of articular cartilage leads to an imbalance in tissue homeostasis, and due to the poor self-healing capacity of cartilage the affected tissue often exhibits osteoarthritic changes. In recent years, injectable and highly tunable composite hydrogels for cartilage tissue engineering and drug delivery have been introduced as a desirable alternative to invasive treatments. In this study, we aimed to formulate injectable hydrogels for drug delivery and cartilage tissue engineering by combining different concentrations of hyaluronic acid-tyramine (HA-Tyr) with regenerated silk-fibroin (SF) solutions. Upon enzymatic crosslinking, the gelation and mechanical properties were characterized over time. To evaluate the effect of the hydrogel compositions and properties on extracellular matrix (ECM) deposition, bovine chondrocytes were embedded in enzymatically crosslinked HA-Tyr/SF composites (in further work abbreviated as HA/SF) or HA-Tyr hydrogels. We demonstrated that all hydrogel formulations were cytocompatible and could promote the expression of cartilage matrix proteins allowing chondrocytes to produce ECM, while the most prominent chondrogenic effects were observed in hydrogels with HA20/SF80 polymeric ratios. Unconfined mechanical testing showed that the compressive modulus for HA20/SF80 chondrocyte-laden constructs was increased almost 10-fold over 28 days of culture in chondrogenic medium which confirmed the superior production of ECM in this hydrogel compared to other hydrogels in this study. Furthermore, in hydrogels loaded with anabolic and anti-inflammatory drugs, HA20/SF80 hydrogel showed the longest and the most sustained release profile over time which is desirable for the long treatment duration typically necessary for osteoarthritic joints. In conclusion, HA20/SF80 hydrogel was successfully established as a suitable injectable biomaterial for cartilage tissue engineering and drug delivery applications.},
  subject      = {Tissue Engineering},
  language  = {en}
}
@misc{SalzerRiederMonforteVilaetal.,
  author    = {Salzer, Elias and Rieder, Bernhard and Monforte Vila, Xavier and Weihs, Anna and R{\"u}nzler, Dominik and Teuschl, Andreas},
  title     = {Evaluation of a novel hydrostatic pressure bioreactor on bovine cartilage chips},
  subject      = {Bioreactor},
  language  = {en}
}
@article{SchneiderLehmannvanOschetal.,
  author    = {Schneider, Cornelia and Lehmann, Johannes and van Osch, Gerjo and Hildner, Florian and Teuschl, Andreas and Monforte Vila, Xavier and Miosga, David and Heimel, Patrick and Priglinger, Eleni and Redl, Heinz and Wolbank, Susanne and N{\"u}rnberger, Sylvia},
  title     = {Systematic Comparison of Protocols for the Preparation of Human Articular Cartilage for Use as Scaffold Material in Cartilage Tissue Engineering},
  series = {Tissue Eng Part C Methods},
  volume    = {22},
  journal   = {Tissue Eng Part C Methods},
  number    = {12},
  subject      = {Cartilage},
  language  = {en}
}
@misc{SzwarcFuchsWeihsetal.,
  author    = {Szwarc, Dorota and Fuchs, Christiane and Weihs, Anna and Monforte Vila, Xavier and Hanetseder, Dominik and Teuschl, Andreas and R{\"u}nzler, Dominik},
  title     = {The effect of shock waves on in vitro cartilage development in silk scaffolds},
  subject      = {Shockwave treatment},
  language  = {en}
}
@article{RiederWeihsWeidingeretal.,
  author    = {Rieder, Bernhard and Weihs, Anna and Weidinger, Adelheid and Sczwarc, Dorota and N{\"u}rnberger, Sylvia and Redl, Heinz and R{\"u}nzler, Dominik and Huber-Gries, Carina and Teuschl, Andreas},
  title     = {Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures},
  series = {Scientific Reports},
  journal   = {Scientific Reports},
  subject      = {Bioreactor},
  language  = {en}
}
@article{NuernbergerSchneidervanOschetal.,
  author    = {N{\"u}rnberger, Sylvia and Schneider, Cornelia and van Osch, Gerjo and Keibl, Claudia and Rieder, Bernhard and Monforte, Xavier and Teuschl, Andreas and M{\"u}hleder, Severin and Holnthoner, Wolfgang and Sch{\"a}dl, Barbara and Gahleitner, Christoph and Redl, Heinz and Wolbank, Susanne},
  title     = {Repopulation of an auricular cartilage scaffold, AuriScaff, perforated with an enzyme combination.},
  series = {Acta Biomaterialia},
  journal   = {Acta Biomaterialia},
  subject      = {Tissue Engineering},
  language  = {en}
}