TY  - GEN
A1  - Teuschl, Andreas
A1  - Fuchs, Christiane
A1  - Feichtinger, Georg
A1  - Heher, Philipp
A1  - Heimel, Patrick
A1  - Schuh, Christina
A1  - Nürnberger, Sylvia
A1  - Nau, Thomas
A1  - Rünzler, Dominik
A1  - Redl, Heinz
T1  - Fibrin or Fibroin - Not only the "o" Makes the Difference
KW  - Fibrin
KW  - Fibroin
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Weihs, Anna
A1  - Fuchs, Christiane
A1  - Teuschl, Andreas
A1  - Hartinger, Joachim
A1  - Slezak, Paul
A1  - Mittermayr, Rainer
A1  - Redl, Heinz
A1  - Junger, Wolfgang
A1  - Sitte, Harald
A1  - Rünzler, Dominik
T1  - Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation
JF  - The Journal of biological chemistry
KW  - Shockwave
Y1  - 
ER  - 
TY  - GEN
A1  - Fuchs, Christiane
T1  - Shockwave treatment promotes proliferation via purinergic signaling coupled ERK1/2 pathway activation
KW  - Shockwave
Y1  - 
ER  - 
TY  - GEN
A1  - Heher, Philipp
A1  - Fuchs, Christiane
A1  - Prüller, Johanna
A1  - Maleiner, Babette
A1  - Kollmitzer, Josef
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
A1  - Wolbank, Susanne
A1  - Redl, Heinz
T1  - A bioreactor-based 3D culture system for skeletal muscle engineering in fibrin scaffolds
KW  - Bioreactors
KW  - Cell Culture
KW  - Muscle
KW  - Scaffold
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Buta, Christiane
A1  - David, Robert
A1  - Dressel, Ralf
A1  - Emgard, Mia
A1  - Fuchs, Christiane
A1  - Gross, Ulrike
A1  - Healy, Lyn
A1  - Hescheler, Jürgen
A1  - Kolar, Roman
A1  - Martin, Ulrich
A1  - Mikkers, Harald
A1  - Müller, Franz-Josef
A1  - Schneider, Rebekka
A1  - Seiler, Andrea
A1  - Spielmann, Horst
A1  - Weitzer, Georg
T1  - REconsidering pluripotency tests: do we still need teratoma assays?
JF  - Stem Cell Research
KW  - Assay
KW  - Stem Cells
Y1  - 2018
VL  - 11
IS  - 1
SP  - 552
EP  - 562
ER  - 
TY  - JOUR
A1  - Rosner, Margit
A1  - Schipany, Katharina
A1  - Gundacker, Claudia
A1  - Shanmugasundaram, Parthasaraty
A1  - Li, Kongzhao
A1  - Fuchs, Christiane
A1  - Lubec, Gert
A1  - Hengstschläger, Martin
T1  - Renal differentiation of amniotic fluid stem cells: perspectives for clinical application and for studies on specific human genetic diseases
JF  - Eur J Clin Invest
KW  - Stem Cells
KW  - Genetic Diseases
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Gundacker, Claudia
A1  - Scheinast, Matthias
A1  - Damjanovic, Lukas
A1  - Fuchs, Christiane
A1  - Rosner, Margit
A1  - Hengstschläger, Markus
T1  - Proliferation potential of human amniotic fluid stem cells differently respondes to mercury and lead exposure
JF  - Amino Acids
KW  - Stem Cells
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Rosner, Margit
A1  - Fuchs, Christiane
A1  - Dolznig, Helmut
A1  - Hengstschläger, Markus
T1  - Different cytoplasmic/nucelar distribution of S6 protein phosphorylated at S240/244 and S235/236
JF  - Amino Acids
KW  - Proteins
Y1  - 2018
IS  - 40
SP  - 595
EP  - 600
ER  - 
TY  - GEN
A1  - Mühleder, Severin
A1  - Fuchs, Christiane
A1  - Bassilio, Jose
A1  - Sczwarc, Dorota
A1  - Pill, Karoline
A1  - Slezak, Paul
A1  - Labuda, Krystina
A1  - Siehs, Christian
A1  - Pröll, Johannes
A1  - Priglinger, Eleni
A1  - Redl, Heinz
A1  - Holnthoner, Wolfgang
T1  - The purinergic receptor P2Y2 modulates endothelial sprouting and angiogenesis
KW  - Angiogenesis
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Priglinger, Eleni
A1  - Schuh, Christina
A1  - Steffenhagen, Carolin
A1  - Wurzer, Christoph
A1  - Maier, Julia
A1  - Nürnberger, Sylvia
A1  - Holnthoner, Wolfgang
A1  - Fuchs, Christiane
A1  - Suessner, Susanne
A1  - Rünzler, Dominik
A1  - Redl, Heinz
A1  - Wolbank, Susanne
T1  - Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy.
JF  - Cytotherapy
N2  - BACKGROUND:

Cell-based therapies with autologous adipose tissue-derived cells have shown great potential in several clinical studies in the last decades. The majority of these studies have been using the stromal vascular fraction (SVF), a heterogeneous mixture of fibroblasts, lymphocytes, monocytes/macrophages, endothelial cells, endothelial progenitor cells, pericytes and adipose-derived stromal/stem cells (ASC) among others. Although possible clinical applications of autologous adipose tissue-derived cells are manifold, they are limited by insufficient uniformity in cell identity and regenerative potency.
METHODS:

In our experimental set-up, low-energy extracorporeal shock wave therapy (ESWT) was performed on freshly obtained human adipose tissue and isolated adipose tissue SVF cells aiming to equalize and enhance stem cell properties and functionality.
RESULTS:

After ESWT on adipose tissue we could achieve higher cellular adenosine triphosphate (ATP) levels compared with ESWT on the isolated SVF as well as the control. ESWT on adipose tissue resulted in a significantly higher expression of single mesenchymal and vascular marker compared with untreated control. Analysis of SVF protein secretome revealed a significant enhancement in insulin-like growth factor (IGF)-1 and placental growth factor (PLGF) after ESWT on adipose tissue.
DISCUSSION:

Summarizing we could show that ESWT on adipose tissue enhanced the cellular ATP content and modified the expression of single mesenchymal and vascular marker, and thus potentially provides a more regenerative cell population. Because the effectiveness of autologous cell therapy is dependent on the therapeutic potency of the patient's cells, this technology might raise the number of patients eligible for autologous cell transplantation.
KW  - Shockwave Therapy
KW  - Tissue Regeneration
KW  - Regenerative Medicine
Y1  - 
SP  - 1079
EP  - 1095
ER  -