TY - JOUR A1 - Mandl, Thomas A1 - Meyerspeer, Martin A1 - Reichel, Martin A1 - Kern, Helmut A1 - Hofer, Christian A1 - Mayr, Winfried A1 - Moser, Ewald T1 - Functional electrical stimulation of long-term denervated, degenerated human skeletal muscle: estimating activation using T2-parameter magnetic resonance imaging methods JF - Artif Organs KW - Electrical Stimulation KW - Muscle Stimulation Y1 - 2019 IS - 32(8) SP - 604 EP - 608 ER - TY - GEN A1 - Teuschl, Andreas A1 - Fuchs, Christiane T1 - Bioreactors in Musculoskeletal Tissue Engineering KW - Bioreactor KW - Tissue Engineering Y1 - ER - TY - GEN A1 - Heher, Philipp A1 - Tomasch, Janine A1 - Maleiner, Babette A1 - Redl, Heinz A1 - Fuchs, Christiane T1 - The Importance of Biomechanical Cues for In Vitro Skeletal Myogenesis KW - In Vitro KW - Myogenesis Y1 - 2018 ER - TY - GEN A1 - Tomasch, Janine T1 - Generation of 3D skeletal muscle-like scaffolds via the application of mechanical stimuli KW - Scaffold KW - Mechanical Stimuli Y1 - 2018 ER - TY - JOUR A1 - Schuh, Christina A1 - Heher, Philipp A1 - Weihs, Anna A1 - Fuchs, Christiane A1 - Gabriel, Christian A1 - Wolbank, Susanne A1 - Mittermayr, Rainer A1 - Redl, Heinz A1 - Rünzler, Dominik A1 - Teuschl, Andreas T1 - In vitro extracorporeal shock wave treatment enhances stemness and preserves multipotency of rat and human adipose-derived stem cells JF - Journal of Cytotherapy KW - Shockwave Y1 - ER - TY - GEN A1 - Mandl, Thomas A1 - Dohnal, Fahdi A1 - Stickler, Yvonne A1 - Martinek, Johannes A1 - Reichel, Martin A1 - Mayr, Winfried A1 - Rattay, Frank T1 - FE-Modellierung für Implantate als Alternative zur transkutanen Elektrostimulation des langzeitdenervierten Oberschenkels KW - Implants KW - Denervation Y1 - 2019 ER - TY - GEN A1 - Kornfeind, P. A1 - Blaha, A. A1 - Peuschl, M. A1 - Reichel, Martin A1 - Sabo, Anton T1 - 2-Komponentenplattform zur Erfassung der Stemmbrettkräfte am Ruderergometer und im Ruderboot KW - Sport KW - Rowing Y1 - 2019 ER - TY - GEN A1 - Küenburg, Bernhard A1 - Teuschl, Andreas T1 - Regenerative silk ligament: scale up and regulatory strategy of a textile engineered silk implant for tissue regeneration of injured human ACL (anterior cruciate ligament) N2 - 61 a93591 27-SY-1 Regenerative silk ligament: scale up and regulatory strategy of a textile engineered silk implant for tissue regeneration of injured human ACL (anterior cruciate ligament) Bernhard Küenburg，Andreas Teuschl MorphoMed, Austria In the USA around 370.000 annual ACL ruptures in the predominately young population (age 18-30) following sport injuries cause a lot of pain and long term troubles for the affected patients. The well established standard procedure of autologous tissue transplantation stabilizes the knee and allows sport activities after 9-12 months. However, harvest of autologous tissue such as patellar tendon or semitendinosus (the most frequently used autograft) weakens other body areas and long term data show an increased rate of arthroses (up to 50% after 10 years) associated with ACL reconstructions. Based on numerous preclinical data and data from a 12-month sheep study the scale-up as well as regulatory approval process of a novel textile engineered silk implant as ACL graft have been initiated. It is planned to enter a clinical trial and strive for regulatory approval as a medical class 3 implant. The sheep data (1) have revealed an approximately 50% degradation of the purified medical silk, which acts as scaffold for the regrowth of a new endogenous ligament. The formation of oriented collagenous tissue fibers including vascularization proves a ligament tissue regeneration for the first time. Scale-up and implementation of a commercial process require a defined set of specifications of commercial silkworm (Bombyx mori) silk, a biological raw material sourced from the textile industry as well as adequate analytical methods to characterize the depletion of sericin in the course of the production process. Based on first full scale samples, the defined biocompatibility program has to be executed, in the EU following the ISO requirements of the notified bodies, in the USA determined by the FDA. Upon submission of the full technical documentation as well as the biocompati-bility data, approval of a clinical trial can be achieved in order to demonstrate the clinical efficacy of the silk based ACL graft compared to the gold standard method in two different randomized groups. As primary endpoint the knee stability will be tested by an apparatus supported Lachmann test. In this study, besides the clinical benefit the patient safety is an important goal. The results of this study will be used for achievement of regulatory approval. References: 1) Teuschl A, Heimel P, Nürnberger S, van Griensven M, Redl H, Nau T. Am. J. Sports Med. 2016;44:1547–57. 2) Teuschl AH, van Griensven M, Redl H. Tissue Eng. Part C Methods. 2014;20:431–9. KW - Biomaterial KW - Ligament Y1 - ER - TY - GEN A1 - Wilfing, Julia A1 - Frühwirth, Clemens A1 - Lehner, Benjamin T1 - Feldmessungen der Gleit- und Haftreibungskoeffizienten von Skitourenfellen KW - Skiing KW - Measuring KW - Friction Y1 - ER - TY - JOUR A1 - Hackethal, Johannes A1 - Mühleder, Severin A1 - Hofer, Alexandra A1 - Schneider, Karl Heinrich A1 - Prüller, Johanna A1 - Hennerbichler, Simone A1 - Redl, Heinz A1 - Teuschl, Andreas T1 - An Effective Method of Atelocollagen Type 1/3 Isolation from Human Placenta and Its In Vitro Characterization in Two-Dimensional and Three-Dimensional Cell Culture Applications JF - Tissue Eng Part C Methods KW - Placenta KW - In Vitro KW - Cell Culture Y1 - 2018 VL - 23 IS - 5 SP - 274 EP - 285 ER - TY - CHAP A1 - Fuchs, Christiane A1 - Weihs, Anna A1 - Szwarc, Dorota A1 - Mittermayr, Rainer A1 - Rünzler, Dominik A1 - Teuschl, Andreas T1 - Shock wave treatment of muscle (stem) cells - a new implementation for regeneration T2 - Proceedings of the 20th International Congress of the ISMST KW - Shockwave treatment KW - Muscle Cells KW - Regeneration Y1 - 2018 ER - TY - JOUR A1 - Berkovitch, Yulia A1 - Cohen, Talia A1 - Peled, Eli A1 - Schmidhammer, Robert A1 - Hildner, Florian A1 - Teuschl, Andreas A1 - Wolbank, Susanne A1 - Yelin, Dvir A1 - Redl, Heinz A1 - Seliktar, Dror T1 - Hydrogel Composition and Laser Micro-Patterning to Regulate Sciatic Nerve Regeneration JF - Journal of Tissue Engineering and Regenerative Medicine KW - Micro-Patterning KW - Laser KW - Nerve Regeneration Y1 - 2018 VL - 12 IS - 4 ER - TY - GEN A1 - Fuchs, Christiane A1 - Weihs, Anna A1 - Szwarc, Dorota A1 - Mittermayr, Rainer A1 - Rünzler, Dominik A1 - Teuschl, Andreas T1 - Shock wave treatment of muscle (stem) cells - a new implementation for regeneration KW - Shockwave treatment KW - Muscle Cells KW - Regeneration Y1 - 2018 ER - TY - GEN A1 - Teuschl, Andreas A1 - Weihs, Anna A1 - Fuchs, Christiane A1 - Monforte Vila, Xavier T1 - Silk as a versatile biomaterial for musculoskeletal tissue engineering KW - Silk KW - Biomaterials Y1 - 2018 ER - TY - GEN A1 - Szwarc, Dorota A1 - Fuchs, Christiane A1 - Weihs, Anna A1 - Rünzler, Dominik T1 - Molecular mechanisms underlying the potential of shock wave treatment for cardiac therapy KW - Shockwave treatment KW - Cardiac Y1 - 2018 ER - TY - GEN A1 - Szwarc, Dorota A1 - Fuchs, Christiane A1 - Purtscher, Michaela A1 - Rünzler, Dominik T1 - Elucidating the molecular mechanisms underlying cardiac shock wave therapy KW - Shockwave treatment KW - Cardiac Y1 - 2018 ER - TY - GEN A1 - Sabo, Anton A1 - Eckelt, Markus T1 - Running Shoes - Possible Correlations of Biomechanical and Material Tests KW - Shoes KW - Testing Y1 - ER - TY - GEN A1 - Eckelt, Markus T1 - Customizing Shoe Insoles through CAD-FEM Modelling KW - Customized Equipment KW - Arch ratio KW - Footwear design KW - Contact pressure KW - 3D Anthropometry Y1 - ER - TY - JOUR A1 - Bernhard, Jonathan A1 - Ferguson, James A1 - Rieder, Bernhard A1 - Heimel, Patrick A1 - Nau, Thomas A1 - Tangl, Stefan A1 - Redl, Heinz A1 - Vunjak-Novakovic, Gordana T1 - Tissue-engineered hypertrophic chondrocyte grafts enhanced long bone repair biomaterials JF - Biomaterials KW - Grafting KW - Biomaterials Y1 - 2018 IS - 139 SP - 202 EP - 212 ER - TY - GEN A1 - Kotzian, Stefan A1 - Riess, Bernhard A1 - David, Veronika A1 - Haider, Sandra A1 - Spatt, Josef T1 - Virtual Reality Training in der neurologischen Rehabilitation - Eine Praktikabilitätsstudie zu einer Microsoft Kinect-Anwendung KW - Neurology KW - Rehabilitation KW - Virtual Reality Y1 - 2018 ER -