TY  - JOUR
A1  - Teuschl, Andreas
A1  - Tangl, Stefan
A1  - Heimel, Patrick
A1  - Schwarze, Uwe Yacine
A1  - Monforte, Xavier
A1  - Redl, Heinz
A1  - Nau, Thomas
T1  - Osteointegration of a Novel Silk Fiber-Based ACL Scaffold by Formation of a Ligament-Bone Interface.
JF  - American Journal of Sports Medicine
KW  - Tissue Engineering
KW  - Silk
KW  - Scaffold
KW  - ACL
Y1  - 
ER  - 
TY  - GEN
A1  - Teuschl, Andreas
A1  - Heimel, Patrick
A1  - Monforte Vila, Xavier
A1  - Nürnberger, Sylvia
A1  - Tangl, Stefan
A1  - van Griensven, Martijn
A1  - Redl, Heinz
A1  - Nau, Thomas
T1  - Anterior cruciate ligament regeneration using the silk-based RegACL scaffold
KW  - Tissue Engineering
KW  - Silk
KW  - Biomaterial
KW  - Anterior Cruciate Ligament
Y1  - 
ER  - 
TY  - JOUR
A1  - Bernhard, Jonathan
A1  - Ferguson, James
A1  - Rieder, Bernhard
A1  - Heimel, Patrick
A1  - Nau, Thomas
A1  - Tangl, Stefan
A1  - Redl, Heinz
A1  - Vunjak-Novakovic, Gordana
T1  - Tissue-engineered hypertrophic chondrocyte grafts enhanced long bone repair biomaterials
JF  - Biomaterials
KW  - Grafting
KW  - Biomaterials
Y1  - 2018
IS  - 139
SP  - 202
EP  - 212
ER  - 
TY  - JOUR
A1  - Bernhard, Jonathan C
A1  - Marolt Presen, Darja
A1  - Li, Ming
A1  - Monforte, Xavier
A1  - Ferguson, James
A1  - Leinfellner, Gabriele
A1  - Heimel, Patrick
A1  - Betti, Susanne L
A1  - Shu, Sharon
A1  - Teuschl-Woller, Andreas H
A1  - Tangl, Stefan
A1  - Redl, Heinz
A1  - Vunjak-Novakovic, Gordana
T1  - Effects of Endochondral and Intramembranous Ossification Pathways on Bone Tissue Formation and Vascularization in Human Tissue-Engineered Grafts
JF  - Cells
N2  - Bone grafts can be engineered by differentiating human mesenchymal stromal cells (MSCs) via the endochondral and intramembranous ossification pathways. We evaluated the effects of each pathway on the properties of engineered bone grafts and their capacity to drive bone regeneration. Bone-marrow-derived MSCs were differentiated on silk scaffolds into either hypertrophic chondrocytes (hyper) or osteoblasts (osteo) over 5 weeks of in vitro cultivation, and were implanted subcutaneously for 12 weeks. The pathways' constructs were evaluated over time with respect to gene expression, composition, histomorphology, microstructure, vascularization and biomechanics. Hypertrophic chondrocytes expressed higher levels of osteogenic genes and deposited significantly more bone mineral and proteins than the osteoblasts. Before implantation, the mineral in the hyper group was less mature than that in the osteo group. Following 12 weeks of implantation, the hyper group had increased mineral density but a similar overall mineral composition compared with the osteo group. The hyper group also displayed significantly more blood vessel infiltration than the osteo group. Both groups contained M2 macrophages, indicating bone regeneration. These data suggest that, similar to the body's repair processes, endochondral pathway might be more advantageous when regenerating large defects, whereas intramembranous ossification could be utilized to guide the tissue formation pattern with a scaffold architecture.
KW  - bone tissue engineering
KW  - endochondral
KW  - mesenchymal stromal cells
KW  - ossification
KW  - intramembranous
Y1  - 
U6  - http://dx.doi.org/10.3390/cells11193070
VL  - 11
IS  - 19:3070
ER  - 
TY  - JOUR
A1  - Feichtinger, Xaver
A1  - Heimel, Patrick
A1  - Tangl, Stefan
A1  - Keibl, Claudia
A1  - Nürnberger, Sylvia
A1  - Schanda, Jakob Emanuel
A1  - Hercher, David
A1  - Kocijan, Roland
A1  - Redl, Heinz
A1  - Grillari, Johannes
A1  - Fialka, Christian
A1  - Mittermayr, Rainer
T1  - Improved biomechanics in experimental chronic rotator cuff repair after shockwaves is not reflected by bone microarchitecture
JF  - PLoS One
KW  - chronic rotator cuff repair
KW  - bone microarchitecture
Y1  - 
U6  - http://dx.doi.org/10.1371/journal.pone.0262294
VL  - 17
IS  - 1
ER  -