TY  - CHAP
A1  - Fuchs, Christiane
A1  - Weihs, Anna
A1  - Szwarc, Dorota
A1  - Mittermayr, Rainer
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Shock wave treatment of muscle (stem) cells - a new implementation for regeneration
T2  - Proceedings of the 20th International Congress of the ISMST
KW  - Shockwave treatment
KW  - Muscle Cells
KW  - Regeneration
Y1  - 2018
ER  - 
TY  - GEN
A1  - Fuchs, Christiane
A1  - Weihs, Anna
A1  - Szwarc, Dorota
A1  - Mittermayr, Rainer
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Shock wave treatment of muscle (stem) cells - a new implementation for regeneration
KW  - Shockwave treatment
KW  - Muscle Cells
KW  - Regeneration
Y1  - 2018
ER  - 
TY  - GEN
A1  - Szwarc, Dorota
A1  - Fuchs, Christiane
A1  - Weihs, Anna
A1  - Rünzler, Dominik
T1  - Molecular mechanisms underlying the potential of shock wave treatment for cardiac therapy
KW  - Shockwave treatment
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - GEN
A1  - Szwarc, Dorota
A1  - Fuchs, Christiane
A1  - Purtscher, Michaela
A1  - Rünzler, Dominik
T1  - Elucidating the molecular mechanisms underlying cardiac shock wave therapy
KW  - Shockwave treatment
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - GEN
A1  - Szwarc, Dorota
A1  - Fuchs, Christiane
A1  - Weihs, Anna
A1  - Monforte Vila, Xavier
A1  - Hanetseder, Dominik
A1  - Teuschl, Andreas
A1  - Rünzler, Dominik
T1  - The effect of shock waves on in vitro cartilage development in silk scaffolds
KW  - Shockwave treatment
KW  - In Vitro
KW  - Cartilage
KW  - Silk
Y1  - 2018
ER  - 
TY  - CHAP
A1  - Fuchs, Christiane
A1  - Szwarc, Dorota
A1  - Weihs, Anna
A1  - Rünzler, Dominik
T1  - Shock wave treatment of 3D cardiac model systems activates ERK 1/2 signaling pathway and influences cardiomyogenesis
T2  - Proceedings of PACT "Designer Cells go Clinical" Symposium
KW  - Shockwave treatment
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - CHAP
A1  - Fuchs, Christiane
A1  - Szwarc, Dorota
A1  - Weihs, Anna
A1  - Rünzler, Dominik
T1  - Shock wave treatment of 3D cardiac model systems activates ERK 1/2 signaling pathway and influences cardiomyogenesis
T2  - Proceedings of LBG Meeting for Health Sciences 2016
KW  - Shockwave treatment
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - GEN
A1  - Fuchs, Christiane
A1  - Szwarc, Dorota
A1  - Weihs, Anna
A1  - Rünzler, Dominik
T1  - Shock wave treatment of 3D cardiac model systems activates ERK 1/2 signaling pathway and influences cardiomyogenesis
KW  - Shockwave treatment
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - CHAP
A1  - Fuchs, Christiane
A1  - Szwarc, Dorota
A1  - Weihs, Anna
A1  - Rünzler, Dominik
T1  - Shock wave treatment positively influences cardiomyogenesis in an energy-dependent manner
T2  - Proceedings of PACT "Designer Cells go Clinical" Symposium
KW  - Shockwave treatment
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - GEN
A1  - Purtscher, Michaela
A1  - Ergir, Ece
A1  - Szwarc, Dorota
A1  - Monforte Vila, Xavier
A1  - Rünzler, Dominik
A1  - Huber-Gries, Carina
T1  - A microfluidic-based easy-to-use cardiac tissue model for drug screening applications
KW  - Tissue Generation
KW  - Drug Screening
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - GEN
A1  - Purtscher, Michaela
A1  - Ergir, Ece
A1  - Szwarc, Dorota
A1  - Huber-Gries, Carina
T1  - Microfluidic based heart-tissue model for directed development of cardiac specific cell types
KW  - Heart Tissue
KW  - Tissue Generation
KW  - Cardiac
Y1  - 2018
ER  - 
TY  - JOUR
A1  - Holnthoner, Wolfgang
A1  - Szwarc, Dorota
T1  - Purinergic P2Y 2 receptors modulate endothelial sprouting
JF  - Cell Mol Life Sci.
N2  - Purinergic P2 receptors are critical regulators of several functions within the vascular system, including platelet aggregation, vascular inflammation, and vascular tone. However, a role for ATP release and P2Y receptor signalling in angiogenesis remains poorly defined. Here, we demonstrate that blood vessel growth is controlled by P2Y2 receptors. Endothelial sprouting and vascular tube formation were significantly dependent on P2Y2 expression and inhibition of P2Y2 using a selective antagonist blocked microvascular network generation. Mechanistically, overexpression of P2Y2 in endothelial cells induced the expression of the proangiogenic molecules CXCR4, CD34, and angiopoietin-2, while expression of VEGFR-2 was decreased. Interestingly, elevated P2Y2 expression caused constitutive phosphorylation of ERK1/2 and VEGFR-2. However, stimulation of cells with the P2Y2 agonist UTP did not influence sprouting unless P2Y2 was constitutively expressed. Finally, inhibition of VEGFR-2 impaired spontaneous vascular network formation induced by P2Y2 overexpression. Our data suggest that P2Y2 receptors have an essential function in angiogenesis, and that P2Y2 receptors present a therapeutic target to regulate blood vessel growth.
KW  - Angiogenesis
KW  - Endothelial
KW  - Purinergic
KW  - P2Y2
KW  - Cell Sprouting
Y1  - 2020
VL  - 2020
IS  - Mar.
SP  - 885
EP  - 901
ER  -