Refine
Year of publication
Document Type
- Lecture (32)
- Conference Proceeding (24)
- Article (6)
Keywords
- eHealth (20)
- Education (10)
- Rehabilitation (10)
- Biomedical Engineering (8)
- Lung Simulator (8)
- Breathing Simulation (6)
- eLearning (6)
- Interoperability (4)
- Telemonitoring (4)
- Electronic Health Records (3)
- Neurology (3)
- Stroke Patients (3)
- Virtual Reality (3)
- App development (2)
- Breathing (2)
- Exercise database (2)
- Flow Measurement (2)
- Home-based Rehabilitation (2)
- In-silico Models (2)
- Knowledge Profiles (2)
- Low-Cost (2)
- Mathematical Models (2)
- Mechanical Simulation (2)
- Rehabitation (2)
- Telerehabilitation (2)
- Virtual Lab (2)
- mechanical lung-simulator (2)
- Aerosol (1)
- Automation (1)
- Biofeedback System (1)
- Biomedical Engineering, Breathing simulation (1)
- Dry powder inhaler resistance (1)
- Electromechanical lung simulator (1)
- Emergency Room (1)
- Evidence based Decision Support (1)
- Harmonization (1)
- Health Applications (1)
- Healthcare (1)
- Home based rehabilitation (1)
- Hospital (1)
- Human Vision (1)
- Individualized Rehabilitation (1)
- Insoles (1)
- Internationalized Teaching (1)
- Life Science Engineering (1)
- Lung Simulation (1)
- Mechanical Eye (1)
- Medical Training (1)
- Mobile Application (1)
- Neurological Rehabilitation (1)
- Open Data (1)
- Optical Imaging (1)
- PHR (1)
- Pilot Study (1)
- Processes (1)
- Public Transport (1)
- Research Project (1)
- Shoes (1)
- Simulator Sickness (1)
- Spacial Planning (1)
- Teaching (1)
- Telemedicine (1)
- User Centered Design (1)
- Virtual Environment (1)
- Virtual Supermarket (1)
- Weight bearing (1)
- Weight-Bearing (1)
- e-Health (1)
- inspiratory flow rate (1)
- lung simulation (1)
- mechanical upper airway model (1)
- optical aerosol spectrometry (1)
- telemedicine (1)
Department
Entwicklung und Vorstudien zur Implementierung mobiler Rehabilitationssysteme im häuslichen Umfeld
(2015)
Entwicklung und Vorstudien zur Implementierung mobiler Rehabilitationssysteme im häuslichen Umfeld
(2015)
Enhancements of a mechanical lung simulator for ex vivo measuring of aerosol deposition in lungs
(2012)
Dry powder inhalers are used by a large number of patients worldwide to treat respiratory diseases. The objective of this work is to experimentally investigate changes in aerosol particle diameter and particle number concentration of pharmaceutical aerosols generated by four dry powder inhalers under realistic inhalation and exhalation conditions. To simulate patients undergoing inhalation therapy, the active respiratory system model (xPULM™) was used. A mechanical upper airway model was developed, manufactured, and introduced as a part of the xPULM™ to represent the human upper respiratory tract with high fidelity. Integration of optical aerosol spectrometry technique into the setup allowed for evaluation of pharmaceutical aerosols. The results show that there is a significant difference (p < 0.05) in mean particle diameter between inhaled and exhaled particles with the majority of the particles depositing in the lung, while particles with the size of (>0.5 μm) are least influenced by deposition mechanisms. The fraction of exhaled particles ranges from 2.13% (HandiHaler®) over 2.94% (BreezHaler®), and 6.22% (Turbohaler®) to 10.24% (Ellipta®). These values are comparable to previously published studies. Furthermore, the mechanical upper airway model increases the resistance of the overall system and acts as a filter for larger particles (>3 μm). In conclusion, the xPULM™ active respiratory system model is a viable option for studying interactions of pharmaceutical aerosols and the respiratory tract regarding applicable deposition mechanisms. The model strives to support the reduction of animal experimentation in aerosol research and provides an alternative to experiments with human subjects.
Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap between the complex, real anatomical environment and the safe, cost-effective simulation methods. The presented electro-mechanical lung simulator, xPULM, combines in-silico, ex-vivo and mechanical respiratory approaches by realistically replicating an actively breathing human lung. The reproducibility of sinusoidal breathing simulations with xPULM was verified for selected breathing frequencies (10–18 bpm) and tidal volumes (400–600 ml) physiologically occurring during human breathing at rest. Human lung anatomy was modelled using latex bags and primed porcine lungs. High reproducibility of flow and pressure characteristics was shown by evaluating breathing cycles (nTotal = 3273) with highest standard deviation |3σ| for both, simplified lung equivalents (μV˙ = 23.98 ± 1.04 l/min, μP = −0.78 ± 0.63 hPa) and primed porcine lungs (μV˙ = 18.87 ± 2.49 l/min, μP = −21.13 ± 1.47 hPa). The adaptability of the breathing simulation parameters, coupled with the use of porcine lungs salvaged from a slaughterhouse process, represents an advancement towards anatomically and physiologically realistic modelling of human respiration.