@article{TomaschMaleinerHromadaetal.,
  author    = {Tomasch, Janine and Maleiner, Babette and Hromada, Carina and Szwarc-Hofbauer, Dorota and Teuschl-Woller, Andreas},
  title     = {Cyclic Tensile Stress Induces Skeletal Muscle Hypertrophy and Myonuclear Accretion in a 3D Model},
  series = {Tissue Eng. Part A.},
  volume    = {2023},
  journal   = {Tissue Eng. Part A.},
  number    = {Mar},
  pages     = {257 -- 268},
  abstract  = {Skeletal muscle is highly adaptive to mechanical stress due to its resident stem cells and the pronounced level of myotube plasticity. Herein, we study the adaptation to mechanical stress and its underlying molecular mechanisms in a tissue-engineered skeletal muscle model. We subjected differentiated 3D skeletal muscle-like constructs to cyclic tensile stress using a custom-made bioreactor system, which resulted in immediate activation of stress-related signal transducers (Erk1/2, p38). Cell cycle re-entry, increased proliferation, and onset of myogenesis indicated subsequent myoblast activation. Furthermore, elevated focal adhesion kinase and β-catenin activity in mechanically stressed constructs suggested increased cell adhesion and migration. After 3 days of mechanical stress, gene expression of the fusogenic markers MyoMaker and MyoMixer, myotube diameter, myonuclear accretion, as well as S6 activation, were significantly increased. Our results highlight that we established a promising tool to study sustained adaptation to mechanical stress in healthy, hypertrophic, or regenerating skeletal muscle.},
  subject      = {fibrin},
  language  = {en}
}
@misc{NemecFrohner,
  author    = {Nemec, Iris and Frohner, Matthias},
  title     = {How can life science students, especially biomedical engineering students, benefit from the extra-curricular offerings and systems already established in other scientific fields?},
  series = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation},
  journal   = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation},
  doi       = {https://doi.org/10.1515/bmt-2022-2001},
  pages     = {348},
  subject      = {extra-curricular offerings},
  language  = {en}
}
@misc{NemecMalaskovaPereiraetal.,
  author    = {Nemec, Iris and Malaskova, Michaela and Pereira, Luis and Pavao, Joao and Frohner, Matthias},
  title     = {Experiences of intercultural teaching activities in the field of eHealth},
  series = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation},
  journal   = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation},
  doi       = {https://doi.org/10.1515/bmt-2022-2001},
  pages     = {351},
  subject      = {intercultural teaching},
  language  = {en}
}
@misc{TraxlerBalz,
  author    = {Traxler, Lukas and Balz, Andrea},
  title     = {Current Advances in the Optical Characterization of Intraocular Lenses},
  series = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation},
  journal   = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation},
  doi       = {https://doi.org/10.1515/bmt-2022-2001},
  pages     = {102},
  subject      = {Intraocular Lenses},
  language  = {en}
}
@article{HanetsederLevstekTeuschlWolleretal.,
  author    = {Hanetseder, Dominik and Levstek, Tina and Teuschl-Woller, Andreas and Frank, Julia Katharina and Schaedl, Barbara and Redl, Heinz and Marolt Presen, Darja},
  title     = {Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age},
  series = {Front Bioeng Biotechnol},
  volume    = {11},
  journal   = {Front Bioeng Biotechnol},
  doi       = {https://doi.org/10.3389/fbioe.2023.1214019},
  abstract  = {Regeneration of bone defects is often limited due to compromised bone tissue physiology. Previous studies suggest that engineered extracellular matrices enhance the regenerative capacity of mesenchymal stromal cells. In this study, we used human-induced pluripotent stem cells, a scalable source of young mesenchymal progenitors (hiPSC-MPs), to generate extracellular matrix (iECM) and test its effects on the osteogenic capacity of human bone-marrow mesenchymal stromal cells (BMSCs). iECM was deposited as a layer on cell culture dishes and into three-dimensional (3D) silk-based spongy scaffolds. After decellularization, iECM maintained inherent structural proteins including collagens, fibronectin and laminin, and contained minimal residual DNA. Young adult and aged BMSCs cultured on the iECM layer in osteogenic medium exhibited a significant increase in proliferation, osteogenic marker expression, and mineralization as compared to tissue culture plastic. With BMSCs from aged donors, matrix mineralization was only detected when cultured on iECM, but not on tissue culture plastic. When cultured in 3D iECM/silk scaffolds, BMSCs exhibited significantly increased osteogenic gene expression levels and bone matrix deposition. iECM layer showed a similar enhancement of aged BMSC proliferation, osteogenic gene expression, and mineralization compared with extracellular matrix layers derived from young adult or aged BMSCs. However, iECM increased osteogenic differentiation and decreased adipocyte formation compared with single protein substrates including collagen and fibronectin. Together, our data suggest that the microenvironment comprised of iECM can enhance the osteogenic activity of BMSCs, providing a bioactive and scalable biomaterial strategy for enhancing bone regeneration in patients with delayed or failed bone healing.},
  subject      = {aging},
  language  = {en}
}
@article{BernhardMaroltPresenLietal.,
  author    = {Bernhard, Jonathan C and Marolt Presen, Darja and Li, Ming and Monforte, Xavier and Ferguson, James and Leinfellner, Gabriele and Heimel, Patrick and Betti, Susanne L and Shu, Sharon and Teuschl-Woller, Andreas H and Tangl, Stefan and Redl, Heinz and Vunjak-Novakovic, Gordana},
  title     = {Effects of Endochondral and Intramembranous Ossification Pathways on Bone Tissue Formation and Vascularization in Human Tissue-Engineered Grafts},
  series = {Cells},
  volume    = {11},
  journal   = {Cells},
  number    = {19:3070},
  doi       = {10.3390/cells11193070},
  abstract  = {Bone grafts can be engineered by differentiating human mesenchymal stromal cells (MSCs) via the endochondral and intramembranous ossification pathways. We evaluated the effects of each pathway on the properties of engineered bone grafts and their capacity to drive bone regeneration. Bone-marrow-derived MSCs were differentiated on silk scaffolds into either hypertrophic chondrocytes (hyper) or osteoblasts (osteo) over 5 weeks of in vitro cultivation, and were implanted subcutaneously for 12 weeks. The pathways' constructs were evaluated over time with respect to gene expression, composition, histomorphology, microstructure, vascularization and biomechanics. Hypertrophic chondrocytes expressed higher levels of osteogenic genes and deposited significantly more bone mineral and proteins than the osteoblasts. Before implantation, the mineral in the hyper group was less mature than that in the osteo group. Following 12 weeks of implantation, the hyper group had increased mineral density but a similar overall mineral composition compared with the osteo group. The hyper group also displayed significantly more blood vessel infiltration than the osteo group. Both groups contained M2 macrophages, indicating bone regeneration. These data suggest that, similar to the body's repair processes, endochondral pathway might be more advantageous when regenerating large defects, whereas intramembranous ossification could be utilized to guide the tissue formation pattern with a scaffold architecture.},
  subject      = {bone tissue engineering},
  language  = {en}
}
@article{GollmannTepekoeylueGraberHirschetal.,
  author    = {Gollmann-Tepek{\"o}yl{\"u}, Can and Graber, Michael and Hirsch, Jakob and Mair, Sophia and Naschberger, Andreas and P{\"o}lzl, Leo and N{\"a}gele, Felix and Kirchmair, Elke and Degenhart, Gerald and Demetz, Egon and Hilbe, Richard and Chen, Hao-Yu and Engert, James C and B{\"o}hm, Anna and Franz, Nadja and Lobenwein, Daniela and Lener, Daniela and Fuchs, Christiane and Weihs, Anna and T{\"o}chterle, Sonja and Vogel, Georg F and Schweiger, Victor and Eder, Jonas and Pietschmann, Peter and Seifert, Markus and Kronenberg, Florian and Coassin, Stefan and Blumer, Michael and Hackl, Hubert and Meyer, Dirk and Feuchtner, Gudrun and Kirchmair, Rudolf and Troppmair, Jakob and Krane, Markus and Weiss, G{\"u}nther and Tsimikas, Sotirios and Thanassoulis, George and Grimm, Michael and Rupp, Bernhard and Huber, Lukas A and Zhang, Shen-Ying and Casanova, Jean-Laurent and Tancevski, Ivan and Holfeld, Johannes},
  title     = {Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification},
  series = {Circulation},
  volume    = {147},
  journal   = {Circulation},
  number    = {20},
  doi       = {10.1161/CIRCULATIONAHA.122.063481},
  pages     = {1518 -- 1533},
  subject      = {Toll-like receptor 3},
  language  = {en}
}
@misc{BalzLangerFrohneretal.,
  author    = {Balz, Andrea and Langer, Sarah and Frohner, Matthias and Forjan, Mathias},
  title     = {Development of Internationalized Teaching and Training Modules for Healthcare Professionals},
  series = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation},
  journal   = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation},
  doi       = {https://doi.org/10.1515/bmt-2022-2001},
  pages     = {353},
  subject      = {Internationalized Teaching},
  language  = {en}
}
@article{XuGeppLenggeretal.,
  author    = {Xu, Yingyang and Gepp, Barbara and Lengger, Nina and Yin, Jia and Breiteneder, Heimo},
  title     = {Identification of probable pectinesterase as a major allergen of pollen of the Asian white birch (Betula platyphylla) in northern China},
  series = {Asian Pac J Allergy Immunol},
  journal   = {Asian Pac J Allergy Immunol},
  doi       = {10.12932/AP-100722-1409},
  subject      = {birch pollen allergy},
  language  = {en}
}
@misc{EidiBalzForjan,
  author    = {Eidi, Nada and Balz, Andrea and Forjan, Mathias},
  title     = {MedTech-mR - Creating a Virtual Enviroment for Medical Training and Room Planning},
  series = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation},
  journal   = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation},
  doi       = {https://doi.org/10.1515/bmt-2022-2001},
  pages     = {349},
  subject      = {Medical Training},
  language  = {en}
}