TY - GEN A1 - Kubinger, Wilfried T1 - DARPA Grand / Urban Challenge, Course "New Technologies” KW - Urban Challenge KW - Training Y1 - 2019 ER - TY - CHAP A1 - Veigl, Christoph A1 - Kutschera, Christof A1 - Rössler, Peter T1 - Ausgelagerte Uhrensynchronisation für verteilte eingebettete Systeme T2 - 3. Forschungsforum der österreichischen Fachhochschulen (FFH2009), Villach, Austria, April 15-16 2009 KW - Embedded Systems KW - Synchronization Y1 - 2019 ER - TY - CHAP A1 - Pucher, Robert A1 - Brezowar, Gabriela A1 - Kollmitzer, Christian A1 - Schmöllebeck, Fritz T1 - Audio Files for Mobile Devices - A Valuable Method for Teaching? T2 - Proceedings of the International Conference on E-Learning in the Workplace KW - Mobile Application KW - Teaching KW - Education Y1 - 2019 ER - TY - GEN A1 - Pucher, Robert A1 - Brezowar, Gabriela A1 - Kollmitzer, Christian A1 - Schmöllebeck, Fritz T1 - Audio Files for Mobile Devices - A Valuable Method for Teaching? KW - Mobile Application KW - Teaching KW - Education Y1 - 2019 ER - TY - JOUR A1 - Catalanotti, Federica A1 - Reyes, Gloria Ximena A1 - Jesenberger, Veronika A1 - Galabova-Kovacs, Gergana A1 - de Matos Simoes, Ricardo A1 - Carugo, Oliviero A1 - Baccarini, Manuela T1 - A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal JF - Nat Struct Mol Biol. N2 - Mek1 and Mek2 (also known as Map2k1 and Map2k2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion and growth factor signaling. Here we describe a previously uncharacterized, unexpected role of Mek1 in downregulating Mek2-dependent Erk signaling. Mek1 mediates the regulation of Mek2 in the context of a previously undiscovered Mek1-Mek2 complex. The Mek heterodimer is negatively regulated by Erk-mediated phosphorylation of Mek1 on Thr292, a residue missing in Mek2. Disabling this Erk-proximal negative-feedback step stabilizes the phosphorylation of both Mek2 and Erk in cultured cells and in vivo in Mek1 knockout embryos and mice. Thus, in disagreement with the current perception of the pathway, the role of Mek1 and Mek2 in growth factor-induced Erk phosphorylation is not interchangeable. Our data establish Mek1 as the crucial modulator of Mek and Erk signaling and have potential implications for the role of Mek1 and Mek2 in tumorigenesis. KW - Mek1-Mek2 pathway KW - tumorigenesis KW - ERK activation KW - cancer biology Y1 - 2020 VL - 2009 IS - 16(3) SP - 294 EP - 303 ER - TY - JOUR A1 - Milan-Lobo, Laura A1 - Gsandtner, Ingrid A1 - Gaubitzer, Erwin A1 - Rünzler, Dominik A1 - Buchmayer, Florian A1 - Köhler, Gottfried A1 - Bonci, Antonello A1 - Freissmuth, Michael A1 - Sitte, Harald H. T1 - Subtype-specific differences in corticotropin-releasing factor receptor complexes detected by fluorescence spectroscopy JF - Molecular Pharmacology (mol pharmacol) KW - Spectroscopy Y1 - 2019 IS - 76(6) SP - 1196 EP - 1210 ER - TY - CHAP A1 - Weihs, Anna A1 - Knebl, Gerald A1 - Redl, Heinz A1 - Rünzler, Dominik T1 - Evaluation of cell migration methods in 3D hydrogels for tissue engineering applications T2 - 3. Forschungsforum der österreichischen Fachhochschulen / Fachhochschule Kärnten KW - Cells Y1 - 2019 SN - 978-3-853912850 SP - 490 EP - 491 ER - TY - CHAP A1 - Mandl, Thomas A1 - Martinek, Johannes A1 - Mayr, Winfried A1 - Rattay, Frank A1 - Reichel, Martin T1 - Towards a numerical 3D model of Functional Electrical Stimulation of denervated, degenerated human skeletal muscle T2 - Proceedings of the 21st European Modeling and Simulation Symposium KW - Electrical Stimulation KW - Muscle Stimulation KW - Skeletal Muscle Y1 - 2019 ER - TY - CHAP A1 - Martinek, Johannes A1 - Mandl, Thomas A1 - Mayr, Winfried A1 - Rattay, Frank A1 - Reichel, Martin T1 - Coupling Effects in the Bidomain Model of Functional Electrical Stimulation T2 - Proceedings of the 21st European Modeling and Simulation Symposium KW - Electrical Stimulation Y1 - 2019 ER - TY - CHAP A1 - Reinbacher, Thomas A1 - Brauer, Jörg A1 - Horauer, Martin A1 - Schlich, Bastian T1 - Refining Assembly Code Static Analysis for the Intel MCS-51 Microcontroller T2 - Proceedings of the 4th IEEE Symposium of Industrial Embedded Systems (SIES 2009), July 8-10, 2009, Lausanne, Switzerland KW - Embedded Systems KW - Microcontroller Y1 - 2019 SP - 161 EP - 170 ER -