TY - CHAP A1 - Pasteka, Richard A1 - Forjan, Mathias A1 - David, Veronika T1 - A Single Point of Contact Data Platform for Rehabilitative Exercises and Equipment T2 - DSAI 2018 - 8th International Conference on Software Development and Technologies for Enhancing Accessibility and Fighting Info-exclusion KW - Telemedicine KW - Rehabilitation KW - Exercise database KW - Home based rehabilitation Y1 - ER - TY - GEN A1 - Scherer, Matthias A1 - Zapf, Stefan A1 - Salomon, Cornelia A1 - Kotzian, Stefan A1 - Forjan, Mathias T1 - Development of a virtual environment for the rehabilitation of neurological patients KW - Virtual Supermarket KW - Neurological Rehabilitation KW - Simulator Sickness KW - Rehabilitation Y1 - ER - TY - CHAP A1 - Frohner, Matthias A1 - Gottschalk, Marion A1 - Franzl, Gerald A1 - Pasteka, Richard A1 - Uslar, Mathias A1 - Sauermann, Stefan T1 - Smart Grid Interoperability Profiles Development T2 - IEEE International Conference on Smart Grid Communications KW - Smart Grid KW - Interoperability KW - Computer Architecture KW - Medical Services KW - Standards Y1 - ER - TY - GEN A1 - Tkachenko Bril, Andres Igor A1 - David, Veronika A1 - Forjan, Mathias A1 - Gaudernak, Jakob A1 - Pils, Katharina T1 - Evaluation of the feasibility of a partial weight-bearing supporting biofeedback system based on instrumented insoles and an Android application KW - Weight-Bearing KW - Insoles KW - Biofeedback System KW - Mobile Application KW - Pilot Study Y1 - ER - TY - GEN A1 - David, Veronika A1 - Forjan, Mathias A1 - Paštěka, Richard A1 - Scherer, Matthias A1 - Hofstätter, Otto T1 - Development of a Multi-Purpose Easy-to-Use Set of Tools for Home Based Rehabilitation KW - Rehabitation KW - Low-Cost KW - eHealth KW - Home-based Rehabilitation KW - Telerehabilitation Y1 - ER - TY - GEN A1 - Frohner, Matthias A1 - Forjan, Mathias T1 - Interoperability Challenges - How to integrate medical devices KW - Interoperability KW - eHealth KW - Hospital Y1 - ER - TY - GEN A1 - David, Veronika A1 - Forjan, Mathias T1 - Rehabilitation at Home - a Device supported Approach KW - Rehabilitation KW - Individualized Rehabilitation KW - Weight bearing KW - Exercise database KW - eHealth Y1 - ER - TY - GEN A1 - Mühleder, Severin A1 - Fuchs, Christiane A1 - Bassilio, Jose A1 - Sczwarc, Dorota A1 - Pill, Karoline A1 - Slezak, Paul A1 - Labuda, Krystina A1 - Siehs, Christian A1 - Pröll, Johannes A1 - Priglinger, Eleni A1 - Redl, Heinz A1 - Holnthoner, Wolfgang T1 - The purinergic receptor P2Y2 modulates endothelial sprouting and angiogenesis KW - Angiogenesis Y1 - 2018 ER - TY - JOUR A1 - Schneider, Karl Heinrich A1 - Enayati, Marjan A1 - Grasl, Christian A1 - Walter, Ingrid A1 - Budinsky, Lubos A1 - Zebic, Gabriel A1 - Kaun, Christoph A1 - Wagner, Anja A1 - Kratochwill, Klaus A1 - Redl, Heinz A1 - Teuschl, Andreas A1 - Podesser, Bruno K. A1 - Bergmeister, Helga T1 - Acellular vascular matrix grafts from human placenta chorion: Impact of ECM preservation on graft characteristics, protein composition and in vivo performance. JF - Biomaterials N2 - Small diameter vascular grafts from human placenta, decellularized with either Triton X-100 (Triton) or SDS and crosslinked with heparin were constructed and characterized. Graft biochemical properties, residual DNA, and protein composition were evaluated to compare the effect of the two detergents on graft matrix composition and structural alterations. Biocompatibility was tested in vitro by culturing the grafts with primary human macrophages and in vivo by subcutaneous implantation of graft conduits (n = 7 per group) into the flanks of nude rats. Subsequently, graft performance was evaluated using an aortic implantation model in Sprague Dawley rats (one month, n = 14). In situ graft imaging was performed using MRI angiography. Retrieved specimens were analyzed by electromyography, scanning electron microscopy, histology and immunohistochemistry to evaluate cell migration and the degree of functional tissue remodeling. Both decellularization methods resulted in grafts of excellent biocompatibility in vitro and in vivo, with low immunogenic potential. Proteomic data revealed removal of cytoplasmic proteins with relative enrichment of ECM proteins in decelluarized specimens of both groups. Noteworthy, LC-Mass Spectrometry analysis revealed that 16 proteins were exclusively preserved in Triton decellularized specimens in comparison to SDS-treated specimens. Aortic grafts showed high patency rates, no signs of thrombus formation, aneurysms or rupture. Conduits of both groups revealed tissue-specific cell migration indicative of functional remodeling. This study strongly suggests that decellularized allogenic grafts from the human placenta have the potential to be used as vascular replacement materials. Both detergents produced grafts with low residual immunogenicity and appropriate mechanical properties. Observed differences in graft characteristics due to preservation method had no impact on successful in vivo performance in the rodent model. KW - Biomaterial KW - Tissue Engineering Y1 - SP - 14 EP - 26 ER - TY - JOUR A1 - Priglinger, Eleni A1 - Schuh, Christina A1 - Steffenhagen, Carolin A1 - Wurzer, Christoph A1 - Maier, Julia A1 - Nürnberger, Sylvia A1 - Holnthoner, Wolfgang A1 - Fuchs, Christiane A1 - Suessner, Susanne A1 - Rünzler, Dominik A1 - Redl, Heinz A1 - Wolbank, Susanne T1 - Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy. JF - Cytotherapy N2 - BACKGROUND: Cell-based therapies with autologous adipose tissue-derived cells have shown great potential in several clinical studies in the last decades. The majority of these studies have been using the stromal vascular fraction (SVF), a heterogeneous mixture of fibroblasts, lymphocytes, monocytes/macrophages, endothelial cells, endothelial progenitor cells, pericytes and adipose-derived stromal/stem cells (ASC) among others. Although possible clinical applications of autologous adipose tissue-derived cells are manifold, they are limited by insufficient uniformity in cell identity and regenerative potency. METHODS: In our experimental set-up, low-energy extracorporeal shock wave therapy (ESWT) was performed on freshly obtained human adipose tissue and isolated adipose tissue SVF cells aiming to equalize and enhance stem cell properties and functionality. RESULTS: After ESWT on adipose tissue we could achieve higher cellular adenosine triphosphate (ATP) levels compared with ESWT on the isolated SVF as well as the control. ESWT on adipose tissue resulted in a significantly higher expression of single mesenchymal and vascular marker compared with untreated control. Analysis of SVF protein secretome revealed a significant enhancement in insulin-like growth factor (IGF)-1 and placental growth factor (PLGF) after ESWT on adipose tissue. DISCUSSION: Summarizing we could show that ESWT on adipose tissue enhanced the cellular ATP content and modified the expression of single mesenchymal and vascular marker, and thus potentially provides a more regenerative cell population. Because the effectiveness of autologous cell therapy is dependent on the therapeutic potency of the patient's cells, this technology might raise the number of patients eligible for autologous cell transplantation. KW - Shockwave Therapy KW - Tissue Regeneration KW - Regenerative Medicine Y1 - SP - 1079 EP - 1095 ER - TY - JOUR A1 - Bachmann, Barbara A1 - Spitz, Sarah A1 - Rothbauer, Mario A1 - Jordan, Christian A1 - Purtscher, Michaela A1 - Zirath, Helene A1 - Schuller, Patrick A1 - Eilenberger, Christoph A1 - Ali, Syed Faheem A1 - Mühleder, Severin A1 - Priglinger, Eleni A1 - Harasek, Michael A1 - Redl, Heinz A1 - Holnthoner, Wolfgang A1 - Ertl, Peter T1 - Engineering of three-dimensional pre-vascular networks within fibrin hydrogel constructs by microfluidic control over reciprocal cell signaling JF - Biomicrofluidics KW - Microfluidic KW - Vascularization KW - Tissue Engineering Y1 - 2019 ER - TY - GEN A1 - Traxler, Lukas T1 - Klare Sicht nach Grauem Star KW - Intraocular Lenses KW - Cataract KW - Testing method Y1 - ER -