TY  - JOUR
A1  - Maleiner, Babette
A1  - Tomasch, Janine
A1  - Heher, Philipp
A1  - Spadiut, Oliver
A1  - Rünzler, Dominik
A1  - Fuchs, Christiane
T1  - The Importance of Biophysical and Biochemical Stimuli in Dynamic Skeletal Muscle Models.
JF  - Frontiers in Physiology
N2  - Classical approaches to engineer skeletal muscle tissue based on current regenerative and surgical procedures still do not meet the desired outcome for patient applications. Besides the evident need to create functional skeletal muscle tissue for the repair of volumetric muscle defects, there is also growing demand for platforms to study muscle-related diseases, such as muscular dystrophies or sarcopenia. Currently, numerous studies exist that have employed a variety of biomaterials, cell types and strategies for maturation of skeletal muscle tissue in 2D and 3D environments. However, researchers are just at the beginning of understanding the impact of different culture settings and their biochemical (growth factors and chemical changes) and biophysical cues (mechanical properties) on myogenesis. With this review we intend to emphasize the need for new in vitro skeletal muscle (disease) models to better recapitulate important structural and functional aspects of muscle development. We highlight the importance of choosing appropriate system components, e.g., cell and biomaterial type, structural and mechanical matrix properties or culture format, and how understanding their interplay will enable researchers to create optimized platforms to investigate myogenesis in healthy and diseased tissue. Thus, we aim to deliver guidelines for experimental designs to allow estimation of the potential influence of the selected skeletal muscle tissue engineering setup on the myogenic outcome prior to their implementation. Moreover, we offer a workflow to facilitate identifying and selecting different analytical tools to demonstrate the successful creation of functional skeletal muscle tissue. Ultimately, a refinement of existing strategies will lead to further progression in understanding important aspects of muscle diseases, muscle aging and muscle regeneration to improve quality of life of patients and enable the establishment of new treatment options.
KW  - Bioreactor
KW  - Muscle
KW  - Biomaterial
Y1  - 
ER  - 
TY  - CHAP
A1  - Leitner, Rita
A1  - Gepp, Barbara
A1  - Liousia, Varvara
A1  - Rünzler, Dominik
T1  - Teaching 3R principles in ecotoxicology by performing a problem-based learning project
T2  - ALTEX Proceedings, LINZ 2018 – EUSAAT 2018, Volume 7, No. 2, ISSN 2194-0479 (2018)
KW  - Problem Based Learning
KW  - Teaching
KW  - Ecotoxicology
KW  - 3R Principles
Y1  - 
ER  - 
TY  - GEN
A1  - Gepp, Barbara
A1  - Liousia, Varvara
A1  - Machacek, Thomas
A1  - Praher, Daniela
A1  - Eisner, Katharina
A1  - Limbeck, Sophie
A1  - Gamper, Janine
A1  - Schwarzl, Elisabeth
A1  - Hazod, Till
A1  - Landwehr, Renate
A1  - Wenger, Charlotte
A1  - Olscher, Christoph
A1  - Leitner, Rita
A1  - Rünzler, Dominik
T1  - Pelargonic acid - an alternative to glyphosate-based herbicides?
KW  - Ecotoxicology
KW  - Herbicides
Y1  - 
ER  - 
TY  - GEN
A1  - Teuschl, Andreas
A1  - Schuh, Christina
A1  - Weihs, Anna
A1  - Guillaume, Olivier
A1  - Monforte Vila, Xavier
A1  - Redl, Heinz
A1  - Kaplan, David
A1  - Rünzler, Dominik
T1  - Tailoring bioactivity of silk-based biomaterials via delivering and functionalization strategies with fibrinogen/thrombin, plant lectins or laminin
KW  - Biomaterials
KW  - Tissue Engineering
KW  - Silk
Y1  - 
ER  - 
TY  - GEN
A1  - Salzer, Elias
A1  - Rieder, Bernhard
A1  - Monforte Vila, Xavier
A1  - Weihs, Anna
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Evaluation of a novel hydrostatic pressure bioreactor on bovine cartilage chips
KW  - Bioreactor
KW  - Tissue Engineering
KW  - Cartilage
Y1  - 
ER  - 
TY  - GEN
A1  - Eisner, Katharina
A1  - Gepp, Barbara
A1  - Schnegg, Raimund
A1  - Dallinger, Reinhard
A1  - Rünzler, Dominik
T1  - Investigation of endocrine effects of sublethal cadmium doses on the reproduction system of the freshwater snail B. glabrata
KW  - Ecotoxicology
KW  - Endocrine disruptors
Y1  - 
ER  - 
TY  - GEN
A1  - Salzer, Elias
A1  - Liousia, Varvara
A1  - Monforte Vila, Xavier
A1  - Rünzler, Dominik
T1  - Tracking of small aquatic organisms with custom-made tracking plates
KW  - Ecotoxicology
KW  - Behavior Analysis
KW  - Aquatic Ecotoxicology
Y1  - 
ER  - 
TY  - GEN
A1  - Hromada, Carina
A1  - Tomasch, Janine
A1  - Weihs, Anna
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Engineering of 3D Tissue Constructs Using our Novel MagneTissue Bioreactor as Alternatives to Animal Models
KW  - Bioreactor
KW  - Biomaterials
Y1  - 
ER  - 
TY  - JOUR
A1  - Rieder, Bernhard
A1  - Weihs, Anna
A1  - Weidinger, Adelheid
A1  - Sczwarc, Dorota
A1  - Nürnberger, Sylvia
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Huber-Gries, Carina
A1  - Teuschl, Andreas
T1  - Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures
JF  - Scientific Reports
KW  - Bioreactor
KW  - Osteoarthritis
KW  - Cartilage
KW  - Reactive oxygen species
Y1  - 
ER  -