TY  - GEN
A1  - Teuschl, Andreas
A1  - Fuchs, Christiane
T1  - Bioreactors in Musculoskeletal Tissue Engineering
KW  - Bioreactor
KW  - Tissue Engineering
Y1  - 
ER  - 
TY  - JOUR
A1  - Slezak, Paul
A1  - Slezak, Cyrill
A1  - Hartinger, Joachim
A1  - Teuschl, Andreas
A1  - Nürnberger, Sylvia
A1  - Redl, Heinz
A1  - Mittermayr, Rainer
T1  - A Low Cost Implantation Model in the Rat That Allows a Spatial Assessment of Angiogenesis.
JF  - Frontiers in Bioengineering and Biotechnology
N2  - There is continual demand for animal models that allow a quantitative assessment of angiogenic properties of biomaterials, therapies, and pharmaceuticals. In its simplest form, this is done by subcutaneous material implantation and subsequent vessel counting which usually omits spatial data. We have refined an implantation model and paired it with a computational analytic routine which outputs not only vessel count but also vessel density, distribution, and vessel penetration depth, that relies on a centric vessel as a reference point. We have successfully validated our model by characterizing the angiogenic potential of a fibrin matrix in conjunction with recombinant human vascular endothelial growth factor (rhVEGF165). The inferior epigastric vascular pedicles of rats were sheathed with silicone tubes, which were subsequently filled with 0.2 ml of fibrin and different doses of rhVEGF165, centrically embedding the vessels. Over 4 weeks, tissue samples were harvested and subsequently immunohistologically stained and computationally analyzed. The model was able to detect variations over the angiogenic potentials of growth factor spiked fibrin matrices. Adding 20 ng of rhVEGF165 resulted in a significant increase in vasculature while 200 ng of rhVEGF165 did not improve vascular growth. Vascularized tissue volume increased during the first week and vascular density increased during the second week. Total vessel count increased significantly and exhibited a peak after 2 weeks which was followed by a resorption of vasculature by week 4. In summary, a simple implantation model to study in vivo vascularization with only a minimal workload attached was enhanced to include morphologic data of the emerging vascular tree.
KW  - Tissue Engineering
KW  - Bioreactor
KW  - Biomaterial
Y1  - 
ER  - 
TY  - GEN
A1  - Salzer, Elias
A1  - Rieder, Bernhard
A1  - Monforte Vila, Xavier
A1  - Weihs, Anna
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Evaluation of a novel hydrostatic pressure bioreactor on bovine cartilage chips
KW  - Bioreactor
KW  - Tissue Engineering
KW  - Cartilage
Y1  - 
ER  - 
TY  - JOUR
A1  - Heher, Philipp
A1  - Maleiner, Babette
A1  - Prüller, Johanna
A1  - Teuschl, Andreas
A1  - Kollmitzer, Josef
A1  - Monforte Vila, Xavier
A1  - Wolbank, Susanne
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Fuchs, Christiane
T1  - A novel bioreactor for the generation of highly aligned 3D skeletal muscle-like constructs through orientation of fibrin via application of static strain
JF  - Acta Biomaterialia
KW  - Bioreactor
Y1  - 
ER  - 
TY  - JOUR
A1  - Teuschl, Andreas
A1  - Aigner, Elmar
A1  - Hohlrieder, Martin
A1  - Cicha, Klaus
A1  - Stampfl, Jürgen
A1  - Redl, Heinz
T1  - Stimulation of ligament tissue formation on a silk scaffold with mechanical loading using a custom-made bioreactor system
JF  - Journal of Tissue Engineering and Regenerative Medicine
KW  - Ligament
KW  - Tissue Formation
KW  - Scaffold
KW  - Silk
KW  - Bioreactor
Y1  - 2018
VL  - 1
IS  - 6
SP  - 51
EP  - 51
ER  - 
TY  - GEN
A1  - Hromada, Carina
A1  - Tomasch, Janine
A1  - Weihs, Anna
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Engineering of 3D Tissue Constructs Using our Novel MagneTissue Bioreactor as Alternatives to Animal Models
KW  - Bioreactor
KW  - Biomaterials
Y1  - 
ER  - 
TY  - JOUR
A1  - Rieder, Bernhard
A1  - Weihs, Anna
A1  - Weidinger, Adelheid
A1  - Sczwarc, Dorota
A1  - Nürnberger, Sylvia
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Huber-Gries, Carina
A1  - Teuschl, Andreas
T1  - Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures
JF  - Scientific Reports
KW  - Bioreactor
KW  - Osteoarthritis
KW  - Cartilage
KW  - Reactive oxygen species
Y1  - 
ER  -