TY - CHAP A1 - Basoli, Valentina A1 - Chaudry, Sidrah A1 - Cruciani, Sara A1 - Fuchs, Christiane A1 - Rieger, Sabine A1 - Dungel, Peter A1 - Wolbank, Susanne A1 - Ventura, Carlo A1 - Grillari-Voglauer, Regina A1 - Redl, Heinz A1 - Maioli, Margherita T1 - Epigenetic and molecular behavious of stem cells exposed to biophysical stimuli: new insights in regenerative medicine T2 - Proceedings des Seminars zum 40. Jahresjubiläum der Österreichischen Gesellschaft für Chirurgische Forschung KW - Stem Cells KW - Regeneration KW - Biophysical Stimuli Y1 - 2018 ER - TY - GEN A1 - Basoli, Valentina A1 - Chaudry, Sidrah A1 - Cruciani, Gabriele A1 - Fuchs, Christiane A1 - Rieger, Sabine A1 - Dungel, Peter A1 - Wolbank, Susanne A1 - Ventura, Carlo A1 - Grillari-Voglauer, Regina A1 - Redl, Heinz A1 - Maioli, Margherita T1 - Epigenetic and molecular behavious of stem cells exposed to biophysical stimuli: new insights in regenerative medicine KW - Stem Cells KW - Regeneration KW - Biophysical Stimuli Y1 - 2018 ER - TY - GEN A1 - Fuchs, Christiane T1 - A mechanical stimulation strategy for engineering skeletal muscle-like tissue on a strained fibrin scaffold KW - Muscle Tissue KW - Fibrin KW - Scaffold Y1 - 2018 ER - TY - GEN A1 - Fuchs, Christiane T1 - The beneficial effects of in vitro shock wave treatment on cardiomyogenesis are energy dependent KW - In Vitro KW - Shockwave treatment KW - Myogenesis Y1 - 2018 ER - TY - GEN A1 - Fuchs, Christiane T1 - Mechanotransduction - bioreactors KW - Bioreactors Y1 - 2018 ER - TY - JOUR A1 - Heher, Philipp A1 - Maleiner, Babette A1 - Prüller, Johanna A1 - Teuschl, Andreas A1 - Kollmitzer, Josef A1 - Monforte Vila, Xavier A1 - Wolbank, Susanne A1 - Redl, Heinz A1 - Rünzler, Dominik A1 - Fuchs, Christiane T1 - A novel bioreactor for the generation of highly aligned 3D skeletal muscle-like constructs through orientation of fibrin via application of static strain JF - Acta Biomaterialia KW - Bioreactor Y1 - ER - TY - GEN A1 - Fuchs, Christiane A1 - Weihs, Anna A1 - Teuschl, Andreas A1 - Hartinger, Joachim A1 - Slezak, Paul A1 - Mittermayr, Rainer A1 - Redl, Heinz A1 - Junger, Wolfgang A1 - Sitte, Harald A1 - Rünzler, Dominik T1 - Shockwave Treatment Enhances Proliferation and Improves Wound Healing via Purinergic Signaling Linked ERK 1/2 Pathways KW - Shockwave treatment KW - Healing Processes KW - Signaling Y1 - 2018 ER - TY - GEN A1 - Fuchs, Christiane A1 - Weihs, Anna A1 - Teuschl, Andreas A1 - Hartinger, Joachim A1 - Slezak, Paul A1 - Mittermayr, Rainer A1 - Redl, Heinz A1 - Junger, Wolfgang A1 - Sitte, Harald A1 - Rünzler, Dominik T1 - Shockwave Treatment Augments Proliferation and Improves Wound Healing via Purinergic Signaling Linked ERK 1/2 Pathways KW - Shockwave treatment KW - Healing Processes KW - Signaling Y1 - 2018 ER - TY - GEN A1 - Heher, Philipp A1 - Fuchs, Christiane A1 - Prüller, Johanna A1 - Babette, Maleiner A1 - Rünzler, Dominik A1 - Redl, Heinz T1 - A novel bioreactor for engineering skeletal muscle-like tissue in a strained fibrin scaffold KW - Bioreactor KW - Scaffold KW - Muscle Tissue Y1 - ER - TY - GEN A1 - Weihs, Anna A1 - Fuchs, Christiane A1 - Teuschl, Andreas A1 - Hartinger, Joachim A1 - Slezak, Paul A1 - Mittermayr, Rainer A1 - Redl, Heinz A1 - Junger, Wolfgang A1 - Sitte, Harald A1 - Rünzler, Dominik T1 - Shockwave treatment activates Erk1/2 pathways predominantly via P2Y receptor involvement KW - Shockwave Y1 - ER - TY - GEN A1 - Teuschl, Andreas A1 - Fuchs, Christiane A1 - Feichtinger, Georg A1 - Heher, Philipp A1 - Heimel, Patrick A1 - Schuh, Christina A1 - Nürnberger, Sylvia A1 - Nau, Thomas A1 - Rünzler, Dominik A1 - Redl, Heinz T1 - Fibrin or Fibroin - Not only the "o" Makes the Difference KW - Fibrin KW - Fibroin Y1 - 2018 ER - TY - GEN A1 - Fuchs, Christiane T1 - Shockwave treatment promotes proliferation via purinergic signaling coupled ERK1/2 pathway activation KW - Shockwave Y1 - ER - TY - GEN A1 - Heher, Philipp A1 - Fuchs, Christiane A1 - Prüller, Johanna A1 - Maleiner, Babette A1 - Kollmitzer, Josef A1 - Rünzler, Dominik A1 - Teuschl, Andreas A1 - Wolbank, Susanne A1 - Redl, Heinz T1 - A bioreactor-based 3D culture system for skeletal muscle engineering in fibrin scaffolds KW - Bioreactors KW - Cell Culture KW - Muscle KW - Scaffold Y1 - 2018 ER - TY - JOUR A1 - Buta, Christiane A1 - David, Robert A1 - Dressel, Ralf A1 - Emgard, Mia A1 - Fuchs, Christiane A1 - Gross, Ulrike A1 - Healy, Lyn A1 - Hescheler, Jürgen A1 - Kolar, Roman A1 - Martin, Ulrich A1 - Mikkers, Harald A1 - Müller, Franz-Josef A1 - Schneider, Rebekka A1 - Seiler, Andrea A1 - Spielmann, Horst A1 - Weitzer, Georg T1 - REconsidering pluripotency tests: do we still need teratoma assays? JF - Stem Cell Research KW - Assay KW - Stem Cells Y1 - 2018 VL - 11 IS - 1 SP - 552 EP - 562 ER - TY - JOUR A1 - Rosner, Margit A1 - Schipany, Katharina A1 - Gundacker, Claudia A1 - Shanmugasundaram, Parthasaraty A1 - Li, Kongzhao A1 - Fuchs, Christiane A1 - Lubec, Gert A1 - Hengstschläger, Martin T1 - Renal differentiation of amniotic fluid stem cells: perspectives for clinical application and for studies on specific human genetic diseases JF - Eur J Clin Invest KW - Stem Cells KW - Genetic Diseases Y1 - 2018 ER - TY - JOUR A1 - Gundacker, Claudia A1 - Scheinast, Matthias A1 - Damjanovic, Lukas A1 - Fuchs, Christiane A1 - Rosner, Margit A1 - Hengstschläger, Markus T1 - Proliferation potential of human amniotic fluid stem cells differently respondes to mercury and lead exposure JF - Amino Acids KW - Stem Cells Y1 - 2018 ER - TY - JOUR A1 - Rosner, Margit A1 - Fuchs, Christiane A1 - Dolznig, Helmut A1 - Hengstschläger, Markus T1 - Different cytoplasmic/nucelar distribution of S6 protein phosphorylated at S240/244 and S235/236 JF - Amino Acids KW - Proteins Y1 - 2018 IS - 40 SP - 595 EP - 600 ER - TY - GEN A1 - Mühleder, Severin A1 - Fuchs, Christiane A1 - Bassilio, Jose A1 - Sczwarc, Dorota A1 - Pill, Karoline A1 - Slezak, Paul A1 - Labuda, Krystina A1 - Siehs, Christian A1 - Pröll, Johannes A1 - Priglinger, Eleni A1 - Redl, Heinz A1 - Holnthoner, Wolfgang T1 - The purinergic receptor P2Y2 modulates endothelial sprouting and angiogenesis KW - Angiogenesis Y1 - 2018 ER - TY - JOUR A1 - Priglinger, Eleni A1 - Schuh, Christina A1 - Steffenhagen, Carolin A1 - Wurzer, Christoph A1 - Maier, Julia A1 - Nürnberger, Sylvia A1 - Holnthoner, Wolfgang A1 - Fuchs, Christiane A1 - Suessner, Susanne A1 - Rünzler, Dominik A1 - Redl, Heinz A1 - Wolbank, Susanne T1 - Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy. JF - Cytotherapy N2 - BACKGROUND: Cell-based therapies with autologous adipose tissue-derived cells have shown great potential in several clinical studies in the last decades. The majority of these studies have been using the stromal vascular fraction (SVF), a heterogeneous mixture of fibroblasts, lymphocytes, monocytes/macrophages, endothelial cells, endothelial progenitor cells, pericytes and adipose-derived stromal/stem cells (ASC) among others. Although possible clinical applications of autologous adipose tissue-derived cells are manifold, they are limited by insufficient uniformity in cell identity and regenerative potency. METHODS: In our experimental set-up, low-energy extracorporeal shock wave therapy (ESWT) was performed on freshly obtained human adipose tissue and isolated adipose tissue SVF cells aiming to equalize and enhance stem cell properties and functionality. RESULTS: After ESWT on adipose tissue we could achieve higher cellular adenosine triphosphate (ATP) levels compared with ESWT on the isolated SVF as well as the control. ESWT on adipose tissue resulted in a significantly higher expression of single mesenchymal and vascular marker compared with untreated control. Analysis of SVF protein secretome revealed a significant enhancement in insulin-like growth factor (IGF)-1 and placental growth factor (PLGF) after ESWT on adipose tissue. DISCUSSION: Summarizing we could show that ESWT on adipose tissue enhanced the cellular ATP content and modified the expression of single mesenchymal and vascular marker, and thus potentially provides a more regenerative cell population. Because the effectiveness of autologous cell therapy is dependent on the therapeutic potency of the patient's cells, this technology might raise the number of patients eligible for autologous cell transplantation. KW - Shockwave Therapy KW - Tissue Regeneration KW - Regenerative Medicine Y1 - SP - 1079 EP - 1095 ER - TY - CHAP A1 - Hörzer, S. A1 - Fuchs, Christiane A1 - Gastinger, R. A1 - Sabo, Anton A1 - Mehnen, Lars A1 - Martinek, Johannes A1 - Reichel, Martin T1 - Simulation of spinning soccer ball trajectories influenced by altitude T2 - Procedia Engineering KW - Soccer Y1 - 2019 SP - 2461 EP - 2466 ER - TY - JOUR A1 - Gollmann-Tepeköylü, Can A1 - Graber, Michael A1 - Hirsch, Jakob A1 - Mair, Sophia A1 - Naschberger, Andreas A1 - Pölzl, Leo A1 - Nägele, Felix A1 - Kirchmair, Elke A1 - Degenhart, Gerald A1 - Demetz, Egon A1 - Hilbe, Richard A1 - Chen, Hao-Yu A1 - Engert, James C A1 - Böhm, Anna A1 - Franz, Nadja A1 - Lobenwein, Daniela A1 - Lener, Daniela A1 - Fuchs, Christiane A1 - Weihs, Anna A1 - Töchterle, Sonja A1 - Vogel, Georg F A1 - Schweiger, Victor A1 - Eder, Jonas A1 - Pietschmann, Peter A1 - Seifert, Markus A1 - Kronenberg, Florian A1 - Coassin, Stefan A1 - Blumer, Michael A1 - Hackl, Hubert A1 - Meyer, Dirk A1 - Feuchtner, Gudrun A1 - Kirchmair, Rudolf A1 - Troppmair, Jakob A1 - Krane, Markus A1 - Weiss, Günther A1 - Tsimikas, Sotirios A1 - Thanassoulis, George A1 - Grimm, Michael A1 - Rupp, Bernhard A1 - Huber, Lukas A A1 - Zhang, Shen-Ying A1 - Casanova, Jean-Laurent A1 - Tancevski, Ivan A1 - Holfeld, Johannes T1 - Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification JF - Circulation KW - Toll-like receptor 3 KW - aortic valve disease KW - biglycan KW - extracellular matrix KW - osteogenesis Y1 - U6 - http://dx.doi.org/10.1161/CIRCULATIONAHA.122.063481 VL - 147 IS - 20 SP - 1518 EP - 1533 ER -