TY - CHAP A1 - Salzbrunn, Benedikt A1 - Busch, Marc A1 - della Schiava, Marco A1 - Kipke, Christine T1 - rapid UX-score: Modulare und Adaptive Messung von User Experience T2 - Mensch und Computer 2020 - Workshopband KW - UX Messung KW - Modulare UX Messung KW - Adaptive UX Messung KW - Rasch-Modell Y1 - ER - TY - JOUR A1 - Huber, Albert T1 - The gravitational field of a massless particle on the horizon of a stationary black hole JF - Classical and Quantum Gravity N2 - In this work, the field of a gravitational shockwave generated by a massless point-like particle is calculated at the event horizon of a stationary Kerr–Newman black hole. Using the geometric framework of generalized Kerr–Schild deformations in combination with the spin-coefficient formalism of Newman and Penrose, it is shown that the field equations of the theory, at the event horizon of the black hole, can be reduced to a single linear ordinary differential equation for the so-called profile function of the geometry. This differential relation is solved exactly. Based on the results obtained, a physical interpretation is given for the found shockwave spacetime, and it is clarified how these results lead back to those of previous works on the subject, which deal with the much simpler cases of gravitational shockwaves in static black hole backgrounds. KW - Gravitation Y1 - ER - TY - JOUR A1 - Hoffmann, Michael E. A1 - Kuba, Markus T1 - Logarithmic integrals, zeta values, and tiered binomial coeffcients JF - Monatshefte fuer Mathematik KW - Integrals KW - Binomial KW - Coefficient Y1 - ER - TY - JOUR A1 - Belkacem, Kévin A1 - Kupka, Friedrich A1 - Philidet, Jordan A1 - Samadi, Réza T1 - Surface effects and turbulent pressure. Assessing the Gas-Γ1 and Reduced-Γ1 empirical models. JF - Astronomy & Astrophysics KW - Surface KW - Pressure Y1 - ER - TY - JOUR A1 - Huber, Albert T1 - Junction Conditions and local Spacetimes in General Relativity JF - The European Physical Journal C N2 - In the present work, a theoretical framework focussing on local geometric deformations is introduced in order to cope with the problem of how to join spacetimes with different geometries and physical properties. This framework is used to show that two Lorentzian manifolds can be matched by considering local deformations of the associated spacetime metrics. Based on the fact that metrics can be suitably matched in this way, it is shown that the underlying geometric approach allows the characterization of local spacetimes in general relativity. Furthermore, it is shown that said approach not only extends the conventional thin shell formalism, but also allows the treatment of geometric problems that cannot be treated with standard gluing techniques. KW - Relativity Y1 - ER - TY - JOUR A1 - Schätti, Jonas A1 - Köhler, Valentin A1 - Mayor, Marcel A1 - Fein, Yaakov A1 - Geyer, Philipp A1 - Mairhofer, Lukas A1 - Gerlich, Stefan A1 - Arndt, Markus T1 - Matter-wave interference and deflection of tripeptides decorated with fluorinated alkyl chains JF - Journal of Mass Spectrometry KW - interference KW - quantum KW - meteorology Y1 - IS - Vol 55, issue 6 ER - TY - JOUR A1 - Hoffmann, Michael E. A1 - Kuba, Markus A1 - Levy, Moti A1 - Louchard, Guy T1 - An Asymptotic Series for an Integral JF - Ramanujan Journal KW - Asymptotic KW - Integral Y1 - ER - TY - JOUR A1 - Zupkovitz, Gordin A1 - Kabiljo, Julijan A1 - Kothmayer, Michael A1 - Schlick, Katharina A1 - Schöfer, Christian A1 - Lagger, Sabine A1 - Pusch, Oliver T1 - Analysis of Methylation Dynamics Reveals a Tissue-Specific, Age-Dependent Decline in 5-Methylcytosine Within the Genome of the Vertebrate Aging Model Nothobranchius furzeri. JF - Frontiers in Molecular Biosciences N2 - Erosion of the epigenetic DNA methylation landscape is a widely recognized hallmark of aging. Emerging advances in high throughput sequencing techniques, in particular DNA methylation data analysis, have resulted in the establishment of precise human and murine age prediction tools. In vertebrates, methylation of cytosine at the C5 position of CpG dinucleotides is executed by DNA methyltransferases (DNMTs) whereas the process of enzymatic demethylation is highly dependent on the activity of the ten-eleven translocation methylcytosine dioxygenase (TET) family of enzymes. Here, we report the identification of the key players constituting the DNA methylation machinery in the short-lived teleost aging model Nothobranchius furzeri. We present a comprehensive spatio-temporal expression profile of the methylation-associated enzymes from embryogenesis into late adulthood, thereby covering the complete killifish life cycle. Data mining of the N. furzeri genome produced five dnmt gene family orthologues corresponding to the mammalian DNMTs (DNMT1, 2, 3A, and 3B). Comparable to other teleost species, N. furzeri harbors multiple genomic copies of the de novo DNA methylation subfamily. A related search for the DNMT1 recruitment factor UHRF1 and TET family members resulted in the identification of N. furzeri uhrf1, tet1, tet2, and tet3. Phylogenetic analysis revealed high cross-species similarity on the amino acid level of all individual dnmts, tets, and uhrf1, emphasizing a high degree of functional conservation. During early killifish development all analyzed dnmts and tets showed a similar expression profile characterized by a strong increase in transcript levels after fertilization, peaking either at embryonic day 6 or at the black eye stage of embryonic development. In adult N. furzeri, DNA methylation regulating enzymes showed a ubiquitous tissue distribution. Specifically, we observed an age-dependent downregulation of dnmts, and to some extent uhrf1, which correlated with a significant decrease in global DNA methylation levels in the aging killifish liver and muscle. The age-dependent DNA methylation profile and spatio-temporal expression characteristics of its enzymatic machinery reported here may serve as an essential platform for the identification of an epigenetic aging clock in the new vertebrate model system N. furzeri. KW - Tissue Engineering KW - Killifish KW - Aging Model Y1 - VL - 8 IS - 627143 ER - TY - CHAP A1 - Wießner, Katharina A1 - Machacek-Link, Thomas A1 - Leitner, Rita T1 - Encouraging the development of higher-order cognitive skills via applied exercises and web-based self-assessment to teach the basic principles in molecular biology. T2 - PIXEL NPSE2021, März 2021 N2 - The responsibility of a lecturer is not only to share his or her knowledge with the students in an easy to understand manner, but also to help the students to embed new knowledge and to encourage the development of higher-order cognitive skills via applied exercises. In order to meet the growing demand for blended learning approaches a new course concept was established in autumn 2018. To enhance comprehension and to provide opportunities for self-assessment, web-based training units were implemented by using the interactive learning software “Articulate Storyline”. Students had to prepare at home for the course units by completing interactive chapters. Their learning outcome was assessed by online quizzes at the end of each chapter. Online Training chapters allowed time to focus on selected topics and to repeat key messages in following presence units. Additionally, guided group exercises were performed to promote analytic skills and abstract thinking. The students had to apply and combine their knowledge to solve problem-based challenges. An optional revision course was offered to the students, which allowed for interactive repetition of the acquired knowledge with the focus on student-to-lecturer dialog. An analysis based on a written evaluation of this course resulted in a positive feedback from the students, in particular regarding the guided exercises and the offered revision course. According to the students the group exercises allowed to process the learned subjects, promoted the group climate and were a convenient diversion from the frontal lecture format. Students who attended the revision course on a regular basis showed a better performance at the final exam and exceeded especially at interdisciplinary questions. The first implementation of this master´s degree course indicated that the combination of web-based training elements with frontal lecture elements, guided exercises stimulating cognitive skills and an optional revision course can teach students the basics of biology in an understandable way. This course structure is especially applicable to teach basic subjects for groups of students with varying initial knowledge. Financial support from the City of Vienna project PBL in Molecular Life Science (21-06) is gratefully acknowledged. KW - PBL KW - Didaktik KW - Lehre Y1 - ER - TY - JOUR A1 - Khimich, Margarita A. A1 - Prosolov, Konstantin A. A1 - Mishurova, Tatiana A1 - Evsevleev, Sergej A1 - Monforte, Xavier A1 - Teuschl, Andreas H. A1 - Slezak, Paul A1 - Ibragimov, Egor A. A1 - Saprykin, Alexander A. A1 - Kovalevskaya, Zhanna G. A1 - Dmitriev, Andrey I. A1 - Bruno, Giovanni A1 - Sharkeev, Yurii P. T1 - Advances in Laser Additive Manufacturing of Ti-Nb Alloys: From Nanostructured Powders to Bulk Objects JF - Nanomaterials (Basel) N2 - The additive manufacturing of low elastic modulus alloys that have a certain level of porosity for biomedical needs is a growing area of research. Here, we show the results of manufacturing of porous and dense samples by a laser powder bed fusion (LPBF) of Ti-Nb alloy, using two distinctive fusion strategies. The nanostructured Ti-Nb alloy powders were produced by mechanical alloying and have a nanostructured state with nanosized grains up to 90 nm. The manufactured porous samples have pronounced open porosity and advanced roughness, contrary to dense samples with a relatively smooth surface profile. The structure of both types of samples after LPBF is formed by uniaxial grains having micro- and nanosized features. The inner structure of the porous samples is comprised of an open interconnected system of pores. The volume fraction of isolated porosity is 2 vol. % and the total porosity is 20 vol. %. Cell viability was assessed in vitro for 3 and 7 days using the MG63 cell line. With longer culture periods, cells showed an increased cell density over the entire surface of a porous Ti-Nb sample. Both types of samples are not cytotoxic and could be used for further in vivo studies. KW - Tissue Engineering KW - Biomaterials KW - Laser Additive Manufacturing KW - Bulk Objects Y1 - VL - 11 IS - 5 / 1159 ER - TY - JOUR A1 - Farokhi, Maryam A1 - Aleemardani, Mina A1 - Solouk, Atefeh A1 - Mirzadeh, Hamid A1 - Teuschl, Andreas Herbert A1 - Redl, Heinz T1 - Crosslinking strategies for silk fibroin hydrogels: promising biomedical materials JF - Biomedical Materials N2 - Due to their strong biomimetic potential, silk fibroin (SF) hydrogels are impressive candidates for tissue engineering, due to their tunable mechanical properties, biocompatibility, low immunotoxicity, controllable biodegradability, and a remarkable capacity for biomaterial modification and the realization of a specific molecular structure. The fundamental chemical and physical structure of SF allows its structure to be altered using various crosslinking strategies. The established crosslinking methods enable the formation of three-dimensional (3D) networks under physiological conditions. There are different chemical and physical crosslinking mechanisms available for the generation of SF hydrogels (SFHs). These methods, either chemical or physical, change the structure of SF and improve its mechanical stability, although each method has its advantages and disadvantages. While chemical crosslinking agents guarantee the mechanical strength of SFH through the generation of covalent bonds, they could cause some toxicity, and their usage is not compatible with a cell-friendly technology. On the other hand, physical crosslinking approaches have been implemented in the absence of chemical solvents by the induction of β-sheet conformation in the SF structure. Unfortunately, it is not easy to control the shape and properties of SFHs when using this method. The current review discusses the different crosslinking mechanisms of SFH in detail, in order to support the development of engineered SFHs for biomedical applications. KW - Tissue Engineering KW - hydrogels KW - Biomaterials KW - silk fibroin Y1 - VL - 16 IS - 2 SP - 022004 ER - TY - JOUR A1 - Bachmann, Barbara A1 - Spitz, Sarah A1 - Schädl, Barbara A1 - Teuschl, Andreas A1 - Redl, Heinz A1 - Nürnberger, Sylvia A1 - Ertl, Peter T1 - Stiffness Matters: Fine-Tuned Hydrogel Elasticity Alters Chondrogenic Redifferentiation JF - Froniers in Bioengineering and Biotechnology N2 - Biomechanical cues such as shear stress, stretching, compression, and matrix elasticity are vital in the establishment of next generation physiological in vitro tissue models. Matrix elasticity, for instance, is known to guide stem cell differentiation, influence healing processes and modulate extracellular matrix (ECM) deposition needed for tissue development and maintenance. To better understand the biomechanical effect of matrix elasticity on the formation of articular cartilage analogs in vitro, this study aims at assessing the redifferentiation capacity of primary human chondrocytes in three different hydrogel matrices of predefined matrix elasticities. The hydrogel elasticities were chosen to represent a broad spectrum of tissue stiffness ranging from very soft tissues with a Young's modulus of 1 kPa up to elasticities of 30 kPa, representative of the perichondral-space. In addition, the interplay of matrix elasticity and transforming growth factor beta-3 (TGF-β3) on the redifferentiation of primary human articular chondrocytes was studied by analyzing both qualitative (viability, morphology, histology) and quantitative (RT-qPCR, sGAG, DNA) parameters, crucial to the chondrotypic phenotype. Results show that fibrin hydrogels of 30 kPa Young's modulus best guide chondrocyte redifferentiation resulting in a native-like morphology as well as induces the synthesis of physiologic ECM constituents such as glycosaminoglycans (sGAG) and collagen type II. This comprehensive study sheds light onto the mechanobiological impact of matrix elasticity on formation and maintenance of articular cartilage and thus represents a major step toward meeting the need for advanced in vitro tissue models to study both re- and degeneration of articular cartilage. KW - Tissue Engineering KW - Chondrogenic Redifferentiation KW - Biomaterials Y1 - 2021 VL - 2020 IS - 8 SP - 373 ER - TY - JOUR A1 - Ziadlou, Reihane A1 - Rotman, Stijn A1 - Teuschl, Andreas A1 - Salzer, Elias A1 - Barbero, Andrea A1 - Martin, Ivan A1 - Alini, Mauro A1 - Eglin, David A1 - Grad, Sibylle T1 - Optimization of hyaluronic acid-tyramine/silk-fibroin composite hydrogels for cartilage tissue engineering and delivery of anti-inflammatory and anabolic drugs JF - Materials Science and Engineering: C N2 - Injury of articular cartilage leads to an imbalance in tissue homeostasis, and due to the poor self-healing capacity of cartilage the affected tissue often exhibits osteoarthritic changes. In recent years, injectable and highly tunable composite hydrogels for cartilage tissue engineering and drug delivery have been introduced as a desirable alternative to invasive treatments. In this study, we aimed to formulate injectable hydrogels for drug delivery and cartilage tissue engineering by combining different concentrations of hyaluronic acid-tyramine (HA-Tyr) with regenerated silk-fibroin (SF) solutions. Upon enzymatic crosslinking, the gelation and mechanical properties were characterized over time. To evaluate the effect of the hydrogel compositions and properties on extracellular matrix (ECM) deposition, bovine chondrocytes were embedded in enzymatically crosslinked HA-Tyr/SF composites (in further work abbreviated as HA/SF) or HA-Tyr hydrogels. We demonstrated that all hydrogel formulations were cytocompatible and could promote the expression of cartilage matrix proteins allowing chondrocytes to produce ECM, while the most prominent chondrogenic effects were observed in hydrogels with HA20/SF80 polymeric ratios. Unconfined mechanical testing showed that the compressive modulus for HA20/SF80 chondrocyte-laden constructs was increased almost 10-fold over 28 days of culture in chondrogenic medium which confirmed the superior production of ECM in this hydrogel compared to other hydrogels in this study. Furthermore, in hydrogels loaded with anabolic and anti-inflammatory drugs, HA20/SF80 hydrogel showed the longest and the most sustained release profile over time which is desirable for the long treatment duration typically necessary for osteoarthritic joints. In conclusion, HA20/SF80 hydrogel was successfully established as a suitable injectable biomaterial for cartilage tissue engineering and drug delivery applications. KW - Tissue Engineering KW - Cartilage KW - Mechanical Testing KW - Biomaterials KW - Chondrocytes Y1 - VL - 120 IS - 111701 ER - TY - JOUR A1 - Mandl, Thomas A1 - Sinelnikova, Anna A1 - Östlin, Christofer A1 - Grånäs, Oscar A1 - Brodmerkel, Maxim N. A1 - Markl, Erik G. A1 - Caleman, Carl T1 - Reproducibility in the unfolding process of protein induced by an external electric field JF - Chemical Science N2 - The dynamics of proteins are crucial for their function. However, commonly used techniques for studying protein structures are limited in monitoring time-resolved dynamics at high resolution. Combining electric fields with existing techniques to study gas-phase proteins, such as single particle imaging using free-electron lasers and gas-phase small angle X-ray scattering, has the potential to open up a new era in time-resolved studies of gas-phase protein dynamics. Using molecular dynamics simulations, we identify well-defined unfolding pathways of a protein, induced by experimentally achievable external electric fields. Our simulations show that strong electric fields in conjunction with short-pulsed X-ray sources such as free-electron lasers can be a new path for imaging dynamics of gas-phase proteins at high spatial and temporal resolution. KW - Reproducibility protein Y1 - ER - TY - JOUR A1 - Sinelnikova, Anna A1 - Mandl, Thomas A1 - Agelii, Harald A1 - Grånäs, Oscar A1 - Marklund, Erik G. A1 - Caleman, Carl A1 - De Santis, Emiliano T1 - Protein orientation in time-dependent electric fields: orientation before destruction JF - Biophysical Journal KW - Protein KW - Electric Fields Y1 - IS - Volume 120, Issue 17 SP - 3709 EP - 3717 ER - TY - JOUR A1 - Munsch, Nicolas A1 - Martin, Alistair A1 - Gruarin, Stefanie A1 - Nateqi, Jama A1 - Abdarahmane, Isselmou A1 - Weingartner-Ortner, Rafael A1 - Knapp, Bernhard T1 - Authors’ Reply to: Screening Tools: Their Intended Audiences and Purposes. Comment on “Diagnostic Accuracy of Web-Based COVID-19 Symptom Checkers: Comparison Study” JF - Journal of Medical Internet Research KW - COVID-19 KW - Symptom Checkers KW - Digital Health Y1 - IS - Vol 23, No 5 (2021) ER - TY - CHAP A1 - Dolezal, Dominik T1 - Educational Design Patterns for Student-Centered 21st Century Learning in Technology-Enhanced Learning Environments T2 - Educating Engineers for Future Industrial Revolutions: Proceedings of the 23rd International Conference on Interactive Collaborative Learning (ICL2020) KW - 21st century skills KW - student-centered learning KW - educational design patterns Y1 - ER - TY - CHAP A1 - Dolezal, Dominik T1 - The Learning Office Approach to Modern 21st Century Education: Third Evaluation of a Self-Driven Concept for Student-Centered Engineering Education T2 - IEEE 50th Annual Frontiers in Education Conference KW - learning office KW - 21st century skills KW - student-centered learning KW - computer science education KW - person-centered approach Y1 - ER - TY - JOUR A1 - Kuba, Markus A1 - Varvak, Anna T1 - On Path diagrams and Stirling permutations JF - Séminaire Lotharingien de Combinatoire N2 - A permutation can be locally classified according to the four local types: peaks, valleys, double rises and double falls. The corresponding classification of binary increasing trees uses four different types of nodes. Flajolet demonstrated the continued fraction representation of the generating function of local types, using a classical bijection between permutations, binary increasing trees, and suitably defined path diagrams induced by Motzkin paths. The aim of this article is to extend the notion of local types from permutations to k-Stirling permutations (also known as k-multipermutations). We establish a bijection of these local types to node types of (k+1)-ary increasing trees. We present a branched continued fraction representation of the generating function of these local types through a bijection with path diagrams induced by Łukasiewicz paths, generalizing the results from permutations to arbitrary k-Stirling permutations. We further show that the generating function of ordinary Stirling permutation has at least three branched continued fraction representations, using correspondences between non-standard increasing trees, k-Stirling permutations and path diagrams. KW - Kettenbruch KW - Formale Potenzreihe KW - Continued fractions KW - Łukasiewicz paths KW - Path diagrams KW - Stirling permutations KW - Multipermutations KW - Increasing trees Y1 - 2021 IS - B82c (2021) ER - TY - GEN A1 - Kupka, Friedrich T1 - Improvements to the Short-Characteristics Method in 3D RHD Simulations and some Unsolved Problems in Spectral Line Shapes of A-type Stars KW - Convection KW - Radiative transfer KW - Methods: spectroscopy KW - Methods: numerical Y1 - ER - TY - GEN A1 - Kupka, Friedrich T1 - Improvements in Numerical and Analytical Modelling Techniques to Study the Solar Surface KW - Convection KW - Stars: Sun KW - Methods: numerical KW - Radiative transfer Y1 - ER - TY - GEN A1 - Kupka, Friedrich T1 - Advanced Convection Modelling in Asteroseismology and Stellar Evolution KW - Convection KW - Asteroseismology KW - Stars: evolution Y1 - ER - TY - GEN A1 - Knapp, Bernhard T1 - Ten simple rules for a successful cross-disciplinary collaboration N2 - Cross-disciplinary collaborations have become an increasingly important part of science. They are seen as key if we are to find solutions to pressing, global-scale societal challenges, including green technologies, sustainable food production, and drug development. The synergistic and skillful combining of different disciplines can achieve insight beyond current borders and thereby generate novel solutions to complex problems. The combination of methods and data from different fields can achieve more than the sum of the individual parts could do alone. Initiating and successfully maintaining cross-disciplinary collaborations can be challenging but highly rewarding. In this talk I will focus on the specific challenges associated with cross-disciplinary research, from the perspective of the theoretician in particular. Based on “10 simple rules” (https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004214) I will describe the key benefits, as well as some possible pitfalls, arising from collaborations between scientists with very different backgrounds. KW - Cross-disciplinary collaboration Y1 - ER - TY - BOOK A1 - Lehner, Martin T1 - Didaktische Reduktion KW - Didaktik Y1 - 2020 PB - Haupt CY - Bern, Stuttgart, Wien ER - TY - BOOK A1 - Lehner, Martin T1 - Viel Stoff – wenig Zeit, Wege aus der Vollständigkeitsfalle KW - Zeit Y1 - 2020 PB - Haupt CY - Bern, Stuttgart, Wien ER - TY - BOOK A1 - Wala, Thomas T1 - Innovations- und Technologiemanagement KW - Innovationsmanagement Y1 - 2020 SN - 9798681627715 PB - Amazon ER - TY - JOUR A1 - Wala, Thomas T1 - Die betriebswirtschaftliche Klausur: Controlling JF - WISU KW - Controlling Y1 - 2020 IS - 5 ER - TY - JOUR A1 - Knoll, Leonhard A1 - Tartler, Thomas A1 - Wala, Thomas T1 - Marktrisikoprämie in Österreich: ein halbes Jahrhundert kein klarer Sieger bei Aktie vs Anleihe JF - CFO Aktuell KW - Aktie KW - Marktrisikoprämie Y1 - IS - Jänner 2021 SP - 12 EP - 15 ER - TY - JOUR A1 - Wala, Thomas T1 - Die betriebswirtschaftliche Klausur: Kostenrechnung. JF - WISU KW - Betriebswirtschaftslehre KW - Kostenrechnung Y1 - IS - 6, 2021 SP - 681 EP - 684 ER - TY - CHAP A1 - Wala, Thomas A1 - Felleitner-Goll, Katharina T1 - Rahmenbedingungen der betrieblichen Innovationsarbeit T2 - Multidisziplinäre Perspektiven im Innovations-und Wissensmanagement T2 - Multidisciplinary Perspectives in Innovation and Knowledge Management KW - Betriebswirtschaftslehre KW - Innovationsarbeit Y1 - SP - 37 EP - 58 PB - Peter Lang CY - Berlin ER - TY - CHAP A1 - Salmen, Christine T1 - Erzählungen vom Umbruch in Rumänien 1989 T2 - Der Fall des Eisernen Vorhangs 1989 und die Folgen: europäische pädagogische Perspektiven KW - Eiserne Vorhang KW - Rumänien Y1 - PB - LIT Verlag ER - TY - JOUR A1 - Wöber, Wilfried A1 - Rauer, Johannes A1 - Papa, Maximilian A1 - Aburaia, Ali A1 - Schwaiger, Simon A1 - Novotny, Georg A1 - Aburaia, Mohamed A1 - Kubinger, Wilfried T1 - Evaluierung von Navigationsmethoden für mobile Roboter JF - e & i Elektrotechnik und Informationstechnik KW - Robotics KW - Machine Learning KW - Industry 4.0 Y1 - 2020 ER - TY - CHAP A1 - Kriegler, Andreas A1 - Wöber, Wilfried A1 - Aburaia, Mohamed T1 - Artificial Neural Networks Based Place Categorization T2 - Digital Conversion on the Way to Industry 4.0 KW - Artificial Intelligence Y1 - SP - 201 EP - 209 PB - Springer Verlag ER - TY - BOOK A1 - Wala, Thomas A1 - Ellinger, Florian A1 - Franz, Peter A1 - Kriz, Agnes A1 - Zangl, Sabine A1 - Sohm, Kurt A1 - Tabakovic, Momir A1 - Gollner, Helmut A1 - Adams, Mark A1 - Litzenberger, Stefan T1 - Internationalisierung von Fachhochschulstudiengängen.: Ideen, Konzepte & Erfahrungsberichte KW - Internationalisation Y1 - SN - ISBN-13 : ‎979-8650872184 PB - Independently Published ER - TY - JOUR A1 - Engelhardt-Nowitzki, Corinna A1 - Aburaia, Mohamed A1 - Otrebski, Richard A1 - Rauer, Johannes A1 - Orsolits, Horst T1 - Research-based teaching in Digital Manufacturing and Robotics – the Digital Factory at the UAS Technikum Wien as a Case Example JF - Procedia Manufacturing KW - Digital Factory KW - Virtual Reality KW - Robotics KW - Machine Learning Y1 - 2020 IS - Volume 45 SP - 164 EP - 170 ER - TY - JOUR A1 - Aburaia, Mohamed A1 - Bucher, Christoph A1 - Lackner, Maximilian A1 - Gonzalez-Gutierrez, Joamin A1 - Zhang, Haiguang A1 - Lammer, Herfried T1 - A Production Method for Standardized Continuous Fiber Reinforced FFF Filament JF - Biomaterials and Medical Applications KW - Filament KW - Production Y1 - 2020 ER - TY - CHAP A1 - Felber, Stefan Otto A1 - Aburaia, Mohamed A1 - Wöber, Wilfried A1 - Lackner, Maximilian T1 - Parameter Optimization for the 3D Print of Thermo-Plastic Pellets with an Industrial Robot T2 - Digital Conversion on the Way to Industry 4.0 KW - Thermo Plastics KW - Industrial Robot Y1 - SP - 236 EP - 247 ER - TY - JOUR A1 - Rauer, Johannes A1 - Aburaia, Mohamed A1 - Wöber, Wilfried T1 - Semi-Automatic Generation of Training Data for Neural Networks for 6D Pose Estimation and Robotic Graspin JF - Proceedings of Joint Austrian Computer Vision and Robotics Workshop 2020 KW - Robotics KW - Neural Networks Y1 - 2020 SP - 2 EP - 3 ER - TY - CHAP A1 - Kriegler, Andreas A1 - Wöber, Wilfried T1 - Vision-based Docking of a Mobile Robot T2 - Proceedings of the Joint Austrian Computer Vision and Robotics Workshop 2020 KW - Automation KW - Robotics Y1 - SP - 6 EP - 12 ER - TY - CHAP A1 - Orsolits, Horst T1 - Virtual Engineering Applied in a Digital Learning Factory T2 - Perspectives in Industry Digitalization and Advanced Manufacturing in the Black Sea Region KW - Virtual Engineering Y1 - 2021 ER - TY - CHAP A1 - Lackner, Maximilian A1 - Zangl, Sabine A1 - Lembacher, Harald A1 - Rüttinger, Norbert A1 - Fochler, Claus T1 - Non-wovens and recycling – An overview, International Conference on Recycling and Waste Water Management T2 - International Conference on Recycling and Waste Water Management KW - Environment KW - Sustainability KW - Recycling Y1 - 2020 ER - TY - GEN A1 - Markl, Erich A1 - Orsolits, Horst A1 - Stojicic, Dario T1 - Virtuelle Technologien in der Robotik KW - Robotics Y1 - ER - TY - CHAP A1 - Waller, Daniela T1 - Did COVID19 improve our teaching? T2 - ICERI - 13th annual International Conference of Education, Research and Innovation KW - Covid19 KW - teaching KW - eLearning KW - Distance Learning KW - didactic Y1 - ER - TY - GEN A1 - Tabakovic, Momir A1 - Hemis, Herbert T1 - Energieversorgungslösungen auf Quartiersebene KW - Energy Systems Y1 - ER - TY - JOUR A1 - Wagner, Isabella A1 - Lackner, Maximilian T1 - Extraction and Analysis of Natural Rubber from the Latex of Ficus carica, Artocarpus heterophyllus and Polymer Analysis of Durio zibethinus JF - Austin Journal of Biotechnology & Bioengineering N2 - In tropical fruits such as durian (Durio zibethinus) and jackfruit (Artocarpus heterophyllus), only one quarter to one third of the fruit is edible. Finding more ways to industrially use the other components of the fruit can reduce the waste burned or dumped in landfills. Another fruit tree of interest that can also grow in Austria is the fig tree (Ficus carica). Currently, the fruits are the main product of that plant; however, components in the latex of the tree are of interest too. The latex is known to contain natural rubber, which could potentially be used for industrial applications. Jackfruit trees also produce latex, which contains natural rubber. In both cases, the natural rubber has different properties compared to the conventionally used rubber from the rubber tree (Hevea brasiliensis). This could provide new opportunities in various applications. Therefore, the purpose of this research is to analyze the properties of the natural rubber obtained from the jackfruit and fig trees. Additionally, durian fruit also produces a sticky liquid, so the same experiments were also carried out with durian samples. The experimental procedure included extraction with acetone and cyclohexane as well as polymer length determination with gel permeation chromatography and polymer analysis with differential scanning calorimetry. The results show that in both jackfruit and fig tree latex, there is natural rubber of similar polymer length. Durian pulp also contains a polymer; however, with these experiments, it could not be identified. Further research is required to identify the durian polymer and to confirm the results of this experiment. KW - Extraction KW - Rubber Y1 - IS - Vol. 8 (2) ER - TY - JOUR A1 - Petrov, Timothy A1 - Neussner, Wolfgang A1 - Lackner, Maximilian T1 - Digitalization of the Process Landscape for Proprietary Bond Trading JF - Sustainable Future and Technology Development N2 - On the surface, the process landscape for fixed income securities trading within most banks has changed only slightly in the past four decades. The value chain remains divided amongst front-, middle-, and back office, with IT in support. Front office negotiates deals with customers and other banks, middle office manages risks and reporting, and back office ensures that payments are made in exchange for a transfer of the bonds that have been traded. Though these processes have gradually migrated to electronic mediums, much of the work in all functional areas remains manual. But the advent of digital technologies, primarily process automation software and data integration in an open software architecture, allows banks to dramatically change how the processes along the value chain are carried out. Repetitive and predictable tasks can be performed by automated software, allowing humans to concentrate on complex activities that require flexibility and discretion. Those tasks that remain in the hands of humans can also be made more efficient by extracting data from software applications along the entire process chain and providing them to the human user at the right point in time in the right system. KW - Digitalization KW - Process Automation Y1 - IS - Vol 3, No 6, 2021 ER - TY - CHAP A1 - Lackner, Maximilian A1 - Novotny, Florian A. A1 - Zangl, Sabine A1 - Lembacher, Harald T1 - Contribution of waste heat to the anthropogenic greenhouse effect T2 - 2nd International Conference on Environmental Sustainability and Climate Change” KW - Sustainability KW - Environment Y1 - 2020 ER - TY - CHAP A1 - Tabakovic, Momir A1 - Böckl, Benjamin A1 - Berger, Michael A. A1 - Hermis, Herbert A1 - Nauschegg, Daniel A1 - Wall, Johannes T1 - Energieversorgungslösungen auf Quartiersebene T2 - World Energy Council Austria Young Energy Professionals KW - Energy Systems Y1 - ER - TY - BOOK A1 - Orsolits, Horst A1 - Lackner, Maximilian ED - Lackner, Maximilian ED - Orsolits, Horst T1 - Virtual Reality und Augmented Reality in der Digitalen Produktion KW - Virtual Reality KW - Production KW - Augmented Reality Y1 - SN - 978-3-658-29009-2 PB - Springer Gabler ER - TY - JOUR A1 - Zangl, Sabine A1 - Husetic, Mirza A1 - Lackner, Maximilian A1 - Lembacher, Harald T1 - Sustainability – bringing about a value changes amongst employees JF - Techniumscience KW - Sustainability Y1 - 2020 ER - TY - GEN A1 - Rohatsch, Lukas T1 - Open Data Projects KW - Open Data KW - Open Government Data KW - Smart City Wien KW - Datenanalyse KW - Softwareentwicklung Y1 - ER - TY - JOUR A1 - Haas, Theodor A1 - Markl, Erich A1 - Lackner, Maximilian T1 - Innovative use of waste tyres: Noise-barriers and geoengineering JF - World Journal of Advanced Engineering Technology and Sciences KW - Engineering KW - Wastemanagement Y1 - ER - TY - CHAP A1 - Lackner, Maximilian T1 - Combination of Devulcanization and Reactive Extrusion for Value-Added Rubber Recycling T2 - Webinar on Biopolymers & Bioplastics, Meetings International, KW - Recycling Y1 - 2020 ER - TY - GEN A1 - Tabakovic, Momir T1 - International Weeks als Plattformen für länderübergreifende Zusammenarbeit KW - Internationalisation Y1 - ER - TY - JOUR A1 - Zangl, Sabine A1 - Pingitzer, D. A1 - Lembacher, Harald A1 - Lackner, Maximilian T1 - Carbon footprint reduction in households using professional services – example of laundry cleaning JF - Pubtexto KW - Sustainability Y1 - 2020 ER - TY - JOUR A1 - Pasteka, Richard A1 - Santos da Costa, Joao Pedro A1 - Barros, Nelson A1 - Kolar, Radim A1 - Forjan, Mathias T1 - Patient–Ventilator Interaction Testing Using the Electromechanical Lung Simulator xPULMTM during V/A-C and PSV Ventilation Mode JF - Applied Sciences N2 - During mechanical ventilation, a disparity between flow, pressure and volume demands of the patient and the assistance delivered by the mechanical ventilator often occurs. This paper introduces an alternative approach of simulating and evaluating patient–ventilator interactions with high fidelity using the electromechanical lung simulator xPULM™. The xPULM™ approximates respiratory activities of a patient during alternating phases of spontaneous breathing and apnea intervals while connected to a mechanical ventilator. Focusing on different triggering events, volume assist-control (V/A-C) and pressure support ventilation (PSV) modes were chosen to test patient–ventilator interactions. In V/A-C mode, a double-triggering was detected every third breathing cycle, leading to an asynchrony index of 16.67%, which is classified as severe. This asynchrony causes a significant increase of peak inspiratory pressure (7.96 ± 6.38 vs. 11.09 ± 0.49 cmH2O, p < 0.01)) and peak expiratory flow (−25.57 ± 8.93 vs. 32.90 ± 0.54 L/min, p < 0.01) when compared to synchronous phases of the breathing simulation. Additionally, events of premature cycling were observed during PSV mode. In this mode, the peak delivered volume during simulated spontaneous breathing phases increased significantly (917.09 ± 45.74 vs. 468.40 ± 31.79 mL, p < 0.01) compared to apnea phases. Various dynamic clinical situations can be approximated using this approach and thereby could help to identify undesired patient–ventilation interactions in the future. Rapidly manufactured ventilator systems could also be tested using this approach. View Full-Text KW - Breathing Simulation KW - Biomedical Engineering KW - Electromechanical lung simulator Y1 - VL - 11 IS - 9 ER - TY - CHAP A1 - Wahl, Harald T1 - The Curriculum Re-Design of an Academic Work-Integrated Computer Science Program T2 - 28th International Conference on Teaching, Education & Learning (ICTEL), December 19-20, 2020 KW - Academic Education KW - Computer Science KW - Work-Integrated Curriculum Y1 - ER - TY - BOOK A1 - Pasteka, Richard A1 - Hrušková, Jana A1 - Jakubík, Juraj A1 - Hendrych, Michal A1 - Svačinová, Jana A1 - Nováková, Zuzana A1 - Vejtasová, Veronika A1 - Kujalová, Veronika A1 - Budinskaya, Ksenia T1 - Fyziologie – teorie k praktickým cvičením T1 - Physiologie - Theorie zu praktischen Übungen KW - Physiology Y1 - N1 - Erstellt in Zusammenarbeit mit dem Servicezentrum für e-Learning der Masarykova univerzita PB - Masarykova univerzita, Fakulta informatiky Masarykovy univerzity CY - Brno ER - TY - BOOK A1 - Hrušková, Jana A1 - Pasteka, Richard A1 - Jakubík, Juraj A1 - Hendrych, Michal A1 - Svačinová, Jana A1 - Nováková, Zuzana A1 - Vejtasová, Veronika A1 - Kujalová, Veronika A1 - Budinskaya, Ksenia T1 - Workbook fyziologie protokoly BT - Biomedicínská techniky a nelékařské obory KW - Physiology Y1 - SN - 978-80-210-9897-8 PB - Masarykova univerzita CY - Brno ER - TY - CHAP A1 - Kaufmann, Christian A1 - Wahl, Harald A1 - Kramer, Michael A1 - Mense, Alexander T1 - Obstacles in Teaching Secure Software Development - How We Can Overcome Them T2 - 11th International Conference on Information Science and Information Literacy (ICISIL 2021), Brașov, Romania, March 2021 KW - Lernen KW - Lehren KW - Secure Software Development KW - Automated Feedback KW - Technology Acceptance Y1 - 2021 ER - TY - CHAP A1 - Fibich, Christian A1 - Tauner, Stefan A1 - Rössler, Peter A1 - Horauer, Martin T1 - Evaluation of Open-Source Linear Algebra Libraries targeting ARM and RISC-V Architectures T2 - Proceedings of the 2020 15th Conference on Computer Science and Information Systems (FedCSIS), 6-9 September 2020, Sofia, Bulgaria KW - Embedded Systems KW - Basic Linear Algebra Subprograms KW - Benchmarks KW - ARM KW - RISC-V Y1 - SP - 663 EP - 672 ER - TY - CHAP A1 - Urbauer, Philipp A1 - Forjan, Mathias T1 - Integration of Health and Public Transport Data to Enable Decision Support for Seniors to Reduce Risk of Infection with Communicable Diseases. T2 - 9th International Conference on Software Development and Technologies for Enhancing Accessibility and Fighting Info-exclusion DSAI (2020) KW - eHealth KW - Interoperability KW - Open Data KW - Public Transport KW - Evidence based Decision Support Y1 - ER - TY - CHAP A1 - Fibich, Christian A1 - Horauer, Martin A1 - Obermaisser, Roman T1 - Device- and Temperature Dependency of Systematic Fault Injection Results in Artix-7 and iCE40 FPGAs T2 - Proceedings of the 2021 Design, Automation & Test in Europe Conference & Exhibition (DATE), 1-5 February 2021, Grenoble, France KW - FPGA KW - Fault Injection KW - Device Variations Y1 - SP - 1600 EP - 1605 ER - TY - JOUR A1 - Himmelstoß, Felix A1 - Votzi, Helmut T1 - Feedforward Control of Quadratic Converters JF - WSEAS Transactions of Circuits and Systems KW - DC/DC converters KW - quadratic KW - feedforward control KW - step-down Y1 - VL - 20 IS - 2021 SP - 147 EP - 155 ER - TY - JOUR A1 - Kostogryz, Nadiia M. A1 - Kupka, Friedrich A1 - Piskunov, Nikolai A1 - Fabbian, Damian A1 - Krüger, Daniel A1 - Gizon, Laurent T1 - Accurate Short-Characteristics Radiative Transfer in A Numerical Tool for Astrophysical Research (ANTARES) JF - Solar Physics KW - Astrophysics Y1 - ER - TY - JOUR A1 - Nürnberger, S. A1 - Schneider, C. A1 - Keibl, C. A1 - Schädl, Barbara A1 - Heimel, P. A1 - Monforte, X. A1 - Teuschl, A. H. A1 - Nalbach, M. A1 - Thurner, P. J. A1 - Grillari, J. A1 - Redl, Heinz A1 - Wolbank, S. T1 - Repopulation of decellularised articular cartilage by laser-based matrix engraving JF - EBioMedicine. N2 - Background: In spite of advances in the treatment of cartilage defects using cell and scaffold-based therapeutic strategies, the long-term outcome is still not satisfying since clinical scores decline years after treatment. Scaffold materials currently used in clinical settings have shown limitations in providing suitable biomechanical properties and an authentic and protective environment for regenerative cells. To tackle this problem, we developed a scaffold material based on decellularised human articular cartilage. Methods: Human articular cartilage matrix was engraved using a CO2 laser and treated for decellularisation and glycosaminoglycan removal. Characterisation of the resulting scaffold was performed via mechanical testing, DNA and GAG quantification and in vitro cultivation with adipose-derived stromal cells (ASC). Cell vitality, adhesion and chondrogenic differentiation were assessed. An ectopic, unloaded mouse model was used for the assessment of the in vivo performance of the scaffold in combination with ASC and human as well as bovine chondrocytes. The novel scaffold was compared to a commercial collagen type I/III scaffold. Findings: Crossed line engravings of the matrix allowed for a most regular and ubiquitous distribution of cells and chemical as well as enzymatic matrix treatment was performed to increase cell adhesion. The biomechanical characteristics of this novel scaffold that we term CartiScaff were found to be superior to those of commercially available materials. Neo-tissue was integrated excellently into the scaffold matrix and new collagen fibres were guided by the laser incisions towards a vertical alignment, a typical feature of native cartilage important for nutrition and biomechanics. In an ectopic, unloaded in vivo model, chondrocytes and mesenchymal stromal cells differentiated within the incisions despite the lack of growth factors and load, indicating a strong chondrogenic microenvironment within the scaffold incisions. Cells, most noticeably bone marrow-derived cells, were able to repopulate the empty chondrocyte lacunae inside the scaffold matrix. Interpretation: Due to the better load-bearing, its chondrogenic effect and the ability to guide matrix-deposition, CartiScaff is a promising biomaterial to accelerate rehabilitation and to improve long term clinical success of cartilage defect treatment. Funding: Austrian Research Promotion Agency FFG ("CartiScaff" #842455), Lorenz Böhler Fonds (16/13), City of Vienna Competence Team Project Signaltissue (MA23, #18-08). Keywords: Cartilage regeneration; Decellularisation; Ectopic animal model; Laser engraving; Mechanical testing; Repopulation. KW - Tissue Engineering KW - Cartilage regeneration KW - Mechanical Testing KW - Decellularization KW - Biomaterials Y1 - 2021 VL - 64 IS - 103196. ER - TY - CHAP A1 - Lietze, Stefanie A1 - Langer, Karin A1 - Krizek, Gerd Christian T1 - Getting started – eigene Lehrvideos gestalten T2 - Conference: Hochschulen im digitalen (Klima)Wandel KW - Lehrvideos KW - Lernvideos KW - E-Learning KW - Mobile Learning Y1 - ER - TY - CHAP A1 - Himmelstoß, Felix A1 - Votzi, Helmut T1 - Converters to drive two brushed DC machines T2 - 2021 IEEE 15th International Conference on Compatibility, Power Electronics and Power Engineering (CPE-POWERENG), 14-16 July 2021, Florence, Italy KW - DC converters KW - signal flow graph KW - step-up-down KW - permanent magnet (PM) DC machine Y1 - ER - TY - CHAP A1 - Himmelstoß, Felix A1 - Poepperl, Florian T1 - Inverting Zero-Current-Switching Buck Converter T2 - 2021 IEEE 19th International Power Electronics and Motion Control Conference (PEMC), 26.-29. April 2021, Glivice, Poland KW - DC/DC converter KW - zero current switching KW - resonant converter Y1 - SP - 108 EP - 113 ER - TY - JOUR A1 - Wöber, Wilfried A1 - Curto, Manuel A1 - Tibihika, Papius D. A1 - Meulenboek, Paul A1 - Alemayehu, Esayas A1 - Mehnen, Lars A1 - Meimberg, Harald A1 - Sykacek, Peter T1 - Identifying geographically differentiated features of Ethopian Nile tilapia (Oreochromis niloticus) morphology with machine learning JF - PlosONE KW - Machine Learning Y1 - VL - 16 IS - 4 ER - TY - JOUR A1 - Lietze, Stefanie A1 - Langer, Karin T1 - Individualität statt Diversität. Ein Plädoyer für einen neuen (alten) Fokus im Umgang mit Studierenden JF - Zeitschrift für Diversitätsforschung und -management KW - Hochschullehre KW - Diversität KW - Individualität Y1 - IS - Jahrgang 5, Ausgabe 2, 2020 SP - 205 EP - 209 ER - TY - JOUR A1 - Himmelstoß, Felix A1 - Edelmoser, Karl T1 - Modified Fourth-Order Buck-Boost Converter JF - WSEAS Transactions of Circuits and Systems KW - buck-boost converter KW - constant input current KW - large signal model KW - small signal model KW - simulation Y1 - SP - 33 EP - 40 ER - TY - CHAP A1 - Himmelstoß, Felix A1 - Edelmoser, Karl T1 - Modified Basic Converters in the Discontinuous Mode T2 - 2021 IEEE 19th International Power Electronics and Motion Control Conference (PEMC), 26.-29. April 2021, Glivice, Poland KW - buck-boost converter KW - discontinuous mode KW - ringing cancelation Y1 - SP - 118 EP - 123 ER - TY - JOUR A1 - Himmelstoß, Felix A1 - Votzi, Helmut T1 - Converter for the Drive of two Brushed DC motors JF - WSEAS Transactions of Circuits and Systems KW - brushed DC machine KW - PMDC motor KW - DC/DC converter KW - three-port converter Y1 - VL - 15 IS - 2020 SP - 249 EP - 256 ER - TY - JOUR A1 - Schneider, Karl A1 - Rohringer, Sabrina A1 - Kapeller, Barbara A1 - Grasl, Christian A1 - Kiss, Herbert A1 - Heber, Stefan A1 - Walter, Ingrid A1 - Teuschl, Andreas A1 - Podesser, Bruno K. A1 - Bergmeister, Helga T1 - Riboflavin-mediated photooxidation to improve the characteristics of decellularized human arterial small diameter vascular grafts JF - Acta Biomater. N2 - Vascular grafts with a diameter of less than 6 mm are made from a variety of materials and techniques to provide alternatives to autologous vascular grafts. Decellularized materials have been proposed as a possible approach to create extracellular matrix (ECM) vascular prostheses as they are naturally derived and inherently support various cell functions. However, these desirable graft characteristics may be limited by alterations of the ECM during the decellularization process leading to decreased biomechanical properties and hemocompatibility. In this study, arteries from the human placenta chorion were decellularized using two distinct detergents (Triton X-100 or SDS), which differently affect ECM ultrastructure. To overcome biomechanical strength loss and collagen fiber exposure after decellularization, riboflavin-mediated UV (RUV) crosslinking was used to uniformly crosslink the collagenous ECM of the grafts. Graft characteristics and biocompatibility with and without RUV crosslinking were studied in vitro and in vivo. RUV-crosslinked ECM grafts showed significantly improved mechanical strength and smoothening of the luminal graft surfaces. Cell seeding using human endothelial cells revealed no cytotoxic effects of the RUV treatment. Short-term aortic implants in rats showed cell migration and differentiation of host cells. Functional graft remodeling was evident in all grafts. Thus, RUV crosslinking is a preferable tool to improve graft characteristics of decellularized matrix conduits. KW - Tissue Engineering KW - Biomaterials KW - Vascularization Y1 - 2021 VL - 2020 IS - 116 SP - 246 EP - 258 ER - TY - JOUR A1 - Himmelstoß, Felix A1 - Edelmoser, Karl T1 - Modified Buck-Boost Converter as DC Motor Driver with Continuous Input Current JF - WSEAS Transactions of Circuits and Systems KW - DC/DC converter KW - DC motor drive KW - modified Buck-Boost KW - large and small signal model Y1 - VL - 2020 IS - 19 SP - 186 EP - 194 ER - TY - JOUR A1 - Schneider, Jaana A1 - Pultar, Marianne A1 - Oesterreicher, Johannes A1 - Bobbili, Madhusudhan Reddy A1 - Mühleder, Severin A1 - Priglinger, Eleni A1 - Redl, Heinz A1 - Spittler, Andreas A1 - Grillari, Johannes A1 - Holnthoner, Wolfgang T1 - Cre mRNA Is Not Transferred by EVs from Endothelial and Adipose-Derived Stromal/Stem Cells during Vascular Network Formation JF - Int J Mol Sci. N2 - Coculture systems employing adipose tissue-derived mesenchymal stromal/stem cells (ASC) and endothelial cells (EC) represent a widely used technique to model vascularization. Within this system, cell-cell communication is crucial for the achievement of functional vascular network formation. Extracellular vesicles (EVs) have recently emerged as key players in cell communication by transferring bioactive molecules between cells. In this study we aimed to address the role of EVs in ASC/EC cocultures by discriminating between cells, which have received functional EV cargo from cells that have not. Therefore, we employed the Cre-loxP system, which is based on donor cells expressing the Cre recombinase, whose mRNA was previously shown to be packaged into EVs and reporter cells containing a construct of floxed dsRed upstream of the eGFP coding sequence. The evaluation of Cre induced color switch in the reporter system via EVs indicated that there is no EV-mediated RNA transmission either between EC themselves or EC and ASC. However, since Cre mRNA was not found present in EVs, it remains unclear if Cre mRNA is generally not packaged into EVs or if EVs are not taken up by the utilized cell types. Our data indicate that this technique may not be applicable to evaluate EV-mediated cell-to-cell communication in an in vitro setting using EC and ASC. Further investigations will require a functional system showing efficient and specific loading of Cre mRNA or protein into EVs. KW - Tissue Engineering KW - Stem Cells KW - Vascular Network Formation KW - EVs KW - Endothelial Cells Y1 - VL - 2021 IS - 22(8) SP - 4050 ER - TY - JOUR A1 - Schneider, Karl H. A1 - Rohringer, Sabrina A1 - Kapeller, Barbara A1 - Grasl, Christian A1 - Kiss, Herbert A1 - Heber, Stefan A1 - Walter, Ingrid A1 - Teuschl, Andreas H. A1 - Podesser, Bruno K. A1 - Bergmeister, Helga T1 - Riboflavin-mediated photooxidation to improve the characteristics of decellularized human arterial small diameter vascular grafts JF - Acta Biomaterialia N2 - Vascular grafts with a diameter of less than 6 mm are made from a variety of materials and techniques to provide alternatives to autologous vascular grafts. Decellularized materials have been proposed as a possible approach to create extracellular matrix (ECM) vascular prostheses as they are naturally derived and inherently support various cell functions. However, these desirable graft characteristics may be limited by alterations of the ECM during the decellularization process leading to decreased biomechanical properties and hemocompatibility. In this study, arteries from the human placenta chorion were decellularized using two distinct detergents (Triton X-100 or SDS), which differently affect ECM ultrastructure. To overcome biomechanical strength loss and collagen fiber exposure after decellularization, riboflavin-mediated UV (RUV) crosslinking was used to uniformly crosslink the collagenous ECM of the grafts. Graft characteristics and biocompatibility with and without RUV crosslinking were studied in vitro and in vivo. RUV-crosslinked ECM grafts showed significantly improved mechanical strength and smoothening of the luminal graft surfaces. Cell seeding using human endothelial cells revealed no cytotoxic effects of the RUV treatment. Short-term aortic implants in rats showed cell migration and differentiation of host cells. Functional graft remodeling was evident in all grafts. Thus, RUV crosslinking is a preferable tool to improve graft characteristics of decellularized matrix conduits. KW - Tissue Engineering KW - Small diameter vascular graft KW - Biomaterials KW - Decellularization KW - Surface modification Y1 - VL - 116 SP - 246 EP - 258 ER - TY - JOUR A1 - Wöber, Wilfried A1 - Novotny, Georg A1 - Mehnen, Lars A1 - Olaverri-Monreal, Cristina T1 - Autonomous Vehicles: Vehicle Parameter Estimation Using Variational Bayes and Kinematics JF - Applied Sciences KW - Variational bayes KW - Vehicle parameter estimation KW - Probabilistic robotics Y1 - VL - 10 IS - 18 ER - TY - JOUR A1 - Langer, Karin A1 - Lietze, Stefanie A1 - Krizek, Gerd Christian T1 - Vector AR3-App. A Good-Practice Example of Learning with Augmented Reality JF - European Journal of Open, Distance and E-Learning N2 - After a discussion about the possibilities and status of augmented reality in education, a good practice example of an augmented reality application is presented. This case study examines the use of an augmented reality app in higher education to support abstract STEM content, such as vectors. Based on this example, the implementation of such apps in didactic concepts and self - directed learning will be discussed. Furthermore, aspects of integration into digital learning and teaching will be addressed. N2 - Nach einem Überblick über die Möglichkeiten und den Status von Augmented Reality im Bildungswesen wird ein Good-Practice-Beispiel einer Augmented-Reality-Anwendung vorgestellt. Dieses Fallbeispiel untersucht anhand dieser App die Verwendung von Augmented Reality in der Hochschulbildung zur Unterstützung abstrakter STEM-Inhalte, wie z.B. Vektoren. Mittels dieses Beispiels wird die Implementierung solcher Apps in didaktische Konzepte sowie ihr Nutzen unter dem Gesichtspunkt des selbstgesteuerten Lernens diskutiert. Darüber hinaus werden Aspekte der Einbindung in das digitale Lernen und Lehren adressiert. KW - Mathematics KW - E-learning KW - App based learning KW - Mobile learning KW - Augmented reality Y1 - VL - 23 IS - 2 ER - TY - JOUR A1 - Yalcin, Faruk A1 - Himmelstoß, Felix T1 - Buck-type Single-phase AC-AC Active Tracking Voltage Regulator Controlled by an Enhanced Hybrid Control Method JF - Sakarya University Journal of Science KW - AC-AC regulator KW - active tracking KW - buck converter Y1 - VL - 2021 IS - 25 SP - 926 EP - 937 ER - TY - JOUR A1 - Spada, Federico A1 - Demarque, Pierre A1 - Kupka, Friedrich T1 - Stellar evolution models with entropy-calibrated mixing-length parameter: application to red giants JF - Mon. Not. Roy. Astron. Soc. KW - solar KW - stellar KW - astrophysics Y1 - U6 - http://dx.doi.org/https://doi.org/10.1093/mnras/stab1106 ER -