TY  - JOUR
A1  - Jesenberger, Veronika
A1  - Zmajkovicova, Katarina
A1  - Catalanotti, Federica
A1  - Baumgartner, Christian
A1  - Reyes, Gloria Ximena
A1  - Baccarini, Manuela
T1  - MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance
JF  - Mol. Cell
N2  - The Raf/MEK/ERK and PI3K/Akt pathways are prominent effectors of oncogenic Ras. These pathways negatively regulate each other, but the mechanism involved is incompletely understood. We now identify MEK1 as an essential regulator of lipid/protein phosphatase PTEN, through which it controls phosphatidylinositol-3-phosphate accumulation and AKT signaling. MEK1 ablation stabilizes AKT activation and, in vivo, causes a lupus-like autoimmune disease and myeloproliferation. Mechanistically, MEK1 is necessary for PTEN membrane recruitment as part of a ternary complex containing the multidomain adaptor MAGI1. Complex formation is independent of MEK1 kinase activity but requires phosphorylation of T292 on MEK1 by activated ERK. Thus, inhibiting the ERK pathway reduces PTEN membrane recruitment, increasing phosphatidylinositol-3-phosphate accumulation and AKT activation. Our data offer a conceptual framework for the observation that activation of the PI3K pathway frequently mediate resistance to MEK inhibitors and for the promising results obtained by combined MEK/PI3K inhibition in preclinical cancer models.
KW  - MEK1 pathway
KW  - membrane recruitment
KW  - preclinical cancer models
Y1  - 2020
VL  - 2013
IS  - 50
SP  - 43
EP  - 55
ER  - 
TY  - JOUR
A1  - Buta, Christiane
A1  - David, Robert
A1  - Dressel, Ralf
A1  - Emgard, Mia
A1  - Fuchs, Christiane
A1  - Gross, Ulrike
A1  - Healy, Lyn
A1  - Hescheler, Jürgen
A1  - Kolar, Roman
A1  - Martin, Ulrich
A1  - Mikkers, Harald
A1  - Müller, Franz-Josef
A1  - Schneider, Rebekka
A1  - Seiler, Andrea
A1  - Spielmann, Horst
A1  - Weitzer, Georg
T1  - REconsidering pluripotency tests: do we still need teratoma assays?
JF  - Stem Cell Research
KW  - Assay
KW  - Stem Cells
Y1  - 2018
VL  - 11
IS  - 1
SP  - 552
EP  - 562
ER  - 
TY  - JOUR
A1  - Dungel, Peter
A1  - Teuschl, Andreas
A1  - Banerjee, Asmita
A1  - Paier-Pourani, Jamile
A1  - Redl, Heinz
A1  - Kozlov, Andrey
T1  - Impact of mitochondria on nitrite metabolism in HL-1 cardiomyocytes
JF  - Frontiers in Physiology
KW  - Nitrite
KW  - Metabolism
Y1  - 2018
IS  - 4
ER  - 
TY  - JOUR
A1  - Teuschl, Andreas
A1  - van Griensven, Martijn
A1  - Redl, Heinz
T1  - Sericin removal from raw Bombys mori silk scaffolds of high hierarchical order
JF  - Tissue Eng Part C Methods
KW  - Scaffold
KW  - Sericin
Y1  - 2018
ER  - 
TY  - CHAP
A1  - Ghaemi, Sara
A1  - Schneider, Simon
T1  - Potential analysis of residential Demand Response using GridLAB-D
T2  - IECON 2013 - 39th Annual Conference of the IEEE Industrial Electronics Society
KW  - Potential Analysis
Y1  - 
SP  - 8039
EP  - 8045
ER  - 
TY  - GEN
A1  - Pucher, Robert
T1  - Computer Science
KW  - Project Based Learning
KW  - Computer Science
Y1  - 2019
ER  - 
TY  - CHAP
A1  - Horauer, Martin
A1  - Schuster, Harald
A1  - Balog, Peter
T1  - Experimental Assessment of the Clique Problem in FlexRay
T2  - Proceedings of the 8th ASME/IEEE International Conference on Mechatronic and Embedded Systems and Applications, Portland OR, USA, Aug. 04-07, 2013
KW  - Embedded Systems
KW  - FlexRay
Y1  - 2019
ER  - 
TY  - CHAP
A1  - Wagner, Richard
A1  - Wolff, Peter
A1  - Schaeffer, Klaus
A1  - Praus, Friedrich
T1  - Ambient Assitive Technologies: The mobile robot P3AAT
T2  - Proceedings of the Austrian Robotics Workshop (ARW-13), May 2013, Vienna
KW  - Assistive Technologies
Y1  - 2019
ER  - 
TY  - CHAP
A1  - Isaacs, Richard
A1  - Praus, Friedrich
T1  - Design & development of a prototype android app for a KNX home
T2  - KNX Scientific Conference
KW  - Embedded Systems
KW  - KNX
Y1  - 2019
ER  - 
TY  - CHAP
A1  - Samardzija, Luka
A1  - Praus, Friedrich
T1  - ANT goes KNX - an open platform gateway for ANT and KNX
T2  - KNX Scientific Conference
KW  - Embedded Systems
KW  - KNX
KW  - ANT
Y1  - 2019
ER  -