TY  - JOUR
A1  - Romanelli, Pasquale
A1  - Bieler, Lara
A1  - Heimel, Patrick
A1  - Škokić, Siniša
A1  - Jakubecova, Dominika
A1  - Kreutzer, Christina
A1  - Zaunmair, Pia
A1  - Smolčić, Tomislav
A1  - Benedetti, Bruno
A1  - Rohde, Eva
A1  - Gimona, Mario
A1  - Hercher, David
A1  - Dobrivojević Radmilović, Marina
A1  - Couillard-Despres, Sebastien
T1  - Enhancing Functional Recovery Through Intralesional Application of Extracellular Vesicles in a Rat Model of Traumatic Spinal Cord Injury
JF  - Front Cell Neurosci
N2  - Local inflammation plays a pivotal role in the process of secondary damage after spinal cord injury. We recently reported that acute intravenous application of extracellular vesicles (EVs) secreted by human umbilical cord mesenchymal stromal cells dampens the induction of inflammatory processes following traumatic spinal cord injury. However, systemic application of EVs is associated with delayed delivery to the site of injury and the necessity for high doses to reach therapeutic levels locally. To resolve these two constraints, we injected EVs directly at the lesion site acutely after spinal cord injury. We report here that intralesional application of EVs resulted in a more robust improvement of motor recovery, assessed with the BBB score and sub-score, as compared to the intravenous delivery. Moreover, the intralesional application was more potent in reducing inflammation and scarring after spinal cord injury than intravenous administration. Hence, the development of EV-based therapy for spinal cord injury should aim at an early application of vesicles close to the lesion.
KW  - exosomes
KW  - inflammation
KW  - locomotion
KW  - neuroimaging
KW  - motor function
Y1  - 
U6  - http://dx.doi.org/10.3389/fncel.2021.795008
VL  - 15
ER  - 
TY  - JOUR
A1  - Feichtinger, Xaver
A1  - Heimel, Patrick
A1  - Tangl, Stefan
A1  - Keibl, Claudia
A1  - Nürnberger, Sylvia
A1  - Schanda, Jakob Emanuel
A1  - Hercher, David
A1  - Kocijan, Roland
A1  - Redl, Heinz
A1  - Grillari, Johannes
A1  - Fialka, Christian
A1  - Mittermayr, Rainer
T1  - Improved biomechanics in experimental chronic rotator cuff repair after shockwaves is not reflected by bone microarchitecture
JF  - PLoS One
KW  - chronic rotator cuff repair
KW  - bone microarchitecture
Y1  - 
U6  - http://dx.doi.org/10.1371/journal.pone.0262294
VL  - 17
IS  - 1
ER  - 
TY  - THES
A1  - Tomasch, Janine
T1  - Strategies to improve the myogenic outcome of skeletal muscle tissue engineering approaches through optimization of biomaterial properties and mechanical stimuli
KW  - muscle
KW  - bioreactor
KW  - tissue engineering
KW  - fibrin
KW  - biomaterial
Y1  - 
ER  -