TY  - JOUR
A1  - Jesenberger, Veronika
A1  - Zmajkovicova, Katarina
A1  - Catalanotti, Federica
A1  - Baumgartner, Christian
A1  - Reyes, Gloria Ximena
A1  - Baccarini, Manuela
T1  - MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance
JF  - Mol. Cell
N2  - The Raf/MEK/ERK and PI3K/Akt pathways are prominent effectors of oncogenic Ras. These pathways negatively regulate each other, but the mechanism involved is incompletely understood. We now identify MEK1 as an essential regulator of lipid/protein phosphatase PTEN, through which it controls phosphatidylinositol-3-phosphate accumulation and AKT signaling. MEK1 ablation stabilizes AKT activation and, in vivo, causes a lupus-like autoimmune disease and myeloproliferation. Mechanistically, MEK1 is necessary for PTEN membrane recruitment as part of a ternary complex containing the multidomain adaptor MAGI1. Complex formation is independent of MEK1 kinase activity but requires phosphorylation of T292 on MEK1 by activated ERK. Thus, inhibiting the ERK pathway reduces PTEN membrane recruitment, increasing phosphatidylinositol-3-phosphate accumulation and AKT activation. Our data offer a conceptual framework for the observation that activation of the PI3K pathway frequently mediate resistance to MEK inhibitors and for the promising results obtained by combined MEK/PI3K inhibition in preclinical cancer models.
KW  - MEK1 pathway
KW  - membrane recruitment
KW  - preclinical cancer models
Y1  - 2020
VL  - 2013
IS  - 50
SP  - 43
EP  - 55
ER  - 
TY  - JOUR
A1  - Buta, Christiane
A1  - David, Robert
A1  - Dressel, Ralf
A1  - Emgard, Mia
A1  - Fuchs, Christiane
A1  - Gross, Ulrike
A1  - Healy, Lyn
A1  - Hescheler, Jürgen
A1  - Kolar, Roman
A1  - Martin, Ulrich
A1  - Mikkers, Harald
A1  - Müller, Franz-Josef
A1  - Schneider, Rebekka
A1  - Seiler, Andrea
A1  - Spielmann, Horst
A1  - Weitzer, Georg
T1  - REconsidering pluripotency tests: do we still need teratoma assays?
JF  - Stem Cell Research
KW  - Assay
KW  - Stem Cells
Y1  - 2018
VL  - 11
IS  - 1
SP  - 552
EP  - 562
ER  - 
TY  - JOUR
A1  - Dungel, Peter
A1  - Teuschl, Andreas
A1  - Banerjee, Asmita
A1  - Paier-Pourani, Jamile
A1  - Redl, Heinz
A1  - Kozlov, Andrey
T1  - Impact of mitochondria on nitrite metabolism in HL-1 cardiomyocytes
JF  - Frontiers in Physiology
KW  - Nitrite
KW  - Metabolism
Y1  - 2018
IS  - 4
ER  - 
TY  - JOUR
A1  - Teuschl, Andreas
A1  - van Griensven, Martijn
A1  - Redl, Heinz
T1  - Sericin removal from raw Bombys mori silk scaffolds of high hierarchical order
JF  - Tissue Eng Part C Methods
KW  - Scaffold
KW  - Sericin
Y1  - 2018
ER  - 
TY  - JOUR
A1  - King, J.
A1  - Unterkofler, K.
A1  - Teschl, G.
A1  - Teschl, S.
A1  - Mochalski, P.
A1  - Hinterhuber, H.
A1  - Koc, H.
A1  - Amann, Anton
T1  - A modeling-based evaluation of isothermal rebreathing for breath gas analyses of highly soluble volatile organic compounds
JF  - Journal of Breath Research
KW  - Breath
Y1  - 
ER  - 
TY  - JOUR
A1  - Ruess, Christian
A1  - Kristen, Karl-Heinz
A1  - Eckelt, Markus
A1  - Mally, Franziska
A1  - Litzenberger, Stefan
A1  - Sabo, Anton
T1  - Stand up Paddle Surfing - An Aerobic Workout and Balance Training
JF  - Procedia Engineering
KW  - Stand-Up Paddling
Y1  - 2018
VL  - 60
IS  - 0
SP  - 62
EP  - 66
ER  - 
TY  - JOUR
A1  - Mally, Franziska
A1  - Litzenberger, Stefan
A1  - Sabo, Anton
T1  - Surface Electromyography Measurements of Dorsal Muscle Cross-Activation in Therapeutic Climbing
JF  - Procedia Engineering
KW  - Muscle Activity
KW  - Climbing
Y1  - 2018
VL  - 60
IS  - 0
SP  - 22
EP  - 27
ER  - 
TY  - JOUR
A1  - Urbauer, Philipp
A1  - Frohner, Matthias
A1  - Forjan, Mathias
A1  - Pohn, Birgit
A1  - Sauermann, Stefan
A1  - Mense, Alexander
T1  - A Closer Look on Standards Based Personal Health Device Communication: A Résumé over Four Years Implementing Telemonitoring Solutions
JF  - European Journal for Biomedical Informatics
KW  - eHealth
KW  - Telemonitoring
Y1  - 2019
VL  - 2012
IS  - Vol 8, Issue 3
SP  - 65
EP  - 70
ER  - 
TY  - JOUR
A1  - Snizek, S.
A1  - Risser, Ralf
A1  - Bell, Daniel
A1  - Füssl, E.
A1  - Hulmak, M.
A1  - Kaufmann, C.
T1  - Effiziente Verkehrsabwicklung durch Alternativerouten – EVA
JF  - Bundesministerium für Verkehr, Innovation und Technologie. Straßenforschung
KW  - Mobility
KW  - Transport
Y1  - 
IS  - Heft 593
ER  - 
TY  - JOUR
A1  - Risser, Ralf
A1  - Bell, Daniel
T1  - TECHNOLOGICAL SUPPORT TO PROVISION OF INCLUSIVENESS OF TRANSPORT SYSTEMS
JF  - JNHA, Journal of Nutrition, Health & Ageing
KW  - Mobility
KW  - Transport
Y1  - 
VL  - 2013
IS  - Volume 17
SP  - 126
EP  - 127
ER  - 
TY  - JOUR
A1  - Risser, Ralf
A1  - Bell, Daniel
T1  - Junge Autofahrer in ArRiyadh
JF  - Zeitschrift für Verkehrssicherheit
KW  - Mobility
Y1  - 
IS  - 59
SP  - 107
ER  - 
TY  - JOUR
A1  - Kriebernegg, G.
A1  - Bell, Daniel
T1  - TrafficCheck.at. Planen Sie Ihre Ampel!
JF  - Zoll+ - Österreichische Schriftenreihe für Landschaft und Freiraum
KW  - Mobility
Y1  - 
VL  - 23
IS  - 22
ER  -