TY  - JOUR
A1  - Henderson, Ben
A1  - Slingers, Gitte
A1  - Pedrotti, Michele
A1  - Pugliese, Giovanni
A1  - Malaskova, Michaela
A1  - Bryant, Luke
A1  - Lomonaco, Tommaso
A1  - Ghimenti, Silvia
A1  - Moreno, Sergi
A1  - Cordell, Rebecca
A1  - Harren, Frans J M
A1  - Schubert, Jochen
A1  - Mayhew, Chris A
A1  - Wilde, Michael
A1  - Di Francesco, Fabio
A1  - Koppen, Gudrun
A1  - Beauchamp, Jonathan D
A1  - Cristescu, Simona M
T1  - The peppermint breath test benchmark for PTR-MS and SIFT-MS
JF  - Journal of Breath Research
N2  - A major challenge for breath research is the lack of standardization in sampling and analysis. To address this, a test that utilizes a standardized intervention and a defined study protocol has been proposed to explore disparities in breath research across different analytical platforms and to provide benchmark values for comparison. Specifically, the Peppermint Experiment involves the targeted analysis in exhaled breath of volatile constituents of peppermint oil after ingestion of the encapsulated oil. Data from the Peppermint Experiment performed by proton transfer reaction mass spectrometry (PTR-MS) and selected ion flow tube mass spectrometry (SIFT-MS) are presented and discussed herein, including the product ions associated with the key peppermint volatiles, namely limonene, α- and β-pinene, 1,8-cineole, menthol, menthone and menthofuran. The breath washout profiles of these compounds from 65 individuals were collected, comprising datasets from five PTR-MS and two SIFT-MS instruments. The washout profiles of these volatiles were evaluated by comparing the log-fold change over time of the product ion intensities associated with each volatile. Benchmark values were calculated from the lower 95% confidence interval of the linear time-to-washout regression analysis for all datasets combined. Benchmark washout values from PTR-MS analysis were 353 min for the sum of monoterpenes and 1,8-cineole (identical product ions), 173 min for menthol, 330 min for menthofuran, and 218 min for menthone; from SIFT-MS analysis values were 228 min for the sum of monoterpenes, 281 min for the sum of monoterpenes and 1,8-cineole, and 370 min for menthone plus 1,8-cineole. Large inter- and intra-dataset variations were observed, whereby the latter suggests that biological variability plays a key role in how the compounds are absorbed, metabolized and excreted from the body via breath. This variability seems large compared to the influence of sampling and analytical procedures, but further investigations are recommended to clarify the effects of these factors.
KW  - standardization
KW  - breathomics
KW  - peppermint
KW  - benchmark
KW  - TR-MS
Y1  - 
U6  - http://dx.doi.org/https://doi.org/10.1088/1752-7163/ac1fcf
IS  - 15
SP  - Artikelnr. 046005
ER  - 
TY  - GEN
A1  - Nemec, Iris
A1  - Malaskova, Michaela
A1  - Pereira, Luis
A1  - Pavao, Joao
A1  - Frohner, Matthias
T1  - Experiences of intercultural teaching activities in the field of eHealth
T2  - Abstracts of the 2022 Joint Annual Conference of the Austrian (ÖGBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation
KW  - intercultural teaching
KW  - eHealth
Y1  - 
U6  - http://dx.doi.org/https://doi.org/10.1515/bmt-2022-2001
SP  - 351
ER  - 
TY  - GEN
A1  - Malaskova, Michaela
A1  - Forjan, Mathias
T1  - Current topics in Life Science Engineering lectures
T2  - Abstracts of the 2022 Joint Annual Conference of the Austrian (ÖGBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation
KW  - Life Science Engineering
KW  - Teaching
Y1  - 
U6  - http://dx.doi.org/https://doi.org/10.1515/bmt-2022-2001
SP  - 350
ER  -