TY  - JOUR
A1  - Maleiner, Babette
A1  - Tomasch, Janine
A1  - Heher, Philipp
A1  - Spadiut, Oliver
A1  - Rünzler, Dominik
A1  - Fuchs, Christiane
T1  - The Importance of Biophysical and Biochemical Stimuli in Dynamic Skeletal Muscle Models.
JF  - Frontiers in Physiology
N2  - Classical approaches to engineer skeletal muscle tissue based on current regenerative and surgical procedures still do not meet the desired outcome for patient applications. Besides the evident need to create functional skeletal muscle tissue for the repair of volumetric muscle defects, there is also growing demand for platforms to study muscle-related diseases, such as muscular dystrophies or sarcopenia. Currently, numerous studies exist that have employed a variety of biomaterials, cell types and strategies for maturation of skeletal muscle tissue in 2D and 3D environments. However, researchers are just at the beginning of understanding the impact of different culture settings and their biochemical (growth factors and chemical changes) and biophysical cues (mechanical properties) on myogenesis. With this review we intend to emphasize the need for new in vitro skeletal muscle (disease) models to better recapitulate important structural and functional aspects of muscle development. We highlight the importance of choosing appropriate system components, e.g., cell and biomaterial type, structural and mechanical matrix properties or culture format, and how understanding their interplay will enable researchers to create optimized platforms to investigate myogenesis in healthy and diseased tissue. Thus, we aim to deliver guidelines for experimental designs to allow estimation of the potential influence of the selected skeletal muscle tissue engineering setup on the myogenic outcome prior to their implementation. Moreover, we offer a workflow to facilitate identifying and selecting different analytical tools to demonstrate the successful creation of functional skeletal muscle tissue. Ultimately, a refinement of existing strategies will lead to further progression in understanding important aspects of muscle diseases, muscle aging and muscle regeneration to improve quality of life of patients and enable the establishment of new treatment options.
KW  - Bioreactor
KW  - Muscle
KW  - Biomaterial
Y1  - 
ER  - 
TY  - JOUR
A1  - Schuh, Christina
A1  - Heher, Philipp
A1  - Weihs, Anna
A1  - Fuchs, Christiane
A1  - Gabriel, Christian
A1  - Wolbank, Susanne
A1  - Mittermayr, Rainer
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - In vitro extracorporeal shock wave treatment enhances stemness and preserves multipotency of rat and human adipose-derived stem cells
JF  - Journal of Cytotherapy
KW  - Shockwave
Y1  - 
ER  - 
TY  - JOUR
A1  - Heher, Philipp
A1  - Maleiner, Babette
A1  - Prüller, Johanna
A1  - Teuschl, Andreas
A1  - Kollmitzer, Josef
A1  - Monforte Vila, Xavier
A1  - Wolbank, Susanne
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Fuchs, Christiane
T1  - A novel bioreactor for the generation of highly aligned 3D skeletal muscle-like constructs through orientation of fibrin via application of static strain
JF  - Acta Biomaterialia
KW  - Bioreactor
Y1  - 
ER  - 
TY  - JOUR
A1  - Teuschl, Andreas
A1  - Schuh, Christina
A1  - Halbweis, Robert
A1  - Pajer, Krisztian
A1  - Marton, Gabor
A1  - Hopf, Rudolf
A1  - Mosia, Shorena
A1  - Rünzler, Dominik
A1  - Redl, Heinz
A1  - Nogradi, Antal
A1  - Hausner, Thomas
T1  - A new preparation method for anisotropic silk fibroin nerve guidance conduits and its evaluation in vitro and in a rat sciatic nerve defect model
JF  - Tissue Engineering Part C: Methods
KW  - Fibrin
KW  - Nerve Defect
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Weihs, Anna
A1  - Fuchs, Christiane
A1  - Teuschl, Andreas
A1  - Hartinger, Joachim
A1  - Slezak, Paul
A1  - Mittermayr, Rainer
A1  - Redl, Heinz
A1  - Junger, Wolfgang
A1  - Sitte, Harald
A1  - Rünzler, Dominik
T1  - Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation
JF  - The Journal of biological chemistry
KW  - Shockwave
Y1  - 
ER  - 
TY  - JOUR
A1  - Schuh, Christina
A1  - Heher, Philipp
A1  - Weihs, Anna
A1  - Asmita, Banerjee
A1  - Wolbank, Susanne
A1  - Mittermayr, Rainer
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Adipose derived stem cells respond to in vitro extracorporeal shockwave treatment with increased stemness and multipotency
JF  - New Biotechnology
KW  - Shockwave
Y1  - 
ER  - 
TY  - JOUR
A1  - Teuschl, Andreas
A1  - Neutsch, Lukas
A1  - Monforte Vila, Xavier
A1  - Rünzler, Dominik
A1  - van Griensven, Martijn
A1  - Gabor, Franz
A1  - Redl, Heinz
T1  - Enhanced cell adhesion on silk fibroin via lectin surface modification.
JF  - Acta Biomaterialia
KW  - Silk
KW  - Fibrin
Y1  - 
ER  - 
TY  - JOUR
A1  - Schuh, Christina
A1  - Banerjee, Asmita
A1  - Mosia, Shorena
A1  - Hopf, Rudolf
A1  - Grasl, Christian
A1  - Schima, Heinrich
A1  - Schmidhammer, Robert
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Morton, Tatjana J.
T1  - Activated Schwann-like cells guided by fibrin structures enhance Axonal Regeneration
JF  - JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
KW  - Cells
KW  - Fibrin
Y1  - 2019
VL  - 2012
IS  - vol. 6/no. 1
ER  - 
TY  - JOUR
A1  - Rieder, Bernhard
A1  - Weihs, Anna
A1  - Teuschl, Andreas
A1  - Knebl, Gerald
A1  - Kollmitzer, Josef
A1  - Redl, Heinz
A1  - Rünzler, Dominik
T1  - Evaluation of cell response on permanent and pulsed atmospheric pressure stressed cells
JF  - Journal of Tissue Engineering and Regenerative Medicine
KW  - Cells
KW  - Atmospheric Pressure
Y1  - 2018
VL  - 1
IS  - 6
SP  - 240
EP  - 240
ER  - 
TY  - JOUR
A1  - Weihs, Anna
A1  - Junger, Wolfgang
A1  - Schaden, Wolfgang
A1  - Sitte, Harald
A1  - Rünzler, Dominik
T1  - Extracorporeal shockwave treatment induced extracellular ATP release - a potential mechanism to activate wound healing
JF  - Journal of Tissue Engineering and Regenerative Medicine
KW  - Shockwave treatment
KW  - Healing Processes
Y1  - 2018
VL  - 1
IS  - 6
SP  - 381
EP  - 381
ER  - 
TY  - JOUR
A1  - Rünzler, Dominik
A1  - Weihs, Anna
A1  - Junger, Wolfgang
A1  - Sitte, Harald
A1  - Schaden, Wolfgang
T1  - Extracorporeal shock waves - a novel method of mechanostimulation in tissue regeneration
JF  - Journal of Tissue Engineering and Regenerative Medicine
KW  - Shockwave treatment
KW  - Mechanostimulation
Y1  - 2018
VL  - 1
IS  - 6
SP  - 380
EP  - 380
ER  - 
TY  - JOUR
A1  - Martin M., Frank
A1  - Kollmitzer, Josef
A1  - Redl, Heinz
A1  - Rünzler, Dominik
T1  - Shear force stimulation of adipose-tissue derived stem cells in a novel bioreactor
JF  - Journal of Tissue Engineering and Regenerative Medicine
KW  - Stem Cells
KW  - Adipose
Y1  - 2018
VL  - 1
IS  - 6
SP  - 340
EP  - 340
ER  - 
TY  - JOUR
A1  - Milan-Lobo, Laura
A1  - Gsandtner, Ingrid
A1  - Gaubitzer, Erwin
A1  - Rünzler, Dominik
A1  - Buchmayer, Florian
A1  - Köhler, Gottfried
A1  - Bonci, Antonello
A1  - Freissmuth, Michael
A1  - Sitte, Harald H.
T1  - Subtype-specific differences in corticotropin-releasing factor receptor complexes detected by fluorescence spectroscopy
JF  - Molecular Pharmacology (mol pharmacol)
KW  - Spectroscopy
Y1  - 2019
IS  - 76(6)
SP  - 1196
EP  - 1210
ER  - 
TY  - JOUR
A1  - Grunt, Thomas
A1  - Tomek, Katharina
A1  - Wagner, Renate
A1  - Puckmair, Klaudia
A1  - Kainz, Birgit
A1  - Rünzler, Dominik
A1  - Gaiger, Alexander
A1  - Köhler, Gottfried
A1  - Zielinski, Christoph
T1  - Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways
JF  - Journal of Cell Physiology
KW  - Cells
Y1  - 2019
IS  - 211(3)
SP  - 803
EP  - 815
ER  - 
TY  - JOUR
A1  - Spurny, Radovan
A1  - Abdoulrahman, Kamaran
A1  - Janda, Lubomir
A1  - Rünzler, Dominik
A1  - Köhler, Gottfried
A1  - Castanon, Maria J.
A1  - Wiche, Gerhard
T1  - Oxidation and nitrosylation of cysteines proximal to the intermediate filament (IF)-binding site of plectin: effects on structure and vimentin binding and involvement in IF collapse
JF  - Journal of Biological Chemistry
KW  - Oxidation
Y1  - 2019
IS  - 282(11)
SP  - 8175
EP  - 8187
ER  - 
TY  - JOUR
A1  - Wruss, Jürgen
A1  - Rünzler, Dominik
A1  - Steiger, Christina
A1  - Chiba, Peter
A1  - Köhler, Gottfried
A1  - Blaas, Dieter
T1  - Attachment of VLDL receptors to an icosahedral virus along the 5-fold symmetry axis: multiple binding modes evidenced by fluorescence correlation spectroscopy
JF  - Biochemistry
KW  - Cells
Y1  - 2019
IS  - 46(21)
SP  - 6331
EP  - 6339
ER  - 
TY  - JOUR
A1  - Maier, Christina
A1  - Rünzler, Dominik
A1  - Schindelar, Julia
A1  - Grabner, Gottfried
A1  - Waldhäusl, Werner Klaus
A1  - Köhler, Gottfried
A1  - Luger, Anton
T1  - G-protein-coupled glucocorticoid receptors on the pituitary cell membrane
JF  - Journal of Cell Science
KW  - Cells
Y1  - 2019
IS  - 118(15)
SP  - 3353
EP  - 3361
ER  - 
TY  - JOUR
A1  - Maier, Christina
A1  - Rünzler, Dominik
A1  - Wagner, Ludwig
A1  - Grabner, Günther
A1  - Köhler, Gottfried
A1  - Lugner, Anton
T1  - Evidence for specific glucocorticoid binding sites on the cell membrane by fluorescence correlation spectroscopy
JF  - Single Moleculus
KW  - Cells
Y1  - 2019
IS  - 3(4)
SP  - 211
EP  - 216
ER  - 
TY  - JOUR
A1  - Huber-Gries, Carina
A1  - Ilk, Nicola
A1  - Rünzler, Dominik
A1  - Egelseer, Eva-Maria
A1  - Weigert, Stefan
A1  - Sleytr, Uwe
T1  - The three S-layer-like homology motifs of the S-layer protein SbpA of Bacillus sphaericus CCM 2177 are not sufficient for binding to the pyruvylated secondary cell wall polymer
JF  - Molecular Microbiology
KW  - Proteins
Y1  - 2018
VL  - 55
IS  - 1
SP  - 197
EP  - 205
ER  - 
TY  - JOUR
A1  - Leeb, Christine
A1  - Leitner, Rita
A1  - Pichler, Verena
A1  - Huber-Gries, Carina
A1  - Rünzler, Dominik
A1  - Jesenberger, Veronika
T1  - Einführung und Optimierung eines praxisorientierten PBL-Moduls im Life-Science-Bereich
JF  - Zeitschrift für Hochschulentwicklung (ZFHE)
KW  - Life Science
KW  - Problem Based Learning
KW  - Education
Y1  - 2018
VL  - 11
IS  - 3
SP  - 107
EP  - 121
ER  -