@article{QuartinelloTallianAueretal.,
  author    = {Quartinello, Felice and Tallian, Claudia and Auer, Julia and Sch{\"o}n, Herta and Vielnascher, Robert and Weinberger, Simone and Wieland, Karin and Weihs, Anna and Rollett, Alexandra and Lendl, Bernhard and Teuschl, Andreas and Pellis, Alessandro and G{\"u}bitz, Georg},
  title     = {Smart Textiles in Wound Care: Functionalization of Cotton/PET Blends with Antimicrobial Nanocapsules},
  series = {Journal of Materials Chemistry B},
  journal   = {Journal of Materials Chemistry B},
  subject      = {Smart textiles},
  language  = {en}
}
@article{TeuschlTanglHeimeletal.,
  author    = {Teuschl, Andreas and Tangl, Stefan and Heimel, Patrick and Schwarze, Uwe Yacine and Monforte, Xavier and Redl, Heinz and Nau, Thomas},
  title     = {Osteointegration of a Novel Silk Fiber-Based ACL Scaffold by Formation of a Ligament-Bone Interface.},
  series = {American Journal of Sports Medicine},
  journal   = {American Journal of Sports Medicine},
  subject      = {Tissue Engineering},
  language  = {en}
}
@article{SimsaMonforteSalzeretal.,
  author    = {Simsa, Robin and Monforte, Xavier and Salzer, Elias and Teuschl, Andreas and Jenndahl, Lachmi and Bergh, Niklas and Fogelstrand, Per},
  title     = {Effect of fluid dynamics on decellularization efficacy and mechanical properties of blood vessels.},
  series = {PLoS One},
  journal   = {PLoS One},
  subject      = {Tissue Engineering},
  language  = {en}
}
@article{TallianHerreroRollettStadleretal.,
  author    = {Tallian, Claudia and Herrero-Rollett, Alexandra and Stadler, Karina and Vielnascher, Robert and Wieland, Karin and Weihs, Anna and Pellis, Alessandro and Teuschl, Andreas and Lendl, Bernhard and Amenitsch, Heinz and Guebitz, Georg M.},
  title     = {Structural insights into pH-responsive drug release of self-assembling human serum albumin-silk fibroin nanocapsules.},
  series = {European Journal of Pharmaceutics and Biopharmaceutics},
  journal   = {European Journal of Pharmaceutics and Biopharmaceutics},
  abstract  = {Inflammation processes are associated with significant decreases in tissue or lysosomal pH from 7.4 to 4, a fact that argues for the application of pH-responsive drug delivery systems. However, for their design and optimization a full understanding of the release mechanism is crucial. In this study we investigated the pH-depending drug release mechanism and the influence of silk fibroin (SF) concentration and SF degradation degree of human serum albumin (HSA)-SF nanocapsules. Sonochemically produced nanocapsules were investigated regarding particle size, colloidal stability, protein encapsulation, thermal stability and drug loading properties. Particles of the monodisperse phase showed average hydrodynamic radii between 438 and 888 nm as measured by DLS and AFM and a zeta potential of -11.12 ± 3.27 mV. Together with DSC results this indicated the successful production of stable nanocapsules. ATR-FTIR analysis demonstrated that SF had a positive effect on particle formation and stability due to induced beta-sheet formation and enhanced crosslinking. The pH-responsive release was found to depend on the SF concentration. In in-vitro release studies, HSA-SF nanocapsules composed of 50\% SF showed an increased pH-responsive release for all tested model substances (Rhodamine B, Crystal Violet and Evans Blue) and methotrexate at the lowered pH of 4.5 to pH 5.4, while HSA capsules without SF did not show any pH-responsive drug release. Mechanistic studies using confocal laser scanning microscopy (CLSM) and small angle X-ray scattering (SAXS) analyses showed that increases in particle porosity and decreases in particle densities are directly linked to pH-responsive release properties. Therefore, the pH-responsive release mechanism was identified as diffusion controlled in a novel and unique approach by linking scattering results with in vitro studies. Finally, cytotoxicity studies using the human monocytic THP-1 cell line indicated non-toxic behavior of the drug loaded nanocapsules when applied in a concentration of 62.5 µg mL-1.},
  subject      = {Biomaterial},
  language  = {en}
}
@misc{TeuschlSchuhWeihsetal.,
  author    = {Teuschl, Andreas and Schuh, Christina and Weihs, Anna and Guillaume, Olivier and Monforte Vila, Xavier and Redl, Heinz and Kaplan, David and R{\"u}nzler, Dominik},
  title     = {Tailoring bioactivity of silk-based biomaterials via delivering and functionalization strategies with fibrinogen/thrombin, plant lectins or laminin},
  subject      = {Biomaterials},
  language  = {en}
}
@article{SlezakSlezakHartingeretal.,
  author    = {Slezak, Paul and Slezak, Cyrill and Hartinger, Joachim and Teuschl, Andreas and N{\"u}rnberger, Sylvia and Redl, Heinz and Mittermayr, Rainer},
  title     = {A Low Cost Implantation Model in the Rat That Allows a Spatial Assessment of Angiogenesis.},
  series = {Frontiers in Bioengineering and Biotechnology},
  journal   = {Frontiers in Bioengineering and Biotechnology},
  abstract  = {There is continual demand for animal models that allow a quantitative assessment of angiogenic properties of biomaterials, therapies, and pharmaceuticals. In its simplest form, this is done by subcutaneous material implantation and subsequent vessel counting which usually omits spatial data. We have refined an implantation model and paired it with a computational analytic routine which outputs not only vessel count but also vessel density, distribution, and vessel penetration depth, that relies on a centric vessel as a reference point. We have successfully validated our model by characterizing the angiogenic potential of a fibrin matrix in conjunction with recombinant human vascular endothelial growth factor (rhVEGF165). The inferior epigastric vascular pedicles of rats were sheathed with silicone tubes, which were subsequently filled with 0.2 ml of fibrin and different doses of rhVEGF165, centrically embedding the vessels. Over 4 weeks, tissue samples were harvested and subsequently immunohistologically stained and computationally analyzed. The model was able to detect variations over the angiogenic potentials of growth factor spiked fibrin matrices. Adding 20 ng of rhVEGF165 resulted in a significant increase in vasculature while 200 ng of rhVEGF165 did not improve vascular growth. Vascularized tissue volume increased during the first week and vascular density increased during the second week. Total vessel count increased significantly and exhibited a peak after 2 weeks which was followed by a resorption of vasculature by week 4. In summary, a simple implantation model to study in vivo vascularization with only a minimal workload attached was enhanced to include morphologic data of the emerging vascular tree.},
  subject      = {Tissue Engineering},
  language  = {en}
}
@article{BerkovitchCohenPeledetal.,
  author    = {Berkovitch, Yulia and Cohen, Talia and Peled, Eli and Schmidhammer, Robert and Hildner, Florian and Teuschl, Andreas and Wolbank, Susanne and Yelin, Dvir and Redl, Heinz and Seliktar, Dror},
  title     = {Hydrogel composition and laser micropatterning to regulate sciatic nerve regeneration.},
  series = {Journal of Tissue Engineering and Regenerative Medicine},
  journal   = {Journal of Tissue Engineering and Regenerative Medicine},
  pages     = {1049 -- 1061},
  abstract  = {Treatment of peripheral nerve injuries has evolved over the past several decades to include the use of sophisticated new materials endowed with trophic and topographical cues that are essential for in vivo nerve fibre regeneration. In this research, we explored the use of an advanced design strategy for peripheral nerve repair, using biological and semi-synthetic hydrogels that enable controlled environmental stimuli to regenerate neurons and glial cells in a rat sciatic nerve resection model. The provisional nerve growth conduits were composed of either natural fibrin or adducts of synthetic polyethylene glycol and fibrinogen or gelatin. A photo-patterning technique was further applied to these 3D hydrogel biomaterials, in the form of laser-ablated microchannels, to provide contact guidance for unidirectional growth following sciatic nerve injury. We tested the regeneration capacity of subcritical nerve gap injuries in rats treated with photo-patterned materials and compared these with injuries treated with unpatterned hydrogels, either stiff or compliant. Among the factors tested were shear modulus, biological composition, and micropatterning of the materials. The microchannel guidance patterns, combined with appropriately matched degradation and stiffness properties of the material, proved most essential for the uniform tissue propagation during the nerve regeneration process.},
  subject      = {Tissue Engineering},
  language  = {en}
}
@article{NauTeuschlEbneretal.,
  author    = {Nau, Thomas and Teuschl, Andreas and Ebner, Anna and Jung, Ilse and Schenk, Christian},
  title     = {Low revision rate and excellent outcome of primary ACL repair with a minimum follow-up of 5 years.},
  series = {Muscle, ligaments and tendons Journal},
  journal   = {Muscle, ligaments and tendons Journal},
  pages     = {185 -- 190},
  abstract  = {Introduction: Due to limitations of ACL reconstruction, primary ACL repair has recently regained research interest. Although abandoned in the past, primary repair with conservation of the original ligament demonstrates considerable advantages compared to reconstruction. We hypothesized that early repair, strictly limited to patients with a proximal ACL rupture and excellent tissue quality of the remaining ACL stump, would lead to equal revision rates and subjective outcomes as reported for ACL reconstruction after a minimum of 5 years. Methods: In this questionnaire study, patients who had a primary ACL repair between 2002 and 2009 were invited to participate. Besides any potential revision surgery, the Tegner activity scale and the Knee Injury and Osteoarthritis Outcome Score were included in the evaluation. Results: Out of 1912 patients who had ACL related surgery during the observation period, 221 (11.4\%) had a primary ACL repair. 60 patients (61 knees) were available for follow-up. In 2/61 (3.3\%) cases ACL revision surgery was performed and one patient had meniscus surgery of the affected side. The median Tegner activity scale was 6 (range, 3 to 10). The mean KOOS subscores were 88.8\% (Function/Sports), 86.6\% (Quality of life), 94.6 (Symptoms), 94.0 (Pain) and 97.0 (Activities of Daily Living). Conclusion: Primary ACL repair, strictly limited to proximal ruptures with good tissue quality leads to revision rates and subjective outcome comparable to ACL reconstruction. Level of evidence: IV.},
  subject      = {Regeneration},
  language  = {en}
}
@misc{TeuschlHeimelMonforteVilaetal.,
  author    = {Teuschl, Andreas and Heimel, Patrick and Monforte Vila, Xavier and N{\"u}rnberger, Sylvia and Tangl, Stefan and van Griensven, Martijn and Redl, Heinz and Nau, Thomas},
  title     = {Anterior cruciate ligament regeneration using the silk-based RegACL scaffold},
  subject      = {Tissue Engineering},
  language  = {en}
}
@incollection{HackethalSchuhHoferetal.,
  author    = {Hackethal, Johannes and Schuh, Christina and Hofer, Alexandra and Meixner, Barbara and Hennerbichler, Simone and Redl, Heinz and Teuschl, Andreas},
  title     = {Human Placenta Laminin-111 as a Multifunctional Protein for Tissue Engineering and Regenerative Medicine},
  series = {Advances in Experimental Medicine and Biology},
  booktitle = {Advances in Experimental Medicine and Biology},
  publisher = {Springer},
  publisher      = {Fachhochschule Technikum Wien},
  subject      = {Biomaterial},
  language  = {en}
}
@misc{SalzerRiederMonforteVilaetal.,
  author    = {Salzer, Elias and Rieder, Bernhard and Monforte Vila, Xavier and Weihs, Anna and R{\"u}nzler, Dominik and Teuschl, Andreas},
  title     = {Evaluation of a novel hydrostatic pressure bioreactor on bovine cartilage chips},
  subject      = {Bioreactor},
  language  = {en}
}
@misc{SlezakRoseHercheretal.,
  author    = {Slezak, Paul and Rose, Roland and Hercher, David and Weihs, Anna and Fuchs, Christiane and Redl, Heinz and Mittermayr, Rainer and Slezak, Cyrill},
  title     = {Tracking therapeutic shockwaves and their impact on regeneration},
  subject      = {Shockwave Therapy},
  language  = {en}
}
@techreport{Freistetter,
  author    = {Freistetter, Florian},
  title     = {The Power of Lauf},
  organization    = {ORF Sendung "Science Busters"},
  subject      = {Bioreactor},
  language  = {de}
}
@misc{HromadaTomaschWeihsetal.,
  author    = {Hromada, Carina and Tomasch, Janine and Weihs, Anna and R{\"u}nzler, Dominik and Teuschl, Andreas},
  title     = {Engineering of 3D Tissue Constructs Using our Novel MagneTissue Bioreactor as Alternatives to Animal Models},
  subject      = {Bioreactor},
  language  = {en}
}
@misc{MuehlederFuchsBassilioetal.,
  author    = {M{\"u}hleder, Severin and Fuchs, Christiane and Bassilio, Jose and Sczwarc, Dorota and Pill, Karoline and Slezak, Paul and Labuda, Krystina and Siehs, Christian and Pr{\"o}ll, Johannes and Priglinger, Eleni and Redl, Heinz and Holnthoner, Wolfgang},
  title     = {The purinergic receptor P2Y2 modulates endothelial sprouting and angiogenesis},
  subject      = {Angiogenesis},
  language  = {en}
}
@article{SimsaPadmaHeheretal.,
  author    = {Simsa, Robin and Padma, Arvind and Heher, Philipp and Hellstr{\"o}m, Mats and Teuschl, Andreas and Jenndahl, Lachmi and Bergh, Niklas and Fogelstrand, Per},
  title     = {Systematic in vitro comparison of decellularization protocols for blood vessels.},
  series = {PLoS One},
  journal   = {PLoS One},
  subject      = {Tissue Engineering},
  language  = {en}
}
@article{SchneiderEnayatiGrasletal.,
  author    = {Schneider, Karl Heinrich and Enayati, Marjan and Grasl, Christian and Walter, Ingrid and Budinsky, Lubos and Zebic, Gabriel and Kaun, Christoph and Wagner, Anja and Kratochwill, Klaus and Redl, Heinz and Teuschl, Andreas and Podesser, Bruno K. and Bergmeister, Helga},
  title     = {Acellular vascular matrix grafts from human placenta chorion: Impact of ECM preservation on graft characteristics, protein composition and in vivo performance.},
  series = {Biomaterials},
  journal   = {Biomaterials},
  pages     = {14 -- 26},
  abstract  = {Small diameter vascular grafts from human placenta, decellularized with either Triton X-100 (Triton) or SDS and crosslinked with heparin were constructed and characterized. Graft biochemical properties, residual DNA, and protein composition were evaluated to compare the effect of the two detergents on graft matrix composition and structural alterations. Biocompatibility was tested in vitro by culturing the grafts with primary human macrophages and in vivo by subcutaneous implantation of graft conduits (n = 7 per group) into the flanks of nude rats. Subsequently, graft performance was evaluated using an aortic implantation model in Sprague Dawley rats (one month, n = 14). In situ graft imaging was performed using MRI angiography. Retrieved specimens were analyzed by electromyography, scanning electron microscopy, histology and immunohistochemistry to evaluate cell migration and the degree of functional tissue remodeling. Both decellularization methods resulted in grafts of excellent biocompatibility in vitro and in vivo, with low immunogenic potential. Proteomic data revealed removal of cytoplasmic proteins with relative enrichment of ECM proteins in decelluarized specimens of both groups. Noteworthy, LC-Mass Spectrometry analysis revealed that 16 proteins were exclusively preserved in Triton decellularized specimens in comparison to SDS-treated specimens. Aortic grafts showed high patency rates, no signs of thrombus formation, aneurysms or rupture. Conduits of both groups revealed tissue-specific cell migration indicative of functional remodeling. This study strongly suggests that decellularized allogenic grafts from the human placenta have the potential to be used as vascular replacement materials. Both detergents produced grafts with low residual immunogenicity and appropriate mechanical properties. Observed differences in graft characteristics due to preservation method had no impact on successful in vivo performance in the rodent model.},
  subject      = {Biomaterial},
  language  = {en}
}
@article{NuernbergerSchneidervanOschetal.,
  author    = {N{\"u}rnberger, Sylvia and Schneider, Cornelia and van Osch, Gerjo and Keibl, Claudia and Rieder, Bernhard and Monforte, Xavier and Teuschl, Andreas and M{\"u}hleder, Severin and Holnthoner, Wolfgang and Sch{\"a}dl, Barbara and Gahleitner, Christoph and Redl, Heinz and Wolbank, Susanne},
  title     = {Repopulation of an auricular cartilage scaffold, AuriScaff, perforated with an enzyme combination.},
  series = {Acta Biomaterialia},
  journal   = {Acta Biomaterialia},
  subject      = {Tissue Engineering},
  language  = {en}
}
@article{HeimelSwiadekSlezaketal.,
  author    = {Heimel, Patrick and Swiadek, Nicole V. and Slezak, Paul and Kerbl, Markus and Schneider, Cornelia and N{\"u}rnberger, Sylvia and Redl, Heinz and Teuschl, Andreas and Hercher, David},
  title     = {Iodine-Enhanced Micro-CT Imaging of Soft Tissue on the Example of Peripheral Nerve Regeneration},
  series = {Contrast Media \& Molecular Imaging},
  journal   = {Contrast Media \& Molecular Imaging},
  subject      = {µCT},
  language  = {en}
}