TY - CHAP A1 - Hörzer, S. A1 - Fuchs, Christiane A1 - Gastinger, R. A1 - Sabo, Anton A1 - Mehnen, Lars A1 - Martinek, Johannes A1 - Reichel, Martin T1 - Simulation of spinning soccer ball trajectories influenced by altitude T2 - Procedia Engineering KW - Soccer Y1 - 2019 SP - 2461 EP - 2466 ER - TY - GEN A1 - Reutterer, Bernd A1 - Traxler, Lukas A1 - Bayer, Natascha A1 - Drauschke, Andreas T1 - Further improvement of an intraocular lens holder for more physiological measurements within a mechanical eye model KW - Mechanical Eye Y1 - 2018 ER - TY - CHAP A1 - Reutterer, Bernd A1 - Traxler, Lukas A1 - Bayer, Natascha A1 - Drauschke, Andreas T1 - Experiments for practical education in process parameter optimization for selective laser sintering to increase workpiece quality T2 - Proceedings of the 3rd Conference on Laser 3D Manufacturing 2016 KW - Laser Sintering Y1 - 2018 ER - TY - CHAP A1 - Knebl, Gerald A1 - Morton, Tatjana J. A1 - Redl, Heinz A1 - Rünzler, Dominik T1 - Mechanical stimulation of cells in 3-dimensional fibrin constructs using a bioreactor T2 - 3. Forschungsforum der österreichischen Fachhochschulen / Fachhochschule Kärnten KW - Cells KW - Bioreactor Y1 - 2019 SP - 492 EP - 493 ER - TY - CHAP A1 - Mense, Alexander A1 - Frohner, Matthias A1 - Kaufmann, Christian A1 - Pohn, Birgit A1 - Sauermann, Stefan A1 - Urbauer, Philipp A1 - Wahl, Harald T1 - Federated Identity Management for management and integration of personal health data archives T2 - PROCEEDINGS of the 10th International Conference on INFORMATION COMMUNICATION TECHNOLOGIES IN HEALTH, Chrysovaladis Prachalias (ed.), National and Kapodistrian University of Athens KW - Identity Management KW - Personal Health Y1 - 2019 ER - TY - JOUR A1 - Traxler, Lukas A1 - Bayer, Natascha A1 - Reutterer, Bernd A1 - Drauschke, Andreas A1 - Husinsky, Wolfgang T1 - Prüfung der optischen Qualität von Intraokularlinsen auf Tolerant gegenüber Fehlplatzierungen im Auge JF - Proceedings der Jahrestagung der Österreichischen Gesellschaft für Biomedizinische Technik (ÖGBMT) 2015 KW - Eye Lens KW - Mechanical Eye KW - Measurement Error Y1 - 2018 ER - TY - JOUR A1 - Verstraeten, Valerie A1 - Holnthoner, Wolfgang A1 - Van Steensel, Maurice A1 - Veraart, Joep C J M A1 - Bladergroen, Reno S A1 - Heckmann, Caronline A A1 - Keskitalo, Salla A1 - Frank, Jorge A1 - Alitalo, Kari A1 - van Geel, Michel A1 - Steijlen, Peter M T1 - Functional analysis of FLT4 mutations associated with Nonne-Milroy lymphedema JF - Journal of Investigative Dermatology KW - Nonne-Milroy iymphedema KW - Mutation Y1 - 2019 IS - 129(2) SP - 509 EP - 512 ER - TY - JOUR A1 - Schneider, Karl Heinrich A1 - Aigner, Petra A1 - Holnthoner, Wolfgang A1 - Monforte Vila, Xavier A1 - Nürnberger, Sylvia A1 - Rünzler, Dominik A1 - Redl, Heinz A1 - Teuschl, Andreas T1 - Decellularized human placenta chorion matrix as a favorable source of small-diameter vascular grafts JF - Acta Biomaterialia KW - Grafting KW - Tissue Engineering Y1 - 2018 ER - TY - GEN A1 - Reutterer, Bernd A1 - Traxler, Lukas A1 - Bayer, Natascha A1 - Drauschke, Andreas T1 - Experiments for practical education in process parameter optimization for selective laser sintering to increase workpiece quality KW - Laser Sintering KW - Education Y1 - 2018 ER - TY - JOUR A1 - Rohringer, Sabrina A1 - Holnthoner, Wolfgang A1 - Hackl, Matthias A1 - Weihs, Anna A1 - Rünzler, Dominik A1 - Skalicky, Susanna A1 - Karbiener, Michael A1 - Scheideler, Marcel A1 - Pröll, Johannes A1 - Gabriel, Christian A1 - Schweighofer, Bernhard A1 - Gröger, Marion A1 - Spittler, Andreas A1 - Grillari, Johannes A1 - Redl, Heinz T1 - Molecular and cellular effects of in vitro shockwave treatment on lymphatic endothelial cells. JF - PLoS one KW - Shockwave Y1 - ER - TY - CHAP A1 - Bayer, Natascha A1 - Rank, Elisabet A1 - Traxler, Lukas A1 - Beckert, Erik A1 - Drauschke, Andreas T1 - Implementation of a capsular bag model to enable sufficient lens stabilization within a mechanical eye model T2 - Proc.SPIE 9307, Ophthalmic Technologies XXV KW - Mechanical Eye Y1 - ER - TY - GEN A1 - Gerbovics, Ferenc A1 - Haller, Michael A1 - Traxler, Lukas A1 - Urbauer, Philipp A1 - Frohner, Matthias A1 - Sauermann, Stefan A1 - Mense, Alexander T1 - Implementation of a wrist wearable Health Data Hub-prototype for context based telemonitoring of elderly people using standardized data transfer methods KW - Health data KW - Telemonitoring Y1 - 2019 SN - 978-1-60750-658-4 SN - 0926-9630 ER - TY - CHAP A1 - Rank, Elisabet A1 - Traxler, Lukas A1 - Bayer, Natascha A1 - Reutterer, Bernd A1 - Lux, Kirsten A1 - Drauschke, Andreas T1 - Reproducibility analysis of measurements with a mechanical semiautomatic eye model for evaluation of intraocular lenses T2 - Proc.SPIE 8936, Design and Quality for Biomedical Technologies VII KW - Mechanical Eye Y1 - ER - TY - JOUR A1 - Ferner-Ortner-Bleckmann, Judith A1 - Huber-Gries, Carina A1 - Pavkov-Keller, Tea A1 - Keller, Walter A1 - Mader, Christoph A1 - Ilk, Nicola A1 - Sleytr, Uwe B. A1 - Egelseer, Eva-Maria T1 - The high-molecular-mass amylase (HMMA) of Geobacillus stearothermophilus ATCC 12980 interacts with the cell wall components by virtue of three specific binding regions JF - Molecular Microbiology KW - Cells Y1 - 2019 IS - 72(6) SP - 1448 EP - 1461 ER - TY - CHAP A1 - Pfützner, Helmut A1 - Kaniusas, Eugenijus A1 - Kosel, Jürgen A1 - Mehnen, Lars A1 - Meydan, Turgut A1 - Borza, Firuta A1 - Vazquez, Manuel A1 - Rohn, Michael A1 - Marquardt, Bernd T1 - First Magnetic Materials with Sensitivity for the Physical Quantity of 'Curvature' T2 - 4th Japanese Mediterranean Workshop on Applied Electromagnetic Engineering for Magnetic, Superconducting and Nano Materials KW - Magnetic KW - Materials Y1 - 2019 SP - 177 EP - 178 ER - TY - GEN A1 - Liousia, Varvara A1 - Salzer, Elias A1 - Mandt, Denise A1 - Rünzler, Dominik T1 - The impact of ethanol in vitro and in vivo: a comparative study KW - In Vivo KW - In Vitro KW - Ethanol Y1 - 2018 ER - TY - JOUR A1 - Ghalamkarpour, A. A1 - Holnthoner, Wolfgang A1 - Saharinen, Pipsa A1 - Boon, Laurence M A1 - Mulliken, J B A1 - Alitalo, Kari T1 - Recessive primary congenital lymphoedema caused by a VEGFR3 mutation JF - Journal of Medical Genetics KW - Lymphoedema Y1 - 2019 IS - 46(6) SP - 399 EP - 404 ER - TY - JOUR A1 - Bayer, Natascha A1 - Hirnschall, Nino A1 - Traxler, Lukas A1 - Drauschke, Andreas A1 - Find, Oliver T1 - Analysis of customized ocular data and wave front aberrations concerning their deviations from generic eye models JF - Proceedings der Dreiländertagung der biomedizinischen Technik (BMT) KW - Mechanical Eye Y1 - 2018 ER - TY - GEN A1 - Liousia, Varvara A1 - Rünzler, Dominik T1 - Stage- and dose-dependent effects of methanol and ethanol on the locomotor activity of zebrafish larvae KW - Locomotor Activity KW - Zebrafish Y1 - 2018 ER - TY - JOUR A1 - Henderson, Ben A1 - Slingers, Gitte A1 - Pedrotti, Michele A1 - Pugliese, Giovanni A1 - Malaskova, Michaela A1 - Bryant, Luke A1 - Lomonaco, Tommaso A1 - Ghimenti, Silvia A1 - Moreno, Sergi A1 - Cordell, Rebecca A1 - Harren, Frans J M A1 - Schubert, Jochen A1 - Mayhew, Chris A A1 - Wilde, Michael A1 - Di Francesco, Fabio A1 - Koppen, Gudrun A1 - Beauchamp, Jonathan D A1 - Cristescu, Simona M T1 - The peppermint breath test benchmark for PTR-MS and SIFT-MS JF - Journal of Breath Research N2 - A major challenge for breath research is the lack of standardization in sampling and analysis. To address this, a test that utilizes a standardized intervention and a defined study protocol has been proposed to explore disparities in breath research across different analytical platforms and to provide benchmark values for comparison. Specifically, the Peppermint Experiment involves the targeted analysis in exhaled breath of volatile constituents of peppermint oil after ingestion of the encapsulated oil. Data from the Peppermint Experiment performed by proton transfer reaction mass spectrometry (PTR-MS) and selected ion flow tube mass spectrometry (SIFT-MS) are presented and discussed herein, including the product ions associated with the key peppermint volatiles, namely limonene, α- and β-pinene, 1,8-cineole, menthol, menthone and menthofuran. The breath washout profiles of these compounds from 65 individuals were collected, comprising datasets from five PTR-MS and two SIFT-MS instruments. The washout profiles of these volatiles were evaluated by comparing the log-fold change over time of the product ion intensities associated with each volatile. Benchmark values were calculated from the lower 95% confidence interval of the linear time-to-washout regression analysis for all datasets combined. Benchmark washout values from PTR-MS analysis were 353 min for the sum of monoterpenes and 1,8-cineole (identical product ions), 173 min for menthol, 330 min for menthofuran, and 218 min for menthone; from SIFT-MS analysis values were 228 min for the sum of monoterpenes, 281 min for the sum of monoterpenes and 1,8-cineole, and 370 min for menthone plus 1,8-cineole. Large inter- and intra-dataset variations were observed, whereby the latter suggests that biological variability plays a key role in how the compounds are absorbed, metabolized and excreted from the body via breath. This variability seems large compared to the influence of sampling and analytical procedures, but further investigations are recommended to clarify the effects of these factors. KW - standardization KW - breathomics KW - peppermint KW - benchmark KW - TR-MS Y1 - U6 - http://dx.doi.org/https://doi.org/10.1088/1752-7163/ac1fcf IS - 15 SP - Artikelnr. 046005 ER - TY - GEN A1 - Nemec, Iris A1 - Frohner, Matthias T1 - How can life science students, especially biomedical engineering students, benefit from the extra-curricular offerings and systems already established in other scientific fields? T2 - Abstracts of the 2022 Joint Annual Conference of the Austrian (ÖGBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation KW - extra-curricular offerings KW - education Y1 - U6 - http://dx.doi.org/https://doi.org/10.1515/bmt-2022-2001 SP - 348 ER - TY - GEN A1 - Nemec, Iris A1 - Malaskova, Michaela A1 - Pereira, Luis A1 - Pavao, Joao A1 - Frohner, Matthias T1 - Experiences of intercultural teaching activities in the field of eHealth T2 - Abstracts of the 2022 Joint Annual Conference of the Austrian (ÖGBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation KW - intercultural teaching KW - eHealth Y1 - U6 - http://dx.doi.org/https://doi.org/10.1515/bmt-2022-2001 SP - 351 ER - TY - GEN A1 - Traxler, Lukas A1 - Balz, Andrea T1 - Current Advances in the Optical Characterization of Intraocular Lenses T2 - Abstracts of the 2022 Joint Annual Conference of the Austrian (ÖGBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation KW - Intraocular Lenses Y1 - U6 - http://dx.doi.org/https://doi.org/10.1515/bmt-2022-2001 SP - 102 ER - TY - JOUR A1 - Hanetseder, Dominik A1 - Levstek, Tina A1 - Teuschl-Woller, Andreas A1 - Frank, Julia Katharina A1 - Schaedl, Barbara A1 - Redl, Heinz A1 - Marolt Presen, Darja T1 - Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age JF - Front Bioeng Biotechnol N2 - Regeneration of bone defects is often limited due to compromised bone tissue physiology. Previous studies suggest that engineered extracellular matrices enhance the regenerative capacity of mesenchymal stromal cells. In this study, we used human-induced pluripotent stem cells, a scalable source of young mesenchymal progenitors (hiPSC-MPs), to generate extracellular matrix (iECM) and test its effects on the osteogenic capacity of human bone-marrow mesenchymal stromal cells (BMSCs). iECM was deposited as a layer on cell culture dishes and into three-dimensional (3D) silk-based spongy scaffolds. After decellularization, iECM maintained inherent structural proteins including collagens, fibronectin and laminin, and contained minimal residual DNA. Young adult and aged BMSCs cultured on the iECM layer in osteogenic medium exhibited a significant increase in proliferation, osteogenic marker expression, and mineralization as compared to tissue culture plastic. With BMSCs from aged donors, matrix mineralization was only detected when cultured on iECM, but not on tissue culture plastic. When cultured in 3D iECM/silk scaffolds, BMSCs exhibited significantly increased osteogenic gene expression levels and bone matrix deposition. iECM layer showed a similar enhancement of aged BMSC proliferation, osteogenic gene expression, and mineralization compared with extracellular matrix layers derived from young adult or aged BMSCs. However, iECM increased osteogenic differentiation and decreased adipocyte formation compared with single protein substrates including collagen and fibronectin. Together, our data suggest that the microenvironment comprised of iECM can enhance the osteogenic activity of BMSCs, providing a bioactive and scalable biomaterial strategy for enhancing bone regeneration in patients with delayed or failed bone healing. KW - aging KW - iPSCs KW - osteogenic differentiation KW - bone marrow stromal cells KW - extracellular matrix Y1 - U6 - http://dx.doi.org/https://doi.org/10.3389/fbioe.2023.1214019 VL - 11 ER - TY - JOUR A1 - Bernhard, Jonathan C A1 - Marolt Presen, Darja A1 - Li, Ming A1 - Monforte, Xavier A1 - Ferguson, James A1 - Leinfellner, Gabriele A1 - Heimel, Patrick A1 - Betti, Susanne L A1 - Shu, Sharon A1 - Teuschl-Woller, Andreas H A1 - Tangl, Stefan A1 - Redl, Heinz A1 - Vunjak-Novakovic, Gordana T1 - Effects of Endochondral and Intramembranous Ossification Pathways on Bone Tissue Formation and Vascularization in Human Tissue-Engineered Grafts JF - Cells N2 - Bone grafts can be engineered by differentiating human mesenchymal stromal cells (MSCs) via the endochondral and intramembranous ossification pathways. We evaluated the effects of each pathway on the properties of engineered bone grafts and their capacity to drive bone regeneration. Bone-marrow-derived MSCs were differentiated on silk scaffolds into either hypertrophic chondrocytes (hyper) or osteoblasts (osteo) over 5 weeks of in vitro cultivation, and were implanted subcutaneously for 12 weeks. The pathways' constructs were evaluated over time with respect to gene expression, composition, histomorphology, microstructure, vascularization and biomechanics. Hypertrophic chondrocytes expressed higher levels of osteogenic genes and deposited significantly more bone mineral and proteins than the osteoblasts. Before implantation, the mineral in the hyper group was less mature than that in the osteo group. Following 12 weeks of implantation, the hyper group had increased mineral density but a similar overall mineral composition compared with the osteo group. The hyper group also displayed significantly more blood vessel infiltration than the osteo group. Both groups contained M2 macrophages, indicating bone regeneration. These data suggest that, similar to the body's repair processes, endochondral pathway might be more advantageous when regenerating large defects, whereas intramembranous ossification could be utilized to guide the tissue formation pattern with a scaffold architecture. KW - bone tissue engineering KW - endochondral KW - mesenchymal stromal cells KW - ossification KW - intramembranous Y1 - U6 - http://dx.doi.org/10.3390/cells11193070 VL - 11 IS - 19:3070 ER - TY - JOUR A1 - Gollmann-Tepeköylü, Can A1 - Graber, Michael A1 - Hirsch, Jakob A1 - Mair, Sophia A1 - Naschberger, Andreas A1 - Pölzl, Leo A1 - Nägele, Felix A1 - Kirchmair, Elke A1 - Degenhart, Gerald A1 - Demetz, Egon A1 - Hilbe, Richard A1 - Chen, Hao-Yu A1 - Engert, James C A1 - Böhm, Anna A1 - Franz, Nadja A1 - Lobenwein, Daniela A1 - Lener, Daniela A1 - Fuchs, Christiane A1 - Weihs, Anna A1 - Töchterle, Sonja A1 - Vogel, Georg F A1 - Schweiger, Victor A1 - Eder, Jonas A1 - Pietschmann, Peter A1 - Seifert, Markus A1 - Kronenberg, Florian A1 - Coassin, Stefan A1 - Blumer, Michael A1 - Hackl, Hubert A1 - Meyer, Dirk A1 - Feuchtner, Gudrun A1 - Kirchmair, Rudolf A1 - Troppmair, Jakob A1 - Krane, Markus A1 - Weiss, Günther A1 - Tsimikas, Sotirios A1 - Thanassoulis, George A1 - Grimm, Michael A1 - Rupp, Bernhard A1 - Huber, Lukas A A1 - Zhang, Shen-Ying A1 - Casanova, Jean-Laurent A1 - Tancevski, Ivan A1 - Holfeld, Johannes T1 - Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification JF - Circulation KW - Toll-like receptor 3 KW - aortic valve disease KW - biglycan KW - extracellular matrix KW - osteogenesis Y1 - U6 - http://dx.doi.org/10.1161/CIRCULATIONAHA.122.063481 VL - 147 IS - 20 SP - 1518 EP - 1533 ER - TY - GEN A1 - Balz, Andrea A1 - Langer, Sarah A1 - Frohner, Matthias A1 - Forjan, Mathias T1 - Development of Internationalized Teaching and Training Modules for Healthcare Professionals T2 - Abstracts of the 2022 Joint Annual Conference of the Austrian (ÖGBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation KW - Internationalized Teaching KW - Healthcare Y1 - U6 - http://dx.doi.org/https://doi.org/10.1515/bmt-2022-2001 SP - 353 ER - TY - JOUR A1 - Xu, Yingyang A1 - Gepp, Barbara A1 - Lengger, Nina A1 - Yin, Jia A1 - Breiteneder, Heimo T1 - Identification of probable pectinesterase as a major allergen of pollen of the Asian white birch (Betula platyphylla) in northern China JF - Asian Pac J Allergy Immunol KW - birch pollen allergy KW - betula platyphylla KW - chinese population KW - major allergen KW - pectinesterase Y1 - U6 - http://dx.doi.org/10.12932/AP-100722-1409 ER - TY - GEN A1 - Eidi, Nada A1 - Balz, Andrea A1 - Forjan, Mathias T1 - MedTech-mR - Creating a Virtual Enviroment for Medical Training and Room Planning T2 - Abstracts of the 2022 Joint Annual Conference of the Austrian (ÖGBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation KW - Medical Training KW - Virtual Environment Y1 - U6 - http://dx.doi.org/https://doi.org/10.1515/bmt-2022-2001 SP - 349 ER - TY - GEN A1 - Malaskova, Michaela A1 - Forjan, Mathias T1 - Current topics in Life Science Engineering lectures T2 - Abstracts of the 2022 Joint Annual Conference of the Austrian (ÖGBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, including the 14th Vienna International Workshop on Functional Electrical Stimulation KW - Life Science Engineering KW - Teaching Y1 - U6 - http://dx.doi.org/https://doi.org/10.1515/bmt-2022-2001 SP - 350 ER - TY - JOUR A1 - Romanelli, Pasquale A1 - Bieler, Lara A1 - Heimel, Patrick A1 - Škokić, Siniša A1 - Jakubecova, Dominika A1 - Kreutzer, Christina A1 - Zaunmair, Pia A1 - Smolčić, Tomislav A1 - Benedetti, Bruno A1 - Rohde, Eva A1 - Gimona, Mario A1 - Hercher, David A1 - Dobrivojević Radmilović, Marina A1 - Couillard-Despres, Sebastien T1 - Enhancing Functional Recovery Through Intralesional Application of Extracellular Vesicles in a Rat Model of Traumatic Spinal Cord Injury JF - Front Cell Neurosci N2 - Local inflammation plays a pivotal role in the process of secondary damage after spinal cord injury. We recently reported that acute intravenous application of extracellular vesicles (EVs) secreted by human umbilical cord mesenchymal stromal cells dampens the induction of inflammatory processes following traumatic spinal cord injury. However, systemic application of EVs is associated with delayed delivery to the site of injury and the necessity for high doses to reach therapeutic levels locally. To resolve these two constraints, we injected EVs directly at the lesion site acutely after spinal cord injury. We report here that intralesional application of EVs resulted in a more robust improvement of motor recovery, assessed with the BBB score and sub-score, as compared to the intravenous delivery. Moreover, the intralesional application was more potent in reducing inflammation and scarring after spinal cord injury than intravenous administration. Hence, the development of EV-based therapy for spinal cord injury should aim at an early application of vesicles close to the lesion. KW - exosomes KW - inflammation KW - locomotion KW - neuroimaging KW - motor function Y1 - U6 - http://dx.doi.org/10.3389/fncel.2021.795008 VL - 15 ER - TY - JOUR A1 - Feichtinger, Xaver A1 - Heimel, Patrick A1 - Tangl, Stefan A1 - Keibl, Claudia A1 - Nürnberger, Sylvia A1 - Schanda, Jakob Emanuel A1 - Hercher, David A1 - Kocijan, Roland A1 - Redl, Heinz A1 - Grillari, Johannes A1 - Fialka, Christian A1 - Mittermayr, Rainer T1 - Improved biomechanics in experimental chronic rotator cuff repair after shockwaves is not reflected by bone microarchitecture JF - PLoS One KW - chronic rotator cuff repair KW - bone microarchitecture Y1 - U6 - http://dx.doi.org/10.1371/journal.pone.0262294 VL - 17 IS - 1 ER - TY - THES A1 - Tomasch, Janine T1 - Strategies to improve the myogenic outcome of skeletal muscle tissue engineering approaches through optimization of biomaterial properties and mechanical stimuli KW - muscle KW - bioreactor KW - tissue engineering KW - fibrin KW - biomaterial Y1 - ER -