TY  - JOUR
A1  - Rünzler, Dominik
A1  - Weihs, Anna
A1  - Junger, Wolfgang
A1  - Sitte, Harald
A1  - Schaden, Wolfgang
T1  - Extracorporeal shock waves - a novel method of mechanostimulation in tissue regeneration
JF  - Journal of Tissue Engineering and Regenerative Medicine
KW  - Shockwave treatment
KW  - Mechanostimulation
Y1  - 2018
VL  - 1
IS  - 6
SP  - 380
EP  - 380
ER  - 
TY  - GEN
A1  - Weihs, Anna
A1  - Junger, Wolgang G.
A1  - Schaden, Wolfgang
A1  - Sitte, Harald H.
A1  - Rünzler, Dominik
T1  - Extracellular ATP release - a potential benefit in shock wave treatment
KW  - Shockwave
Y1  - 2019
ER  - 
TY  - CHAP
A1  - Weihs, Anna
A1  - Knebl, Gerald
A1  - Redl, Heinz
A1  - Rünzler, Dominik
T1  - Evaluation of cell migration methods in 3D hydrogels for tissue engineering applications
T2  - 3. Forschungsforum der österreichischen Fachhochschulen / Fachhochschule Kärnten
KW  - Cells
Y1  - 2019
SN  - 978-3-853912850
SP  - 490
EP  - 491
ER  - 
TY  - GEN
A1  - Weihs, Anna
T1  - Establishment of an in vitro experimental set-up to evaluate the biological effects of extracorporeal shock wave treatment
KW  - Shockwave
Y1  - 2019
ER  - 
TY  - CHAP
A1  - Knebl, Gerald
A1  - Weihs, Anna
A1  - Weingant, Michaela
A1  - Steininger, Thomas
A1  - Redl, Heinz
A1  - Rünzler, Dominik
T1  - Automatisierte Datenauswertung eines Boyden-Mikro-Chemotaxis-Kammer Zell-Migrations Assays.
T2  - 2. Forschungsforum der österreichischen Fachhochschulen
KW  - Cells
KW  - Data Analysis
Y1  - 2019
SN  - 978-3-8322-7023-0
SP  - 412
EP  - 417
ER  - 
TY  - GEN
A1  - Hromada, Carina
A1  - Tomasch, Janine
A1  - Weihs, Anna
A1  - Rünzler, Dominik
A1  - Teuschl, Andreas
T1  - Engineering of 3D Tissue Constructs Using our Novel MagneTissue Bioreactor as Alternatives to Animal Models
KW  - Bioreactor
KW  - Biomaterials
Y1  - 
ER  - 
TY  - JOUR
A1  - Rieder, Bernhard
A1  - Weihs, Anna
A1  - Weidinger, Adelheid
A1  - Sczwarc, Dorota
A1  - Nürnberger, Sylvia
A1  - Redl, Heinz
A1  - Rünzler, Dominik
A1  - Huber-Gries, Carina
A1  - Teuschl, Andreas
T1  - Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures
JF  - Scientific Reports
KW  - Bioreactor
KW  - Osteoarthritis
KW  - Cartilage
KW  - Reactive oxygen species
Y1  - 
ER  - 
TY  - JOUR
A1  - Johannes, Hackethal
A1  - Weihs, Anna
A1  - Karner, Lisa
A1  - Metzger, Magdalena
A1  - Dungel, Peter
A1  - Hennerbichler, Simone
A1  - Redl, Heinz
A1  - Teuschl-Woller, Andreas Herbert
T1  - Novel Human Placenta-Based Extract for Vascularization Strategies in Tissue Engineering
JF  - Tissue Eng Part C Methods
N2  - There is critical unmet need for new vascularized tissues to support or replace injured tissues and organs. Various synthetic and natural materials were already established for use of two-dimensional (2D) and three-dimensional (3D) in vitro neovascularization assays, however, they still cannot mimic the complex functions of the sum of the extracellular matrix (ECM) in native intact tissue. Currently, this issue is only addressed by artificial products such as Matrigel™, which comprises a complex mixture of ECM proteins, extracted from animal tumor tissue. Despite its outstanding bioactivity, the isolation from tumor tissue hinders its translation into clinical applications. Since nonhuman ECM proteins may cause immune reactions, as are frequently observed in clinical trials, human ECM proteins represent the best option when aiming for clinical applications. Here, we describe an effective method of isolating a human placenta substrate (hpS) that induces the spontaneous formation of an interconnected network of green fluorescence-labeled human umbilical vein endothelial cells (gfpHUVECs) in vitro. The substrate was biochemically characterized by using a combination of bicinchoninic acid (BCA) assay, DNA, and glycosaminoglycan (GAG) content assays, sodium dodecyl sulfate/polyacrylamide gel electrophoresis (SDS-PAGE) analysis and Western blot, angiogenesis arrays, chromatographic thrombin detection, high performance liquid chromatography (HPLC)-based amino acid quantification analysis, and assessment of antimicrobial properties. 2D in vitro cell culture experiments have been performed to determine the vasculogenic potential of hpS, which demonstrated that cell networks developed on hpS show a significantly higher degree of complexity (number of tubules/junctions; total/mean tube length) when compared with Matrigel. As 3D cell culture techniques represent a more accurate representation of the in vivo condition, the substrate was 3D solidified using various natural polymers. 3D in vitro vasculogenesis assays have been performed by seeding gfpHUVECs in an hpS-fibrinogen clot. In conclusion, hpS provides a potent human/material-based alternative to xenogenic-material-based biomaterials for vascularization strategies in tissue engineering.
KW  - Tissue Engineering
KW  - Biomaterials
KW  - HUVEC
KW  - Acellular biological matrices
KW  - Angiogenesis and vasculogenesis
Y1  - 
VL  - 27
IS  - 11
SP  - 616
EP  - 632
ER  - 
TY  - JOUR
A1  - Rohringer, Sabrina
A1  - Holnthoner, Wolfgang
A1  - Hackl, Matthias
A1  - Weihs, Anna
A1  - Rünzler, Dominik
A1  - Skalicky, Susanna
A1  - Karbiener, Michael
A1  - Scheideler, Marcel
A1  - Pröll, Johannes
A1  - Gabriel, Christian
A1  - Schweighofer, Bernhard
A1  - Gröger, Marion
A1  - Spittler, Andreas
A1  - Grillari, Johannes
A1  - Redl, Heinz
T1  - Molecular and cellular effects of in vitro shockwave treatment on lymphatic endothelial cells.
JF  - PLoS one
KW  - Shockwave
Y1  - 
ER  - 
TY  - JOUR
A1  - Gollmann-Tepeköylü, Can
A1  - Graber, Michael
A1  - Hirsch, Jakob
A1  - Mair, Sophia
A1  - Naschberger, Andreas
A1  - Pölzl, Leo
A1  - Nägele, Felix
A1  - Kirchmair, Elke
A1  - Degenhart, Gerald
A1  - Demetz, Egon
A1  - Hilbe, Richard
A1  - Chen, Hao-Yu
A1  - Engert, James C
A1  - Böhm, Anna
A1  - Franz, Nadja
A1  - Lobenwein, Daniela
A1  - Lener, Daniela
A1  - Fuchs, Christiane
A1  - Weihs, Anna
A1  - Töchterle, Sonja
A1  - Vogel, Georg F
A1  - Schweiger, Victor
A1  - Eder, Jonas
A1  - Pietschmann, Peter
A1  - Seifert, Markus
A1  - Kronenberg, Florian
A1  - Coassin, Stefan
A1  - Blumer, Michael
A1  - Hackl, Hubert
A1  - Meyer, Dirk
A1  - Feuchtner, Gudrun
A1  - Kirchmair, Rudolf
A1  - Troppmair, Jakob
A1  - Krane, Markus
A1  - Weiss, Günther
A1  - Tsimikas, Sotirios
A1  - Thanassoulis, George
A1  - Grimm, Michael
A1  - Rupp, Bernhard
A1  - Huber, Lukas A
A1  - Zhang, Shen-Ying
A1  - Casanova, Jean-Laurent
A1  - Tancevski, Ivan
A1  - Holfeld, Johannes
T1  - Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification
JF  - Circulation
KW  - Toll-like receptor 3
KW  - aortic valve disease
KW  - biglycan
KW  - extracellular matrix
KW  - osteogenesis
Y1  - 
U6  - http://dx.doi.org/10.1161/CIRCULATIONAHA.122.063481
VL  - 147
IS  - 20
SP  - 1518
EP  - 1533
ER  -