@article{RiederWeihsWeidingeretal., author = {Rieder, Bernhard and Weihs, Anna and Weidinger, Adelheid and Sczwarc, Dorota and N{\"u}rnberger, Sylvia and Redl, Heinz and R{\"u}nzler, Dominik and Huber-Gries, Carina and Teuschl, Andreas}, title = {Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures}, series = {Scientific Reports}, journal = {Scientific Reports}, subject = {Bioreactor}, language = {en} } @article{PriglingerSchuhSteffenhagenetal., author = {Priglinger, Eleni and Schuh, Christina and Steffenhagen, Carolin and Wurzer, Christoph and Maier, Julia and N{\"u}rnberger, Sylvia and Holnthoner, Wolfgang and Fuchs, Christiane and Suessner, Susanne and R{\"u}nzler, Dominik and Redl, Heinz and Wolbank, Susanne}, title = {Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy.}, series = {Cytotherapy}, journal = {Cytotherapy}, pages = {1079 -- 1095}, abstract = {BACKGROUND: Cell-based therapies with autologous adipose tissue-derived cells have shown great potential in several clinical studies in the last decades. The majority of these studies have been using the stromal vascular fraction (SVF), a heterogeneous mixture of fibroblasts, lymphocytes, monocytes/macrophages, endothelial cells, endothelial progenitor cells, pericytes and adipose-derived stromal/stem cells (ASC) among others. Although possible clinical applications of autologous adipose tissue-derived cells are manifold, they are limited by insufficient uniformity in cell identity and regenerative potency. METHODS: In our experimental set-up, low-energy extracorporeal shock wave therapy (ESWT) was performed on freshly obtained human adipose tissue and isolated adipose tissue SVF cells aiming to equalize and enhance stem cell properties and functionality. RESULTS: After ESWT on adipose tissue we could achieve higher cellular adenosine triphosphate (ATP) levels compared with ESWT on the isolated SVF as well as the control. ESWT on adipose tissue resulted in a significantly higher expression of single mesenchymal and vascular marker compared with untreated control. Analysis of SVF protein secretome revealed a significant enhancement in insulin-like growth factor (IGF)-1 and placental growth factor (PLGF) after ESWT on adipose tissue. DISCUSSION: Summarizing we could show that ESWT on adipose tissue enhanced the cellular ATP content and modified the expression of single mesenchymal and vascular marker, and thus potentially provides a more regenerative cell population. Because the effectiveness of autologous cell therapy is dependent on the therapeutic potency of the patient's cells, this technology might raise the number of patients eligible for autologous cell transplantation.}, subject = {Shockwave Therapy}, language = {en} } @article{NuernbergerSchneidervanOschetal., author = {N{\"u}rnberger, Sylvia and Schneider, Cornelia and van Osch, Gerjo and Keibl, Claudia and Rieder, Bernhard and Monforte, Xavier and Teuschl, Andreas and M{\"u}hleder, Severin and Holnthoner, Wolfgang and Sch{\"a}dl, Barbara and Gahleitner, Christoph and Redl, Heinz and Wolbank, Susanne}, title = {Repopulation of an auricular cartilage scaffold, AuriScaff, perforated with an enzyme combination.}, series = {Acta Biomaterialia}, journal = {Acta Biomaterialia}, subject = {Tissue Engineering}, language = {en} } @article{SchneiderAignerHolnthoneretal., author = {Schneider, Karl Heinrich and Aigner, Petra and Holnthoner, Wolfgang and Monforte Vila, Xavier and N{\"u}rnberger, Sylvia and R{\"u}nzler, Dominik and Redl, Heinz and Teuschl, Andreas}, title = {Decellularized human placenta chorion matrix as a favorable source of small-diameter vascular grafts}, series = {Acta Biomaterialia}, journal = {Acta Biomaterialia}, subject = {Grafting}, language = {en} } @article{HeimelSwiadekSlezaketal., author = {Heimel, Patrick and Swiadek, Nicole V. and Slezak, Paul and Kerbl, Markus and Schneider, Cornelia and N{\"u}rnberger, Sylvia and Redl, Heinz and Teuschl, Andreas and Hercher, David}, title = {Iodine-Enhanced Micro-CT Imaging of Soft Tissue on the Example of Peripheral Nerve Regeneration}, series = {Contrast Media \& Molecular Imaging}, journal = {Contrast Media \& Molecular Imaging}, subject = {µCT}, language = {en} } @article{FeichtingerHeimelTangletal., author = {Feichtinger, Xaver and Heimel, Patrick and Tangl, Stefan and Keibl, Claudia and N{\"u}rnberger, Sylvia and Schanda, Jakob Emanuel and Hercher, David and Kocijan, Roland and Redl, Heinz and Grillari, Johannes and Fialka, Christian and Mittermayr, Rainer}, title = {Improved biomechanics in experimental chronic rotator cuff repair after shockwaves is not reflected by bone microarchitecture}, series = {PLoS One}, volume = {17}, journal = {PLoS One}, number = {1}, doi = {10.1371/journal.pone.0262294}, subject = {chronic rotator cuff repair}, language = {en} }