TY - GEN A1 - Drauschke, Andreas T1 - Neues aus der Welt der Optik - von Laserschwertern und Tarnvorrichtungen KW - Optics Y1 - ER - TY - GEN A1 - Drauschke, Andreas T1 - Effiziente Solarzellen mit Metamaterialien KW - Photonics Y1 - ER - TY - GEN A1 - Drauschke, Andreas T1 - Applications of Optogenetics KW - Optogenetics Y1 - 2018 ER - TY - CHAP A1 - Drauschke, Andreas T1 - Comparison of Numerical Eye Models and its Representation within a Mechanical Eye Model T2 - IFAC-Papers Online KW - Mechanical Eye Y1 - 2018 SP - 133 EP - 138 ER - TY - GEN A1 - Drauschke, Andreas T1 - Comparison of Numerical Eye Models and its Representation within a Mechanical Eye Model KW - Mechanical Eye Y1 - 2018 ER - TY - CHAP A1 - Pasteka, Richard A1 - Forjan, Mathias A1 - Drauschke, Andreas T1 - Comparison of Mathematical and Controlled Mechanical Lung Simulation in Active Breathing and Ventilated State T2 - Proceedings of the 15th IFAC Conference on Programmable Devices and Embedded Systems PDeS 2018 KW - Breathing Simulation KW - Mathematical Models KW - In-silico Models KW - Flow Measurement KW - Mechanical Simulation Y1 - ER - TY - JOUR A1 - Pasteka, Richard A1 - Forjan, Mathias A1 - Sauermann, Stefan A1 - Drauschke, Andreas T1 - Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation JF - Scientific Reports N2 - Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap between the complex, real anatomical environment and the safe, cost-effective simulation methods. The presented electro-mechanical lung simulator, xPULM, combines in-silico, ex-vivo and mechanical respiratory approaches by realistically replicating an actively breathing human lung. The reproducibility of sinusoidal breathing simulations with xPULM was verified for selected breathing frequencies (10–18 bpm) and tidal volumes (400–600 ml) physiologically occurring during human breathing at rest. Human lung anatomy was modelled using latex bags and primed porcine lungs. High reproducibility of flow and pressure characteristics was shown by evaluating breathing cycles (nTotal = 3273) with highest standard deviation |3σ| for both, simplified lung equivalents (μV˙ = 23.98 ± 1.04 l/min, μP = −0.78 ± 0.63 hPa) and primed porcine lungs (μV˙ = 18.87 ± 2.49 l/min, μP = −21.13 ± 1.47 hPa). The adaptability of the breathing simulation parameters, coupled with the use of porcine lungs salvaged from a slaughterhouse process, represents an advancement towards anatomically and physiologically realistic modelling of human respiration. KW - Breathing Simulation KW - Lung Simulator KW - Biomedical Engineering Y1 - 2020 VL - Vol 9 IS - No. 1 SP - Article number: 19778 ER - TY - GEN A1 - Pasteka, Richard A1 - Forjan, Mathias A1 - Drauschke, Andreas T1 - Comparison of Mathematical and Controlled Mechanical Lung Simulation in Active Breathing and Ventilated State KW - Breathing Simulation KW - Flow Measurement KW - In-silico Models KW - Mathematical Models KW - Mechanical Simulation Y1 - ER - TY - GEN A1 - Pasteka, Richard A1 - Forjan, Mathias A1 - Drauschke, Andreas T1 - Comparison of breathing patterns for aerosol inhalation using an electro-mechanical lung simulator T2 - ALTEX Proceedings - EUSAAT 2018, Linz KW - Biomedical Engineering KW - mechanical lung-simulator Y1 - 2018 ER - TY - GEN A1 - Forjan, Mathias A1 - Pasteka, Richard A1 - Drauschke, Andreas T1 - Lung simulation – an alterna� tive approach to animal testing for applications in aerosol and respiratory research T2 - ALTEX Proceedings - EUSAAT 2018, Linz KW - Biomedical Engineering KW - lung simulation Y1 - ER -