TY - JOUR A1 - Maleiner, Babette A1 - Tomasch, Janine A1 - Heher, Philipp A1 - Spadiut, Oliver A1 - Rünzler, Dominik A1 - Fuchs, Christiane T1 - The Importance of Biophysical and Biochemical Stimuli in Dynamic Skeletal Muscle Models. JF - Frontiers in Physiology N2 - Classical approaches to engineer skeletal muscle tissue based on current regenerative and surgical procedures still do not meet the desired outcome for patient applications. Besides the evident need to create functional skeletal muscle tissue for the repair of volumetric muscle defects, there is also growing demand for platforms to study muscle-related diseases, such as muscular dystrophies or sarcopenia. Currently, numerous studies exist that have employed a variety of biomaterials, cell types and strategies for maturation of skeletal muscle tissue in 2D and 3D environments. However, researchers are just at the beginning of understanding the impact of different culture settings and their biochemical (growth factors and chemical changes) and biophysical cues (mechanical properties) on myogenesis. With this review we intend to emphasize the need for new in vitro skeletal muscle (disease) models to better recapitulate important structural and functional aspects of muscle development. We highlight the importance of choosing appropriate system components, e.g., cell and biomaterial type, structural and mechanical matrix properties or culture format, and how understanding their interplay will enable researchers to create optimized platforms to investigate myogenesis in healthy and diseased tissue. Thus, we aim to deliver guidelines for experimental designs to allow estimation of the potential influence of the selected skeletal muscle tissue engineering setup on the myogenic outcome prior to their implementation. Moreover, we offer a workflow to facilitate identifying and selecting different analytical tools to demonstrate the successful creation of functional skeletal muscle tissue. Ultimately, a refinement of existing strategies will lead to further progression in understanding important aspects of muscle diseases, muscle aging and muscle regeneration to improve quality of life of patients and enable the establishment of new treatment options. KW - Bioreactor KW - Muscle KW - Biomaterial Y1 - ER - TY - JOUR A1 - Kuba, Markus T1 - A Note on the generating function of p-Bernoulli numbers JF - Quaestiones Mathematicae KW - Mathematics Y1 - ER - TY - JOUR A1 - Teschl, Susanne A1 - Unterkofler, Karl A1 - Mochalski, Pawel A1 - Teschl, Gerald A1 - Ager, C. A1 - Mayhew, C.A. A1 - King, Julian T1 - Modeling-based determination of physiological parameters of systemic VOCs by breath gas analysis, part 2. JF - Journal of Breath Research KW - Breath KW - Gas KW - Analysis Y1 - VL - 12 ER - TY - JOUR A1 - Schanda, Jakob A1 - Keibl, Claudia A1 - Heimel, Patrick A1 - Monforte, Xavier A1 - Feichtinger, Xaver A1 - Teuschl, Andreas A1 - Baierl, Andreas A1 - Muschitz, Christian A1 - Redl, Heinz A1 - Fialka, Christian A1 - Mittermayr, Rainer T1 - Zoledronic Acid Substantially Improves Bone Microarchitecture and Biomechanical Properties After Rotator Cuff Repair in a Rodent Chronic Defect Model JF - Am J Sports Med N2 - Background: Bone mineral density at the humeral head is reduced in patients with chronic rotator cuff tears. Bone loss in the humeral head is associated with repair failure after rotator cuff reconstruction. Bisphosphonates (eg, zoledronic acid) increase bone mineral density. Hypothesis: Zoledronic acid improves bone mineral density of the humeral head and biomechanical properties of the enthesis after reconstruction of chronic rotator cuff tears in rats. Study design: Controlled laboratory study. Methods: A total of 32 male Sprague-Dawley rats underwent unilateral (left) supraspinatus tenotomy with delayed transosseous rotator cuff reconstruction after 3 weeks. All rats were sacrificed 8 weeks after rotator cuff repair. Animals were randomly assigned to 1 of 2 groups. At 1 day after rotator cuff reconstruction, the intervention group was treated with a single subcutaneous dose of zoledronic acid at 100 µg/kg bodyweight, and the control group received 1 mL of subcutaneous saline solution. In 12 animals of each group, micro-computed tomography scans of both shoulders were performed as well as biomechanical testing of the supraspinatus enthesis of both sides. In 4 animals of each group, histological analyses were conducted. Results: In the intervention group, bone volume fraction (bone volume/total volume [BV/TV]) of the operated side was higher at the lateral humeral head (P = .005) and the medial humeral head (P = .010) compared with the control group. Trabecular number on the operated side was higher at the lateral humeral head (P = .004) and the medial humeral head (P = .001) in the intervention group. Maximum load to failure rates on the operated side were higher in the intervention group (P < .001). Cortical thickness positively correlated with higher maximum load to failure rates in the intervention group (r = 0.69; P = .026). Histological assessment revealed increased bone formation in the intervention group. Conclusion: Single-dose therapy of zoledronic acid provided an improvement of bone microarchitecture at the humeral head as well as an increase of maximum load to failure rates after transosseous reconstruction of chronic rotator cuff lesions in rats. Clinical relevance: Zoledronic acid improves bone microarchitecture as well as biomechanical properties after reconstruction of chronic rotator cuff tears in rodents. These results need to be verified in clinical investigations. KW - Tissue Engineering KW - Rotator Cuff Tears Y1 - VL - 2020 Jul IS - 48 (9) SP - 2151 EP - 2160 ER - TY - JOUR A1 - Slezak, Paul A1 - Slezak, Cyrill A1 - Hartinger, Joachim A1 - Teuschl, Andreas A1 - Nürnberger, Sylvia A1 - Redl, Heinz A1 - Mittermayr, Rainer T1 - A Low Cost Implantation Model in the Rat That Allows a Spatial Assessment of Angiogenesis. JF - Frontiers in Bioengineering and Biotechnology N2 - There is continual demand for animal models that allow a quantitative assessment of angiogenic properties of biomaterials, therapies, and pharmaceuticals. In its simplest form, this is done by subcutaneous material implantation and subsequent vessel counting which usually omits spatial data. We have refined an implantation model and paired it with a computational analytic routine which outputs not only vessel count but also vessel density, distribution, and vessel penetration depth, that relies on a centric vessel as a reference point. We have successfully validated our model by characterizing the angiogenic potential of a fibrin matrix in conjunction with recombinant human vascular endothelial growth factor (rhVEGF165). The inferior epigastric vascular pedicles of rats were sheathed with silicone tubes, which were subsequently filled with 0.2 ml of fibrin and different doses of rhVEGF165, centrically embedding the vessels. Over 4 weeks, tissue samples were harvested and subsequently immunohistologically stained and computationally analyzed. The model was able to detect variations over the angiogenic potentials of growth factor spiked fibrin matrices. Adding 20 ng of rhVEGF165 resulted in a significant increase in vasculature while 200 ng of rhVEGF165 did not improve vascular growth. Vascularized tissue volume increased during the first week and vascular density increased during the second week. Total vessel count increased significantly and exhibited a peak after 2 weeks which was followed by a resorption of vasculature by week 4. In summary, a simple implantation model to study in vivo vascularization with only a minimal workload attached was enhanced to include morphologic data of the emerging vascular tree. KW - Tissue Engineering KW - Bioreactor KW - Biomaterial Y1 - ER - TY - JOUR A1 - Berkovitch, Yulia A1 - Cohen, Talia A1 - Peled, Eli A1 - Schmidhammer, Robert A1 - Hildner, Florian A1 - Teuschl, Andreas A1 - Wolbank, Susanne A1 - Yelin, Dvir A1 - Redl, Heinz A1 - Seliktar, Dror T1 - Hydrogel composition and laser micropatterning to regulate sciatic nerve regeneration. JF - Journal of Tissue Engineering and Regenerative Medicine N2 - Treatment of peripheral nerve injuries has evolved over the past several decades to include the use of sophisticated new materials endowed with trophic and topographical cues that are essential for in vivo nerve fibre regeneration. In this research, we explored the use of an advanced design strategy for peripheral nerve repair, using biological and semi-synthetic hydrogels that enable controlled environmental stimuli to regenerate neurons and glial cells in a rat sciatic nerve resection model. The provisional nerve growth conduits were composed of either natural fibrin or adducts of synthetic polyethylene glycol and fibrinogen or gelatin. A photo-patterning technique was further applied to these 3D hydrogel biomaterials, in the form of laser-ablated microchannels, to provide contact guidance for unidirectional growth following sciatic nerve injury. We tested the regeneration capacity of subcritical nerve gap injuries in rats treated with photo-patterned materials and compared these with injuries treated with unpatterned hydrogels, either stiff or compliant. Among the factors tested were shear modulus, biological composition, and micropatterning of the materials. The microchannel guidance patterns, combined with appropriately matched degradation and stiffness properties of the material, proved most essential for the uniform tissue propagation during the nerve regeneration process. KW - Tissue Engineering KW - Biomaterials KW - Nerve Regeneration Y1 - SP - 1049 EP - 1061 ER - TY - JOUR A1 - Nau, Thomas A1 - Teuschl, Andreas A1 - Ebner, Anna A1 - Jung, Ilse A1 - Schenk, Christian T1 - Low revision rate and excellent outcome of primary ACL repair with a minimum follow-up of 5 years. JF - Muscle, ligaments and tendons Journal N2 - Introduction: Due to limitations of ACL reconstruction, primary ACL repair has recently regained research interest. Although abandoned in the past, primary repair with conservation of the original ligament demonstrates considerable advantages compared to reconstruction. We hypothesized that early repair, strictly limited to patients with a proximal ACL rupture and excellent tissue quality of the remaining ACL stump, would lead to equal revision rates and subjective outcomes as reported for ACL reconstruction after a minimum of 5 years. Methods: In this questionnaire study, patients who had a primary ACL repair between 2002 and 2009 were invited to participate. Besides any potential revision surgery, the Tegner activity scale and the Knee Injury and Osteoarthritis Outcome Score were included in the evaluation. Results: Out of 1912 patients who had ACL related surgery during the observation period, 221 (11.4%) had a primary ACL repair. 60 patients (61 knees) were available for follow-up. In 2/61 (3.3%) cases ACL revision surgery was performed and one patient had meniscus surgery of the affected side. The median Tegner activity scale was 6 (range, 3 to 10). The mean KOOS subscores were 88.8% (Function/Sports), 86.6% (Quality of life), 94.6 (Symptoms), 94.0 (Pain) and 97.0 (Activities of Daily Living). Conclusion: Primary ACL repair, strictly limited to proximal ruptures with good tissue quality leads to revision rates and subjective outcome comparable to ACL reconstruction. Level of evidence: IV. KW - Regeneration Y1 - SP - 185 EP - 190 ER - TY - JOUR A1 - Berkovitch, Yulia A1 - Cohen, Talia A1 - Peled, Eli A1 - Schmidhammer, Robert A1 - Hildner, Florian A1 - Teuschl, Andreas A1 - Wolbank, Susanne A1 - Yelin, Dvir A1 - Redl, Heinz A1 - Seliktar, Dror T1 - Hydrogel Composition and Laser Micro-Patterning to Regulate Sciatic Nerve Regeneration JF - Journal of Tissue Engineering and Regenerative Medicine KW - Micro-Patterning KW - Laser KW - Nerve Regeneration Y1 - 2018 VL - 12 IS - 4 ER - TY - JOUR A1 - Bernhard, Jonathan A1 - Ferguson, James A1 - Rieder, Bernhard A1 - Heimel, Patrick A1 - Nau, Thomas A1 - Tangl, Stefan A1 - Redl, Heinz A1 - Vunjak-Novakovic, Gordana T1 - Tissue-engineered hypertrophic chondrocyte grafts enhanced long bone repair biomaterials JF - Biomaterials KW - Grafting KW - Biomaterials Y1 - 2018 IS - 139 SP - 202 EP - 212 ER - TY - JOUR A1 - Heher, Philipp A1 - Maleiner, Babette A1 - Prüller, Johanna A1 - Teuschl, Andreas A1 - Kollmitzer, Josef A1 - Monforte Vila, Xavier A1 - Wolbank, Susanne A1 - Redl, Heinz A1 - Rünzler, Dominik A1 - Fuchs, Christiane T1 - A novel bioreactor for the generation of highly aligned 3D skeletal muscle-like constructs through orientation of fibrin via application of static strain JF - Acta Biomaterialia KW - Bioreactor Y1 - ER - TY - JOUR A1 - Jagos, Harald A1 - David, Veronika A1 - Reichel, Martin A1 - Kotzian, Stefan A1 - Schlossarek, Stefan A1 - Haller, Michael A1 - Rafolt, Dietmar T1 - Tele-monitoring of the rehabilitation progress in stroke patients JF - Studies in Health Technology and Informatics KW - Rehabilitation KW - Stroke Patients Y1 - 2018 ER - TY - JOUR A1 - Ettwein, Frederike A1 - Rohrer-Vanzo, Valentina A1 - Langthaler, Georg A1 - Werner, Andrea A1 - Stern, Tobias A1 - Moser, Olivia A1 - Leitner, Raimund A1 - Regenfelder, Katja T1 - Consumer’s perception of high gloss furniture: instrumental gloss measurement versus visual gloss evaluation JF - European Journal of Wood and Wood Products N2 - The overall impression of a glossy surface is an important parameter for consumer’s choice of wooden products. A new gloss parameter, called gloss impression, which calculates a reflexion structure image, was developed in order to complement the measurements made by industrial glossmeters, which are highly limited in describing the visual human perception, for example the commonly used gloss value. The objective of this study is to investigate to what extent the new measurement method of surface gloss is applicable to describe human gloss perception, in other words, to validate the new method. In order to analyse the concordance of the new methodology with human perception, 113 naïve observers had to rank the glossiness of eight series of black and white samples. The results were compared to both gloss impression and gloss value. The statistical evaluation by means of Pearson’s chi-squared tests revealed that the new method has an overall better correspondence to human perception than the gloss value. For black samples, it describes human perception significantly better than the gloss value and gives better results than those which would be achieved by guessing. KW - Perception KW - Wood Products Y1 - IS - 75 SP - 1009 EP - 1016 ER - TY - JOUR A1 - Fairbrother, Andrew A1 - Boyd, Matthew A1 - Lyu, Yadong A1 - Avenet, Julien A1 - Illich, Peter A1 - Wang, Yu A1 - Kempe, Michael A1 - Dougherty, Brian A1 - Bruckman, Laura A1 - Gu, Xiaohong T1 - Differential degradation patterns of photovoltaic backsheets at the array level JF - Solar Energy KW - Photovoltaics KW - Degradation KW - Field Survey KW - Solar Power Y1 - VL - 2018 IS - 163 ER - TY - JOUR A1 - Himmelstoß, Felix A1 - Edelmoser, Karl T1 - Equipment for Rotating Light Radiation JF - Proceedings of the International Conference on Electrical Drives and Power Electronics (EDPE) 2015 KW - Rotating Light KW - Light Radiation Y1 - 2018 ER - TY - JOUR A1 - Mense, Alexander A1 - Athanasiadis, Leandros T1 - Concept for Sharing Distributed Personal Health Records with Blockchains JF - DATA, INFORMATICS AND TECHNOLOGY: AN INSPIRATION FOR IMPROVED HEALTHCARE, Studies in Health Technology and Informatics, vol 251 KW - Personal Health KW - Blockchain Y1 - SN - 0926-9630 (print) SN - 1879-8365 (online) PB - IOS Press ER - TY - JOUR A1 - Mense, Alexander A1 - Blobel, Bernd T1 - HL7 Standards and Components to Support Implementation of the European General Data Protection Regulation (GDPR) JF - Re-Shaping Healthcare System, European Journal of Biomedical Informatics. KW - Privacy KW - Security KW - HL7 KW - CDA KW - FHIR Y1 - VL - Special Issue 2017 IS - ISSN: 1801-5603 SP - 27 EP - 33 ER - TY - JOUR A1 - Veigl, Christoph A1 - Miesenberger, Klaus T1 - A toolkit for user-centered design of assistive technology solutions JF - Journal on Technology & Persons with Disabilities KW - Assistive Technology KW - User Centered Design KW - Personalization KW - Motor Disabilities KW - Human Computer Interface Y1 - VL - 6 SP - 43 EP - 61 ER - TY - JOUR A1 - Veigl, Christoph A1 - Miesenberger, Klaus T1 - A toolkit for user-centered design of assistive technology solutions JF - Journal on Technology & Persons with Disabilities, Volume 6 (2018) KW - Toolkit KW - Assistive Technology KW - Embedded Systems Y1 - 2019 ER - TY - JOUR A1 - Polzer, Thomas A1 - Huerner, Florian T1 - Refined metastability characterization using a time-to-digital converter JF - Microelectronics Reliability, January 2018 KW - Microelectronic KW - Embedded Systems Y1 - 2019 IS - Microelectronics Reliability, January 2018, Volume 80 ER - TY - JOUR A1 - Hauser, H. A1 - Himmelstoß, Felix A1 - Wurm, P. T1 - Application of the Energetic Model of Ferromagnetic Loss Calculation During Start-Up of a DC/DC Converter JF - JSAEM Studies in Applied Electromagnetics and Mechanics KW - Power Conversion Y1 - IS - 9 SP - 207 EP - 208 ER - TY - JOUR A1 - Dolezal, Dominik A1 - Posekany, Alexandra A1 - Roschger, Christoph A1 - Koppensteiner, Gottfried A1 - Pucher, Robert T1 - Person-Centered Learning using Peer Review Method – An Evaluation and a Concept for Student-Centered Classrooms JF - International Journal of Engineering Pedagogy 8 (1) KW - Computer Science Education KW - Person-Centered Learning KW - Peer Review Y1 - VL - 2018 IS - 1 SP - 127 EP - 147 ER - TY - JOUR A1 - Reinhard, Oeser A1 - Klein, Matthias A1 - Prömer, M A1 - Kaiser, B A1 - Seitinger, F A1 - Grabenberger, K T1 - Epidemiologische Analyse bei allen Versicherten der Oberösterreichischen Gebietskrankenkasse mit Schädel-Hirn-Trauma (SHT) und Vergleichsgruppe (Zeitraum 2005–2011) JF - Neurologie & Rehabilitation N2 - Die vorliegende epidemiologische Analyse schließt über 1,6 Millionen Versicherte der Oberösterreichischen Gebietskrankenkasse im Zeitraum 2005–2011 ein. Personen, die im Beobachtungszeitraum wegen eines Ereignisses aus der ICD-10-Diagnosegruppe »Verletzungen des Kopfes« (S00–S09) im Krankenhaus waren, wiesen eine Inzidenz von 579/100.000 pro Jahr auf. Anhand der Aufenthaltszeiten im Krankenhaus oder der stationären Rehabilitation (> 42, 8–42, und < 8 Tage) wurden drei Schweregrade definiert. Von der schweren über die mittelschwere bis zur leichten Gruppe (G1, G2, G3) war die prozentuelle Aufteilung 2 %, 11 % und 87 %. Zusammen mit einer Gruppe (G4), bei der der Aufnahmegrund im Krankenhaus in einer Operation am Bewegungsapparat bestand, wurden die vier Gruppen untereinander anhand der Variablen Alter, Geschlecht, Arbeitslosigkeit, Pensionierung, Krankenhausaufenthalte, Arbeitsunfähigkeit und Sterberisiko verglichen. Es konnte bestätigt werden, dass ein Schädel-Hirn-Trauma häufiger bei Männern auftritt, je schwerer es ist (bis zu 2/3), und dass es zwei Altersgipfel gibt, bei den Jüngeren eher mit einer leichteren, bei den Älteren eher mit einer schwereren Betroffenheit. Unerwartet war, dass in Gruppe 1 (G1) schon vor dem Ereignis häufigere Krankenhaus- oder Rehabilitationsaufenthalte vorlagen, also eine Prädisposition bei schwerem Schädel-Hirn-Trauma vorzuliegen scheint. Da die Betroffenen mit großem Leid konfrontiert sind und die Behandlung dieser Patienten sehr viele Ressourcen benötigt, wird dieser Frage im Rahmen einer Masterarbeit nachgegangen. Bei Gruppe 3 (G3) , die jüngere Patienten beinhaltete und den Großteil der Schädel- Hirn-Trauma-Patienten ausmachte, fiel auf, dass doppelt so viele Versicherungsunterbrechungen und gleich hohe Arbeitslosigkeitsereignisse wie in der schwerer betrofferen Gruppe 2 (G2) auftraten. Auch hier wären weitere Studien angebracht, weil die absolute Zahl der Betroffenen in Gruppe 3 (G3) sehr hoch ist. KW - Craniocerebral trauma KW - Incidence KW - Mortality KW - Severities Y1 - VL - 2017 IS - 2017 ; 23(4) SP - 315 EP - 324 ER - TY - JOUR A1 - Paminger, Christian T1 - OpenSource GIS-Lösungen mit topologischen Datenstrukturen JF - GeoNews KW - Open Source Y1 - 2019 IS - 1 ER - TY - JOUR A1 - Klementschitz, Roman A1 - Dietrich, Tobias T1 - Process evaluation of CIVITAS II measures. Results of the first wave of data collection JF - Suvremeni promet KW - Data Collection Y1 - 2019 VL - Vol. 1/2 SP - 32 EP - 40 ER - TY - JOUR A1 - Bernsteiner, Clemens A1 - Miernicki, Martin ED - und andere, Schweighofer T1 - Überlegung zur Erfüllung von Schuldverhältnissen sowie zum Instrument des "Käuferschutzes" bei PayPal JF - Datenschutz / Legal Tech KW - Buyer protection Y1 - SP - 661 ER - TY - JOUR A1 - Wala, Thomas A1 - Leutgeb, Daniel ED - Eschenbach, Rolf ED - Baumüller, Josef ED - Siller, Helmut T1 - Investitionscontrolling. Systematische Identifikation und Umsetzung von Wertsteigerungspotenzialen JF - Controlling. 21-MalBindestrich-Controlling für die Praxis KW - Investment KW - Controlling Y1 - SP - 247ff ER - TY - JOUR A1 - Lehner, Martin ED - Dittler, Ullrich ED - Kreidl, Michael T1 - Lehren und Lernen an der Hochschule der Zukunft JF - Hochschule der Zukunft – Zukunft der Hochschule KW - Teaching KW - University Y1 - ER - TY - JOUR A1 - Wala, Thomas A1 - Felleitner, Katharina T1 - Digital Leadership. Führung in volatile Zeiten JF - CFO Aktuell KW - Digital Leadership Y1 - IS - 5 SP - 211 ER - TY - JOUR A1 - Wala, Thomas A1 - Baumüller, Josef T1 - Der "Fall Steinhof". Ein spektakulärer Bilanzskandal JF - CFO Aktuell KW - Accounting Y1 - IS - 2 SP - 68ff ER - TY - JOUR A1 - Wala, Thomas T1 - Organisationsmodell Holokratie: So funktioniert Unternehmensführung ohne Hierarchien JF - Cooperativ KW - Management Y1 - IS - 4 SP - 16 ff ER - TY - JOUR A1 - Shooman, Diane T1 - Poets Engineering the Material of Language JF - Conference Proceedings, 9th ESP Conference KW - Language Y1 - ER - TY - JOUR A1 - Wala, Thomas T1 - New Work. Wie wir in Zukunft arbeiten werden JF - ASoK KW - Work KW - Future Y1 - IS - 8 SP - 306ff ER - TY - JOUR A1 - Wala, Thomas T1 - Die betriebswirtschaftliche Klausur: Controlling JF - WISU KW - Controlling Y1 - IS - 5 SP - 588ff ER - TY - JOUR A1 - Gröger, Herbert T1 - Einige Gedanken zu Mutterbildern im übertragenen Sinn: Erwartungen an Mütter, Väter und Kinder JF - Mutterikonen:. Ein Buch über die Bilder von Müttern. KW - Psychology KW - Mothers Y1 - SP - 58 EP - 59 ER - TY - JOUR A1 - Wala, Thomas T1 - Kreative Raumkonzepte fördern die Innovationskraft JF - Wissensmanagement KW - Innovation KW - Raumkonzept Y1 - IS - 2, 2021 SP - 29 ER - TY - JOUR A1 - Kubinger, Wilfried A1 - Peschak, Bernhard A1 - Wöber, Wilfried A1 - Sulz, Clemens T1 - Bildgebende Sensorsystems für robotische Systeme in der Agrar- und Landtechnik JF - e&i Elektrotechnik und Informationstechnik KW - Sensor KW - Robotics KW - Agriculture Y1 - 2018 VL - 134 IS - 6 SP - 316 EP - 322 ER - TY - JOUR A1 - Wahl, Harald A1 - Kaufmann, Christian A1 - Eckkrammer, Florian A1 - Mense, Alexander A1 - Gollner, Helmut A1 - Himmler, Christian A1 - Rogner, Wolfgang A1 - Baierl, Thomas A1 - Slobodian, Roman T1 - Soft Skills In Practice And In Education: An Evaluation JF - American Journal Of Business Education KW - Education KW - Soft Skills Y1 - 2019 VL - 2012 IS - Vol. 5/No. 2 ER - TY - JOUR A1 - Schneider, Karl Heinrich A1 - Enayati, Marjan A1 - Grasl, Christian A1 - Walter, Ingrid A1 - Budinsky, Lubos A1 - Zebic, Gabriel A1 - Kaun, Christoph A1 - Wagner, Anja A1 - Kratochwill, Klaus A1 - Redl, Heinz A1 - Teuschl, Andreas A1 - Podesser, Bruno K. A1 - Bergmeister, Helga T1 - Acellular vascular matrix grafts from human placenta chorion: Impact of ECM preservation on graft characteristics, protein composition and in vivo performance. JF - Biomaterials N2 - Small diameter vascular grafts from human placenta, decellularized with either Triton X-100 (Triton) or SDS and crosslinked with heparin were constructed and characterized. Graft biochemical properties, residual DNA, and protein composition were evaluated to compare the effect of the two detergents on graft matrix composition and structural alterations. Biocompatibility was tested in vitro by culturing the grafts with primary human macrophages and in vivo by subcutaneous implantation of graft conduits (n = 7 per group) into the flanks of nude rats. Subsequently, graft performance was evaluated using an aortic implantation model in Sprague Dawley rats (one month, n = 14). In situ graft imaging was performed using MRI angiography. Retrieved specimens were analyzed by electromyography, scanning electron microscopy, histology and immunohistochemistry to evaluate cell migration and the degree of functional tissue remodeling. Both decellularization methods resulted in grafts of excellent biocompatibility in vitro and in vivo, with low immunogenic potential. Proteomic data revealed removal of cytoplasmic proteins with relative enrichment of ECM proteins in decelluarized specimens of both groups. Noteworthy, LC-Mass Spectrometry analysis revealed that 16 proteins were exclusively preserved in Triton decellularized specimens in comparison to SDS-treated specimens. Aortic grafts showed high patency rates, no signs of thrombus formation, aneurysms or rupture. Conduits of both groups revealed tissue-specific cell migration indicative of functional remodeling. This study strongly suggests that decellularized allogenic grafts from the human placenta have the potential to be used as vascular replacement materials. Both detergents produced grafts with low residual immunogenicity and appropriate mechanical properties. Observed differences in graft characteristics due to preservation method had no impact on successful in vivo performance in the rodent model. KW - Biomaterial KW - Tissue Engineering Y1 - SP - 14 EP - 26 ER - TY - JOUR A1 - Priglinger, Eleni A1 - Schuh, Christina A1 - Steffenhagen, Carolin A1 - Wurzer, Christoph A1 - Maier, Julia A1 - Nürnberger, Sylvia A1 - Holnthoner, Wolfgang A1 - Fuchs, Christiane A1 - Suessner, Susanne A1 - Rünzler, Dominik A1 - Redl, Heinz A1 - Wolbank, Susanne T1 - Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy. JF - Cytotherapy N2 - BACKGROUND: Cell-based therapies with autologous adipose tissue-derived cells have shown great potential in several clinical studies in the last decades. The majority of these studies have been using the stromal vascular fraction (SVF), a heterogeneous mixture of fibroblasts, lymphocytes, monocytes/macrophages, endothelial cells, endothelial progenitor cells, pericytes and adipose-derived stromal/stem cells (ASC) among others. Although possible clinical applications of autologous adipose tissue-derived cells are manifold, they are limited by insufficient uniformity in cell identity and regenerative potency. METHODS: In our experimental set-up, low-energy extracorporeal shock wave therapy (ESWT) was performed on freshly obtained human adipose tissue and isolated adipose tissue SVF cells aiming to equalize and enhance stem cell properties and functionality. RESULTS: After ESWT on adipose tissue we could achieve higher cellular adenosine triphosphate (ATP) levels compared with ESWT on the isolated SVF as well as the control. ESWT on adipose tissue resulted in a significantly higher expression of single mesenchymal and vascular marker compared with untreated control. Analysis of SVF protein secretome revealed a significant enhancement in insulin-like growth factor (IGF)-1 and placental growth factor (PLGF) after ESWT on adipose tissue. DISCUSSION: Summarizing we could show that ESWT on adipose tissue enhanced the cellular ATP content and modified the expression of single mesenchymal and vascular marker, and thus potentially provides a more regenerative cell population. Because the effectiveness of autologous cell therapy is dependent on the therapeutic potency of the patient's cells, this technology might raise the number of patients eligible for autologous cell transplantation. KW - Shockwave Therapy KW - Tissue Regeneration KW - Regenerative Medicine Y1 - SP - 1079 EP - 1095 ER - TY - JOUR A1 - Bachmann, Barbara A1 - Spitz, Sarah A1 - Rothbauer, Mario A1 - Jordan, Christian A1 - Purtscher, Michaela A1 - Zirath, Helene A1 - Schuller, Patrick A1 - Eilenberger, Christoph A1 - Ali, Syed Faheem A1 - Mühleder, Severin A1 - Priglinger, Eleni A1 - Harasek, Michael A1 - Redl, Heinz A1 - Holnthoner, Wolfgang A1 - Ertl, Peter T1 - Engineering of three-dimensional pre-vascular networks within fibrin hydrogel constructs by microfluidic control over reciprocal cell signaling JF - Biomicrofluidics KW - Microfluidic KW - Vascularization KW - Tissue Engineering Y1 - 2019 ER - TY - JOUR A1 - Bell, Daniel A1 - Chaloupka-Risser, Christine T1 - Demenz und Mobilität JF - Psychologie in Österreich 1 & 2 KW - Dementia KW - Mobility Y1 - VL - 2018 IS - Volume 38 ER - TY - JOUR A1 - Votzi, Helmut A1 - Himmelstoß, Felix A1 - Ertl, Hans T1 - Active Hybrid Filter Applied with a Multi-Cell Switch-Mode Power Amplifier JF - Power Electronics and Motion Control PEMC 2018, 27-29 August 2018, Budapest, Hungary KW - Amplifier KW - Hybrid filter KW - Linear amplifier KW - Switch-mode power amplifier Y1 - 2019 ER - TY - JOUR A1 - Muehleisen, Wolfgang A1 - Eder, Gabriele C. A1 - Voronko, Yuliya A1 - Spielberger, Markus A1 - Sonnleitner, Horst A1 - Knöbl, Karl A1 - Ebner, Rita A1 - Ujvari, Gusztáv A1 - Hirschl, Christina T1 - Outdoor detection and visualization of hailstorm damages of photovoltaic plants JF - Renewable Energy KW - Photovoltaics KW - Damage Detection KW - Hailstorms Y1 - 2018 IS - 118 SP - 138 EP - 145 ER - TY - JOUR A1 - Bell, Daniel A1 - Wolf-Eberl, Susanne A1 - Posch, Patrick T1 - Dementia and mobility – issues, needs and solutions JF - Transactions on Transport Sciences N2 - Structural transition in Austrian society in the larger context of demographic change and growing demands on infrastructure, organization and planning in the public sphere have been discussed profusely in recent years in the context of some projects. While a number of national and international research projects especially focussed on the older age groups and their requirements for staying mobile by developing solutions on the individual, technological and infrastructural level, solutions for people who suffer from cognitive impairment as a result of dementia are still missing. The Austrian research project KOMPETENZ takes the first step in identifying the requirements that people with dementia, their caregivers and other relevant stakeholders in this context have towards public space in order to be able to maintain physical mobility of people affected by dementia. One of the main outcomes of the project included an assessment methodology linking barriers and collective mobility needs to high potential solutions, which supports all relevant stakeholders in the process. KW - Mobility KW - Transportation Y1 - VL - 2018 IS - Vol. 9, Issue 1 ER -