@article{JesenbergerZmajkovicovaCatalanottietal., author = {Jesenberger, Veronika and Zmajkovicova, Katarina and Catalanotti, Federica and Baumgartner, Christian and Reyes, Gloria Ximena and Baccarini, Manuela}, title = {MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance}, series = {Mol. Cell}, volume = {2013}, journal = {Mol. Cell}, number = {50}, pages = {43 -- 55}, abstract = {The Raf/MEK/ERK and PI3K/Akt pathways are prominent effectors of oncogenic Ras. These pathways negatively regulate each other, but the mechanism involved is incompletely understood. We now identify MEK1 as an essential regulator of lipid/protein phosphatase PTEN, through which it controls phosphatidylinositol-3-phosphate accumulation and AKT signaling. MEK1 ablation stabilizes AKT activation and, in vivo, causes a lupus-like autoimmune disease and myeloproliferation. Mechanistically, MEK1 is necessary for PTEN membrane recruitment as part of a ternary complex containing the multidomain adaptor MAGI1. Complex formation is independent of MEK1 kinase activity but requires phosphorylation of T292 on MEK1 by activated ERK. Thus, inhibiting the ERK pathway reduces PTEN membrane recruitment, increasing phosphatidylinositol-3-phosphate accumulation and AKT activation. Our data offer a conceptual framework for the observation that activation of the PI3K pathway frequently mediate resistance to MEK inhibitors and for the promising results obtained by combined MEK/PI3K inhibition in preclinical cancer models.}, subject = {MEK1 pathway}, language = {en} } @article{ButaDavidDresseletal., author = {Buta, Christiane and David, Robert and Dressel, Ralf and Emgard, Mia and Fuchs, Christiane and Gross, Ulrike and Healy, Lyn and Hescheler, J{\"u}rgen and Kolar, Roman and Martin, Ulrich and Mikkers, Harald and M{\"u}ller, Franz-Josef and Schneider, Rebekka and Seiler, Andrea and Spielmann, Horst and Weitzer, Georg}, title = {REconsidering pluripotency tests: do we still need teratoma assays?}, series = {Stem Cell Research}, volume = {11}, journal = {Stem Cell Research}, number = {1}, pages = {552 -- 562}, subject = {Assay}, language = {en} } @article{DungelTeuschlBanerjeeetal., author = {Dungel, Peter and Teuschl, Andreas and Banerjee, Asmita and Paier-Pourani, Jamile and Redl, Heinz and Kozlov, Andrey}, title = {Impact of mitochondria on nitrite metabolism in HL-1 cardiomyocytes}, series = {Frontiers in Physiology}, journal = {Frontiers in Physiology}, number = {4}, subject = {Nitrite}, language = {en} } @article{TeuschlvanGriensvenRedl, author = {Teuschl, Andreas and van Griensven, Martijn and Redl, Heinz}, title = {Sericin removal from raw Bombys mori silk scaffolds of high hierarchical order}, series = {Tissue Eng Part C Methods}, journal = {Tissue Eng Part C Methods}, subject = {Scaffold}, language = {en} } @article{RuessKristenEckeltetal., author = {Ruess, Christian and Kristen, Karl-Heinz and Eckelt, Markus and Mally, Franziska and Litzenberger, Stefan and Sabo, Anton}, title = {Stand up Paddle Surfing - An Aerobic Workout and Balance Training}, series = {Procedia Engineering}, volume = {60}, journal = {Procedia Engineering}, number = {0}, pages = {62 -- 66}, subject = {Stand-Up Paddling}, language = {en} } @article{MallyLitzenbergerSabo, author = {Mally, Franziska and Litzenberger, Stefan and Sabo, Anton}, title = {Surface Electromyography Measurements of Dorsal Muscle Cross-Activation in Therapeutic Climbing}, series = {Procedia Engineering}, volume = {60}, journal = {Procedia Engineering}, number = {0}, pages = {22 -- 27}, subject = {Muscle Activity}, language = {en} } @misc{UrbauerFrohnerForjanetal., author = {Urbauer, Philipp and Frohner, Matthias and Forjan, Mathias and Pohn, Birgit and Sauermann, Stefan and Mense, Alexander}, title = {A Closer Look on Standards Based Personal Health Device Communication: A R{\´e}sum{\´e} over Four Years Implementing Telemonitoring Solutions}, subject = {eHealth}, language = {en} } @misc{FrohnerUrbauerForjanetal., author = {Frohner, Matthias and Urbauer, Philipp and Forjan, Mathias and Pohn, Birgit and Gerbovics, Ferenc and Sauermann, Stefan and Mense, Alexander}, title = {Development of an Android App in compliance with the Continua Health Alliance Design Guidelines for medical device connectivity in mHealth}, subject = {App development}, language = {en} } @article{UrbauerFrohnerForjanetal., author = {Urbauer, Philipp and Frohner, Matthias and Forjan, Mathias and Pohn, Birgit and Sauermann, Stefan and Mense, Alexander}, title = {A Closer Look on Standards Based Personal Health Device Communication: A R{\´e}sum{\´e} over Four Years Implementing Telemonitoring Solutions}, series = {European Journal for Biomedical Informatics}, volume = {2012}, journal = {European Journal for Biomedical Informatics}, number = {Vol 8, Issue 3}, pages = {65 -- 70}, subject = {eHealth}, language = {en} } @inproceedings{FrohnerUrbauerForjanetal., author = {Frohner, Matthias and Urbauer, Philipp and Forjan, Mathias and Pohn, Birgit and Gerbovics, Ferenc and Sauermann, Stefan and Mense, Alexander}, title = {Development of an Android App in compliance with the Continua Health Alliance Design Guidelines for medical device connectivity in mHealth}, series = {46th annual conference of the German Society for Biomedical Engineering(BMT 2012)}, booktitle = {46th annual conference of the German Society for Biomedical Engineering(BMT 2012)}, pages = {1051 -- 1053}, subject = {App development}, language = {en} }