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Deadly encounter: ubiquitin meets apoptosis

  • The ubiquitin/proteasome pathway is the main non-lysosomal route for intracellular protein degradation in eukaryotes. It is instrumental to various cellular processes, such as cell-cycle progression, transcription and antigen processing. Recent findings also substantiate a pivotal role of the ubiquitin/proteasome pathway in the regulation of apoptosis. Regulatory molecules that are involved in programmed cell death have been identified as substrates of the proteasome. Moreover, key regulators of apoptosis themselves seem to have an active part in the proteolytic inactivation of death executors.

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Metadaten
Author:Veronika Jesenberger, Stefan Jentsch
DOI:https://doi.org/https://doi.org/10.1038/nrm731
Parent Title (English):Nat Rev Mol Cell Biol.
Document Type:Article
Language:English
Completed Date:2002/02/01
Date of first Publication:2020/11/27
Responsibility for metadata:Fachhochschule Technikum Wien
Release Date:2020/11/27
GND Keyword:Molecular Cell Biology; programmed cell death
Volume:2002
Issue:3(2)
First Page:112
Last Page:121
Publish on Website:1
Open Access:0
Reviewed:1
Link to Publication:https://pubmed.ncbi.nlm.nih.gov/11836513/
Department:Department Life Science Engineering
Research Focus:Tissue Engineering & Molecular Life Science Technologies
Projects:Eigenmittel
Studienjahr:2001/2002