TY - JOUR A1 - Mandl, Thomas A1 - Meyerspeer, Martin A1 - Reichel, Martin A1 - Kern, Helmut A1 - Hofer, Christian A1 - Mayr, Winfried A1 - Moser, Ewald T1 - Functional electrical stimulation of long-term denervated, degenerated human skeletal muscle: estimating activation using T2-parameter magnetic resonance imaging methods JF - Artif Organs KW - Electrical Stimulation KW - Muscle Stimulation Y1 - 2019 IS - 32(8) SP - 604 EP - 608 ER - TY - JOUR A1 - Lanmüller, Hermann A1 - Ashley, Z. A1 - Unger, E. A1 - Sutherland, H. A1 - Reichel, Martin A1 - Russold, M. A1 - Jarvis, J. A1 - Mayr, Winfried A1 - Salmons, S. T1 - Implantable device for long-term electrical stimulation of denervated muscles in rabbits JF - Med Biol Eng Comput KW - Electrical Stimulation KW - Muscle Stimulation KW - Muscle Denervation Y1 - 2019 VL - 43 IS - 4 SP - 535 EP - 540 ER - TY - JOUR A1 - Pucher, Robert A1 - Holweg, Gerd A1 - Mandl, Thomas A1 - Salzbrunn, Benedikt T1 - Optimizing higher education for the professional student. The example of Computer Science education at the University of Applied Sciences Technikum Wien JF - Digital Universities. International Best Practices and Applications KW - Education KW - Computer Science Y1 - 2018 ER - TY - JOUR A1 - Maleiner, Babette A1 - Tomasch, Janine A1 - Heher, Philipp A1 - Spadiut, Oliver A1 - Rünzler, Dominik A1 - Fuchs, Christiane T1 - The Importance of Biophysical and Biochemical Stimuli in Dynamic Skeletal Muscle Models. JF - Frontiers in Physiology N2 - Classical approaches to engineer skeletal muscle tissue based on current regenerative and surgical procedures still do not meet the desired outcome for patient applications. Besides the evident need to create functional skeletal muscle tissue for the repair of volumetric muscle defects, there is also growing demand for platforms to study muscle-related diseases, such as muscular dystrophies or sarcopenia. Currently, numerous studies exist that have employed a variety of biomaterials, cell types and strategies for maturation of skeletal muscle tissue in 2D and 3D environments. However, researchers are just at the beginning of understanding the impact of different culture settings and their biochemical (growth factors and chemical changes) and biophysical cues (mechanical properties) on myogenesis. With this review we intend to emphasize the need for new in vitro skeletal muscle (disease) models to better recapitulate important structural and functional aspects of muscle development. We highlight the importance of choosing appropriate system components, e.g., cell and biomaterial type, structural and mechanical matrix properties or culture format, and how understanding their interplay will enable researchers to create optimized platforms to investigate myogenesis in healthy and diseased tissue. Thus, we aim to deliver guidelines for experimental designs to allow estimation of the potential influence of the selected skeletal muscle tissue engineering setup on the myogenic outcome prior to their implementation. Moreover, we offer a workflow to facilitate identifying and selecting different analytical tools to demonstrate the successful creation of functional skeletal muscle tissue. Ultimately, a refinement of existing strategies will lead to further progression in understanding important aspects of muscle diseases, muscle aging and muscle regeneration to improve quality of life of patients and enable the establishment of new treatment options. KW - Bioreactor KW - Muscle KW - Biomaterial Y1 - ER - TY - JOUR A1 - Tomasch, Janine A1 - Maleiner, Babette A1 - Heher, Philipp A1 - Rufin, Manuel A1 - Andriotis, Orestis G. A1 - Thurner, Philipp J. A1 - Redl, Heinz A1 - Fuchs, Christiane A1 - Teuschl-Woller, Andreas H. T1 - Changes in Elastic Moduli of Fibrin Hydrogels Within the Myogenic Range Alter Behavior of Murine C2C12 and Human C25 Myoblasts Differently JF - Froniers in Bioengineering and Biotechnology N2 - Fibrin hydrogels have proven highly suitable scaffold materials for skeletal muscle tissue engineering in the past. Certain parameters of those types of scaffolds, however, greatly affect cellular mechanobiology and therefore the myogenic outcome. The aim of this study was to identify the influence of apparent elastic properties of fibrin scaffolds in 2D and 3D on myoblasts and evaluate if those effects differ between murine and human cells. Therefore, myoblasts were cultured on fibrin-coated multiwell plates (“2D”) or embedded in fibrin hydrogels (“3D”) with different elastic moduli. Firstly, we established an almost linear correlation between hydrogels’ fibrinogen concentrations and apparent elastic moduli in the range of 7.5 mg/ml to 30 mg/ml fibrinogen (corresponds to a range of 7.7–30.9 kPa). The effects of fibrin hydrogel elastic modulus on myoblast proliferation changed depending on culture type (2D vs 3D) with an inhibitory effect at higher fibrinogen concentrations in 3D gels and vice versa in 2D. The opposite effect was evident in differentiating myoblasts as shown by gene expression analysis of myogenesis marker genes and altered myotube morphology. Furthermore, culture in a 3D environment slowed down proliferation compared to 2D, with a significantly more pronounced effect on human myoblasts. Differentiation potential was also substantially impaired upon incorporation into 3D gels in human, but not in murine, myoblasts. With this study, we gained further insight in the influence of apparent elastic modulus and culture type on cellular behavior and myogenic outcome of skeletal muscle tissue engineering approaches. Furthermore, the results highlight the need to adapt parameters of 3D culture setups established for murine cells when applied to human cells. KW - Tissue Engineering KW - Fibrin KW - Hydrogel KW - Biomaterials KW - Cell Culture Y1 - VL - 10 SP - 836520 ER - TY - JOUR A1 - Angelova, Liliya A1 - Daskalova, Albena A1 - Filipov, Emil A1 - Monforte Vila, Xavier A1 - Tomasch, Janine A1 - Avdeev, Georgi A1 - Teuschl-Woller, Andreas Herbert A1 - Buchvarov, Ivan T1 - Optimizing the Surface Structural and Morphological Properties of Silk Thin Films via Ultra-Short Laser Texturing for Creation of Muscle Cell Matrix Model JF - Polymers N2 - Temporary scaffolds that mimic the extracellular matrix's structure and provide a stable substratum for the natural growth of cells are an innovative trend in the field of tissue engineering. The aim of this study is to obtain and design porous 2D fibroin-based cell matrices by femtosecond laser-induced microstructuring for future applications in muscle tissue engineering. Ultra-fast laser treatment is a non-contact method, which generates controlled porosity-the creation of micro/nanostructures on the surface of the biopolymer that can strongly affect cell behavior, while the control over its surface characteristics has the potential of directing the growth of future muscle tissue in the desired direction. The laser structured 2D thin film matrices from silk were characterized by means of SEM, EDX, AFM, FTIR, Micro-Raman, XRD, and 3D-roughness analyses. A WCA evaluation and initial experiments with murine C2C12 myoblasts cells were also performed. The results show that by varying the laser parameters, a different structuring degree can be achieved through the initial lifting and ejection of the material around the area of laser interaction to generate porous channels with varying widths and depths. The proper optimization of the applied laser parameters can significantly improve the bioactive properties of the investigated 2D model of a muscle cell matrix. Keywords: biopolymers; femtosecond laser processing; muscle cell matrix 2D model; muscle tissue engineering; silk fibroin. KW - Tissue Engineering KW - Muscle Cell matrix Model KW - Silk Scaffold KW - Surface Structure Y1 - VL - 2022 IS - 14(13), 2584 ER - TY - JOUR A1 - Schuh, Christina A1 - Heher, Philipp A1 - Weihs, Anna A1 - Fuchs, Christiane A1 - Gabriel, Christian A1 - Wolbank, Susanne A1 - Mittermayr, Rainer A1 - Redl, Heinz A1 - Rünzler, Dominik A1 - Teuschl, Andreas T1 - In vitro extracorporeal shock wave treatment enhances stemness and preserves multipotency of rat and human adipose-derived stem cells JF - Journal of Cytotherapy KW - Shockwave Y1 - ER - TY - JOUR A1 - Unterkofler, Karl A1 - Teschl, Susanne T1 - On the influence of inhaled volatile organic compounds (VOCs) on exhaled VOCs concentrations JF - Proceedings of the 10. Forschungsforum der Österreichischen Fachhochschulen KW - Organic Compounds Y1 - 2018 ER - TY - JOUR A1 - Kubinger, Wilfried A1 - Sommer, Roland T1 - Industrie 4.0 - Auswirkungen von Digitalisierung und Internet auf den Industriestandort JF - e&i Elektrotechnik und Informationstechnik KW - Industry 4.0 KW - Digitalisation KW - Industry Location Y1 - 2018 VL - 133 IS - 7 SP - 330 EP - 333 ER - TY - JOUR A1 - Urbauer, Philipp T1 - The Social Platform: Profiling FHIR to Support Community-Dwelling Older Adults JF - Journal of Medical Systems KW - Elderly People KW - eHealth KW - Residential Care KW - Integrated Care KW - FHIR Y1 - VL - 4 IS - 43 ER - TY - JOUR A1 - Munsch, Nicolas A1 - Gruarin, Stefanie A1 - Nateqi, Jama A1 - Lutz, Thomas A1 - Binder, Michael A1 - Aberle, Judith H. A1 - Martin, Alistair A1 - Knapp, Bernhard T1 - Symptoms associated with a COVID-19 infection among a non-hospitalized cohort in Vienna JF - Wiener Klinische Wochenschrift / The Central European Journal of Medicine N2 - Background: Most clinical studies report the symptoms experienced by those infected with coronavirus disease 2019 (COVID-19) via patients already hospitalized. Here we analyzed the symptoms experienced outside of a hospital setting. Methods: The Vienna Social Fund (FSW; Vienna, Austria), the Public Health Services of the City of Vienna (MA15) and the private company Symptoma collaborated to implement Vienna's official online COVID-19 symptom checker. Users answered 12 yes/no questions about symptoms to assess their risk for COVID-19. They could also specify their age and sex, and whether they had contact with someone who tested positive for COVID-19. Depending on the assessed risk of COVID-19 positivity, a SARS-CoV‑2 nucleic acid amplification test (NAAT) was performed. In this publication, we analyzed which factors (symptoms, sex or age) are associated with COVID-19 positivity. We also trained a classifier to correctly predict COVID-19 positivity from the collected data. Results: Between 2 November 2020 and 18 November 2021, 9133 people experiencing COVID-19-like symptoms were assessed as high risk by the chatbot and were subsequently tested by a NAAT. Symptoms significantly associated with a positive COVID-19 test were malaise, fatigue, headache, cough, fever, dysgeusia and hyposmia. Our classifier could successfully predict COVID-19 positivity with an area under the curve (AUC) of 0.74. Conclusion: This study provides reliable COVID-19 symptom statistics based on the general population verified by NAATs. Keywords: Chatbot; Machine learning; Self-reported; Symptom assessment; Symptom checker. KW - COVID-19 KW - Chatbot KW - Machine learning KW - Self-reported KW - Symptom assessment Y1 - VL - 2022 IS - 134 (9-10) SP - 344 EP - 350 PB - Springer ER - TY - JOUR A1 - Pucher, Robert A1 - Tesar, Michael A1 - Mandl, Thomas A1 - Holweg, Gerd A1 - Schmöllebeck, Fritz T1 - Improving Didactics in Computer Science - The Example of the GEMIS and the QUADRO Projects JF - International Journal of Education and Information Technologies KW - Didactics KW - Computer Science KW - Education Y1 - 2019 VL - 1 IS - 5 ER - TY - JOUR A1 - Pucher, Robert A1 - Lehner, Martin T1 - Project Based Learning in Computer Science JF - Procedia - Social and Behavioral Sciences, Volume 29, 2011, Pages 1561-1566, ISSN 1877-0428, KW - Project Based Learning KW - Computer Science Y1 - 2019 ER - TY - JOUR A1 - Kuba, Markus A1 - Panholzer, Alois T1 - On bucket increasing trees, clustered increasing trees and increasing diamonds JF - Combinatorics, Probability and Computing N2 - In this work we analyse bucket increasing tree families. We introduce two simple stochastic growth processes, generating random bucket increasing trees of size n, complementing the earlier result of Mahmoud and Smythe (1995, Theoret. Comput. Sci.144 221–249.) for bucket recursive trees. On the combinatorial side, we define multilabelled generalisations of the tree families d-ary increasing trees and generalised plane-oriented recursive trees. Additionally, we introduce a clustering process for ordinary increasing trees and relate it to bucket increasing trees. We discuss in detail the bucket size two and present a bijection between such bucket increasing tree families and certain families of graphs called increasing diamonds, providing an explanation for phenomena observed by Bodini et al. (2016, Lect. Notes Comput. Sci.9644 207–219.). Concerning structural properties of bucket increasing trees, we analyse the tree parameter Kn . It counts the initial bucket size of the node containing label n in a tree of size n and is closely related to the distribution of node types. Additionally, we analyse the parameters descendants of label j and degree of the bucket containing label j, providing distributional decompositions, complementing and extending earlier results (Kuba and Panholzer (2010), Theoret. Comput. Sci.411(34–36) 3255–3273.). KW - bucket-increasing-trees KW - clustered-trees KW - stochastic-growth-processes KW - descendants KW - nodedegrees Y1 - 2021 IS - Volume 31 , Issue 4 SP - 629 EP - 661 ER - TY - JOUR A1 - Huber, Albert T1 - Remark on the quasilocal calculation of tidal heating: Energy transfer through the quasilocal surface JF - American Physical Society - Physical Review D N2 - In this paper, using the quasilocal formalism of Brown and York, the flow of energy through a closed surface containing a gravitating physical system is calculated in a way that augments earlier results on the subject by Booth and Creighton. To this end, by performing a variation of the total gravitational Hamiltonian (bulk plus boundary part), it is shown that associated tidal heating and deformation effects generally are larger than expected. This is because the aforementioned variation leads to previously unrecognized correction terms, including a bulk-to-boundary inflow term that does not appear in the original calculation of the time derivative of the Brown-York energy and leads to corrective extensions of Einstein’s quadrupole formula in the large sphere limit. KW - gravitation KW - cosmology KW - fields Y1 - VL - 105 IS - 2 ER - TY - JOUR A1 - Mairhofer, Lukas A1 - Passon, Oliver T1 - Reconsidering the Relation Between “Matter Wave Interference” and “Wave–Particle Duality” JF - Foundations of Physics N2 - Interference of more and more massive objects provides a spectacular confirmation of quantum theory. It is usually regarded as support for “wave–particle duality” and in an extension of this duality even as support for “complementarity”. We first give an outline of the historical development of these notions. Already here it becomes evident that they are hard to define rigorously, i.e. have mainly a heuristic function. Then we discuss recent interference experiments of large and complex molecules which seem to support this heuristic function of “duality”. However, we show that in these experiments the diffraction of a delocalized center-of-mass wave function depends on the interaction of the localized structure of the molecule with the diffraction element. Thus, the molecules display “dual features” at the same time, which contradicts the usual understanding of wave–particle duality. We conclude that the notion of “wave–particle duality” deserves no place in modern quantum physics. KW - Quantenmechanik KW - Welle-Teilchen-Dualismus KW - Interferenz Y1 - IS - 52/32 PB - Springer ER - TY - JOUR A1 - Huber, Albert T1 - The gravitational field of a massless particle on the horizon of a stationary black hole JF - Classical and Quantum Gravity N2 - In this work, the field of a gravitational shockwave generated by a massless point-like particle is calculated at the event horizon of a stationary Kerr–Newman black hole. Using the geometric framework of generalized Kerr–Schild deformations in combination with the spin-coefficient formalism of Newman and Penrose, it is shown that the field equations of the theory, at the event horizon of the black hole, can be reduced to a single linear ordinary differential equation for the so-called profile function of the geometry. This differential relation is solved exactly. Based on the results obtained, a physical interpretation is given for the found shockwave spacetime, and it is clarified how these results lead back to those of previous works on the subject, which deal with the much simpler cases of gravitational shockwaves in static black hole backgrounds. KW - Gravitation Y1 - ER - TY - JOUR A1 - Kuba, Markus T1 - On multisets, interpolated multiple zeta values and limit laws. JF - Electronic Journal of Combinatorics N2 - In this work we discuss a parameter σ on weighted k-element multisets of [n]={1,…,n}. The sums of weighted k-multisets are related to k-subsets, k-multisets, as well as special instances of truncated interpolated multiple zeta values. We study properties of this parameter using symbolic combinatorics. We rederive and extend certain identities for ζtn({m}k). Moreover, we introduce random variables on the k-element multisets and derive their distributions, as well as limit laws for k or n tending to infinity. KW - k-multisets KW - k-subsets KW - truncated-multiple-zeta-values KW - interpolated-multiple-zeta-values KW - harmonic-numbers Y1 - IS - Vol. 29, Issue 1 ER - TY - JOUR A1 - Hoffmann, Michael E. A1 - Kuba, Markus T1 - Logarithmic integrals, zeta values, and tiered binomial coeffcients JF - Monatshefte fuer Mathematik KW - Integrals KW - Binomial KW - Coefficient Y1 - ER - TY - JOUR A1 - Belkacem, Kévin A1 - Kupka, Friedrich A1 - Philidet, Jordan A1 - Samadi, Réza T1 - Surface effects and turbulent pressure. Assessing the Gas-Γ1 and Reduced-Γ1 empirical models. JF - Astronomy & Astrophysics KW - Surface KW - Pressure Y1 - ER -