TY - GEN A1 - Pasteka, Richard T1 - Applications of Biomedical Engineering in Respiratory Care KW - Biomedical Engineering Y1 - ER - TY - CHAP A1 - Pasteka, Richard A1 - Forjan, Mathias T1 - Changes of particle deposition caused by different breathing patterns during active lung simulation T2 - 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019 KW - Lung Simulation KW - Breathing Simulation KW - Biomedical Engineering Y1 - 2020 SP - 4969 EP - 4972 ER - TY - JOUR A1 - Fibich, Christian A1 - Tauner, Stefan A1 - Rössler, Peter A1 - Horauer, Martin A1 - Matschnig, Martin A1 - Taucher, Herbert T1 - FIJI – Fault InJection Instrumenter JF - EURASIP Journal on Embedded Systems KW - Fault injection KW - FPGA KW - Safety-critical system KW - Verification KW - Electronic design automation Y1 - 2019 VL - 2019 IS - Februar 2019 ER - TY - JOUR A1 - Krizek, Gerd Christian A1 - Hausleitner, Rene A1 - Böhme, Laura A1 - Olaverri-Monreal, Cristina T1 - Empirical Analysis of Safe Distance Calculation by the Stereoscopic Capturing and Processing of Images Through the Tailigator System JF - sensors N2 - Driver disregard for the minimum safety distance increases the probability of rear-end collisions. In order to contribute to active safety on the road, we propose in this work a low-cost Forward Collision Warning system that captures and processes images. Using cameras located in the rear section of a leading vehicle, this system serves the purpose of discouraging tailgating behavior from the vehicle driving behind. We perform in this paper the pertinent field tests to assess system performance, focusing on the calculated distance from the processing of images and the error margins in a straight line, as well as in a curve. Based on the evaluation results, the current version of the Tailigator can be used at speeds up to 50 km per hour without any restrictions. The measurements showed similar characteristics both on the straight line and in the curve. At close distances, between 3 and 5 m, the values deviated from the real value. At average distances, around 10 to 15 m, the Tailigator achieved the best results. From distances higher than 20 m, the deviations increased steadily with the distance. We contribute to the state of the art with an innovative low-cost system to identify tailgating behavior and raise awareness, which works independently of the rear vehicle's communication capabilities or equipment. KW - tailgating KW - stereoscopy Y1 - 2020 ER - TY - CHAP A1 - Himmelstoß, Felix A1 - Votzi, Helmut T1 - Four quadratic DC/DC converters with one low-side switch and a tapped inductor at the input side T2 - Proceedings of IECON 2019, 45th Annual Conference of the IEEE Industrial Electronics Society, Lisbon, Portugal, Sep. 14-17, Lisbon Portugal KW - DC/DC Converter KW - Quadratic KW - Tapped Inductor Y1 - 2020 SP - 1774 EP - 1779 ER - TY - JOUR A1 - Teuschl, Andreas A1 - Holnthoner, Wolfgang A1 - Monforte, Xavier T1 - Repopulation of an auricular cartilage scaffold, AuriScaff, perforated with an enzyme combination JF - Acta Biomater. N2 - Biomaterials currently in use for articular cartilage regeneration do not mimic the composition or architecture of hyaline cartilage, leading to the formation of repair tissue with inferior characteristics. In this study we demonstrate the use of "AuriScaff", an enzymatically perforated bovine auricular cartilage scaffold, as a novel biomaterial for repopulation with regenerative cells and for the formation of high-quality hyaline cartilage. AuriScaff features a traversing channel network, generated by selective depletion of elastic fibers, enabling uniform repopulation with therapeutic cells. The complex collagen type II matrix is left intact, as observed by immunohistochemistry, SEM and TEM. The compressive modulus is diminished, but three times higher than in the clinically used collagen type I/III scaffold that served as control. Seeding tests with human articular chondrocytes (hAC) alone and in co-culture with human adipose-derived stromal/stem cells (ASC) confirmed that the network enabled cell migration throughout the scaffold. It also guides collagen alignment along the channels and, due to the generally traverse channel alignment, newly deposited cartilage matrix corresponds with the orientation of collagen within articular cartilage. In an osteochondral plug model, AuriScaff filled the complete defect with compact collagen type II matrix and enabled chondrogenic differentiation inside the channels. Using adult articular chondrocytes from bovine origin (bAC), filling of even deep defects with high-quality hyaline-like cartilage was achieved after 6 weeks in vivo. With its composition and spatial organization, AuriScaff provides an optimal chondrogenic environment for therapeutic cells to treat cartilage defects and is expected to improve long-term outcome by channel-guided repopulation followed by matrix deposition and alignment. STATEMENT OF SIGNIFICANCE: After two decades of tissue engineering for cartilage regeneration, there is still no optimal strategy available to overcome problems such as inconsistent clinical outcome, early and late graft failures. Especially large defects are dependent on biomaterials and their scaffolding, guiding and protective function. Considering the currently used biomaterials, structure and mechanical properties appear to be insufficient to fulfill this task. The novel scaffold developed within this study is the first approach enabling the use of dense cartilage matrix, repopulate it via channels and provide the cells with a compact collagen type II environment. Due to its density, it also provides better mechanical properties than materials currently used in clinics. We therefore think, that the auricular cartilage scaffold (AuriScaff) has a high potential to improve future cartilage regeneration approaches. KW - Auricular cartilage KW - Cartilage Regeneration KW - Human adipose derived stromal/stem cells KW - Tissue Engineering KW - Decellularization Y1 - 2020 VL - 2019 IS - Mar/86 SP - 207 EP - 222 ER - TY - CHAP A1 - Wöber, Wilfried A1 - Tibihika, Papius D A1 - Olaverri-Monreal, Cristina A1 - Mehnen, Lars A1 - Sykacek, Peter A1 - Meimberg, Harald T1 - Comparison of Unsupervised Learning Methods for Natural Image Processing T2 - Biodiversity Information Science and Standards KW - Machine Learning KW - Deep Learning KW - Image Processing Y1 - IS - 3 ER - TY - CHAP A1 - Himmelstoß, Felix A1 - Jungmayer, Michael T1 - Zero-Current-Switching Buck Converter T2 - Proceedings of 2019 International Conference on Electrical Drives & Power Electronics (EDPE), Novy Smokovec, Slovakia, 24-26 Sept. 2019 KW - DC/DC Converter KW - Zero Current Switching KW - Resonance Converter Y1 - 2020 SP - 36 EP - 41 ER - TY - JOUR A1 - Nürnberger, Sylvia A1 - Schneider, Cornelia A1 - van Osch, Gerjo A1 - Keibl, Claudia A1 - Rieder, Bernhard A1 - Monforte, Xavier A1 - Teuschl, Andreas A1 - Mühleder, Severin A1 - Holnthoner, Wolfgang A1 - Schädl, Barbara A1 - Gahleitner, Christoph A1 - Redl, Heinz A1 - Wolbank, Susanne T1 - Repopulation of an auricular cartilage scaffold, AuriScaff, perforated with an enzyme combination. JF - Acta Biomaterialia KW - Tissue Engineering KW - Decellularization KW - Cartilage Y1 - ER - TY - CHAP A1 - Wöber, Wilfried A1 - Aburaia, Mohamed A1 - Olaverri-Monreal, Cristina T1 - Classification of Streetsigns Using Gaussian Process Latent Variable Models T2 - 2019 IEEE International Conference on Connected Vehicles and Expo (ICCVE), Graz, Austria KW - Streetsigns KW - Gaussian KW - Vehicles Y1 - 2020 ER - TY - JOUR A1 - Holnthoner, Wolfgang T1 - Adipose-tissue-derived therapeutic cells in their natural environment as an autologous cell therapy strategy: the microtissue-stromal vascular fraction JF - Eur Cell Mater. N2 - The prerequisite for a successful clinical use of autologous adipose-tissue-derived cells is the highest possible regenerative potential of the applied cell population, the stromal vascular fraction (SVF). Current isolation methods depend on high enzyme concentration, lysis buffer, long incubation steps and mechanical stress, resulting in single cell dissociation. The aim of the study was to limit cell manipulation and obtain a derivative comprising therapeutic cells (microtissue-SVF) without dissociation from their natural extracellular matrix, by employing a gentle good manufacturing practice (GMP)-grade isolation. The microtissue-SVF yielded larger numbers of viable cells as compared to the improved standard-SVF, both with low enzyme concentration and minimal dead cell content. It comprised stromal tissue compounds (collagen, glycosaminoglycans, fibroblasts), capillaries and vessel structures (CD31+, smooth muscle actin+). A broad range of cell types was identified by surface-marker characterisation, including mesenchymal, haematopoietic, pericytic, blood and lymphatic vascular and epithelial cells. Subpopulations such as supra-adventitial adipose-derived stromal/stem cells and endothelial progenitor cells were significantly more abundant in the microtissue-SVF, corroborated by significantly higher potency for angiogenic tube-like structure formation in vitro. The microtissue-SVF showed the characteristic phenotype and tri-lineage mesenchymal differentiation potential in vitro and an immunomodulatory and pro-angiogenic secretome. In vivo implantation of the microtissue-SVF combined with fat demonstrated successful graft integration in nude mice. The present study demonstrated a fast and gentle isolation by minor manipulation of liposuction material, achieving a therapeutically relevant cell population with high vascularisation potential and immunomodulatory properties still embedded in a fraction of its original matrix. KW - Adipose-tissue KW - autologous cell therapy KW - microtissue KW - stromal vascular fraction KW - vascularization Y1 - 2020 VL - 2019 IS - Feb, 37 SP - 113 EP - 133 ER - TY - JOUR A1 - Sattinger, Vinzenz A1 - Papa, Maximilian A1 - Stuja, Kemajl A1 - Kubinger, Wilfried T1 - Methodik zur Entwicklung sicherer kollaborativer Produktionssysteme im Rahmen von Industrie 4.0 JF - e & i Elektrotechnik und Informationstechnik KW - Robotics KW - Industry 4.0 Y1 - ER - TY - JOUR A1 - Heimel, Patrick A1 - Swiadek, Nicole V. A1 - Slezak, Paul A1 - Kerbl, Markus A1 - Schneider, Cornelia A1 - Nürnberger, Sylvia A1 - Redl, Heinz A1 - Teuschl, Andreas A1 - Hercher, David T1 - Iodine-Enhanced Micro-CT Imaging of Soft Tissue on the Example of Peripheral Nerve Regeneration JF - Contrast Media & Molecular Imaging KW - µCT KW - Imaging KW - Tissue Engineering KW - Tissue Regeneration Y1 - ER - TY - CHAP A1 - Himmelstoß, Felix A1 - Edelmoser, Karl T1 - Zero-Current-Switching Boost Converter, Power Conversion and Intelligent Motion T2 - Proceedings of PCIM 2019, Nuernberg, Germany, May 7-9, 2019 KW - Discontinuous Conduction Mode KW - DC/DC Converter KW - Resonant Converter KW - ZCS KW - DCM Y1 - 2019 SN - 978-3-8007-4938-6 SP - 1686 EP - 1691 ER - TY - CHAP A1 - Himmelstoß, Felix A1 - Votzi, Helmut T1 - A family of quadratic DC/DC converters with one low-side switch and a tapped inductor at the output side T2 - Aegean Conference on Electrical Machines and Power Electronics & Optimization of Electrical & Electronic Equipment Conference, Istanbul Turkey, August, 27 – 29, 2019 KW - DC/DC Converter KW - Tapped Inductor Y1 - 2019 ER -