TY - JOUR A1 - Maleiner, Babette A1 - Tomasch, Janine A1 - Heher, Philipp A1 - Spadiut, Oliver A1 - Rünzler, Dominik A1 - Fuchs, Christiane T1 - The Importance of Biophysical and Biochemical Stimuli in Dynamic Skeletal Muscle Models. JF - Frontiers in Physiology N2 - Classical approaches to engineer skeletal muscle tissue based on current regenerative and surgical procedures still do not meet the desired outcome for patient applications. Besides the evident need to create functional skeletal muscle tissue for the repair of volumetric muscle defects, there is also growing demand for platforms to study muscle-related diseases, such as muscular dystrophies or sarcopenia. Currently, numerous studies exist that have employed a variety of biomaterials, cell types and strategies for maturation of skeletal muscle tissue in 2D and 3D environments. However, researchers are just at the beginning of understanding the impact of different culture settings and their biochemical (growth factors and chemical changes) and biophysical cues (mechanical properties) on myogenesis. With this review we intend to emphasize the need for new in vitro skeletal muscle (disease) models to better recapitulate important structural and functional aspects of muscle development. We highlight the importance of choosing appropriate system components, e.g., cell and biomaterial type, structural and mechanical matrix properties or culture format, and how understanding their interplay will enable researchers to create optimized platforms to investigate myogenesis in healthy and diseased tissue. Thus, we aim to deliver guidelines for experimental designs to allow estimation of the potential influence of the selected skeletal muscle tissue engineering setup on the myogenic outcome prior to their implementation. Moreover, we offer a workflow to facilitate identifying and selecting different analytical tools to demonstrate the successful creation of functional skeletal muscle tissue. Ultimately, a refinement of existing strategies will lead to further progression in understanding important aspects of muscle diseases, muscle aging and muscle regeneration to improve quality of life of patients and enable the establishment of new treatment options. KW - Bioreactor KW - Muscle KW - Biomaterial Y1 - ER - TY - JOUR A1 - Munsch, Nicolas A1 - Gruarin, Stefanie A1 - Nateqi, Jama A1 - Lutz, Thomas A1 - Binder, Michael A1 - Aberle, Judith H. A1 - Martin, Alistair A1 - Knapp, Bernhard T1 - Symptoms associated with a COVID-19 infection among a non-hospitalized cohort in Vienna JF - Wiener Klinische Wochenschrift / The Central European Journal of Medicine N2 - Background: Most clinical studies report the symptoms experienced by those infected with coronavirus disease 2019 (COVID-19) via patients already hospitalized. Here we analyzed the symptoms experienced outside of a hospital setting. Methods: The Vienna Social Fund (FSW; Vienna, Austria), the Public Health Services of the City of Vienna (MA15) and the private company Symptoma collaborated to implement Vienna's official online COVID-19 symptom checker. Users answered 12 yes/no questions about symptoms to assess their risk for COVID-19. They could also specify their age and sex, and whether they had contact with someone who tested positive for COVID-19. Depending on the assessed risk of COVID-19 positivity, a SARS-CoV‑2 nucleic acid amplification test (NAAT) was performed. In this publication, we analyzed which factors (symptoms, sex or age) are associated with COVID-19 positivity. We also trained a classifier to correctly predict COVID-19 positivity from the collected data. Results: Between 2 November 2020 and 18 November 2021, 9133 people experiencing COVID-19-like symptoms were assessed as high risk by the chatbot and were subsequently tested by a NAAT. Symptoms significantly associated with a positive COVID-19 test were malaise, fatigue, headache, cough, fever, dysgeusia and hyposmia. Our classifier could successfully predict COVID-19 positivity with an area under the curve (AUC) of 0.74. Conclusion: This study provides reliable COVID-19 symptom statistics based on the general population verified by NAATs. Keywords: Chatbot; Machine learning; Self-reported; Symptom assessment; Symptom checker. KW - COVID-19 KW - Chatbot KW - Machine learning KW - Self-reported KW - Symptom assessment Y1 - VL - 2022 IS - 134 (9-10) SP - 344 EP - 350 PB - Springer ER - TY - JOUR A1 - Quartinello, Felice A1 - Tallian, Claudia A1 - Auer, Julia A1 - Schön, Herta A1 - Vielnascher, Robert A1 - Weinberger, Simone A1 - Wieland, Karin A1 - Weihs, Anna A1 - Rollett, Alexandra A1 - Lendl, Bernhard A1 - Teuschl, Andreas A1 - Pellis, Alessandro A1 - Gübitz, Georg T1 - Smart Textiles in Wound Care: Functionalization of Cotton/PET Blends with Antimicrobial Nanocapsules JF - Journal of Materials Chemistry B KW - Smart textiles KW - Tissue Engineering KW - Regenerative Medicine KW - Antimicrobial KW - Wound Y1 - 2019 ER - TY - JOUR A1 - Feichtinger, Xaver A1 - Monforte, Xavier A1 - Keibl, Claudia A1 - Hercher, David A1 - Schanda, Jakob A1 - Teuschl, Andreas A1 - Muschitz, Christian A1 - Redl, Heinz A1 - Fialka, Christian A1 - Mittermayr, Rainer T1 - Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears. JF - American Journal of Sports Medicine KW - Shockwave Therapy KW - Tissue Engineering KW - Regeneration KW - Surgery Y1 - ER - TY - JOUR A1 - Teuschl, Andreas A1 - Tangl, Stefan A1 - Heimel, Patrick A1 - Schwarze, Uwe Yacine A1 - Monforte, Xavier A1 - Redl, Heinz A1 - Nau, Thomas T1 - Osteointegration of a Novel Silk Fiber-Based ACL Scaffold by Formation of a Ligament-Bone Interface. JF - American Journal of Sports Medicine KW - Tissue Engineering KW - Silk KW - Scaffold KW - ACL Y1 - ER - TY - GEN A1 - Veigl, Christoph A1 - Deinhofer, Martin A1 - Aigner, Benjamin A1 - Miesenberger, Klaus T1 - Personalized Computer Access for People with Severe Motor Disabilities - AsTeRICS, FlipMouse and the Two-Level Personalization Software Engineering Method KW - Disabilities KW - Ambient Assisted Living KW - Input Devices KW - Software Engineering Y1 - 2018 ER - TY - JOUR A1 - Simsa, Robin A1 - Monforte, Xavier A1 - Salzer, Elias A1 - Teuschl, Andreas A1 - Jenndahl, Lachmi A1 - Bergh, Niklas A1 - Fogelstrand, Per T1 - Effect of fluid dynamics on decellularization efficacy and mechanical properties of blood vessels. JF - PLoS One KW - Tissue Engineering KW - Decellularization KW - Blood Vessel Y1 - ER - TY - JOUR A1 - Tallian, Claudia A1 - Herrero-Rollett, Alexandra A1 - Stadler, Karina A1 - Vielnascher, Robert A1 - Wieland, Karin A1 - Weihs, Anna A1 - Pellis, Alessandro A1 - Teuschl, Andreas A1 - Lendl, Bernhard A1 - Amenitsch, Heinz A1 - Guebitz, Georg M. T1 - Structural insights into pH-responsive drug release of self-assembling human serum albumin-silk fibroin nanocapsules. JF - European Journal of Pharmaceutics and Biopharmaceutics N2 - Inflammation processes are associated with significant decreases in tissue or lysosomal pH from 7.4 to 4, a fact that argues for the application of pH-responsive drug delivery systems. However, for their design and optimization a full understanding of the release mechanism is crucial. In this study we investigated the pH-depending drug release mechanism and the influence of silk fibroin (SF) concentration and SF degradation degree of human serum albumin (HSA)-SF nanocapsules. Sonochemically produced nanocapsules were investigated regarding particle size, colloidal stability, protein encapsulation, thermal stability and drug loading properties. Particles of the monodisperse phase showed average hydrodynamic radii between 438 and 888 nm as measured by DLS and AFM and a zeta potential of -11.12 ± 3.27 mV. Together with DSC results this indicated the successful production of stable nanocapsules. ATR-FTIR analysis demonstrated that SF had a positive effect on particle formation and stability due to induced beta-sheet formation and enhanced crosslinking. The pH-responsive release was found to depend on the SF concentration. In in-vitro release studies, HSA-SF nanocapsules composed of 50% SF showed an increased pH-responsive release for all tested model substances (Rhodamine B, Crystal Violet and Evans Blue) and methotrexate at the lowered pH of 4.5 to pH 5.4, while HSA capsules without SF did not show any pH-responsive drug release. Mechanistic studies using confocal laser scanning microscopy (CLSM) and small angle X-ray scattering (SAXS) analyses showed that increases in particle porosity and decreases in particle densities are directly linked to pH-responsive release properties. Therefore, the pH-responsive release mechanism was identified as diffusion controlled in a novel and unique approach by linking scattering results with in vitro studies. Finally, cytotoxicity studies using the human monocytic THP-1 cell line indicated non-toxic behavior of the drug loaded nanocapsules when applied in a concentration of 62.5 µg mL-1. KW - Biomaterial KW - Tissue Engineering Y1 - ER - TY - JOUR A1 - Slezak, Paul A1 - Slezak, Cyrill A1 - Hartinger, Joachim A1 - Teuschl, Andreas A1 - Nürnberger, Sylvia A1 - Redl, Heinz A1 - Mittermayr, Rainer T1 - A Low Cost Implantation Model in the Rat That Allows a Spatial Assessment of Angiogenesis. JF - Frontiers in Bioengineering and Biotechnology N2 - There is continual demand for animal models that allow a quantitative assessment of angiogenic properties of biomaterials, therapies, and pharmaceuticals. In its simplest form, this is done by subcutaneous material implantation and subsequent vessel counting which usually omits spatial data. We have refined an implantation model and paired it with a computational analytic routine which outputs not only vessel count but also vessel density, distribution, and vessel penetration depth, that relies on a centric vessel as a reference point. We have successfully validated our model by characterizing the angiogenic potential of a fibrin matrix in conjunction with recombinant human vascular endothelial growth factor (rhVEGF165). The inferior epigastric vascular pedicles of rats were sheathed with silicone tubes, which were subsequently filled with 0.2 ml of fibrin and different doses of rhVEGF165, centrically embedding the vessels. Over 4 weeks, tissue samples were harvested and subsequently immunohistologically stained and computationally analyzed. The model was able to detect variations over the angiogenic potentials of growth factor spiked fibrin matrices. Adding 20 ng of rhVEGF165 resulted in a significant increase in vasculature while 200 ng of rhVEGF165 did not improve vascular growth. Vascularized tissue volume increased during the first week and vascular density increased during the second week. Total vessel count increased significantly and exhibited a peak after 2 weeks which was followed by a resorption of vasculature by week 4. In summary, a simple implantation model to study in vivo vascularization with only a minimal workload attached was enhanced to include morphologic data of the emerging vascular tree. KW - Tissue Engineering KW - Bioreactor KW - Biomaterial Y1 - ER - TY - JOUR A1 - Nau, Thomas A1 - Teuschl, Andreas A1 - Ebner, Anna A1 - Jung, Ilse A1 - Schenk, Christian T1 - Low revision rate and excellent outcome of primary ACL repair with a minimum follow-up of 5 years. JF - Muscle, ligaments and tendons Journal N2 - Introduction: Due to limitations of ACL reconstruction, primary ACL repair has recently regained research interest. Although abandoned in the past, primary repair with conservation of the original ligament demonstrates considerable advantages compared to reconstruction. We hypothesized that early repair, strictly limited to patients with a proximal ACL rupture and excellent tissue quality of the remaining ACL stump, would lead to equal revision rates and subjective outcomes as reported for ACL reconstruction after a minimum of 5 years. Methods: In this questionnaire study, patients who had a primary ACL repair between 2002 and 2009 were invited to participate. Besides any potential revision surgery, the Tegner activity scale and the Knee Injury and Osteoarthritis Outcome Score were included in the evaluation. Results: Out of 1912 patients who had ACL related surgery during the observation period, 221 (11.4%) had a primary ACL repair. 60 patients (61 knees) were available for follow-up. In 2/61 (3.3%) cases ACL revision surgery was performed and one patient had meniscus surgery of the affected side. The median Tegner activity scale was 6 (range, 3 to 10). The mean KOOS subscores were 88.8% (Function/Sports), 86.6% (Quality of life), 94.6 (Symptoms), 94.0 (Pain) and 97.0 (Activities of Daily Living). Conclusion: Primary ACL repair, strictly limited to proximal ruptures with good tissue quality leads to revision rates and subjective outcome comparable to ACL reconstruction. Level of evidence: IV. KW - Regeneration Y1 - SP - 185 EP - 190 ER - TY - GEN A1 - Teuschl, Andreas A1 - Heimel, Patrick A1 - Monforte Vila, Xavier A1 - Nürnberger, Sylvia A1 - Tangl, Stefan A1 - van Griensven, Martijn A1 - Redl, Heinz A1 - Nau, Thomas T1 - Anterior cruciate ligament regeneration using the silk-based RegACL scaffold KW - Tissue Engineering KW - Silk KW - Biomaterial KW - Anterior Cruciate Ligament Y1 - ER - TY - GEN A1 - Slezak, Paul A1 - Rose, Roland A1 - Hercher, David A1 - Weihs, Anna A1 - Fuchs, Christiane A1 - Redl, Heinz A1 - Mittermayr, Rainer A1 - Slezak, Cyrill T1 - Tracking therapeutic shockwaves and their impact on regeneration KW - Shockwave Therapy KW - Tissue Regeneration Y1 - ER - TY - RPRT A1 - Freistetter, Florian T1 - The Power of Lauf KW - Bioreactor KW - Muscle KW - Tissue Engineering Y1 - ER - TY - CHAP A1 - Drauschke, Andreas T1 - Comparison of Numerical Eye Models and its Representation within a Mechanical Eye Model T2 - IFAC-Papers Online KW - Mechanical Eye Y1 - 2018 SP - 133 EP - 138 ER - TY - GEN A1 - Drauschke, Andreas T1 - Comparison of Numerical Eye Models and its Representation within a Mechanical Eye Model KW - Mechanical Eye Y1 - 2018 ER - TY - BOOK A1 - Bilinski, Wolfgang T1 - Resilienz - Krisen erfolgreich meistern und nutzen KW - Resilience KW - Crises Y1 - 2018 PB - Haufe-Lexware ET - 2 ER - TY - CHAP A1 - Veigl, Christoph A1 - Deinhofer, Martin A1 - Aigner, Benjamin A1 - Miesenberger, Klaus T1 - Personalized Computer Access for People with Severe Motor Disabilities - AsTeRICS, FlipMouse and the Two-Level Personalization Software Engineering Method T2 - International Conference on Human Aspects of IT for the Aged Population 2017 KW - Disabilities KW - Input Devices KW - Software Engineering Y1 - 2018 SP - 397 EP - 415 ER - TY - CHAP A1 - Aigner, Benjamin A1 - David, Veronika A1 - Deinhofer, Martin A1 - Veigl, Christoph T1 - FLipMouse - a Flexible Alternative Input Solution for People with Severe Motor Restrictions T2 - 7th International Conference on Software Development and Technologies for Enhancing Accessibility and Fighting Info-exclusion, December 1-3, 2016 - UTAD, Vila Real, Portugal KW - Disabilities KW - Input Devices Y1 - 2018 ER - TY - GEN A1 - Aigner, Benjamin A1 - David, Veronika A1 - Deinhofer, Martin A1 - Veigl, Christoph T1 - FLipMouse - a Flexible Alternative Input Solution for People with Severe Motor Restrictions KW - Input Devices KW - Disabilities Y1 - 2018 ER - TY - JOUR A1 - Gröger, Herbert A1 - Unterholzer, Carmen T1 - Eigene Stärken wieder entdecken. Systemische Gruppenpsychotherapie und der Einsatz von Feedbackinstrumenten am Beispiel einer Jahresgruppe JF - Systeme KW - Systemic Therapy KW - Group Therapy Y1 - 2018 IS - 2 ER - TY - JOUR A1 - Gröger, Herbert A1 - Kampas, Elisabeth A1 - Reiner, Melanie A1 - Unterholzer, Carmen T1 - Im Gespräch: Systemische Gruppenpsychotherapie JF - ÖAS-Netzwerke KW - Systemic Therapy KW - Group Therapy Y1 - 2018 IS - 2 ER - TY - JOUR A1 - Wala, Thomas T1 - Fitness im Büro mit Active Workplace Design JF - Wirtschaft und Management : Schriftenreihe zur wirtschaftswissenschaftlichen Forschung und Praxis N2 - Wissensarbeiter:innen verbringen den überwiegenden Teil ihrer Arbeitszeit sitzend vor dem Computer. Die negativen Folgen von langem Sitzen für die Gesundheit sind bekannt: Zu langes Sitzen bedingt einen niedrigen Kalorienverbrauch, der Stoffwechsel und das Herz-Kreislaufsystem laufen auf Sparflamme. Entsprechend steigt das Risiko für Übergewicht, Diabetes, Bandscheibenvorfall und Herz-Kreislauf- Erkrankungen. Unter den Folgen von langem Sitzen leiden aber nicht nur die betroffenen Mitarbeiter:innen selbst, sondern auch deren Arbeitgeber:innen, weil Mitarbeiter:innen mit einem auf Bewegungsmangel zurückzuführenden reduzierten physischen und psychischen Wohlbefinden weniger produktiv und kreativ arbeiten bzw. aufgrund von Erkrankungen erst gar nicht arbeiten können. Der vorliegende Beitrag zeigt auf, wie Unternehmen durch das Setzen sanfter Bewegungszwänge, den Einsatz dynamischer Arbeitsstationen sowie die Integration niederschwelliger Fitnessmodule in die Bürolandschaft für mehr körperliche Aktivität im Arbeitsalltag sorgen können. KW - Arbeitsplatz KW - Gesundheitsverhalten KW - Fitness Y1 - IS - 31 SP - 47 EP - 58 ER - TY - GEN A1 - Stoiber, Stefan A1 - Purtscher, Michaela A1 - Gepp, Barbara A1 - Huber-Gries, Carina T1 - Towards a platform for spatially defined cell characterization of a miniturized heart tissue model KW - Microfluidic KW - Tissue Engineering KW - Heart Y1 - ER - TY - GEN A1 - Sauermann, Stefan A1 - David, Veronika A1 - Schlögl, Alois A1 - Egelkraut, Reinhard A1 - Frohner, Matthias A1 - Pohn, Birgit A1 - Urbauer, Philipp A1 - Mense, Alexander T1 - Biosignals, Standards and FHIR – The Way to Go? KW - Biosignals KW - IT Standards Y1 - 2018 ER - TY - GEN A1 - Hromada, Carina A1 - Tomasch, Janine A1 - Weihs, Anna A1 - Rünzler, Dominik A1 - Teuschl, Andreas T1 - Engineering of 3D Tissue Constructs Using our Novel MagneTissue Bioreactor as Alternatives to Animal Models KW - Bioreactor KW - Biomaterials Y1 - ER - TY - CHAP A1 - Mally, Franziska A1 - Litzenberger, Stefan A1 - Sabo, Anton T1 - Kinematics of Elite Unilateral Below-elbow Amputee Treadmill-running - A Case Study T2 - Procedia Engineering KW - Amputation KW - Treadmill Y1 - 2018 SP - 449 EP - 454 ER - TY - JOUR A1 - Rieder, Bernhard A1 - Weihs, Anna A1 - Weidinger, Adelheid A1 - Sczwarc, Dorota A1 - Nürnberger, Sylvia A1 - Redl, Heinz A1 - Rünzler, Dominik A1 - Huber-Gries, Carina A1 - Teuschl, Andreas T1 - Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures JF - Scientific Reports KW - Bioreactor KW - Osteoarthritis KW - Cartilage KW - Reactive oxygen species Y1 - ER - TY - CHAP A1 - Sauermann, Stefan A1 - David, Veronika A1 - Schlögl, Alois A1 - Egelkraut, Reinhard A1 - Frohner, Matthias A1 - Pohn, Birgit A1 - Urbauer, Philipp A1 - Mense, Alexander T1 - Biosignals, Standards and FHIR – The Way to Go? T2 - Stud Health Technol Inform KW - Biosignals KW - Standards Y1 - 2018 SP - 356 EP - 362 ER - TY - CHAP A1 - Frohner, Matthias A1 - Windisch, Michael A1 - Sauermann, Stefan A1 - Sekora, Jiri A1 - Forjan, Mathias T1 - Organ Telemonitoring in Ex-vivo Nutrition Circulation of Porcine Lungs Using Interoperability Standards T2 - Proceedings of the 12th IFAC/IEEE International Conference on Programmable Devices and Embedded Systems (PDeS 2013) KW - Telemonitoring KW - Lung Simulator KW - Interoperability Y1 - 2018 SP - 335 EP - 340 ER - TY - GEN A1 - David, Veronika A1 - Forjan, Mathias A1 - Tkachenko Bril, Andres Igor T1 - Klinische Pilotstudie zur Prüfung der Machbarkeit und Akzeptanz eines Biofeedbacksystems zur Unterstützung der teilbelastenden Mobilisation KW - eHealth Y1 - 2018 ER - TY - CHAP A1 - David, Veronika A1 - Forjan, Mathias A1 - Martinek, Johannes A1 - Kotzian, Stefan A1 - Jagos, Harald A1 - Rafolt, Dietmar T1 - Evaluation of Wearable Multimodal Sensor Insoles for Motion-pattern Measurements in Stroke Rehabilitation – a Pilot Study T2 - IEEE-RAS-EMBS International Conference on Rehabilitation Robotics (ICORR 2017) KW - Stroke Patients KW - Rehabilitation Y1 - 2018 ER - TY - JOUR A1 - Riess, Bernhard A1 - David, Veronika A1 - Scherer, Matthias A1 - Kotzian, Stefan A1 - Forjan, Mathias T1 - Development and Usability Test of an Innovative Low-Cost Rehabilitation Game for the Upper Extremities of Neurological Patients JF - Journal of Functional Neurology, Rehabilitation, and Ergonomics KW - Neurology KW - Rehabilitation Y1 - 2018 VL - 7 IS - 4 SP - 34 EP - 39 ER - TY - GEN A1 - Salomon, Cornelia A1 - Scherer, Matthias A1 - David, Veronika A1 - Kotzian, Stefan A1 - Forjan, Mathias T1 - Simulation Development of a Virtual Shopping Scenario via HTC VIVE for Neuropsychological Rehabilitation KW - Neurology KW - Rehabilitation KW - Virtual Reality Y1 - 2018 ER - TY - GEN A1 - David, Veronika A1 - Jagos, Harald A1 - Kotzian, Stefan A1 - Forjan, Mathias A1 - Sabo, Anton T1 - Instrumentation of Timed-up-and-Go Test for Stroke Patients using Multisensor Insoles KW - Stroke Patients Y1 - 2018 ER - TY - GEN A1 - David, Veronika A1 - Forjan, Mathias A1 - Martinek, Johannes A1 - Kotzian, Stefan A1 - Jagos, Harald A1 - Rafolt, Dietmar T1 - Evaluation of Wearable Multimodal Sensor Insoles for Motion-pattern Measurements in Stroke Rehabilitation – a Pilot Study KW - Stroke Patients KW - Rehabilitation KW - Shoes Y1 - 2018 ER - TY - JOUR A1 - Schneider, Karl Heinrich A1 - Enayati, Marjan A1 - Grasl, Christian A1 - Walter, Ingrid A1 - Budinsky, Lubos A1 - Zebic, Gabriel A1 - Kaun, Christoph A1 - Wagner, Anja A1 - Kratochwill, Klaus A1 - Redl, Heinz A1 - Teuschl, Andreas A1 - Podesser, Bruno K. A1 - Bergmeister, Helga T1 - Acellular vascular matrix grafts from human placenta chorion: Impact of ECM preservation on graft characteristics, protein composition and in vivo performance. JF - Biomaterials N2 - Small diameter vascular grafts from human placenta, decellularized with either Triton X-100 (Triton) or SDS and crosslinked with heparin were constructed and characterized. Graft biochemical properties, residual DNA, and protein composition were evaluated to compare the effect of the two detergents on graft matrix composition and structural alterations. Biocompatibility was tested in vitro by culturing the grafts with primary human macrophages and in vivo by subcutaneous implantation of graft conduits (n = 7 per group) into the flanks of nude rats. Subsequently, graft performance was evaluated using an aortic implantation model in Sprague Dawley rats (one month, n = 14). In situ graft imaging was performed using MRI angiography. Retrieved specimens were analyzed by electromyography, scanning electron microscopy, histology and immunohistochemistry to evaluate cell migration and the degree of functional tissue remodeling. Both decellularization methods resulted in grafts of excellent biocompatibility in vitro and in vivo, with low immunogenic potential. Proteomic data revealed removal of cytoplasmic proteins with relative enrichment of ECM proteins in decelluarized specimens of both groups. Noteworthy, LC-Mass Spectrometry analysis revealed that 16 proteins were exclusively preserved in Triton decellularized specimens in comparison to SDS-treated specimens. Aortic grafts showed high patency rates, no signs of thrombus formation, aneurysms or rupture. Conduits of both groups revealed tissue-specific cell migration indicative of functional remodeling. This study strongly suggests that decellularized allogenic grafts from the human placenta have the potential to be used as vascular replacement materials. Both detergents produced grafts with low residual immunogenicity and appropriate mechanical properties. Observed differences in graft characteristics due to preservation method had no impact on successful in vivo performance in the rodent model. KW - Biomaterial KW - Tissue Engineering Y1 - SP - 14 EP - 26 ER - TY - CHAP A1 - Reutterer, Bernd A1 - Traxler, Lukas A1 - Bayer, Natascha A1 - Drauschke, Andreas T1 - Further improvement of an intraocular lens holder for more physiological measurements within a mechanical eye model T2 - Proc.SPIE Biomedical Imaging and Sensing Conference KW - Mechanical Eye Y1 - 2018 ER - TY - JOUR A1 - Priglinger, Eleni A1 - Schuh, Christina A1 - Steffenhagen, Carolin A1 - Wurzer, Christoph A1 - Maier, Julia A1 - Nürnberger, Sylvia A1 - Holnthoner, Wolfgang A1 - Fuchs, Christiane A1 - Suessner, Susanne A1 - Rünzler, Dominik A1 - Redl, Heinz A1 - Wolbank, Susanne T1 - Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy. JF - Cytotherapy N2 - BACKGROUND: Cell-based therapies with autologous adipose tissue-derived cells have shown great potential in several clinical studies in the last decades. The majority of these studies have been using the stromal vascular fraction (SVF), a heterogeneous mixture of fibroblasts, lymphocytes, monocytes/macrophages, endothelial cells, endothelial progenitor cells, pericytes and adipose-derived stromal/stem cells (ASC) among others. Although possible clinical applications of autologous adipose tissue-derived cells are manifold, they are limited by insufficient uniformity in cell identity and regenerative potency. METHODS: In our experimental set-up, low-energy extracorporeal shock wave therapy (ESWT) was performed on freshly obtained human adipose tissue and isolated adipose tissue SVF cells aiming to equalize and enhance stem cell properties and functionality. RESULTS: After ESWT on adipose tissue we could achieve higher cellular adenosine triphosphate (ATP) levels compared with ESWT on the isolated SVF as well as the control. ESWT on adipose tissue resulted in a significantly higher expression of single mesenchymal and vascular marker compared with untreated control. Analysis of SVF protein secretome revealed a significant enhancement in insulin-like growth factor (IGF)-1 and placental growth factor (PLGF) after ESWT on adipose tissue. DISCUSSION: Summarizing we could show that ESWT on adipose tissue enhanced the cellular ATP content and modified the expression of single mesenchymal and vascular marker, and thus potentially provides a more regenerative cell population. Because the effectiveness of autologous cell therapy is dependent on the therapeutic potency of the patient's cells, this technology might raise the number of patients eligible for autologous cell transplantation. KW - Shockwave Therapy KW - Tissue Regeneration KW - Regenerative Medicine Y1 - SP - 1079 EP - 1095 ER - TY - CHAP A1 - Reutterer, Bernd A1 - Traxler, Lukas A1 - Bayer, Natascha A1 - Drauschke, Andreas T1 - Comparison of different wavefront measurement setups to judge the position tolerance of intraocular lenses in a model eye T2 - Proc.SPIE Biomedical Imaging and Sensing Conference KW - Mechanical Eye KW - Eye Lens Y1 - 2018 ER - TY - JOUR A1 - Nürnberger, Sylvia A1 - Schneider, Cornelia A1 - van Osch, Gerjo A1 - Keibl, Claudia A1 - Rieder, Bernhard A1 - Monforte, Xavier A1 - Teuschl, Andreas A1 - Mühleder, Severin A1 - Holnthoner, Wolfgang A1 - Schädl, Barbara A1 - Gahleitner, Christoph A1 - Redl, Heinz A1 - Wolbank, Susanne T1 - Repopulation of an auricular cartilage scaffold, AuriScaff, perforated with an enzyme combination. JF - Acta Biomaterialia KW - Tissue Engineering KW - Decellularization KW - Cartilage Y1 - ER - TY - GEN A1 - Reutterer, Bernd A1 - Traxler, Lukas A1 - Bayer, Natascha A1 - Drauschke, Andreas T1 - Further improvement of an intraocular lens holder for more physiological measurements within a mechanical eye model KW - Mechanical Eye Y1 - 2018 ER - TY - JOUR A1 - Bell, Daniel A1 - Wolf-Eberl, Susanne A1 - Posch, Patrick T1 - Dementia and mobility – issues, needs and solutions JF - Transactions on Transport Sciences N2 - Structural transition in Austrian society in the larger context of demographic change and growing demands on infrastructure, organization and planning in the public sphere have been discussed profusely in recent years in the context of some projects. While a number of national and international research projects especially focussed on the older age groups and their requirements for staying mobile by developing solutions on the individual, technological and infrastructural level, solutions for people who suffer from cognitive impairment as a result of dementia are still missing. The Austrian research project KOMPETENZ takes the first step in identifying the requirements that people with dementia, their caregivers and other relevant stakeholders in this context have towards public space in order to be able to maintain physical mobility of people affected by dementia. One of the main outcomes of the project included an assessment methodology linking barriers and collective mobility needs to high potential solutions, which supports all relevant stakeholders in the process. KW - Mobility KW - Transportation Y1 - VL - 2018 IS - Vol. 9, Issue 1 ER - TY - CHAP A1 - Wagner, Fabian A1 - Jank, Miran A1 - Balz, Andrea A1 - Forjan, Mathias A1 - Urbauer, Philipp T1 - Immersive Spatial Planning in Healthcare: Developing a Pipeline to Automatically Convert Computer Aided DesignData to Virtual Reality T2 - dHealth 2023, 17th Annual Conference on Health Informatics meets Digital Health N2 - Equipping rooms used for medical purposes, like e.g., intensive care units, is an expensive and time-consuming task. In order to avoid extensive subsequent adjustments due to inappropriate layout visualization or geometric conditions difficult to identify in 2D plans, it is of utmost importance to provide an optimal planning environment to future users such as physicians and nurses. In this paper we present the concept of a fully automatized pipeline, which is designed to visualize computer aided design (CAD) data using virtual reality (VR). The immersive VR experience results in improvement of efficiency in the decision- making process during the planning phase due to better spatial imagination. The pipeline was successfully tested with CAD data from existing Intensive Care Units. The results indicate that the pipeline can be a valuable tool in the field of spatial planning in healthcare, due to simple usage and fast conversion of CAD data. The next step will be the development of a plugin for CAD tools to allow for interactions with the CAD models in Virtual Reality, which is not yet possible without manual intervention KW - Virtual Reality KW - Spacial Planning KW - Automation Y1 - U6 - http://dx.doi.org/https://doi.org/10.3233/shti230019 VL - 301 SP - 96 EP - 101 ER - TY - JOUR A1 - Marc, Zobel A1 - Knapp, Bernhard A1 - Nateqi, Jama A1 - Martin, Alistair T1 - Correlating global trends in COVID-19 cases with online symptom checker self-assessments JF - PLOS ONE N2 - Background Online symptom checkers are digital health solutions that provide a differential diagnosis based on a user’s symptoms. During the coronavirus disease 2019 (COVID-19) pandemic, symptom checkers have become increasingly important due to physical distance constraints and reduced access to in-person medical consultations. Furthermore, various symptom checkers specialised in the assessment of COVID-19 infection have been produced. Objectives Assess the correlation between COVID-19 risk assessments from an online symptom checker and current trends in COVID-19 infections. Analyse whether those correlations are reflective of various country-wise quality of life measures. Lastly, determine whether the trends found in symptom checker assessments predict or lag relative to those of the COVID-19 infections. Materials and methods In this study, we compile the outcomes of COVID-19 risk assessments provided by the symptom checker Symptoma (www.symptoma.com) in 18 countries with suitably large user bases. We analyse this dataset’s spatial and temporal features compared to the number of newly confirmed COVID-19 cases published by the respective countries. Results We find an average correlation of 0.342 between the number of Symptoma users assessed to have a high risk of a COVID-19 infection and the official COVID-19 infection numbers. Further, we show a significant relationship between that correlation and the self-reported health of a country. Lastly, we find that the symptom checker is, on average, ahead (median +3 days) of the official infection numbers for most countries. Conclusion We show that online symptom checkers can capture the national-level trends in coronavirus infections. As such, they provide a valuable and unique information source in policymaking against pandemics, unrestricted by conventional resources. KW - Online symptom checkers KW - coronavirus disease Y1 - U6 - http://dx.doi.org/https://doi.org/10.1371/journal.pone.0281709 VL - 18 IS - 2 ER - TY - GEN A1 - Urbauer, Philipp A1 - Zeidler, Doris T1 - Linked Care – Neueste Entwicklungen in der durchgehenden Informationsversorgung der mobilen Pflege und Betreuung KW - eHealth KW - mobile Pflege KW - Interoperability Y1 - ER -