Deadly encounter: ubiquitin meets apoptosis
- The ubiquitin/proteasome pathway is the main non-lysosomal route for intracellular protein degradation in eukaryotes. It is instrumental to various cellular processes, such as cell-cycle progression, transcription and antigen processing. Recent findings also substantiate a pivotal role of the ubiquitin/proteasome pathway in the regulation of apoptosis. Regulatory molecules that are involved in programmed cell death have been identified as substrates of the proteasome. Moreover, key regulators of apoptosis themselves seem to have an active part in the proteolytic inactivation of death executors.
| Author: | Veronika Jesenberger, Stefan Jentsch |
|---|---|
| DOI: | https://doi.org/https://doi.org/10.1038/nrm731 |
| Parent Title (English): | Nat Rev Mol Cell Biol. |
| Document Type: | Article |
| Language: | English |
| Completed Date: | 2002/02/01 |
| Date of first Publication: | 2020/11/27 |
| Responsibility for metadata: | Fachhochschule Technikum Wien |
| Release Date: | 2020/11/27 |
| GND Keyword: | Molecular Cell Biology; programmed cell death |
| Volume: | 2002 |
| Issue: | 3(2) |
| First Page: | 112 |
| Last Page: | 121 |
| Publish on Website: | 1 |
| Open Access: | 0 |
| Reviewed: | 1 |
| Link to Publication: | https://pubmed.ncbi.nlm.nih.gov/11836513/ |
| Department: | Department Life Science Engineering |
| Research Focus: | Tissue Engineering & Molecular Life Science Technologies |
| Projects: | Eigenmittel |
| Studienjahr: | 2001/2002 |
