@article{DeiningerWagnerHeimeletal.,
  author    = {Deininger, Christian and Wagner, Andrea and Heimel, Patrick and Salzer, Elias and Monforte Vila, Xavier and Weißenbacher, Nadja and Grillari, Johannes and Redl, Heinz and Wichlas, Florian and Freude, Thomas and Tempfer, Herbert and Teuschl-Woller, Andreas and Traweger, Andreas},
  title     = {Enhanced BMP-2-Mediated Bone Repair Using an Anisotropic Silk Fibroin Scaffold Coated with Bone-like Apatite},
  series = {Int. J. Mol. Sci.},
  volume    = {23},
  journal   = {Int. J. Mol. Sci.},
  number    = {1 / 283},
  abstract  = {The repair of large bone defects remains challenging and often requires graft material due to limited availability of autologous bone. In clinical settings, collagen sponges loaded with excessive amounts of bone morphogenetic protein 2 (rhBMP-2) are occasionally used for the treatment of bone non-unions, increasing the risk of adverse events. Therefore, strategies to reduce rhBMP-2 dosage are desirable. Silk scaffolds show great promise due to their favorable biocompatibility and their utility for various biofabrication methods. For this study, we generated silk scaffolds with axially aligned pores, which were subsequently treated with 10× simulated body fluid (SBF) to generate an apatitic calcium phosphate coating. Using a rat femoral critical sized defect model (CSD) we evaluated if the resulting scaffold allows the reduction of BMP-2 dosage to promote efficient bone repair by providing appropriate guidance cues. Highly porous, anisotropic silk scaffolds were produced, demonstrating good cytocompatibility in vitro and treatment with 10× SBF resulted in efficient surface coating. In vivo, the coated silk scaffolds loaded with a low dose of rhBMP-2 demonstrated significantly improved bone regeneration when compared to the unmineralized scaffold. Overall, our findings show that this simple and cost-efficient technique yields scaffolds that enhance rhBMP-2 mediated bone healing.},
  subject      = {Tissue Engineering},
  language  = {en}
}
@article{KhimichProsolovMishurovaetal.,
  author    = {Khimich, Margarita A. and Prosolov, Konstantin A. and Mishurova, Tatiana and Evsevleev, Sergej and Monforte, Xavier and Teuschl, Andreas H. and Slezak, Paul and Ibragimov, Egor A. and Saprykin, Alexander A. and Kovalevskaya, Zhanna G. and Dmitriev, Andrey I. and Bruno, Giovanni and Sharkeev, Yurii P.},
  title     = {Advances in Laser Additive Manufacturing of Ti-Nb Alloys: From Nanostructured Powders to Bulk Objects},
  series = {Nanomaterials (Basel)},
  volume    = {11},
  journal   = {Nanomaterials (Basel)},
  number    = {5 / 1159},
  abstract  = {The additive manufacturing of low elastic modulus alloys that have a certain level of porosity for biomedical needs is a growing area of research. Here, we show the results of manufacturing of porous and dense samples by a laser powder bed fusion (LPBF) of Ti-Nb alloy, using two distinctive fusion strategies. The nanostructured Ti-Nb alloy powders were produced by mechanical alloying and have a nanostructured state with nanosized grains up to 90 nm. The manufactured porous samples have pronounced open porosity and advanced roughness, contrary to dense samples with a relatively smooth surface profile. The structure of both types of samples after LPBF is formed by uniaxial grains having micro- and nanosized features. The inner structure of the porous samples is comprised of an open interconnected system of pores. The volume fraction of isolated porosity is 2 vol. \% and the total porosity is 20 vol. \%. Cell viability was assessed in vitro for 3 and 7 days using the MG63 cell line. With longer culture periods, cells showed an increased cell density over the entire surface of a porous Ti-Nb sample. Both types of samples are not cytotoxic and could be used for further in vivo studies.},
  subject      = {Tissue Engineering},
  language  = {en}
}
@misc{TeuschlSchuhWeihsetal.,
  author    = {Teuschl, Andreas and Schuh, Christina and Weihs, Anna and Guillaume, Olivier and Monforte Vila, Xavier and Redl, Heinz and Kaplan, David and R{\"u}nzler, Dominik},
  title     = {Tailoring bioactivity of silk-based biomaterials via delivering and functionalization strategies with fibrinogen/thrombin, plant lectins or laminin},
  subject      = {Biomaterials},
  language  = {en}
}
@misc{TeuschlWeihsFuchsetal.,
  author    = {Teuschl, Andreas and Weihs, Anna and Fuchs, Christiane and Monforte Vila, Xavier},
  title     = {Silk as a versatile biomaterial for musculoskeletal tissue engineering},
  subject      = {Silk},
  language  = {en}
}