TY - CHAP A1 - Salzbrunn, Benedikt A1 - Kipke, Christine A1 - Busch, Marc A1 - Schiava, Marco della T1 - rapid UX-score: Modulare und Adaptive Messung von User Experience T2 - Mensch und Computer 2020 KW - UX Messung KW - Modulare UX Messung KW - Adaptive UX Messung KW - Rasch-Modell Y1 - 2020 SP - 6 EP - 9 CY - Magdeburg ER - TY - CHAP A1 - Salzbrunn, Benedikt A1 - Busch, Marc A1 - della Schiava, Marco A1 - Kipke, Christine T1 - rapid UX-score: Modulare und Adaptive Messung von User Experience T2 - Mensch und Computer 2020 - Workshopband KW - UX Messung KW - Modulare UX Messung KW - Adaptive UX Messung KW - Rasch-Modell Y1 - ER - TY - CHAP A1 - Mally, Franziska A1 - Hofstätter, Otto A1 - Eckelt, Markus T1 - Influence of Running Shoes and Running Velocity on “Ride” during Running. T2 - ISEA 2020 Online - Proceedings 2020 KW - Sports Equipment Technologies KW - Running Shoes KW - Footwear Y1 - 2020 ER - TY - JOUR A1 - Huber, Albert T1 - Junction Conditions and local Spacetimes in General Relativity JF - The European Physical Journal C N2 - In the present work, a theoretical framework focussing on local geometric deformations is introduced in order to cope with the problem of how to join spacetimes with different geometries and physical properties. This framework is used to show that two Lorentzian manifolds can be matched by considering local deformations of the associated spacetime metrics. Based on the fact that metrics can be suitably matched in this way, it is shown that the underlying geometric approach allows the characterization of local spacetimes in general relativity. Furthermore, it is shown that said approach not only extends the conventional thin shell formalism, but also allows the treatment of geometric problems that cannot be treated with standard gluing techniques. KW - Relativity Y1 - ER - TY - JOUR A1 - Schätti, Jonas A1 - Köhler, Valentin A1 - Mayor, Marcel A1 - Fein, Yaakov A1 - Geyer, Philipp A1 - Mairhofer, Lukas A1 - Gerlich, Stefan A1 - Arndt, Markus T1 - Matter-wave interference and deflection of tripeptides decorated with fluorinated alkyl chains JF - Journal of Mass Spectrometry KW - interference KW - quantum KW - meteorology Y1 - IS - Vol 55, issue 6 ER - TY - JOUR A1 - Fein, Yaakov A1 - Shayeghi, Armin A1 - Mairhofer, Lukas A1 - Kialka, Filip A1 - Rieser, Philipp A1 - Geyer, Philipp A1 - Gerlich, Stefan A1 - Arndt, Markus T1 - Quantum-Assisted Measurement of Atomic Diamagnetism JF - Physical Review KW - diamagnetism KW - quantum KW - meteorology Y1 - IS - Volume 10, Issue 1 ER - TY - JOUR A1 - Hoffman, Michael E. A1 - Kuba, Markus A1 - Levy, Moti A1 - Louchard, Guy T1 - An Asymptotic Series for an Integral JF - Ramanujan Journal KW - asymtotic KW - integral Y1 - 2020 ER - TY - JOUR A1 - Hoffmann, Michael E. A1 - Kuba, Markus A1 - Levy, Moti A1 - Louchard, Guy T1 - An Asymptotic Series for an Integral JF - Ramanujan Journal KW - Asymptotic KW - Integral Y1 - ER - TY - JOUR A1 - Schanda, Jakob A1 - Keibl, Claudia A1 - Heimel, Patrick A1 - Monforte, Xavier A1 - Feichtinger, Xaver A1 - Teuschl, Andreas A1 - Baierl, Andreas A1 - Muschitz, Christian A1 - Redl, Heinz A1 - Fialka, Christian A1 - Mittermayr, Rainer T1 - Zoledronic Acid Substantially Improves Bone Microarchitecture and Biomechanical Properties After Rotator Cuff Repair in a Rodent Chronic Defect Model JF - Am J Sports Med N2 - Background: Bone mineral density at the humeral head is reduced in patients with chronic rotator cuff tears. Bone loss in the humeral head is associated with repair failure after rotator cuff reconstruction. Bisphosphonates (eg, zoledronic acid) increase bone mineral density. Hypothesis: Zoledronic acid improves bone mineral density of the humeral head and biomechanical properties of the enthesis after reconstruction of chronic rotator cuff tears in rats. Study design: Controlled laboratory study. Methods: A total of 32 male Sprague-Dawley rats underwent unilateral (left) supraspinatus tenotomy with delayed transosseous rotator cuff reconstruction after 3 weeks. All rats were sacrificed 8 weeks after rotator cuff repair. Animals were randomly assigned to 1 of 2 groups. At 1 day after rotator cuff reconstruction, the intervention group was treated with a single subcutaneous dose of zoledronic acid at 100 µg/kg bodyweight, and the control group received 1 mL of subcutaneous saline solution. In 12 animals of each group, micro-computed tomography scans of both shoulders were performed as well as biomechanical testing of the supraspinatus enthesis of both sides. In 4 animals of each group, histological analyses were conducted. Results: In the intervention group, bone volume fraction (bone volume/total volume [BV/TV]) of the operated side was higher at the lateral humeral head (P = .005) and the medial humeral head (P = .010) compared with the control group. Trabecular number on the operated side was higher at the lateral humeral head (P = .004) and the medial humeral head (P = .001) in the intervention group. Maximum load to failure rates on the operated side were higher in the intervention group (P < .001). Cortical thickness positively correlated with higher maximum load to failure rates in the intervention group (r = 0.69; P = .026). Histological assessment revealed increased bone formation in the intervention group. Conclusion: Single-dose therapy of zoledronic acid provided an improvement of bone microarchitecture at the humeral head as well as an increase of maximum load to failure rates after transosseous reconstruction of chronic rotator cuff lesions in rats. Clinical relevance: Zoledronic acid improves bone microarchitecture as well as biomechanical properties after reconstruction of chronic rotator cuff tears in rodents. These results need to be verified in clinical investigations. KW - Tissue Engineering KW - Rotator Cuff Tears Y1 - VL - 2020 Jul IS - 48 (9) SP - 2151 EP - 2160 ER - TY - JOUR A1 - Bachmann, Barbara A1 - Spitz, Sarah A1 - Schädl, Barbara A1 - Teuschl, Andreas A1 - Redl, Heinz A1 - Nürnberger, Sylvia A1 - Ertl, Peter T1 - Stiffness Matters: Fine-Tuned Hydrogel Elasticity Alters Chondrogenic Redifferentiation JF - Froniers in Bioengineering and Biotechnology N2 - Biomechanical cues such as shear stress, stretching, compression, and matrix elasticity are vital in the establishment of next generation physiological in vitro tissue models. Matrix elasticity, for instance, is known to guide stem cell differentiation, influence healing processes and modulate extracellular matrix (ECM) deposition needed for tissue development and maintenance. To better understand the biomechanical effect of matrix elasticity on the formation of articular cartilage analogs in vitro, this study aims at assessing the redifferentiation capacity of primary human chondrocytes in three different hydrogel matrices of predefined matrix elasticities. The hydrogel elasticities were chosen to represent a broad spectrum of tissue stiffness ranging from very soft tissues with a Young's modulus of 1 kPa up to elasticities of 30 kPa, representative of the perichondral-space. In addition, the interplay of matrix elasticity and transforming growth factor beta-3 (TGF-β3) on the redifferentiation of primary human articular chondrocytes was studied by analyzing both qualitative (viability, morphology, histology) and quantitative (RT-qPCR, sGAG, DNA) parameters, crucial to the chondrotypic phenotype. Results show that fibrin hydrogels of 30 kPa Young's modulus best guide chondrocyte redifferentiation resulting in a native-like morphology as well as induces the synthesis of physiologic ECM constituents such as glycosaminoglycans (sGAG) and collagen type II. This comprehensive study sheds light onto the mechanobiological impact of matrix elasticity on formation and maintenance of articular cartilage and thus represents a major step toward meeting the need for advanced in vitro tissue models to study both re- and degeneration of articular cartilage. KW - Tissue Engineering KW - Chondrogenic Redifferentiation KW - Biomaterials Y1 - 2021 VL - 2020 IS - 8 SP - 373 ER - TY - CHAP A1 - Mally, Franziska T1 - In-Shoe Plantar Pressure Measurement—Influence of Insole Placement on Selected Parameters during Running. T2 - ISEA 2020 Online - Proceedings 2020, 49(1) KW - Sports Equipment Technologies KW - Running Shoes KW - Motion Analysis Y1 - 2020 SP - 50 EP - 50 ER - TY - CHAP A1 - Wießner, Katharina A1 - Praher, Daniela A1 - Liousia, Varvara A1 - Gepp, Barbara A1 - Leitner, Rita A1 - Rünzler, Dominik T1 - Testing the acute toxicity of an alternative to Glyphosate - Pelargonic acid T2 - SETAC Europe 30th Annual Meeting - Online N2 - Glyphosate-based herbicides were used as plant protection product globally for several decades. However, glyphosate is discussed as showing genotoxicity and many other side-effects such as inhibiting the mitochondrial succinate dehydrogenase, leading to a decreased ATP production. Therefore, finding alternative active substances is necessary. Pelargonic acid (nonanoic acid) and its ammonium salt (saponified form), which are used as alternatives to glyphosate-based herbicides, are biological derived substances considered as environmentally friendly herbicides. To test the effects of pelargonic acid in its acidic form (active substance in TopGun) and its saponified form (in Finalsan Plus) on the aquatic ecosystem, students of the master study program “environmental management and ecotoxicology” compared the toxicity levels of these substances using zebrafish embryos within the scope of a student research course. The project was developed by applying the 7-step problem-based learning method which allowed the students to design their experiments independently with the guidance and feedback of the lecturers. Acute toxicity was determined according to OECD test guideline 236 in D. rerio which revealed a LC50 of 1.55 mg/L of pelargonic acid, a LC50 value of 0.93 mg/L pelargonic acid in TopGun and a LC50 of 36.37 mg/L of Finalsan Plus. Neutral Red Uptake assays were performed on the rainbow trout-derived gill cell-line RTgill-W1 to determine the acute toxicity according to the OECD test guideline 129 which revealed the IC50 value of 12.4 mg/L pelargonic acid in TG. Due to solubility limits, no reliable IC50 could be obtained. The results of the tests indicate differences in the acute toxicity of the pelargonic acid-based formulations TopGun and Finalsan Plus. However, more investigations have to be done in order to analyse if the acidic form is more toxic than the saponified form. Furthermore, detailed ecotoxicological risk assessments and an evaluation of the genotoxicity of both herbicides has to be performed before any conclusion can be drawn. Financial support from the City of Vienna project PBL in Molecular Life Science (21-06) is gratefully acknowledged. KW - Environmental Chemistry KW - Ecotoxicology Y1 - 2020 ER - TY - JOUR A1 - Ziadlou, Reihane A1 - Rotman, Stijn A1 - Teuschl, Andreas A1 - Salzer, Elias A1 - Barbero, Andrea A1 - Martin, Ivan A1 - Alini, Mauro A1 - Eglin, David A1 - Grad, Sibylle T1 - Optimization of hyaluronic acid-tyramine/silk-fibroin composite hydrogels for cartilage tissue engineering and delivery of anti-inflammatory and anabolic drugs JF - Materials Science and Engineering: C N2 - Injury of articular cartilage leads to an imbalance in tissue homeostasis, and due to the poor self-healing capacity of cartilage the affected tissue often exhibits osteoarthritic changes. In recent years, injectable and highly tunable composite hydrogels for cartilage tissue engineering and drug delivery have been introduced as a desirable alternative to invasive treatments. In this study, we aimed to formulate injectable hydrogels for drug delivery and cartilage tissue engineering by combining different concentrations of hyaluronic acid-tyramine (HA-Tyr) with regenerated silk-fibroin (SF) solutions. Upon enzymatic crosslinking, the gelation and mechanical properties were characterized over time. To evaluate the effect of the hydrogel compositions and properties on extracellular matrix (ECM) deposition, bovine chondrocytes were embedded in enzymatically crosslinked HA-Tyr/SF composites (in further work abbreviated as HA/SF) or HA-Tyr hydrogels. We demonstrated that all hydrogel formulations were cytocompatible and could promote the expression of cartilage matrix proteins allowing chondrocytes to produce ECM, while the most prominent chondrogenic effects were observed in hydrogels with HA20/SF80 polymeric ratios. Unconfined mechanical testing showed that the compressive modulus for HA20/SF80 chondrocyte-laden constructs was increased almost 10-fold over 28 days of culture in chondrogenic medium which confirmed the superior production of ECM in this hydrogel compared to other hydrogels in this study. Furthermore, in hydrogels loaded with anabolic and anti-inflammatory drugs, HA20/SF80 hydrogel showed the longest and the most sustained release profile over time which is desirable for the long treatment duration typically necessary for osteoarthritic joints. In conclusion, HA20/SF80 hydrogel was successfully established as a suitable injectable biomaterial for cartilage tissue engineering and drug delivery applications. KW - Tissue Engineering KW - Cartilage KW - Mechanical Testing KW - Biomaterials KW - Chondrocytes Y1 - VL - 120 IS - 111701 ER - TY - JOUR A1 - Frohner, Matthias A1 - Mense, Alexander A1 - Krondraf, Nikolaus A1 - Sabutsch, Stefan T1 - Implementierungsleitfaden HL7 Implementation Guide for CDA® R2: Implementierungsleitfaden Meldung an das Epidemiologische Meldesystem (EMS) – Labor-und Arztmeldung, ELGA GmbH JF - ELGA CDA Implementierungsleitfäden HL7 KW - eHealth KW - ELGA Y1 - VL - 2020 ER - TY - JOUR A1 - Frohner, Matthias A1 - Sabutsch, Stefan A1 - Krondraf, Nikolaus T1 - ELGA CDA Implementierungsleitfäden HL7 Implementation Guide for CDA® R2: Ambulanzbefund, ELGA GmbH JF - ELGA CDA Implementierungsleitfäden HL7 KW - eHealth KW - ELGA Y1 - VL - 2020 ER - TY - CHAP A1 - Eckelt, Markus A1 - Mally, Franziska T1 - Running Shoes—Possible Correlations of Biomechanical and Material Tests. T2 - ISEA 2020 Online - Proceedings 2020, 49(1) KW - Sports Equipment Technologies KW - Running Shoes Y1 - 2020 SP - 25 EP - 25 ER - TY - CHAP A1 - Eckelt, Markus A1 - Mally, Franziska T1 - Use of Acceleration Sensors in Archery T2 - ISEA 2020 Online - Proceedings 2020, 49(1) KW - Sports Equipment Technologies KW - Acceleration Sensors KW - Archery Y1 - 2020 SP - 98 EP - 98 ER - TY - JOUR A1 - Rössler, Peter A1 - Höller, Roland T1 - Programmable Logic Devices – Key Components for Today's and Tomorrow's Electronic-Based Systems JF - e&i (Elektrotechnik und Informationstechnik), Volume 137, Issue 1, 2020 KW - Programmable Logic Devices KW - Field-Programmable Gate Arrays KW - PLD KW - FPGA Y1 - 2020 VL - Vol. 137, 2020 IS - Issue 1, 2020 ER - TY - JOUR A1 - Otrebski, Richard A1 - Rauer, Johannes A1 - Engelhardt-Nowitzki, Corinna A1 - Kryvinska, Natalia A1 - Aburaia, Mohamed A1 - Pospisil, Dominik T1 - Flexibility Enhancements in Digital Manufacturing by means of Ontological Data Modeling JF - International Journal of Ubiquitous Systems and Pervasive Networks (JUSPN) KW - Communication Modeling KW - Data Modeling KW - Digital Manufacturing Y1 - 2020 IS - Volume 12, Issue 2 ER - TY - JOUR A1 - Hu, Qingxi A1 - Feng, Di A1 - Zhang, Haiguang A1 - Yao, Yuan A1 - Aburaia, Mohamed A1 - Lammer, Herfried T1 - Oriented to Multi-Branched Structure Unsupported 3D Printing Method Research JF - Materials, vol. 13, no. 9, p. 2023, Apr. 2020 KW - Structure KW - 3D KW - Printing Y1 - 2020 ER -