@article{BernhardMaroltPresenLietal., author = {Bernhard, Jonathan C and Marolt Presen, Darja and Li, Ming and Monforte, Xavier and Ferguson, James and Leinfellner, Gabriele and Heimel, Patrick and Betti, Susanne L and Shu, Sharon and Teuschl-Woller, Andreas H and Tangl, Stefan and Redl, Heinz and Vunjak-Novakovic, Gordana}, title = {Effects of Endochondral and Intramembranous Ossification Pathways on Bone Tissue Formation and Vascularization in Human Tissue-Engineered Grafts}, series = {Cells}, volume = {11}, journal = {Cells}, number = {19:3070}, doi = {10.3390/cells11193070}, abstract = {Bone grafts can be engineered by differentiating human mesenchymal stromal cells (MSCs) via the endochondral and intramembranous ossification pathways. We evaluated the effects of each pathway on the properties of engineered bone grafts and their capacity to drive bone regeneration. Bone-marrow-derived MSCs were differentiated on silk scaffolds into either hypertrophic chondrocytes (hyper) or osteoblasts (osteo) over 5 weeks of in vitro cultivation, and were implanted subcutaneously for 12 weeks. The pathways' constructs were evaluated over time with respect to gene expression, composition, histomorphology, microstructure, vascularization and biomechanics. Hypertrophic chondrocytes expressed higher levels of osteogenic genes and deposited significantly more bone mineral and proteins than the osteoblasts. Before implantation, the mineral in the hyper group was less mature than that in the osteo group. Following 12 weeks of implantation, the hyper group had increased mineral density but a similar overall mineral composition compared with the osteo group. The hyper group also displayed significantly more blood vessel infiltration than the osteo group. Both groups contained M2 macrophages, indicating bone regeneration. These data suggest that, similar to the body's repair processes, endochondral pathway might be more advantageous when regenerating large defects, whereas intramembranous ossification could be utilized to guide the tissue formation pattern with a scaffold architecture.}, subject = {bone tissue engineering}, language = {en} } @article{GollmannTepekoeylueGraberHirschetal., author = {Gollmann-Tepek{\"o}yl{\"u}, Can and Graber, Michael and Hirsch, Jakob and Mair, Sophia and Naschberger, Andreas and P{\"o}lzl, Leo and N{\"a}gele, Felix and Kirchmair, Elke and Degenhart, Gerald and Demetz, Egon and Hilbe, Richard and Chen, Hao-Yu and Engert, James C and B{\"o}hm, Anna and Franz, Nadja and Lobenwein, Daniela and Lener, Daniela and Fuchs, Christiane and Weihs, Anna and T{\"o}chterle, Sonja and Vogel, Georg F and Schweiger, Victor and Eder, Jonas and Pietschmann, Peter and Seifert, Markus and Kronenberg, Florian and Coassin, Stefan and Blumer, Michael and Hackl, Hubert and Meyer, Dirk and Feuchtner, Gudrun and Kirchmair, Rudolf and Troppmair, Jakob and Krane, Markus and Weiss, G{\"u}nther and Tsimikas, Sotirios and Thanassoulis, George and Grimm, Michael and Rupp, Bernhard and Huber, Lukas A and Zhang, Shen-Ying and Casanova, Jean-Laurent and Tancevski, Ivan and Holfeld, Johannes}, title = {Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification}, series = {Circulation}, volume = {147}, journal = {Circulation}, number = {20}, doi = {10.1161/CIRCULATIONAHA.122.063481}, pages = {1518 -- 1533}, subject = {Toll-like receptor 3}, language = {en} } @misc{BalzLangerFrohneretal., author = {Balz, Andrea and Langer, Sarah and Frohner, Matthias and Forjan, Mathias}, title = {Development of Internationalized Teaching and Training Modules for Healthcare Professionals}, series = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation}, journal = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation}, doi = {https://doi.org/10.1515/bmt-2022-2001}, pages = {353}, subject = {Internationalized Teaching}, language = {en} } @article{XuGeppLenggeretal., author = {Xu, Yingyang and Gepp, Barbara and Lengger, Nina and Yin, Jia and Breiteneder, Heimo}, title = {Identification of probable pectinesterase as a major allergen of pollen of the Asian white birch (Betula platyphylla) in northern China}, series = {Asian Pac J Allergy Immunol}, journal = {Asian Pac J Allergy Immunol}, doi = {10.12932/AP-100722-1409}, subject = {birch pollen allergy}, language = {en} } @misc{EidiBalzForjan, author = {Eidi, Nada and Balz, Andrea and Forjan, Mathias}, title = {MedTech-mR - Creating a Virtual Enviroment for Medical Training and Room Planning}, series = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation}, journal = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation}, doi = {https://doi.org/10.1515/bmt-2022-2001}, pages = {349}, subject = {Medical Training}, language = {en} } @misc{MalaskovaForjan, author = {Malaskova, Michaela and Forjan, Mathias}, title = {Current topics in Life Science Engineering lectures}, series = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation}, journal = {Abstracts of the 2022 Joint Annual Conference of the Austrian ({\"O}GBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation}, doi = {https://doi.org/10.1515/bmt-2022-2001}, pages = {350}, subject = {Life Science Engineering}, language = {en} } @article{RomanelliBielerHeimeletal., author = {Romanelli, Pasquale and Bieler, Lara and Heimel, Patrick and Škokić, Siniša and Jakubecova, Dominika and Kreutzer, Christina and Zaunmair, Pia and Smolčić, Tomislav and Benedetti, Bruno and Rohde, Eva and Gimona, Mario and Hercher, David and Dobrivojević Radmilović, Marina and Couillard-Despres, Sebastien}, title = {Enhancing Functional Recovery Through Intralesional Application of Extracellular Vesicles in a Rat Model of Traumatic Spinal Cord Injury}, series = {Front Cell Neurosci}, volume = {15}, journal = {Front Cell Neurosci}, doi = {10.3389/fncel.2021.795008}, abstract = {Local inflammation plays a pivotal role in the process of secondary damage after spinal cord injury. We recently reported that acute intravenous application of extracellular vesicles (EVs) secreted by human umbilical cord mesenchymal stromal cells dampens the induction of inflammatory processes following traumatic spinal cord injury. However, systemic application of EVs is associated with delayed delivery to the site of injury and the necessity for high doses to reach therapeutic levels locally. To resolve these two constraints, we injected EVs directly at the lesion site acutely after spinal cord injury. We report here that intralesional application of EVs resulted in a more robust improvement of motor recovery, assessed with the BBB score and sub-score, as compared to the intravenous delivery. Moreover, the intralesional application was more potent in reducing inflammation and scarring after spinal cord injury than intravenous administration. Hence, the development of EV-based therapy for spinal cord injury should aim at an early application of vesicles close to the lesion.}, subject = {exosomes}, language = {en} } @article{FeichtingerHeimelTangletal., author = {Feichtinger, Xaver and Heimel, Patrick and Tangl, Stefan and Keibl, Claudia and N{\"u}rnberger, Sylvia and Schanda, Jakob Emanuel and Hercher, David and Kocijan, Roland and Redl, Heinz and Grillari, Johannes and Fialka, Christian and Mittermayr, Rainer}, title = {Improved biomechanics in experimental chronic rotator cuff repair after shockwaves is not reflected by bone microarchitecture}, series = {PLoS One}, volume = {17}, journal = {PLoS One}, number = {1}, doi = {10.1371/journal.pone.0262294}, subject = {chronic rotator cuff repair}, language = {en} } @phdthesis{Tomasch, author = {Tomasch, Janine}, title = {Strategies to improve the myogenic outcome of skeletal muscle tissue engineering approaches through optimization of biomaterial properties and mechanical stimuli}, school = {Fachhochschule Technikum Wien}, subject = {muscle}, language = {en} } @misc{LangerNemecKollmitzeretal., author = {Langer, Sarah and Nemec, Iris and Kollmitzer, Josef and Scherer, Matthias and Martinek, Johannes}, title = {Vergleich des decompositionierten und des {\"u}berlagerten Elektromyogramms zur Analyse der Muskelerm{\"u}dung}, abstract = {Ziel dieser Studie war das {\"u}berlagerte Elektromyogramm (ueEMG) und das decompositionierte (dEMG) auf deren Reliabilit{\"a}t und Aussagekraft zu {\"u}berpr{\"u}fen. Hierf{\"u}r vollzogen zehn gesunde m{\"a}nnliche Probanden zu drei Testzeitpunkten isometrische Erm{\"u}dungsmessungen. Hintergrund Bei der Messung des ueEMG werden die Motor Units Aktionspotentiale (MUAPS) elektrisch {\"u}berlagert. Physiologische Muskelerm{\"u}dung zeigt sich hier unter anderem in der Ver{\"a}nderung des Frequenzspektrums und der Signalamplitude. Letzteres steigt bei Erm{\"u}dung an, wohingegen die mediane Frequenz (MF) sinkt. Eine weitere M{\"o}glichkeit die Muskelerm{\"u}dung mittels Oberfl{\"a}chen-EMG zu ermitteln ist die Anwendung des dEMGs. Dieses erm{\"o}glicht mithilfe einer Mustererkennungssoftware einzelne MUAPS zu erkennen. Studien zeigten, dass aktive Motor Units (MU) bei wiederholten oder anhaltenden submaximalen Kontraktionen als Muskelerm{\"u}dung ihre Feuerungsrate erh{\"o}hen und neue MU rekrutiert werden. Bisher wurden diese Methoden jeweils einzeln betrachtet. Um sicherzustellen welcher Ansatz f{\"u}r klinische Daten geeigneter ist, wurden Datens{\"a}tze zu beiden Methoden gleichzeitig generiert und hinsichtlich ihrer Aussagekraft und Wiederholbarkeit mit statistischen Mitteln verglichen.}, subject = {Elektromyogramm}, language = {de} }