TY  - JOUR
A1  - Maleiner, Babette
A1  - Tomasch, Janine
A1  - Heher, Philipp
A1  - Spadiut, Oliver
A1  - Rünzler, Dominik
A1  - Fuchs, Christiane
T1  - The Importance of Biophysical and Biochemical Stimuli in Dynamic Skeletal Muscle Models.
JF  - Frontiers in Physiology
N2  - Classical approaches to engineer skeletal muscle tissue based on current regenerative and surgical procedures still do not meet the desired outcome for patient applications. Besides the evident need to create functional skeletal muscle tissue for the repair of volumetric muscle defects, there is also growing demand for platforms to study muscle-related diseases, such as muscular dystrophies or sarcopenia. Currently, numerous studies exist that have employed a variety of biomaterials, cell types and strategies for maturation of skeletal muscle tissue in 2D and 3D environments. However, researchers are just at the beginning of understanding the impact of different culture settings and their biochemical (growth factors and chemical changes) and biophysical cues (mechanical properties) on myogenesis. With this review we intend to emphasize the need for new in vitro skeletal muscle (disease) models to better recapitulate important structural and functional aspects of muscle development. We highlight the importance of choosing appropriate system components, e.g., cell and biomaterial type, structural and mechanical matrix properties or culture format, and how understanding their interplay will enable researchers to create optimized platforms to investigate myogenesis in healthy and diseased tissue. Thus, we aim to deliver guidelines for experimental designs to allow estimation of the potential influence of the selected skeletal muscle tissue engineering setup on the myogenic outcome prior to their implementation. Moreover, we offer a workflow to facilitate identifying and selecting different analytical tools to demonstrate the successful creation of functional skeletal muscle tissue. Ultimately, a refinement of existing strategies will lead to further progression in understanding important aspects of muscle diseases, muscle aging and muscle regeneration to improve quality of life of patients and enable the establishment of new treatment options.
KW  - Bioreactor
KW  - Muscle
KW  - Biomaterial
Y1  - 
ER  - 
TY  - JOUR
A1  - Schuh, Christina
A1  - Heher, Philipp
A1  - Weihs, Anna
A1  - Fuchs, Christiane
A1  - Gabriel, Christian
A1  - Wolbank, Susanne
A1  - Mittermayr, Rainer
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - In vitro extracorporeal shock wave treatment enhances stemness and preserves multipotency of rat and human adipose-derived stem cells
JF  - Journal of Cytotherapy
KW  - Shockwave
Y1  - 
ER  - 
TY  - CHAP
A1  - Köhler, Gottfried
A1  - Rünzler, Dominik
A1  - Mayer, B.
A1  - Sára, Margit
A1  - Rasmussen, S.
A1  - Buravkova, L.
T1  - Microgravity. Applications in Biotechnology and Bioorganic Materials Sciences
T2  - 10 Years Space biomedical Research and Development in Austria
KW  - Microgravity
KW  - Biotechnology
KW  - Materials Sciences
Y1  - 2019
SP  - 65
EP  - 85
PB  - Facultas
CY  - Wien
ER  - 
TY  - CHAP
A1  - Wießner, Katharina
A1  - Praher, Daniela
A1  - Liousia, Varvara
A1  - Gepp, Barbara
A1  - Leitner, Rita
A1  - Rünzler, Dominik
T1  - Testing the acute toxicity of an alternative to Glyphosate - Pelargonic acid
T2  - SETAC Europe 30th Annual Meeting - Online
N2  - Glyphosate-based herbicides were used as plant protection product globally for several decades. However, glyphosate is discussed as showing genotoxicity and many other side-effects such as inhibiting the mitochondrial succinate dehydrogenase, leading to a decreased ATP production. Therefore, finding alternative active substances is necessary. Pelargonic acid (nonanoic acid) and its ammonium salt (saponified form), which are used as alternatives to glyphosate-based herbicides, are biological derived substances considered as environmentally friendly herbicides. To test the effects of pelargonic acid in its acidic form (active substance in TopGun) and its saponified form (in Finalsan Plus) on the aquatic ecosystem, students of the master study program “environmental management and ecotoxicology” compared the toxicity levels of these substances using zebrafish embryos within the scope of a student research course. The project was developed by applying the 7-step problem-based learning method which allowed the students to design their experiments independently with the guidance and feedback of the lecturers. Acute toxicity was determined according to OECD test guideline 236 in D. rerio which revealed a LC50 of 1.55 mg/L of pelargonic acid, a LC50 value of 0.93 mg/L pelargonic acid in TopGun and a LC50 of 36.37 mg/L of Finalsan Plus. Neutral Red Uptake assays were performed on the rainbow trout-derived gill cell-line RTgill-W1 to determine the acute toxicity according to the OECD test guideline 129 which revealed the IC50 value of 12.4 mg/L pelargonic acid in TG. Due to solubility limits, no reliable IC50 could be obtained. The results of the tests indicate differences in the acute toxicity of the pelargonic acid-based formulations TopGun and Finalsan Plus. However, more investigations have to be done in order to analyse if the acidic form is more toxic than the saponified form. Furthermore, detailed ecotoxicological risk assessments and an evaluation of the genotoxicity of both herbicides has to be performed before any conclusion can be drawn. Financial support from the City of Vienna project PBL in Molecular Life Science (21-06) is gratefully acknowledged.
KW  - Environmental Chemistry
KW  - Ecotoxicology
Y1  - 2020
ER  - 
TY  - CHAP
A1  - Leitner, Rita
A1  - Gepp, Barbara
A1  - Liousia, Varvara
A1  - Rünzler, Dominik
T1  - Teaching 3R principles in ecotoxicology by performing a problem-based learning project
T2  - ALTEX Proceedings, LINZ 2018 – EUSAAT 2018, Volume 7, No. 2, ISSN 2194-0479 (2018)
KW  - Problem Based Learning
KW  - Teaching
KW  - Ecotoxicology
KW  - 3R Principles
Y1  - 
ER  - 
TY  - GEN
A1  - Gepp, Barbara
A1  - Liousia, Varvara
A1  - Machacek, Thomas
A1  - Praher, Daniela
A1  - Eisner, Katharina
A1  - Limbeck, Sophie
A1  - Gamper, Janine
A1  - Schwarzl, Elisabeth
A1  - Hazod, Till
A1  - Landwehr, Renate
A1  - Wenger, Charlotte
A1  - Olscher, Christoph
A1  - Leitner, Rita
A1  - Rünzler, Dominik
T1  - Pelargonic acid - an alternative to glyphosate-based herbicides?
KW  - Ecotoxicology
KW  - Herbicides
Y1  - 
ER  - 
TY  - GEN
A1  - Teuschl, Andreas
A1  - Schuh, Christina
A1  - Weihs, Anna
A1  - Guillaume, Olivier
A1  - Monforte Vila, Xavier
A1  - Redl, Heinz
A1  - Kaplan, David
A1  - Rünzler, Dominik
T1  - Tailoring bioactivity of silk-based biomaterials via delivering and functionalization strategies with fibrinogen/thrombin, plant lectins or laminin
KW  - Biomaterials
KW  - Tissue Engineering
KW  - Silk
Y1  - 
ER  - 
TY  - GEN
A1  - Salzer, Elias
A1  - Rieder, Bernhard
A1  - Monforte Vila, Xavier
A1  - Weihs, Anna
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Evaluation of a novel hydrostatic pressure bioreactor on bovine cartilage chips
KW  - Bioreactor
KW  - Tissue Engineering
KW  - Cartilage
Y1  - 
ER  - 
TY  - GEN
A1  - Eisner, Katharina
A1  - Gepp, Barbara
A1  - Schnegg, Raimund
A1  - Dallinger, Reinhard
A1  - Rünzler, Dominik
T1  - Investigation of endocrine effects of sublethal cadmium doses on the reproduction system of the freshwater snail B. glabrata
KW  - Ecotoxicology
KW  - Endocrine disruptors
Y1  - 
ER  - 
TY  - GEN
A1  - Salzer, Elias
A1  - Liousia, Varvara
A1  - Monforte Vila, Xavier
A1  - Rünzler, Dominik
T1  - Tracking of small aquatic organisms with custom-made tracking plates
KW  - Ecotoxicology
KW  - Behavior Analysis
KW  - Aquatic Ecotoxicology
Y1  - 
ER  - 
TY  - CHAP
A1  - Fuchs, Christiane
A1  - Weihs, Anna
A1  - Szwarc, Dorota
A1  - Mittermayr, Rainer
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Shock wave treatment of muscle (stem) cells - a new implementation for regeneration
T2  - Proceedings of the 20th International Congress of the ISMST
KW  - Shockwave treatment
KW  - Muscle Cells
KW  - Regeneration
Y1  - 2018
ER  - 
TY  - GEN
A1  - Fuchs, Christiane
A1  - Weihs, Anna
A1  - Szwarc, Dorota
A1  - Mittermayr, Rainer
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Shock wave treatment of muscle (stem) cells - a new implementation for regeneration
KW  - Shockwave treatment
KW  - Muscle Cells
KW  - Regeneration
Y1  - 2018
ER  - 
TY  - GEN
A1  - Szwarc, Dorota
A1  - Fuchs, Christiane
A1  - Weihs, Anna
A1  - Rünzler, Dominik
T1  - Molecular mechanisms underlying the potential of shock wave treatment for cardiac therapy
KW  - Shockwave treatment
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - GEN
A1  - Szwarc, Dorota
A1  - Fuchs, Christiane
A1  - Purtscher, Michaela
A1  - Rünzler, Dominik
T1  - Elucidating the molecular mechanisms underlying cardiac shock wave therapy
KW  - Shockwave treatment
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - GEN
A1  - Rünzler, Dominik
T1  - Alternatives to Animal Experiment Models: Tracking Zebrafish Larvae and Daphnia
KW  - Animal Experiments
KW  - Zebrafish
Y1  - 2018
ER  - 
TY  - CHAP
A1  - Maleiner, Babette
A1  - Heher, Philipp
A1  - Teuschl, Andreas
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Fuchs, Christiane
T1  - Generation of aligned skeletal muscle-like tissue based on the application of strain to a 3D fibrin scaffold
T2  - Proceedings of PACT "Designer Cells go Clinical" Symposium
KW  - Tissue Generation
KW  - Fibrin
KW  - Scaffold
Y1  - 2018
ER  - 
TY  - GEN
A1  - Szwarc, Dorota
A1  - Fuchs, Christiane
A1  - Weihs, Anna
A1  - Monforte Vila, Xavier
A1  - Hanetseder, Dominik
A1  - Teuschl, Andreas
A1  - Rünzler, Dominik
T1  - The effect of shock waves on in vitro cartilage development in silk scaffolds
KW  - Shockwave treatment
KW  - In Vitro
KW  - Cartilage
KW  - Silk
Y1  - 2018
ER  - 
TY  - GEN
A1  - Maleiner, Babette
A1  - Heher, Philipp
A1  - Teuschl, Andreas
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Fuchs, Christiane
T1  - Generation of aligned skeletal muscle-like tissue based on the application of strain to a 3D fibrin scaffold
KW  - Tissue Generation
KW  - Fibrin
KW  - Scaffold
Y1  - 2018
ER  - 
TY  - GEN
A1  - Teuschl, Andreas
A1  - Fuchs, Christiane
A1  - Weihs, Anna
A1  - Heimel, Patrick
A1  - Rünzler, Dominik
A1  - Redl, Heinz
A1  - Nau, Thomas
T1  - The Silk Road from Textiles to Novel Medical Implants
KW  - Silk
Y1  - 2018
ER  - 
TY  - CHAP
A1  - Fuchs, Christiane
A1  - Szwarc, Dorota
A1  - Weihs, Anna
A1  - Rünzler, Dominik
T1  - Shock wave treatment of 3D cardiac model systems activates ERK 1/2 signaling pathway and influences cardiomyogenesis
T2  - Proceedings of PACT "Designer Cells go Clinical" Symposium
KW  - Shockwave treatment
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - CHAP
A1  - Fuchs, Christiane
A1  - Szwarc, Dorota
A1  - Weihs, Anna
A1  - Rünzler, Dominik
T1  - Shock wave treatment of 3D cardiac model systems activates ERK 1/2 signaling pathway and influences cardiomyogenesis
T2  - Proceedings of LBG Meeting for Health Sciences 2016
KW  - Shockwave treatment
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - GEN
A1  - Fuchs, Christiane
A1  - Szwarc, Dorota
A1  - Weihs, Anna
A1  - Rünzler, Dominik
T1  - Shock wave treatment of 3D cardiac model systems activates ERK 1/2 signaling pathway and influences cardiomyogenesis
KW  - Shockwave treatment
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - CHAP
A1  - Fuchs, Christiane
A1  - Szwarc, Dorota
A1  - Weihs, Anna
A1  - Rünzler, Dominik
T1  - Shock wave treatment positively influences cardiomyogenesis in an energy-dependent manner
T2  - Proceedings of PACT "Designer Cells go Clinical" Symposium
KW  - Shockwave treatment
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - GEN
A1  - Mandt, Denise
A1  - Pichler, Verena
A1  - Melchior, Sophie
A1  - Rünzler, Dominik
T1  - Establishment of 2D and 3D cell culture assays using RT-gillW1 cells
KW  - Cell Culture
KW  - Assay
Y1  - 2018
ER  - 
TY  - GEN
A1  - Salzer, Elias
A1  - Rünzler, Dominik
T1  - Acute Immobilization Test with Daphnia magna - A Refined Methodology for the Detection of Immobilization
KW  - Immobilization
Y1  - 2018
ER  - 
TY  - GEN
A1  - Salzer, Elias
A1  - Rünzler, Dominik
T1  - Live or dead is not enough: a large-scale mobility assay with Daphnia magna
KW  - Mobility Assay
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Heher, Philipp
A1  - Maleiner, Babette
A1  - Prüller, Johanna
A1  - Teuschl, Andreas
A1  - Kollmitzer, Josef
A1  - Monforte Vila, Xavier
A1  - Wolbank, Susanne
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Fuchs, Christiane
T1  - A novel bioreactor for the generation of highly aligned 3D skeletal muscle-like constructs through orientation of fibrin via application of static strain
JF  - Acta Biomaterialia
KW  - Bioreactor
Y1  - 
ER  - 
TY  - JOUR
A1  - Teuschl, Andreas
A1  - Schuh, Christina
A1  - Halbweis, Robert
A1  - Pajer, Krisztian
A1  - Marton, Gabor
A1  - Hopf, Rudolf
A1  - Mosia, Shorena
A1  - Rünzler, Dominik
A1  - Redl, Heinz
A1  - Nogradi, Antal
A1  - Hausner, Thomas
T1  - A new preparation method for anisotropic silk fibroin nerve guidance conduits and its evaluation in vitro and in a rat sciatic nerve defect model
JF  - Tissue Engineering Part C: Methods
KW  - Fibrin
KW  - Nerve Defect
Y1  - 2018
ER  - 
TY  - GEN
A1  - Teuschl, Andreas
A1  - Schuh, Christina
A1  - Halbweis, Robert
A1  - Marton, Gábor
A1  - Pajer, Krisztián
A1  - Hopf, Rudolf
A1  - Mosia, Shorena
A1  - Rünzler, Dominik
A1  - Nógrádi, Antal
A1  - Hausner, Thomas
A1  - Redl, Heinz
T1  - Silk fibroin for peripheral nerve regeneration: a novel preparation method improved mechanical characteristics and supports regeneration in rat sciatic nerves
KW  - Fibroin
KW  - Regeneration
Y1  - 2018
ER  - 
TY  - GEN
A1  - Fuchs, Christiane
A1  - Weihs, Anna
A1  - Teuschl, Andreas
A1  - Hartinger, Joachim
A1  - Slezak, Paul
A1  - Mittermayr, Rainer
A1  - Redl, Heinz
A1  - Junger, Wolfgang
A1  - Sitte, Harald
A1  - Rünzler, Dominik
T1  - Shockwave Treatment Enhances Proliferation and Improves Wound Healing via Purinergic Signaling Linked ERK 1/2 Pathways
KW  - Shockwave treatment
KW  - Healing Processes
KW  - Signaling
Y1  - 2018
ER  - 
TY  - GEN
A1  - Fuchs, Christiane
A1  - Weihs, Anna
A1  - Teuschl, Andreas
A1  - Hartinger, Joachim
A1  - Slezak, Paul
A1  - Mittermayr, Rainer
A1  - Redl, Heinz
A1  - Junger, Wolfgang
A1  - Sitte, Harald
A1  - Rünzler, Dominik
T1  - Shockwave Treatment Augments Proliferation and Improves Wound Healing via Purinergic Signaling Linked ERK 1/2 Pathways
KW  - Shockwave treatment
KW  - Healing Processes
KW  - Signaling
Y1  - 2018
ER  - 
TY  - GEN
A1  - Heher, Philipp
A1  - Fuchs, Christiane
A1  - Prüller, Johanna
A1  - Babette, Maleiner
A1  - Rünzler, Dominik
A1  - Redl, Heinz
T1  - A novel bioreactor for engineering skeletal muscle-like tissue in a strained fibrin scaffold
KW  - Bioreactor
KW  - Scaffold
KW  - Muscle Tissue
Y1  - 
ER  - 
TY  - GEN
A1  - Weihs, Anna
A1  - Fuchs, Christiane
A1  - Teuschl, Andreas
A1  - Hartinger, Joachim
A1  - Slezak, Paul
A1  - Mittermayr, Rainer
A1  - Redl, Heinz
A1  - Junger, Wolfgang
A1  - Sitte, Harald
A1  - Rünzler, Dominik
T1  - Shockwave treatment activates Erk1/2 pathways predominantly via P2Y receptor involvement
KW  - Shockwave
Y1  - 
ER  - 
TY  - GEN
A1  - Teuschl, Andreas
A1  - Fuchs, Christiane
A1  - Feichtinger, Georg
A1  - Heher, Philipp
A1  - Heimel, Patrick
A1  - Schuh, Christina
A1  - Nürnberger, Sylvia
A1  - Nau, Thomas
A1  - Rünzler, Dominik
A1  - Redl, Heinz
T1  - Fibrin or Fibroin - Not only the "o" Makes the Difference
KW  - Fibrin
KW  - Fibroin
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Weihs, Anna
A1  - Fuchs, Christiane
A1  - Teuschl, Andreas
A1  - Hartinger, Joachim
A1  - Slezak, Paul
A1  - Mittermayr, Rainer
A1  - Redl, Heinz
A1  - Junger, Wolfgang
A1  - Sitte, Harald
A1  - Rünzler, Dominik
T1  - Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation
JF  - The Journal of biological chemistry
KW  - Shockwave
Y1  - 
ER  - 
TY  - JOUR
A1  - Schuh, Christina
A1  - Heher, Philipp
A1  - Weihs, Anna
A1  - Asmita, Banerjee
A1  - Wolbank, Susanne
A1  - Mittermayr, Rainer
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Adipose derived stem cells respond to in vitro extracorporeal shockwave treatment with increased stemness and multipotency
JF  - New Biotechnology
KW  - Shockwave
Y1  - 
ER  - 
TY  - GEN
A1  - Kroller, Theophil
A1  - Kreuzinger, Norbert
A1  - Rünzler, Dominik
T1  - Validierung und Anwendung eines zellkultur-basierten Assays für Screening von endokrin wirksamen Stoffen in Abwasser
KW  - Assay
KW  - Sewage Water
Y1  - 2018
ER  - 
TY  - GEN
A1  - Heher, Philipp
A1  - Fuchs, Christiane
A1  - Prüller, Johanna
A1  - Maleiner, Babette
A1  - Kollmitzer, Josef
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
A1  - Wolbank, Susanne
A1  - Redl, Heinz
T1  - A bioreactor-based 3D culture system for skeletal muscle engineering in fibrin scaffolds
KW  - Bioreactors
KW  - Cell Culture
KW  - Muscle
KW  - Scaffold
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Teuschl, Andreas
A1  - Neutsch, Lukas
A1  - Monforte Vila, Xavier
A1  - Rünzler, Dominik
A1  - van Griensven, Martijn
A1  - Gabor, Franz
A1  - Redl, Heinz
T1  - Enhanced cell adhesion on silk fibroin via lectin surface modification.
JF  - Acta Biomaterialia
KW  - Silk
KW  - Fibrin
Y1  - 
ER  - 
TY  - JOUR
A1  - Schuh, Christina
A1  - Banerjee, Asmita
A1  - Mosia, Shorena
A1  - Hopf, Rudolf
A1  - Grasl, Christian
A1  - Schima, Heinrich
A1  - Schmidhammer, Robert
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Morton, Tatjana J.
T1  - Activated Schwann-like cells guided by fibrin structures enhance Axonal Regeneration
JF  - JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
KW  - Cells
KW  - Fibrin
Y1  - 2019
VL  - 2012
IS  - vol. 6/no. 1
ER  - 
TY  - JOUR
A1  - Rieder, Bernhard
A1  - Weihs, Anna
A1  - Teuschl, Andreas
A1  - Knebl, Gerald
A1  - Kollmitzer, Josef
A1  - Redl, Heinz
A1  - Rünzler, Dominik
T1  - Evaluation of cell response on permanent and pulsed atmospheric pressure stressed cells
JF  - Journal of Tissue Engineering and Regenerative Medicine
KW  - Cells
KW  - Atmospheric Pressure
Y1  - 2018
VL  - 1
IS  - 6
SP  - 240
EP  - 240
ER  - 
TY  - JOUR
A1  - Weihs, Anna
A1  - Junger, Wolfgang
A1  - Schaden, Wolfgang
A1  - Sitte, Harald
A1  - Rünzler, Dominik
T1  - Extracorporeal shockwave treatment induced extracellular ATP release - a potential mechanism to activate wound healing
JF  - Journal of Tissue Engineering and Regenerative Medicine
KW  - Shockwave treatment
KW  - Healing Processes
Y1  - 2018
VL  - 1
IS  - 6
SP  - 381
EP  - 381
ER  - 
TY  - JOUR
A1  - Rünzler, Dominik
A1  - Weihs, Anna
A1  - Junger, Wolfgang
A1  - Sitte, Harald
A1  - Schaden, Wolfgang
T1  - Extracorporeal shock waves - a novel method of mechanostimulation in tissue regeneration
JF  - Journal of Tissue Engineering and Regenerative Medicine
KW  - Shockwave treatment
KW  - Mechanostimulation
Y1  - 2018
VL  - 1
IS  - 6
SP  - 380
EP  - 380
ER  - 
TY  - JOUR
A1  - Martin M., Frank
A1  - Kollmitzer, Josef
A1  - Redl, Heinz
A1  - Rünzler, Dominik
T1  - Shear force stimulation of adipose-tissue derived stem cells in a novel bioreactor
JF  - Journal of Tissue Engineering and Regenerative Medicine
KW  - Stem Cells
KW  - Adipose
Y1  - 2018
VL  - 1
IS  - 6
SP  - 340
EP  - 340
ER  - 
TY  - GEN
A1  - Weihs, Anna
A1  - Junger, Wolgang G.
A1  - Schaden, Wolfgang
A1  - Sitte, Harald H.
A1  - Rünzler, Dominik
T1  - Extracellular ATP release - a potential benefit in shock wave treatment
KW  - Shockwave
Y1  - 2019
ER  - 
TY  - JOUR
A1  - Milan-Lobo, Laura
A1  - Gsandtner, Ingrid
A1  - Gaubitzer, Erwin
A1  - Rünzler, Dominik
A1  - Buchmayer, Florian
A1  - Köhler, Gottfried
A1  - Bonci, Antonello
A1  - Freissmuth, Michael
A1  - Sitte, Harald H.
T1  - Subtype-specific differences in corticotropin-releasing factor receptor complexes detected by fluorescence spectroscopy
JF  - Molecular Pharmacology (mol pharmacol)
KW  - Spectroscopy
Y1  - 2019
IS  - 76(6)
SP  - 1196
EP  - 1210
ER  - 
TY  - CHAP
A1  - Weihs, Anna
A1  - Knebl, Gerald
A1  - Redl, Heinz
A1  - Rünzler, Dominik
T1  - Evaluation of cell migration methods in 3D hydrogels for tissue engineering applications
T2  - 3. Forschungsforum der österreichischen Fachhochschulen / Fachhochschule Kärnten
KW  - Cells
Y1  - 2019
SN  - 978-3-853912850
SP  - 490
EP  - 491
ER  - 
TY  - CHAP
A1  - Knebl, Gerald
A1  - Weihs, Anna
A1  - Weingant, Michaela
A1  - Steininger, Thomas
A1  - Redl, Heinz
A1  - Rünzler, Dominik
T1  - Automatisierte Datenauswertung eines Boyden-Mikro-Chemotaxis-Kammer Zell-Migrations Assays.
T2  - 2. Forschungsforum der österreichischen Fachhochschulen
KW  - Cells
KW  - Data Analysis
Y1  - 2019
SN  - 978-3-8322-7023-0
SP  - 412
EP  - 417
ER  - 
TY  - CHAP
A1  - Rünzler, Dominik
A1  - Knebl, Gerald
A1  - Peterbauer, A.
A1  - Wolbank, Susanne
A1  - Morton, Tatjana J.
A1  - Redl, Heinz
T1  - Darstellung fluoreszenzmarkierter adulter Stammzellen in drei-dimensionaler Zellkultur mittels Konfokaler Laser Scanning Mikroskopie
T2  - Erstes Forschungsforum der österreichischen Fachhochschulen
KW  - Cells
Y1  - 2019
SP  - 311
EP  - 316
ER  - 
TY  - JOUR
A1  - Grunt, Thomas
A1  - Tomek, Katharina
A1  - Wagner, Renate
A1  - Puckmair, Klaudia
A1  - Kainz, Birgit
A1  - Rünzler, Dominik
A1  - Gaiger, Alexander
A1  - Köhler, Gottfried
A1  - Zielinski, Christoph
T1  - Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways
JF  - Journal of Cell Physiology
KW  - Cells
Y1  - 2019
IS  - 211(3)
SP  - 803
EP  - 815
ER  - 
TY  - JOUR
A1  - Spurny, Radovan
A1  - Abdoulrahman, Kamaran
A1  - Janda, Lubomir
A1  - Rünzler, Dominik
A1  - Köhler, Gottfried
A1  - Castanon, Maria J.
A1  - Wiche, Gerhard
T1  - Oxidation and nitrosylation of cysteines proximal to the intermediate filament (IF)-binding site of plectin: effects on structure and vimentin binding and involvement in IF collapse
JF  - Journal of Biological Chemistry
KW  - Oxidation
Y1  - 2019
IS  - 282(11)
SP  - 8175
EP  - 8187
ER  - 
TY  - GEN
A1  - Rünzler, Dominik
T1  - Darstellung fluoreszenzmarkierter adulter Stammzellen in drei-dimensionaler Zellkultur mittels Konfokaler Laser Scanning Mikroskopie
KW  - Cells
Y1  - 2019
ER  - 
TY  - GEN
A1  - Rünzler, Dominik
T1  - Automatisierte Datenauswertung eines Boyden-Mikro-Chemotaxis-Kammer Zell-Migrations Assays
KW  - Cells
KW  - Data Analysis
Y1  - 2019
ER  - 
TY  - CHAP
A1  - Milan-Lobo, Laura
A1  - Rünzler, Dominik
A1  - Gaubitzer, Erwin
A1  - Köhler, Gottfried
A1  - Bonci, Antonello
A1  - Freissmuth, Michael
A1  - Sitte, Harald H.
T1  - CRF receptors form dynamic complexes at the plasma membrane but only type 2 receptor increases lateral mobility after CRF binding
T2  - FEBS Journal
KW  - Plasma Membrane
Y1  - 2019
ER  - 
TY  - CHAP
A1  - Kaisler, Raphaela
A1  - Pázmándi, Christian
A1  - Ortner, Anna
A1  - Haberl, Ines
A1  - Köhler, Gottfried
A1  - Rünzler, Dominik
A1  - Artl, Andreas
A1  - Andreae, Fritz
A1  - Mosgöller, Wilhelm
T1  - Vasoactive intestinal peptide conjugate internalisation as strategy for cytoplasmic drug delivery
T2  - Journal of Molecular Neuroscience
KW  - Cytplasmic Drug Delivery
Y1  - 2019
ER  - 
TY  - JOUR
A1  - Wruss, Jürgen
A1  - Rünzler, Dominik
A1  - Steiger, Christina
A1  - Chiba, Peter
A1  - Köhler, Gottfried
A1  - Blaas, Dieter
T1  - Attachment of VLDL receptors to an icosahedral virus along the 5-fold symmetry axis: multiple binding modes evidenced by fluorescence correlation spectroscopy
JF  - Biochemistry
KW  - Cells
Y1  - 2019
IS  - 46(21)
SP  - 6331
EP  - 6339
ER  - 
TY  - JOUR
A1  - Maier, Christina
A1  - Rünzler, Dominik
A1  - Schindelar, Julia
A1  - Grabner, Gottfried
A1  - Waldhäusl, Werner Klaus
A1  - Köhler, Gottfried
A1  - Luger, Anton
T1  - G-protein-coupled glucocorticoid receptors on the pituitary cell membrane
JF  - Journal of Cell Science
KW  - Cells
Y1  - 2019
IS  - 118(15)
SP  - 3353
EP  - 3361
ER  - 
TY  - JOUR
A1  - Maier, Christina
A1  - Rünzler, Dominik
A1  - Wagner, Ludwig
A1  - Grabner, Günther
A1  - Köhler, Gottfried
A1  - Lugner, Anton
T1  - Evidence for specific glucocorticoid binding sites on the cell membrane by fluorescence correlation spectroscopy
JF  - Single Moleculus
KW  - Cells
Y1  - 2019
IS  - 3(4)
SP  - 211
EP  - 216
ER  - 
TY  - GEN
A1  - Rünzler, Dominik
A1  - Bergmann, J.
A1  - Sára, Margit
A1  - Köhler, Gottfried
T1  - Protein-Ligand Interactions: Fluorescence Binding Assays performed with FCS and Fluorescence Anisotropy Measurements
KW  - Protein
KW  - Assay
Y1  - 2019
ER  - 
TY  - GEN
A1  - Maier, Christina
A1  - Rünzler, Dominik
A1  - Schindelar, Julia
A1  - Grabner, Gottfried
A1  - Luger, Anton
T1  - High-Affinity Membrane Glucocorticoid Binding Sites on the Living Cell
KW  - Cell Membrane
Y1  - 2019
ER  - 
TY  - GEN
A1  - Rünzler, Dominik
A1  - Sára, Margit
A1  - Köhler, Gottfried
T1  - Biophysical Investigations on the S-layer Protein SbsB
KW  - Protein
Y1  - 2019
ER  - 
TY  - GEN
A1  - Rünzler, Dominik
T1  - Detection of Ultrafine Particles in Living Cells by using Fluorescence Correlation Spectroscopy
KW  - Particle Detection
KW  - Cells
KW  - Spectroscopy
Y1  - 2018
ER  - 
TY  - GEN
A1  - Rünzler, Dominik
A1  - Maier, Christina
A1  - Schindelar, Julia
A1  - Grabner, Gottfried
A1  - Köhler, Gottfried
A1  - Luger, Anton
T1  - High-affinity membrane glucocorticoid binding sites on the pituitary cell line AtT-20 characterized by Fluorescence Correlation Spectroscopy
KW  - Cell
Y1  - 2019
ER  - 
TY  - GEN
A1  - Rünzler, Dominik
A1  - Maier, Christina
A1  - Wagner, Ludwig
A1  - Grabner, Gottfried
A1  - Köhler, Gottfried
A1  - Luger, Anton
T1  - Evidence for specific glucocorticoid binding sites on the cell membrane of a living cell by fluorescence correlation microscopy
KW  - Glucocorticoid
KW  - Cell Membrane
KW  - Spectroscopy
Y1  - 2019
ER  - 
TY  - GEN
A1  - Rünzler, Dominik
A1  - Maier, Christina
A1  - Schindelar, Julia
A1  - Köhler, Gottfried
A1  - Luger, Anton
T1  - Flourescence Correlation Spectroscopy (FCS): A New Tool for Studying Membrane Steroid Receptors
KW  - Spectroscopy
KW  - Steroid Receptors
KW  - Membrane
Y1  - 2019
ER  - 
TY  - GEN
A1  - Maier, Christina
A1  - Rünzler, Dominik
A1  - Wagner, Ludwig
A1  - Grabner, Gottfried
A1  - Luger, Anton
T1  - Functional Characterization of the Putative Membrane Glucocorticoid Receptor using FCS
KW  - Cell Membrane
KW  - Glucocorticoid
Y1  - 2019
ER  - 
TY  - GEN
A1  - Rünzler, Dominik
T1  - Investigation of Putative Membrane Glucocorticoid Binding Sites on Single Living Cells by FCS
KW  - Cell Membrane
KW  - Glucocorticoid
Y1  - 2019
ER  - 
TY  - GEN
A1  - Edetsberger, Michael
A1  - Rünzler, Dominik
A1  - Schindelar, Julia
A1  - Valic, Eva
A1  - Köhler, Gottfried
T1  - Specific glucocorticoid binding sites on the cell membrane of AtT-20 cell line
T2  - 11th Meeting of the European Neuroendocrine Association (ENEA)
KW  - Cell Membrane
Y1  - 2019
ER  - 
TY  - GEN
A1  - Maier, Christina
A1  - Altenberger, T.
A1  - Rünzler, Dominik
T1  - Investigation of Putative Membrane Glucocorticoid Binding Sites on Single Living Cells by FCS
KW  - Cell Membrane
KW  - Glucocorticoid
Y1  - 2019
ER  - 
TY  - GEN
A1  - Edetsberger, Michael
A1  - Rünzler, Dominik
A1  - Schindelar, Julia
A1  - Valic, Eva
A1  - Köhler, Gottfried
T1  - Detection of Ultrafine Particles in Living Cells
KW  - Cell
Y1  - 2019
ER  - 
TY  - JOUR
A1  - Huber-Gries, Carina
A1  - Ilk, Nicola
A1  - Rünzler, Dominik
A1  - Egelseer, Eva-Maria
A1  - Weigert, Stefan
A1  - Sleytr, Uwe
T1  - The three S-layer-like homology motifs of the S-layer protein SbpA of Bacillus sphaericus CCM 2177 are not sufficient for binding to the pyruvylated secondary cell wall polymer
JF  - Molecular Microbiology
KW  - Proteins
Y1  - 2018
VL  - 55
IS  - 1
SP  - 197
EP  - 205
ER  - 
TY  - GEN
A1  - Purtscher, Michaela
A1  - Ergir, Ece
A1  - Szwarc, Dorota
A1  - Monforte Vila, Xavier
A1  - Rünzler, Dominik
A1  - Huber-Gries, Carina
T1  - A microfluidic-based easy-to-use cardiac tissue model for drug screening applications
KW  - Tissue Generation
KW  - Drug Screening
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - GEN
A1  - Hromada, Carina
A1  - Tomasch, Janine
A1  - Weihs, Anna
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Engineering of 3D Tissue Constructs Using our Novel MagneTissue Bioreactor as Alternatives to Animal Models
KW  - Bioreactor
KW  - Biomaterials
Y1  - 
ER  - 
TY  - JOUR
A1  - Leeb, Christine
A1  - Leitner, Rita
A1  - Pichler, Verena
A1  - Huber-Gries, Carina
A1  - Rünzler, Dominik
A1  - Jesenberger, Veronika
T1  - Einführung und Optimierung eines praxisorientierten PBL-Moduls im Life-Science-Bereich
JF  - Zeitschrift für Hochschulentwicklung (ZFHE)
KW  - Life Science
KW  - Problem Based Learning
KW  - Education
Y1  - 2018
VL  - 11
IS  - 3
SP  - 107
EP  - 121
ER  - 
TY  - JOUR
A1  - Rieder, Bernhard
A1  - Weihs, Anna
A1  - Weidinger, Adelheid
A1  - Sczwarc, Dorota
A1  - Nürnberger, Sylvia
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Huber-Gries, Carina
A1  - Teuschl, Andreas
T1  - Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures
JF  - Scientific Reports
KW  - Bioreactor
KW  - Osteoarthritis
KW  - Cartilage
KW  - Reactive oxygen species
Y1  - 
ER  - 
TY  - CHAP
A1  - Huber-Gries, Carina
A1  - Moll, Dieter
A1  - Liu, Jing
A1  - Rünzler, Dominik
A1  - Sára, Margit
A1  - Sleytr, Uwe
T1  - S-layer-streptavidin fusion proteins: Novel Tools in Nanobiotechnology
T2  - 6th Annual Linz Winter Workshop - Book of Abstracts
KW  - Proteins
KW  - Nanobiology
KW  - Nanotechnology
Y1  - 2019
SP  - 11
EP  - 11
ER  - 
TY  - CHAP
A1  - Huber-Gries, Carina
A1  - Liu, Jing
A1  - Egelseer, Eva-Maria
A1  - Rünzler, Dominik
A1  - Sára, Margit
A1  - Sleytr, Uwe
T1  - Application Potential of Bacterial Self-Assembly Systems for Nanobiotechnology
T2  - Nanobionics III (from Molecules to Applications) Book of Abstracts
KW  - Nanotechnology
KW  - Nanobiology
KW  - Bacteria
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Rünzler, Dominik
A1  - Huber-Gries, Carina
A1  - Moll, Dieter
A1  - Sára, Margit
T1  - Biophysical characterization of the entire bacterial surface layer protein SbsB and its two distinct functional domains
JF  - Journal of Biological Chemistry
KW  - Life Sciences
KW  - Protein
Y1  - 2019
IS  - 279(7) / 13.
SP  - 5207
EP  - 5215
ER  - 
TY  - CHAP
A1  - Huber-Gries, Carina
A1  - Moll, Dieter
A1  - Schlegel, Birgit
A1  - Rünzler, Dominik
A1  - Mader, Christoph
A1  - Sára, Margit
A1  - Sleytr, Uwe
T1  - Recombinant S-layer-streptavidin fursion proteins: Functional protein lattices as nanoarrays for biochip development
T2  - Proceedings der 28. Jahrestagung der Österreichischen Gesellschaft für Hygiene, Mikrobiologie und Präventivmedizin, Merano (Italy)
KW  - Proteins
KW  - Biochips
Y1  - 2019
ER  - 
TY  - CHAP
A1  - Leeb, Christine
A1  - Leitner, Rita
A1  - Pichler, Verena
A1  - Huber-Gries, Carina
A1  - Rünzler, Dominik
A1  - Jesenberger, Veronika
T1  - Einführung und Optimierung eines praxisorientierten PBL-Moduls im Life-Science-Bereich
T2  - Proceedings des Kongresses Problem-Based Learning 2016 PBL - Kompetenzen fördern, Zukunft gestalten
KW  - Life Science
KW  - Problem Based Learning
KW  - Education
Y1  - 2018
ER  - 
TY  - GEN
A1  - Rünzler, Dominik
A1  - Moll, Dieter
A1  - Huber-Gries, Carina
A1  - Sleytr, Uwe
A1  - Sára, Margit
A1  - Köhler, Gottfried
T1  - Characterization of the Functional Domains of Bacterial Surface Layer Proteins
T2  - 5th European Symposium of the Protein Society
KW  - Proteins
Y1  - 2019
ER  - 
TY  - GEN
A1  - Leeb, Christine
A1  - Leitner, Rita
A1  - Pichler, Verena
A1  - Huber-Gries, Carina
A1  - Rünzler, Dominik
A1  - Jesenberger, Veronika
T1  - Einführung und Optimierung eines praxisorientierten PBL-Moduls im Life-Science-Bereich
KW  - Life Science
KW  - Problem Based Learning
KW  - Education
Y1  - 2018
ER  - 
TY  - GEN
A1  - Rünzler, Dominik
A1  - Huber-Gries, Carina
A1  - Sára, Margit
A1  - Köhler, Gottfried
T1  - Fluorescence-based Equilibrium and Kinetic Studies on Carbohydrate-Protein Binding: Interaction of Bacterial Surface Layer Proteins with their Specific Secondary Cell Wall Polymers
KW  - Fluorescence
KW  - Proteins
KW  - Polymer
Y1  - 2019
ER  - 
TY  - CHAP
A1  - Huber-Gries, Carina
A1  - Moll, Dieter
A1  - Liu, Jing
A1  - Rünzler, Dominik
A1  - Sára, Margit
A1  - Sleytr, Uwe B.
T1  - Chimaeric S-Layers as Nanopatterned Biomaterials for  Applications in Nanobiotechnology
T2  - Poster presentation at the 7th Annual Linz Winter Workshop / Book of Abstracts / Linz
KW  - Biomaterial
KW  - Nanobiotechnology
Y1  - 2019
SP  - 1
EP  - 10
ER  - 
TY  - JOUR
A1  - Priglinger, Eleni
A1  - Schuh, Christina
A1  - Steffenhagen, Carolin
A1  - Wurzer, Christoph
A1  - Maier, Julia
A1  - Nürnberger, Sylvia
A1  - Holnthoner, Wolfgang
A1  - Fuchs, Christiane
A1  - Suessner, Susanne
A1  - Rünzler, Dominik
A1  - Redl, Heinz
A1  - Wolbank, Susanne
T1  - Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy.
JF  - Cytotherapy
N2  - BACKGROUND:

Cell-based therapies with autologous adipose tissue-derived cells have shown great potential in several clinical studies in the last decades. The majority of these studies have been using the stromal vascular fraction (SVF), a heterogeneous mixture of fibroblasts, lymphocytes, monocytes/macrophages, endothelial cells, endothelial progenitor cells, pericytes and adipose-derived stromal/stem cells (ASC) among others. Although possible clinical applications of autologous adipose tissue-derived cells are manifold, they are limited by insufficient uniformity in cell identity and regenerative potency.
METHODS:

In our experimental set-up, low-energy extracorporeal shock wave therapy (ESWT) was performed on freshly obtained human adipose tissue and isolated adipose tissue SVF cells aiming to equalize and enhance stem cell properties and functionality.
RESULTS:

After ESWT on adipose tissue we could achieve higher cellular adenosine triphosphate (ATP) levels compared with ESWT on the isolated SVF as well as the control. ESWT on adipose tissue resulted in a significantly higher expression of single mesenchymal and vascular marker compared with untreated control. Analysis of SVF protein secretome revealed a significant enhancement in insulin-like growth factor (IGF)-1 and placental growth factor (PLGF) after ESWT on adipose tissue.
DISCUSSION:

Summarizing we could show that ESWT on adipose tissue enhanced the cellular ATP content and modified the expression of single mesenchymal and vascular marker, and thus potentially provides a more regenerative cell population. Because the effectiveness of autologous cell therapy is dependent on the therapeutic potency of the patient's cells, this technology might raise the number of patients eligible for autologous cell transplantation.
KW  - Shockwave Therapy
KW  - Tissue Regeneration
KW  - Regenerative Medicine
Y1  - 
SP  - 1079
EP  - 1095
ER  - 
TY  - JOUR
A1  - Cieślik-Boczula, Katarzyna
A1  - Küpcü, Seta
A1  - Rünzler, Dominik
A1  - Koll, Aleksander
A1  - Köhler, Gottfried
T1  - Effects of the phenolic lipid 3-pentadecylphenol on phospholipid bilayer organization
JF  - Journal of Molecular Structure
KW  - Phospholipid Bilayer
Y1  - 2019
IS  - 919(1-3)
SP  - 373
EP  - 380
ER  - 
TY  - CHAP
A1  - Knebl, Gerald
A1  - Morton, Tatjana J.
A1  - Redl, Heinz
A1  - Rünzler, Dominik
T1  - Mechanical stimulation of cells in 3-dimensional fibrin constructs using a bioreactor
T2  - 3. Forschungsforum der österreichischen Fachhochschulen / Fachhochschule Kärnten
KW  - Cells
KW  - Bioreactor
Y1  - 2019
SP  - 492
EP  - 493
ER  - 
TY  - JOUR
A1  - Schneider, Karl Heinrich
A1  - Aigner, Petra
A1  - Holnthoner, Wolfgang
A1  - Monforte Vila, Xavier
A1  - Nürnberger, Sylvia
A1  - Rünzler, Dominik
A1  - Redl, Heinz
A1  - Teuschl, Andreas
T1  - Decellularized human placenta chorion matrix as a favorable source of small-diameter vascular grafts
JF  - Acta Biomaterialia
KW  - Grafting
KW  - Tissue Engineering
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Rohringer, Sabrina
A1  - Holnthoner, Wolfgang
A1  - Hackl, Matthias
A1  - Weihs, Anna
A1  - Rünzler, Dominik
A1  - Skalicky, Susanna
A1  - Karbiener, Michael
A1  - Scheideler, Marcel
A1  - Pröll, Johannes
A1  - Gabriel, Christian
A1  - Schweighofer, Bernhard
A1  - Gröger, Marion
A1  - Spittler, Andreas
A1  - Grillari, Johannes
A1  - Redl, Heinz
T1  - Molecular and cellular effects of in vitro shockwave treatment on lymphatic endothelial cells.
JF  - PLoS one
KW  - Shockwave
Y1  - 
ER  - 
TY  - GEN
A1  - Liousia, Varvara
A1  - Salzer, Elias
A1  - Mandt, Denise
A1  - Rünzler, Dominik
T1  - The impact of ethanol in vitro and in vivo: a comparative study
KW  - In Vivo
KW  - In Vitro
KW  - Ethanol
Y1  - 2018
ER  - 
TY  - GEN
A1  - Liousia, Varvara
A1  - Rünzler, Dominik
T1  - Stage- and dose-dependent effects of methanol and ethanol on the locomotor activity of zebrafish larvae
KW  - Locomotor Activity
KW  - Zebrafish
Y1  - 2018
ER  -