TY  - JOUR
A1  - Jesenberger, Veronika
A1  - Jentsch, Stefan
T1  - Deadly encounter: ubiquitin meets apoptosis
JF  - Nat Rev Mol Cell Biol.
N2  - The ubiquitin/proteasome pathway is the main non-lysosomal route for intracellular protein degradation in eukaryotes. It is instrumental to various cellular processes, such as cell-cycle progression, transcription and antigen processing. Recent findings also substantiate a pivotal role of the ubiquitin/proteasome pathway in the regulation of apoptosis. Regulatory molecules that are involved in programmed cell death have been identified as substrates of the proteasome. Moreover, key regulators of apoptosis themselves seem to have an active part in the proteolytic inactivation of death executors.
KW  - programmed cell death
KW  - Molecular Cell Biology
Y1  - 2020
U6  - http://dx.doi.org/https://doi.org/10.1038/nrm731
VL  - 2002
IS  - 3(2)
SP  - 112
EP  - 121
ER  -