TY - JOUR A1 - Mandl, Thomas A1 - Meyerspeer, Martin A1 - Reichel, Martin A1 - Kern, Helmut A1 - Hofer, Christian A1 - Mayr, Winfried A1 - Moser, Ewald T1 - Functional electrical stimulation of long-term denervated, degenerated human skeletal muscle: estimating activation using T2-parameter magnetic resonance imaging methods JF - Artif Organs KW - Electrical Stimulation KW - Muscle Stimulation Y1 - 2019 IS - 32(8) SP - 604 EP - 608 ER - TY - GEN A1 - Teuschl, Andreas A1 - Fuchs, Christiane T1 - Bioreactors in Musculoskeletal Tissue Engineering KW - Bioreactor KW - Tissue Engineering Y1 - ER - TY - GEN A1 - Heher, Philipp A1 - Tomasch, Janine A1 - Maleiner, Babette A1 - Redl, Heinz A1 - Fuchs, Christiane T1 - The Importance of Biomechanical Cues for In Vitro Skeletal Myogenesis KW - In Vitro KW - Myogenesis Y1 - 2018 ER - TY - GEN A1 - Tomasch, Janine T1 - Generation of 3D skeletal muscle-like scaffolds via the application of mechanical stimuli KW - Scaffold KW - Mechanical Stimuli Y1 - 2018 ER - TY - JOUR A1 - Schuh, Christina A1 - Heher, Philipp A1 - Weihs, Anna A1 - Fuchs, Christiane A1 - Gabriel, Christian A1 - Wolbank, Susanne A1 - Mittermayr, Rainer A1 - Redl, Heinz A1 - Rünzler, Dominik A1 - Teuschl, Andreas T1 - In vitro extracorporeal shock wave treatment enhances stemness and preserves multipotency of rat and human adipose-derived stem cells JF - Journal of Cytotherapy KW - Shockwave Y1 - ER - TY - GEN A1 - Mandl, Thomas A1 - Dohnal, Fahdi A1 - Stickler, Yvonne A1 - Martinek, Johannes A1 - Reichel, Martin A1 - Mayr, Winfried A1 - Rattay, Frank T1 - FE-Modellierung für Implantate als Alternative zur transkutanen Elektrostimulation des langzeitdenervierten Oberschenkels KW - Implants KW - Denervation Y1 - 2019 ER - TY - GEN A1 - Kornfeind, P. A1 - Blaha, A. A1 - Peuschl, M. A1 - Reichel, Martin A1 - Sabo, Anton T1 - 2-Komponentenplattform zur Erfassung der Stemmbrettkräfte am Ruderergometer und im Ruderboot KW - Sport KW - Rowing Y1 - 2019 ER - TY - GEN A1 - Küenburg, Bernhard A1 - Teuschl, Andreas T1 - Regenerative silk ligament: scale up and regulatory strategy of a textile engineered silk implant for tissue regeneration of injured human ACL (anterior cruciate ligament) N2 - 61 a93591 27-SY-1 Regenerative silk ligament: scale up and regulatory strategy of a textile engineered silk implant for tissue regeneration of injured human ACL (anterior cruciate ligament) Bernhard Küenburg，Andreas Teuschl MorphoMed, Austria In the USA around 370.000 annual ACL ruptures in the predominately young population (age 18-30) following sport injuries cause a lot of pain and long term troubles for the affected patients. The well established standard procedure of autologous tissue transplantation stabilizes the knee and allows sport activities after 9-12 months. However, harvest of autologous tissue such as patellar tendon or semitendinosus (the most frequently used autograft) weakens other body areas and long term data show an increased rate of arthroses (up to 50% after 10 years) associated with ACL reconstructions. Based on numerous preclinical data and data from a 12-month sheep study the scale-up as well as regulatory approval process of a novel textile engineered silk implant as ACL graft have been initiated. It is planned to enter a clinical trial and strive for regulatory approval as a medical class 3 implant. The sheep data (1) have revealed an approximately 50% degradation of the purified medical silk, which acts as scaffold for the regrowth of a new endogenous ligament. The formation of oriented collagenous tissue fibers including vascularization proves a ligament tissue regeneration for the first time. Scale-up and implementation of a commercial process require a defined set of specifications of commercial silkworm (Bombyx mori) silk, a biological raw material sourced from the textile industry as well as adequate analytical methods to characterize the depletion of sericin in the course of the production process. Based on first full scale samples, the defined biocompatibility program has to be executed, in the EU following the ISO requirements of the notified bodies, in the USA determined by the FDA. Upon submission of the full technical documentation as well as the biocompati-bility data, approval of a clinical trial can be achieved in order to demonstrate the clinical efficacy of the silk based ACL graft compared to the gold standard method in two different randomized groups. As primary endpoint the knee stability will be tested by an apparatus supported Lachmann test. In this study, besides the clinical benefit the patient safety is an important goal. The results of this study will be used for achievement of regulatory approval. References: 1) Teuschl A, Heimel P, Nürnberger S, van Griensven M, Redl H, Nau T. Am. J. Sports Med. 2016;44:1547–57. 2) Teuschl AH, van Griensven M, Redl H. Tissue Eng. Part C Methods. 2014;20:431–9. KW - Biomaterial KW - Ligament Y1 - ER - TY - GEN A1 - Wilfing, Julia A1 - Frühwirth, Clemens A1 - Lehner, Benjamin T1 - Feldmessungen der Gleit- und Haftreibungskoeffizienten von Skitourenfellen KW - Skiing KW - Measuring KW - Friction Y1 - ER - TY - JOUR A1 - Hackethal, Johannes A1 - Mühleder, Severin A1 - Hofer, Alexandra A1 - Schneider, Karl Heinrich A1 - Prüller, Johanna A1 - Hennerbichler, Simone A1 - Redl, Heinz A1 - Teuschl, Andreas T1 - An Effective Method of Atelocollagen Type 1/3 Isolation from Human Placenta and Its In Vitro Characterization in Two-Dimensional and Three-Dimensional Cell Culture Applications JF - Tissue Eng Part C Methods KW - Placenta KW - In Vitro KW - Cell Culture Y1 - 2018 VL - 23 IS - 5 SP - 274 EP - 285 ER - TY - CHAP A1 - Fuchs, Christiane A1 - Weihs, Anna A1 - Szwarc, Dorota A1 - Mittermayr, Rainer A1 - Rünzler, Dominik A1 - Teuschl, Andreas T1 - Shock wave treatment of muscle (stem) cells - a new implementation for regeneration T2 - Proceedings of the 20th International Congress of the ISMST KW - Shockwave treatment KW - Muscle Cells KW - Regeneration Y1 - 2018 ER - TY - JOUR A1 - Berkovitch, Yulia A1 - Cohen, Talia A1 - Peled, Eli A1 - Schmidhammer, Robert A1 - Hildner, Florian A1 - Teuschl, Andreas A1 - Wolbank, Susanne A1 - Yelin, Dvir A1 - Redl, Heinz A1 - Seliktar, Dror T1 - Hydrogel Composition and Laser Micro-Patterning to Regulate Sciatic Nerve Regeneration JF - Journal of Tissue Engineering and Regenerative Medicine KW - Micro-Patterning KW - Laser KW - Nerve Regeneration Y1 - 2018 VL - 12 IS - 4 ER - TY - GEN A1 - Fuchs, Christiane A1 - Weihs, Anna A1 - Szwarc, Dorota A1 - Mittermayr, Rainer A1 - Rünzler, Dominik A1 - Teuschl, Andreas T1 - Shock wave treatment of muscle (stem) cells - a new implementation for regeneration KW - Shockwave treatment KW - Muscle Cells KW - Regeneration Y1 - 2018 ER - TY - GEN A1 - Teuschl, Andreas A1 - Weihs, Anna A1 - Fuchs, Christiane A1 - Monforte Vila, Xavier T1 - Silk as a versatile biomaterial for musculoskeletal tissue engineering KW - Silk KW - Biomaterials Y1 - 2018 ER - TY - GEN A1 - Szwarc, Dorota A1 - Fuchs, Christiane A1 - Weihs, Anna A1 - Rünzler, Dominik T1 - Molecular mechanisms underlying the potential of shock wave treatment for cardiac therapy KW - Shockwave treatment KW - Cardiac Y1 - 2018 ER - TY - GEN A1 - Szwarc, Dorota A1 - Fuchs, Christiane A1 - Purtscher, Michaela A1 - Rünzler, Dominik T1 - Elucidating the molecular mechanisms underlying cardiac shock wave therapy KW - Shockwave treatment KW - Cardiac Y1 - 2018 ER - TY - GEN A1 - Sabo, Anton A1 - Eckelt, Markus T1 - Running Shoes - Possible Correlations of Biomechanical and Material Tests KW - Shoes KW - Testing Y1 - ER - TY - GEN A1 - Eckelt, Markus T1 - Customizing Shoe Insoles through CAD-FEM Modelling KW - Customized Equipment KW - Arch ratio KW - Footwear design KW - Contact pressure KW - 3D Anthropometry Y1 - ER - TY - JOUR A1 - Bernhard, Jonathan A1 - Ferguson, James A1 - Rieder, Bernhard A1 - Heimel, Patrick A1 - Nau, Thomas A1 - Tangl, Stefan A1 - Redl, Heinz A1 - Vunjak-Novakovic, Gordana T1 - Tissue-engineered hypertrophic chondrocyte grafts enhanced long bone repair biomaterials JF - Biomaterials KW - Grafting KW - Biomaterials Y1 - 2018 IS - 139 SP - 202 EP - 212 ER - TY - GEN A1 - Kotzian, Stefan A1 - Riess, Bernhard A1 - David, Veronika A1 - Haider, Sandra A1 - Spatt, Josef T1 - Virtual Reality Training in der neurologischen Rehabilitation - Eine Praktikabilitätsstudie zu einer Microsoft Kinect-Anwendung KW - Neurology KW - Rehabilitation KW - Virtual Reality Y1 - 2018 ER - TY - GEN A1 - Menschik, Alfred A1 - Mally, Franziska A1 - Gruber, Martin A1 - Sabo, Anton T1 - EMG-Messungen am Unterwasserlaufband KW - Electromyography KW - Health Y1 - 2018 ER - TY - GEN A1 - Bayer, Natascha T1 - Analysing the Impact of a Misaligned Toric Intraocular Lens on Wave Front Aberrations KW - Mechanical Eye Y1 - 2018 ER - TY - GEN A1 - Rünzler, Dominik T1 - Alternatives to Animal Experiment Models: Tracking Zebrafish Larvae and Daphnia KW - Animal Experiments KW - Zebrafish Y1 - 2018 ER - TY - GEN A1 - Eckelt, Markus T1 - Evaluating the Interaction Between Rim and Brake Pad on a Test Bench KW - Brake KW - Wheels KW - Test Bench Y1 - ER - TY - GEN A1 - Fuchs, Christiane T1 - The importance of mechanotransduction in myogenesis KW - Mechanotransduction KW - Myogenesis Y1 - 2018 ER - TY - JOUR A1 - Schneider, Cornelia A1 - Lehmann, Johannes A1 - van Osch, Gerjo A1 - Hildner, Florian A1 - Teuschl, Andreas A1 - Monforte Vila, Xavier A1 - Miosga, David A1 - Heimel, Patrick A1 - Priglinger, Eleni A1 - Redl, Heinz A1 - Wolbank, Susanne A1 - Nürnberger, Sylvia T1 - Systematic Comparison of Protocols for the Preparation of Human Articular Cartilage for Use as Scaffold Material in Cartilage Tissue Engineering JF - Tissue Eng Part C Methods KW - Cartilage KW - Scaffold Material Y1 - 2018 VL - 22 IS - 12 ER - TY - CHAP A1 - Maleiner, Babette A1 - Heher, Philipp A1 - Teuschl, Andreas A1 - Redl, Heinz A1 - Rünzler, Dominik A1 - Fuchs, Christiane T1 - Generation of aligned skeletal muscle-like tissue based on the application of strain to a 3D fibrin scaffold T2 - Proceedings of PACT "Designer Cells go Clinical" Symposium KW - Tissue Generation KW - Fibrin KW - Scaffold Y1 - 2018 ER - TY - GEN A1 - Szwarc, Dorota A1 - Fuchs, Christiane A1 - Weihs, Anna A1 - Monforte Vila, Xavier A1 - Hanetseder, Dominik A1 - Teuschl, Andreas A1 - Rünzler, Dominik T1 - The effect of shock waves on in vitro cartilage development in silk scaffolds KW - Shockwave treatment KW - In Vitro KW - Cartilage KW - Silk Y1 - 2018 ER - TY - GEN A1 - Maleiner, Babette A1 - Heher, Philipp A1 - Teuschl, Andreas A1 - Redl, Heinz A1 - Rünzler, Dominik A1 - Fuchs, Christiane T1 - Generation of aligned skeletal muscle-like tissue based on the application of strain to a 3D fibrin scaffold KW - Tissue Generation KW - Fibrin KW - Scaffold Y1 - 2018 ER - TY - GEN A1 - Teuschl, Andreas A1 - Fuchs, Christiane A1 - Weihs, Anna A1 - Heimel, Patrick A1 - Rünzler, Dominik A1 - Redl, Heinz A1 - Nau, Thomas T1 - The Silk Road from Textiles to Novel Medical Implants KW - Silk Y1 - 2018 ER - TY - GEN A1 - Teuschl, Andreas A1 - Heimel, Patrick A1 - Nürnberger, Sylvia A1 - Redl, Heinz A1 - Nau, Thomas T1 - ACL Regeneration using a novel silk fiber based scaffold - Histological Results of a Large Animal Study KW - Tissue Regeneration KW - Silk KW - Scaffold Y1 - 2018 ER - TY - GEN A1 - Teuschl, Andreas T1 - Silk Processing - from Gels to ACL Replacement KW - Silk Y1 - 2018 ER - TY - CHAP A1 - Fuchs, Christiane A1 - Szwarc, Dorota A1 - Weihs, Anna A1 - Rünzler, Dominik T1 - Shock wave treatment of 3D cardiac model systems activates ERK 1/2 signaling pathway and influences cardiomyogenesis T2 - Proceedings of PACT "Designer Cells go Clinical" Symposium KW - Shockwave treatment KW - Cardiac Y1 - 2018 ER - TY - CHAP A1 - Fuchs, Christiane A1 - Szwarc, Dorota A1 - Weihs, Anna A1 - Rünzler, Dominik T1 - Shock wave treatment of 3D cardiac model systems activates ERK 1/2 signaling pathway and influences cardiomyogenesis T2 - Proceedings of LBG Meeting for Health Sciences 2016 KW - Shockwave treatment KW - Cardiac Y1 - 2018 ER - TY - GEN A1 - Fuchs, Christiane A1 - Szwarc, Dorota A1 - Weihs, Anna A1 - Rünzler, Dominik T1 - Shock wave treatment of 3D cardiac model systems activates ERK 1/2 signaling pathway and influences cardiomyogenesis KW - Shockwave treatment KW - Cardiac Y1 - 2018 ER - TY - CHAP A1 - Fuchs, Christiane A1 - Szwarc, Dorota A1 - Weihs, Anna A1 - Rünzler, Dominik T1 - Shock wave treatment positively influences cardiomyogenesis in an energy-dependent manner T2 - Proceedings of PACT "Designer Cells go Clinical" Symposium KW - Shockwave treatment KW - Cardiac Y1 - 2018 ER - TY - GEN A1 - Weihs, Anna T1 - Shock wave treatment for in vitro tissue engineering applications KW - Shockwave treatment KW - In Vitro KW - Tissue Engineering Y1 - 2018 ER - TY - CHAP A1 - Basoli, Valentina A1 - Chaudry, Sidrah A1 - Cruciani, Sara A1 - Fuchs, Christiane A1 - Rieger, Sabine A1 - Dungel, Peter A1 - Wolbank, Susanne A1 - Ventura, Carlo A1 - Grillari-Voglauer, Regina A1 - Redl, Heinz A1 - Maioli, Margherita T1 - Epigenetic and molecular behavious of stem cells exposed to biophysical stimuli: new insights in regenerative medicine T2 - Proceedings des Seminars zum 40. Jahresjubiläum der Österreichischen Gesellschaft für Chirurgische Forschung KW - Stem Cells KW - Regeneration KW - Biophysical Stimuli Y1 - 2018 ER - TY - GEN A1 - Basoli, Valentina A1 - Chaudry, Sidrah A1 - Cruciani, Gabriele A1 - Fuchs, Christiane A1 - Rieger, Sabine A1 - Dungel, Peter A1 - Wolbank, Susanne A1 - Ventura, Carlo A1 - Grillari-Voglauer, Regina A1 - Redl, Heinz A1 - Maioli, Margherita T1 - Epigenetic and molecular behavious of stem cells exposed to biophysical stimuli: new insights in regenerative medicine KW - Stem Cells KW - Regeneration KW - Biophysical Stimuli Y1 - 2018 ER - TY - GEN A1 - Hofstätter, Otto A1 - Breyer, Peter A1 - Kafka, Patricia A1 - Sabo, Anton T1 - Development of a prototype for the simulation of human sway to make standardized and reproducible measurements of force and pressure sensors KW - Simulation KW - Human Sway Y1 - 2018 ER - TY - GEN A1 - Höttinger, Hannes A1 - Mally, Franziska A1 - Sabo, Anton T1 - Activity recognition in surfing - a comparative study between hidden markov model and support vector machine KW - Activity KW - Surfing Y1 - 2018 ER - TY - CHAP A1 - Drauschke, Andreas T1 - Comparison of Numerical Eye Models and its Representation within a Mechanical Eye Model T2 - IFAC-Papers Online KW - Mechanical Eye Y1 - 2018 SP - 133 EP - 138 ER - TY - GEN A1 - Drauschke, Andreas T1 - Comparison of Numerical Eye Models and its Representation within a Mechanical Eye Model KW - Mechanical Eye Y1 - 2018 ER - TY - GEN A1 - Weihs, Anna T1 - Shock wave treatment for in vitro tissue engineering applications KW - Shockwave treatment KW - In Vitro KW - Tissue Engineering Y1 - 2018 ER - TY - GEN A1 - Weihs, Anna T1 - Mechanotransduction in shock wave treatment KW - Shockwave treatment KW - Mechanotransduction Y1 - 2018 ER - TY - GEN A1 - Mandt, Denise A1 - Pichler, Verena A1 - Melchior, Sophie A1 - Rünzler, Dominik T1 - Establishment of 2D and 3D cell culture assays using RT-gillW1 cells KW - Cell Culture KW - Assay Y1 - 2018 ER - TY - GEN A1 - Öttl, Georg A1 - Mally, Franziska A1 - Sabo, Anton T1 - The influence of low-friction quickdraws on impact forces in climbing falls KW - Climbing KW - Falling Y1 - 2018 ER - TY - GEN A1 - Salzer, Elias A1 - Rünzler, Dominik T1 - Acute Immobilization Test with Daphnia magna - A Refined Methodology for the Detection of Immobilization KW - Immobilization Y1 - 2018 ER - TY - GEN A1 - Bayer, Natascha T1 - Analysis of Customized Ocular Data and Wave Front Aberrations Concerning their Deviations from Generic Eye Models KW - Mechanical Eye Y1 - 2018 ER - TY - GEN A1 - Salzer, Elias A1 - Rünzler, Dominik T1 - Live or dead is not enough: a large-scale mobility assay with Daphnia magna KW - Mobility Assay Y1 - 2018 ER -